JP2016531871A - 粘膜炎を治療および／または予防するための方法および組成物 - Google Patents

粘膜炎を治療および／または予防するための方法および組成物 Download PDF

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JP2016531871A
JP2016531871A JP2016517444A JP2016517444A JP2016531871A JP 2016531871 A JP2016531871 A JP 2016531871A JP 2016517444 A JP2016517444 A JP 2016517444A JP 2016517444 A JP2016517444 A JP 2016517444A JP 2016531871 A JP2016531871 A JP 2016531871A
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mucositis
formula
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JP2016531871A5 (enExample
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ジョン エル． マグナニ，
ジョン エル． マグナニ，
ジョン エム． ピーターソン，
ジョン エム． ピーターソン，
イングリッド ジー． ウィンクラー，
イングリッド ジー． ウィンクラー，
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グリコミメティクス， インコーポレイテッド
グリコミメティクス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016517444A 2013-09-30 2014-09-29 粘膜炎を治療および／または予防するための方法および組成物 Pending JP2016531871A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361884856P 2013-09-30 2013-09-30
US61/884,856 2013-09-30
PCT/US2014/057978 WO2015048616A1 (en) 2013-09-30 2014-09-29 Methods and compositions for treating and/or preventing mucositis

Publications (2)

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JP2016531871A true JP2016531871A (ja) 2016-10-13
JP2016531871A5 JP2016531871A5 (enExample) 2017-10-05

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JP2016517444A Pending JP2016531871A (ja) 2013-09-30 2014-09-29 粘膜炎を治療および／または予防するための方法および組成物

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US (1) US20170296566A9 (enExample)
EP (1) EP3052510A4 (enExample)
JP (1) JP2016531871A (enExample)
CN (1) CN105683208A (enExample)
AU (1) AU2014324634A1 (enExample)
CA (1) CA2925119A1 (enExample)
WO (1) WO2015048616A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022546277A (ja) * 2019-08-20 2022-11-04 グリコミメティクス， インコーポレイテッド Ｅセレクチン阻害剤中間体を調製するためのプロセス
JP2023145674A (ja) * 2018-03-05 2023-10-11 グリコミメティクス， インコーポレイテッド 急性骨髄性白血病および関連状態を処置する方法

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HUE038423T2 (hu) 2012-12-07 2018-10-29 Glycomimetics Inc E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
CN107108679B (zh) 2014-12-03 2020-10-23 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
CA3002883A1 (en) * 2015-11-03 2017-05-11 Glycomimetics, Inc. Antibodies for targeting cancer stem cells and treating aggressive cancers
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US20200316100A1 (en) * 2016-05-24 2020-10-08 GycoMimetics, Inc. Haloalkyl fucose-containing selectin antagonists
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
WO2020123435A2 (en) * 2018-12-10 2020-06-18 Glycomimetics, Inc. Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
JP2023529485A (ja) * 2020-06-14 2023-07-10 グリコミメティクス， インコーポレイテッド Ｅ－セレクチン標的化を介して微小環境媒介耐性を克服するための組成物および方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506023A (ja) * 1998-03-13 2002-02-26 ミュコーサル セラピューティックス エルエルシー 粘膜炎の処置および予防のための方法および組成物
JP2009507031A (ja) * 2005-09-02 2009-02-19 グリコミメティクス， インコーポレイテッド ヘテロ二官能性全セレクチン阻害剤
WO2013096926A1 (en) * 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160333043A1 (en) * 2014-01-17 2016-11-17 Glycomimetics, Inc. E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506023A (ja) * 1998-03-13 2002-02-26 ミュコーサル セラピューティックス エルエルシー 粘膜炎の処置および予防のための方法および組成物
JP2009507031A (ja) * 2005-09-02 2009-02-19 グリコミメティクス， インコーポレイテッド ヘテロ二官能性全セレクチン阻害剤
WO2013096926A1 (en) * 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARASCH, A. ET AL: "Palifermin for management of treatment-induced oral mucositis in cancer patients", BIOLOGICS: TARGETS & THERAPY, vol. 3, JPN7018001448, 2009, pages 111 - 116, ISSN: 0003932384 *
HANDSCHEL, J. ET AL: "Irradiation induces increase of adhesion molecules and accumulation of beta2-integrin-expressing cel", INT. J. RADIATION BIOL. PHYS., vol. 45, no. 2, JPN6018016535, 1999, pages 475 - 481, ISSN: 0003932385 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023145674A (ja) * 2018-03-05 2023-10-11 グリコミメティクス， インコーポレイテッド 急性骨髄性白血病および関連状態を処置する方法
JP2022546277A (ja) * 2019-08-20 2022-11-04 グリコミメティクス， インコーポレイテッド Ｅセレクチン阻害剤中間体を調製するためのプロセス

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Publication number Publication date
AU2014324634A1 (en) 2016-04-14
WO2015048616A1 (en) 2015-04-02
US20160243145A1 (en) 2016-08-25
CN105683208A (zh) 2016-06-15
CA2925119A1 (en) 2015-04-02
EP3052510A1 (en) 2016-08-10
US20170296566A9 (en) 2017-10-19
EP3052510A4 (en) 2017-03-29

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