CN105683208A - 治疗和/或预防粘膜炎的方法和组合物 - Google Patents

治疗和/或预防粘膜炎的方法和组合物 Download PDF

Info

Publication number
CN105683208A
CN105683208A CN201480057818.5A CN201480057818A CN105683208A CN 105683208 A CN105683208 A CN 105683208A CN 201480057818 A CN201480057818 A CN 201480057818A CN 105683208 A CN105683208 A CN 105683208A
Authority
CN
China
Prior art keywords
compound
haloalkyl
mucositis
alkyl
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480057818.5A
Other languages
English (en)
Chinese (zh)
Inventor
约翰·L·麦格纳尼
约翰·M·彼得逊
英格里德·G·文克勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Crescent Biopharma Inc
Original Assignee
Glycomimetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc filed Critical Glycomimetics Inc
Publication of CN105683208A publication Critical patent/CN105683208A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480057818.5A 2013-09-30 2014-09-29 治疗和/或预防粘膜炎的方法和组合物 Pending CN105683208A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361884856P 2013-09-30 2013-09-30
US61/884,856 2013-09-30
PCT/US2014/057978 WO2015048616A1 (en) 2013-09-30 2014-09-29 Methods and compositions for treating and/or preventing mucositis

Publications (1)

Publication Number Publication Date
CN105683208A true CN105683208A (zh) 2016-06-15

Family

ID=52744558

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480057818.5A Pending CN105683208A (zh) 2013-09-30 2014-09-29 治疗和/或预防粘膜炎的方法和组合物

Country Status (7)

Country Link
US (1) US20170296566A9 (enExample)
EP (1) EP3052510A4 (enExample)
JP (1) JP2016531871A (enExample)
CN (1) CN105683208A (enExample)
AU (1) AU2014324634A1 (enExample)
CA (1) CA2925119A1 (enExample)
WO (1) WO2015048616A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114423772A (zh) * 2019-08-20 2022-04-29 糖模拟物有限公司 用于制备e-选择素抑制剂中间体的方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038423T2 (hu) 2012-12-07 2018-10-29 Glycomimetics Inc E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
CN107108679B (zh) 2014-12-03 2020-10-23 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
CA3002883A1 (en) * 2015-11-03 2017-05-11 Glycomimetics, Inc. Antibodies for targeting cancer stem cells and treating aggressive cancers
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US20200316100A1 (en) * 2016-05-24 2020-10-08 GycoMimetics, Inc. Haloalkyl fucose-containing selectin antagonists
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020123435A2 (en) * 2018-12-10 2020-06-18 Glycomimetics, Inc. Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
JP2023529485A (ja) * 2020-06-14 2023-07-10 グリコミメティクス， インコーポレイテッド Ｅ－セレクチン標的化を介して微小環境媒介耐性を克服するための組成物および方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045910A2 (en) * 1998-03-13 1999-09-16 Mucosal Therapeutics Llc Methods and compositions for treating and preventing mucositis
WO2013096926A1 (en) * 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2264043T1 (en) * 2005-09-02 2018-01-31 Glycomimetics, Inc. HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS
US20160333043A1 (en) * 2014-01-17 2016-11-17 Glycomimetics, Inc. E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045910A2 (en) * 1998-03-13 1999-09-16 Mucosal Therapeutics Llc Methods and compositions for treating and preventing mucositis
WO2013096926A1 (en) * 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARASCH ET AL.: "Palifermin for management of treatment-induced oral mucositis in cancer patients", 《BIOLOGICS: TARGETS & THERAPY》 *
J. HANDSCHEL ET AL.: "IRRADIATION INDUCES INCREASE OF ADHESION MOLECULES AND ACCUMULATION OF β2-INTEGRIN-EXPRESSING CELLS IN HUMANS", 《INT. J. RADIATION ONCOLOGY BIOL. PHYS.》 *
MCLEAN, PETER G., ET AL.: "Effects of a small molecule inhibitor of ICAM-1 and E-selectin expression on colonic inflammatory hyperalgesia and colitis.", 《GASTROENTEROLOGY》 *
WINKLER, INGRID G, ET AL.: "Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery.", 《BLOOD》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114423772A (zh) * 2019-08-20 2022-04-29 糖模拟物有限公司 用于制备e-选择素抑制剂中间体的方法

Also Published As

Publication number Publication date
AU2014324634A1 (en) 2016-04-14
WO2015048616A1 (en) 2015-04-02
US20160243145A1 (en) 2016-08-25
CA2925119A1 (en) 2015-04-02
EP3052510A1 (en) 2016-08-10
US20170296566A9 (en) 2017-10-19
JP2016531871A (ja) 2016-10-13
EP3052510A4 (en) 2017-03-29

Similar Documents

Publication Publication Date Title
JP2016531871A (ja) 粘膜炎を治療および／または予防するための方法および組成物
CN107108679B (zh) E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
JP2021526560A (ja) カンプトテシン誘導体およびその調製方法並びに用途
WO2012142615A2 (en) Auranofin and auranofin analogs useful to treat proliferative disease and disorders
TW202021977A (zh) 含有葡糖苷酸衍生物ｊａｋ抑制劑的前藥及其製備方法和應用
CN104829671B (zh) No供体型的吉西他滨/fta/呋咱缀合物及制备方法和用途
WO2023142518A1 (zh) 羟基萘酮-苯硼酸类化合物、制备方法和用途
CN107216283B (zh) 一种含有二氢吡啶结构的β-榄香烯衍生物及其制备方法和用途
CN102250138A (zh) 一种杂氮锗三环类化合物及其制备方法和应用
CN108473449B (zh) 一种作为吲哚胺-2,3-双加氧酶抑制剂的砜脒及其制备方法和用途
TW201922690A (zh) 環－amp反應元素結合蛋白的抑制劑
CN111171041B (zh) 20位取代的喜树碱衍生物及其制备方法和应用
WO2019192031A1 (zh) 雷公藤内酯醇衍生物及其制备方法和应用
EP4143200A1 (en) Cd33 ligands suitable for incorporation into carriers
JP2011530539A (ja) 腫瘍形成を抑制する脂質化合物
CN116120254B (zh) 13,14-双一氧化氮供体-β-榄香烯衍生物及其制备和应用
RU2720180C2 (ru) Соединения, применяемые в лечении неопластических заболеваний
WO2026026748A1 (zh) 蒽环类衍生物及其制备方法和应用
JP2023544251A (ja) 新規医薬化合物、その方法および使用
JP2023542455A (ja) ３－デオキシ－２－ケトアルドン酸窒素含有誘導体、その製造方法及びその使用
WO2014070988A1 (en) Compounds and methods to enhance the oral availability of glycomimetics
HK1240233A1 (en) Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
HK1240233B (en) Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
TW201945008A (zh) 氯法拉濱（Ｃｌｏｆａｒａｂｉｎｅ）衍生物，其製法及其醫藥組成物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160615