CN105663828A - 一种用于治疗产后抑郁症的药物及制备方法 - Google Patents
一种用于治疗产后抑郁症的药物及制备方法 Download PDFInfo
- Publication number
- CN105663828A CN105663828A CN201610094492.4A CN201610094492A CN105663828A CN 105663828 A CN105663828 A CN 105663828A CN 201610094492 A CN201610094492 A CN 201610094492A CN 105663828 A CN105663828 A CN 105663828A
- Authority
- CN
- China
- Prior art keywords
- parts
- medicine
- root
- treatment
- post
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 55
- 201000009916 postpartum depression Diseases 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 229940079593 drugs Drugs 0.000 title description 7
- 240000006745 Valeriana officinalis Species 0.000 claims abstract description 10
- 235000013832 Valeriana officinalis Nutrition 0.000 claims abstract description 10
- 235000016788 valerian Nutrition 0.000 claims abstract description 10
- 241000244301 Libanotis Species 0.000 claims abstract description 9
- 240000006918 Orchis Species 0.000 claims abstract description 9
- 241000001348 Phtheirospermum Species 0.000 claims abstract description 9
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims abstract description 9
- 241000018646 Pinus brutia Species 0.000 claims abstract description 9
- 235000011613 Pinus brutia Nutrition 0.000 claims abstract description 9
- 241001530209 Swertia Species 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 240000007594 Oryza sativa Species 0.000 claims description 10
- 235000007164 Oryza sativa Nutrition 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 235000009566 rice Nutrition 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 9
- 244000182264 Lucuma nervosa Species 0.000 claims description 8
- 235000000564 Lucuma nervosa Nutrition 0.000 claims description 8
- 235000011779 Menyanthes trifoliata Nutrition 0.000 claims description 8
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 8
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 8
- 241000921453 Rhodobryum Species 0.000 claims description 8
- 241000220317 Rosa Species 0.000 claims description 8
- 241000724115 Ziziphus lotus Species 0.000 claims description 8
- 240000008866 Ziziphus nummularia Species 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000004880 explosion Methods 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 230000001376 precipitating Effects 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 241001105553 Menyanthes Species 0.000 claims 5
- 241001122767 Theaceae Species 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 3
- 235000008216 herbs Nutrition 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 230000001476 alcoholic Effects 0.000 claims 1
- 210000000952 Spleen Anatomy 0.000 abstract description 18
- 208000002193 Pain Diseases 0.000 abstract description 15
- 230000036407 pain Effects 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
- 239000004615 ingredient Substances 0.000 abstract description 8
- 230000001737 promoting Effects 0.000 abstract description 8
- 210000004369 Blood Anatomy 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 6
- 230000002936 tranquilizing Effects 0.000 abstract description 5
- 230000001105 regulatory Effects 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 3
- 231100000486 side effect Toxicity 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 241001646982 Thamnolia vermicularis Species 0.000 abstract 2
- 241000871539 Choerospondias Species 0.000 abstract 1
- 241000037488 Coccoloba pubescens Species 0.000 abstract 1
- 240000008915 Passiflora edulis Species 0.000 abstract 1
- 235000000370 Passiflora edulis Nutrition 0.000 abstract 1
- 240000000793 Pinus armandii Species 0.000 abstract 1
- 235000011612 Pinus armandii Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 241001491006 Pteridium aquilinum subsp. latiusculum Species 0.000 abstract 1
- 210000000582 Semen Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 15
- 206010022437 Insomnia Diseases 0.000 description 12
- 235000009508 confectionery Nutrition 0.000 description 12
- 210000002784 Stomach Anatomy 0.000 description 10
- 241000411851 herbal medicine Species 0.000 description 10
- 210000004185 Liver Anatomy 0.000 description 8
- 206010033557 Palpitations Diseases 0.000 description 8
- 210000003734 Kidney Anatomy 0.000 description 7
- 206010012735 Diarrhoea Diseases 0.000 description 6
- 208000001848 Dysentery Diseases 0.000 description 6
- 206010019233 Headache Diseases 0.000 description 6
- 231100000869 headache Toxicity 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 5
- 206010022114 Injury Diseases 0.000 description 5
- 210000003205 Muscles Anatomy 0.000 description 5
- 201000008286 diarrhea Diseases 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 206010003549 Asthenia Diseases 0.000 description 4
- 210000000988 Bone and Bones Anatomy 0.000 description 4
- 206010015037 Epilepsy Diseases 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 4
- 206010022998 Irritability Diseases 0.000 description 4
- 208000007443 Neurasthenia Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 231100000614 Poison Toxicity 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 201000010238 heart disease Diseases 0.000 description 4
- 206010002368 Anger Diseases 0.000 description 3
- 206010002855 Anxiety Diseases 0.000 description 3
- 206010057666 Anxiety disease Diseases 0.000 description 3
- 208000002894 Beriberi Diseases 0.000 description 3
- 206010013935 Dysmenorrhoea Diseases 0.000 description 3
- 206010022000 Influenza Diseases 0.000 description 3
- 210000004072 Lung Anatomy 0.000 description 3
- 240000008821 Menyanthes trifoliata Species 0.000 description 3
- 206010029216 Nervousness Diseases 0.000 description 3
- 206010072736 Rheumatic disease Diseases 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 3
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 230000003203 everyday Effects 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 231100000862 numbness Toxicity 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000003014 reinforcing Effects 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010000269 Abscess Diseases 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 208000002173 Dizziness Diseases 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 206010018987 Haemorrhage Diseases 0.000 description 2
- 206010019345 Heat stroke Diseases 0.000 description 2
- 208000006572 Human Influenza Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 241000731961 Juncaceae Species 0.000 description 2
- 206010027339 Menstruation irregular Diseases 0.000 description 2
- 210000003800 Pharynx Anatomy 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 2
- 208000004371 Toothache Diseases 0.000 description 2
- 230000003356 anti-rheumatic Effects 0.000 description 2
- 239000003435 antirheumatic agent Substances 0.000 description 2
- 230000000740 bleeding Effects 0.000 description 2
- 231100000319 bleeding Toxicity 0.000 description 2
- 230000001914 calming Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000001976 improved Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 230000001717 pathogenic Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 230000025627 positive regulation of urine volume Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000002522 swelling Effects 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- 210000001015 Abdomen Anatomy 0.000 description 1
- 241000173529 Aconitum napellus Species 0.000 description 1
- 208000005298 Acute Pain Diseases 0.000 description 1
- 206010054196 Affect lability Diseases 0.000 description 1
- 208000007502 Anemia Diseases 0.000 description 1
- 206010002515 Animal bite Diseases 0.000 description 1
- 206010003246 Arthritis Diseases 0.000 description 1
- 206010061590 Blood disease Diseases 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- 206010006451 Bronchitis Diseases 0.000 description 1
- 206010007554 Cardiac failure Diseases 0.000 description 1
- AHOUBRCZNHFOSL-YOEHRIQHSA-N Casbol Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 185.9,144.5 L 171.5,111.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 190.4,136.7 L 180.3,113.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-6 atom-0' d='M 221.7,148.6 L 185.9,144.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 171.5,111.5 L 192.9,82.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 192.9,82.6 L 188.9,73.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 188.9,73.4 L 184.9,64.3' style='fill:none;fill-rule:evenodd;stroke:#77D8ED;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-2 atom-4' d='M 192.9,82.6 L 228.7,86.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-2 atom-4' d='M 197.5,90.3 L 222.5,93.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 228.7,86.6 L 243.1,119.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 243.1,119.6 L 221.7,148.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 234.1,119.6 L 219.1,139.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 221.7,148.6 L 236.2,181.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 236.2,181.6 L 214.8,210.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 242.1,182.8 L 242.2,181.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 248.0,184.1 L 248.2,181.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 253.8,185.4 L 254.2,181.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 259.7,186.6 L 260.3,181.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 265.6,187.9 L 266.3,181.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 271.5,189.2 L 272.3,182.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 214.8,210.5 L 179.4,203.0 L 178.6,210.1 Z' style='fill:#3B4143;fill-rule:evenodd;fill-opacity:1;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path class='bond-19 atom-8 atom-20' d='M 214.8,210.5 L 229.2,243.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 179.0,206.5 L 175.0,197.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 175.0,197.4 L 171.0,188.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 152.2,172.1 L 140.5,170.8' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 140.5,170.8 L 128.8,169.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 128.8,169.5 L 107.4,198.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 119.8,169.6 L 104.8,189.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-11 atom-19' d='M 128.8,169.5 L 114.4,136.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 107.4,198.5 L 71.6,194.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 71.6,194.5 L 63.5,201.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 63.5,201.7 L 55.3,209.0' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-26 atom-17 atom-13' d='M 57.2,161.5 L 71.6,194.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-26 atom-17 atom-13' d='M 66.0,163.6 L 76.1,186.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 33.3,211.7 L 23.5,205.9' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 23.5,205.9 L 13.6,200.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 13.6,200.2 L 15.8,190.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 15.8,190.2 L 18.0,180.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-16 atom-17' d='M 33.8,163.8 L 45.5,162.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-16 atom-17' d='M 45.5,162.7 L 57.2,161.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 57.2,161.5 L 78.6,132.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 78.6,132.5 L 114.4,136.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 83.1,140.3 L 108.2,143.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-20 atom-21' d='M 229.2,243.5 L 240.9,244.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-20 atom-21' d='M 240.9,244.9 L 252.6,246.2' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 273.1,236.5 L 279.7,227.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 279.7,227.6 L 286.4,218.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-22 atom-22 atom-23' d='M 286.4,218.6 L 271.9,185.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='174.2' y='56.8' class='atom-3' style='font-size:14px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#77D8ED' >F</text>
<text x='160.3' y='180.7' class='atom-10' style='font-size:14px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='40.4' y='225.6' class='atom-14' style='font-size:14px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='17.0' y='172.2' class='atom-16' style='font-size:14px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='260.7' y='254.8' class='atom-21' style='font-size:14px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='270.6' y='254.8' class='atom-21' style='font-size:14px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 52.2,40.3 L 48.1,31.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 53.4,38.1 L 50.6,31.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-6 atom-0' d='M 62.3,41.5 L 52.2,40.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 48.1,31.0 L 54.2,22.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 54.2,22.8 L 52.8,19.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 52.8,19.7 L 51.5,16.7' style='fill:none;fill-rule:evenodd;stroke:#77D8ED;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-2 atom-4' d='M 54.2,22.8 L 64.3,23.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-2 atom-4' d='M 55.4,25.0 L 62.5,25.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 64.3,23.9 L 68.4,33.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 68.4,33.2 L 62.3,41.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 65.8,33.3 L 61.6,39.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 62.3,41.5 L 66.4,50.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 66.4,50.8 L 60.4,59.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 69.8,51.5 L 69.8,50.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 73.1,52.2 L 73.2,50.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-7 atom-23' d='M 76.4,53.0 L 76.7,50.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 60.4,59.0 L 50.3,56.9 L 50.1,58.9 Z' style='fill:#3B4143;fill-rule:evenodd;fill-opacity:1;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path class='bond-19 atom-8 atom-20' d='M 60.4,59.0 L 64.4,68.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 50.2,57.9 L 48.9,54.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 48.9,54.8 L 47.6,51.8' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 44.1,48.3 L 40.0,47.8' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 40.0,47.8 L 36.0,47.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 36.0,47.4 L 29.9,55.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 33.4,47.4 L 29.2,53.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-11 atom-19' d='M 36.0,47.4 L 31.9,38.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 29.9,55.6 L 19.8,54.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 19.8,54.5 L 17.0,56.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 17.0,56.9 L 14.2,59.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-26 atom-17 atom-13' d='M 15.7,45.1 L 19.8,54.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-26 atom-17 atom-13' d='M 18.2,45.7 L 21.1,52.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 10.1,60.0 L 6.7,58.1' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 6.7,58.1 L 3.4,56.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 3.4,56.1 L 4.1,52.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 4.1,52.7 L 4.8,49.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-16 atom-17' d='M 7.6,45.9 L 11.7,45.5' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-16 atom-17' d='M 11.7,45.5 L 15.7,45.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 15.7,45.1 L 21.8,36.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 21.8,36.9 L 31.9,38.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 23.1,39.1 L 30.2,39.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-20 atom-21' d='M 64.4,68.4 L 68.5,68.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-20 atom-21' d='M 68.5,68.8 L 72.5,69.3' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 76.1,67.4 L 78.4,64.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 78.4,64.4 L 80.6,61.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-22 atom-22 atom-23' d='M 80.6,61.3 L 76.6,51.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='48.3' y='16.4' class='atom-3' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#77D8ED' >F</text>
<text x='44.3' y='51.5' class='atom-10' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='10.4' y='64.2' class='atom-14' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='3.8' y='49.1' class='atom-16' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='72.8' y='72.5' class='atom-21' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='76.9' y='72.5' class='atom-21' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
</svg>
 C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 206010012378 Depression Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 208000005679 Eczema Diseases 0.000 description 1
- 206010014599 Encephalitis Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 206010016766 Flatulence Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010019280 Heart failure Diseases 0.000 description 1
- 208000005209 Hematologic Disease Diseases 0.000 description 1
- 208000002287 Hemorrhoids Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 210000001624 Hip Anatomy 0.000 description 1
- 208000004356 Hysteria Diseases 0.000 description 1
- 210000001503 Joints Anatomy 0.000 description 1
- 201000009672 Keshan disease Diseases 0.000 description 1
- 206010024855 Loss of consciousness Diseases 0.000 description 1
- 210000003141 Lower Extremity Anatomy 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010028334 Muscle spasms Diseases 0.000 description 1
- 210000002464 Muscle, Smooth, Vascular Anatomy 0.000 description 1
- 208000009525 Myocarditis Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000008425 Protein Deficiency Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000004124 Rheumatic Heart Disease Diseases 0.000 description 1
- 101700050571 SUOX Proteins 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 210000003932 Urinary Bladder Anatomy 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 210000002700 Urine Anatomy 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046901 Vaginal discharge Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000494 adverse effect Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000001754 anti-pyretic Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 201000002574 conversion disease Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000994 depressed Effects 0.000 description 1
- 230000003001 depressive Effects 0.000 description 1
- 201000004624 dermatitis Diseases 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000005059 dormancy Effects 0.000 description 1
- 231100001003 eczema Toxicity 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable Effects 0.000 description 1
- 235000021022 fresh fruits Nutrition 0.000 description 1
- 230000002496 gastric Effects 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 201000001429 intracranial thrombosis Diseases 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 230000002045 lasting Effects 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 201000009906 meningitis Diseases 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental Effects 0.000 description 1
- 230000003020 moisturizing Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000000422 nocturnal Effects 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 201000008125 pain agnosia Diseases 0.000 description 1
- 244000045947 parasites Species 0.000 description 1
- 244000052769 pathogens Species 0.000 description 1
- 230000000607 poisoning Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000003393 splenic Effects 0.000 description 1
- 230000004936 stimulating Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000002142 suicide Effects 0.000 description 1
- 230000001502 supplementation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/09—Lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/10—Bryophyta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
本发明公开了一种用于治疗产后抑郁症的药物及制备方法，属中药领域；本发明药物有效成分的原料组成为：南酸枣、松叶、豆豉姜、鸡蛋果、莲子、谷芽、草柏枝、睡菜、乌金草、蕨根、红门兰、雪茶、茯神、回心草、缬草和长春七；本发明药物配伍相宜，诸药相合具有行气活血、镇静安神、疏肝解郁、健脾和营、理气止痛的功效，对于治疗产后抑郁症具有见效快、治愈率高、无毒副作用、安全方便的优点，有较为显著的作用，同时明显提高了人体的免疫力，可广泛应用于产后抑郁症的临床治疗。
Description
-种用于治疗产后抑郁症的药物及制备方法 所属技术领域
[0001] 本发明设及中药领域，尤其设及一种用于治疗产后抑郁症的药物及制备方法。
背景技术
[0002] 产后抑郁症是女性精神障碍中最为常见的类型，是女性生产之后，由于性激素、社 会角色及屯、理变化所带来的身体、情绪、屯、理等一系列变化。典型的产后抑郁症是产后6周 内发生，可持续整个产稱期，有的甚至持续至幼儿上学前。产后抑郁症的发病率在15%-30%。产后抑郁症通常在6周内发病，可在3-6个月自行恢复，但严重的也可持续1-2年，再次 妊娠则有20 % -30 %的复发率。
[0003] 产稱期抑郁症的患者易激惹、恐怖、焦虑、沮丧和对自身及婴儿健康过度担忧，常 失去生活自理及照料婴儿的能力，有时还会陷入错乱或嗜睡状态。约80%的病例，W失眠、 头痛、身痛、头昏、眼花、耳鸣等躯体症状为主向医生求助。运些症状往往给人体诉多而易变 的感觉，有些症状可W长期存在，但无明显加重或缓解。运些症状多随着抑郁情绪的解除而 消失。
[0004] 研究表明，母婴连接不良时母亲可能拒绝照管宝宝，令宝宝发生损伤，并妨碍宝宝 的正常发育、生长。抑郁母亲对孩子的不利影响，主要包括阅读能力W及运动技巧方面。而 有研究发现，母亲有抑郁症的女孩，会比其他普通女孩提前进入青春期。产后抑郁症患者身 体感到不适。产后抑郁症虽说是精神疾病，但很多病人都有身体不适:如口干、便秘、食欲减 退、消化不良、屯、惇、气短胸闷等。产后抑郁症病情严重时，产妇会出现极度的悲观厌世情 绪，想要一死解脱。但又恐孩子将来无人照顾，便会出现杀婴念头和行为。另外，也有部分抑 郁产妇受病情影响脾气暴躁易怒，嫌半夜哭闹用枕头捂孩子。产后抑郁症常会产生自杀倾 向，应及时疏导治疗。据了解，产后抑郁症的患者明显增多，近年来有许多在产前就表现出 抑郁情绪，严重抑郁发作的患者常会有消极自杀倾向，自杀死亡率可达15%到25%。
[0005] 由于产妇处于哺乳期，用药很容易对婴儿产生一定的副作用，所W治疗产妇贫血 的药物必须安全、有效、无毒副作用；中药学作为我国的传统医学，具有作用强、见效快、药 效持久等优点，且没有依赖性、耐药性W及毒副作用，若从中选择一种药物治疗产后抑郁 症，对于产后抑郁症将具有十分重要的临床意义。
发明内容
[0006] 本发明提供了一种用于治疗产后抑郁症的药物及制备方法;本发明药物配伍相 宜，诸药相合具有行气活血、镇静安神、疏肝解郁、健脾和营、理气止痛的功效，对于治疗产 后抑郁症具有见效快、治愈率高、无毒副作用、安全方便的优点，有较为显著的作用，同时明 显提高了人体的免疫力，可广泛应用于产后抑郁症的临床治疗。
[0007] 为实现上述目的，本发明的技术方案实施如下：
[000引一种用于治疗产后抑郁症的药物，制成所述药物有效成分的原料组成及重量份数 为： 南酸巧34-58份松叶32-日7份豆鼓姜30-日4份鸡蛋果30-日4份 莲子27-日2份谷芽26-日日份草柏枝26-日日份睡菜巧-45份
[0009] 乌金草現-45份藤狼24-42粉紀n兰24-42粉蕾蒸22-4打償 巧神22-37份回也草21-34份鑛草20-32份长春4： 17-27份。
[0010] 制成所述药物有效成分的原料组成及重量份数为： 南酸巧日2份松叶煎餘豆玻姜48份鸡蛋果媽份 莲子巧份谷芽44份草柏枝44份睡菜40份
[0011] 乌金草40份藤根37份红口兰37份雪茶35份 巧神33份回必草渊餘鎌草29份长春屯24份。
[0012] 制成所述药物有效成分的原料组成及重量份数为：
[0013] 南酸要46份松叶M份豆致姜42份鸡蛋果42份 莲子39份谷芽38汾草柏枝％份睡菜35汾
[0014] 乌金草35份藤根33份红口兰33份雪茶31份 巧神3日份回必草巧份鑛草26份长春^^22份。
[0015] 制成所述药物有效成分的原料组成及重量份数为： 南酸麥40份檢叶滞份豆玻姜说粉鸡蛋果36份 莲子33份爸芽32份草柏枝32份睡菜30份
[0016] 乌金草30份藤粮29份组n兰2自份雪茶27份 巧神27份间也草24份顯草23份长春毛20份。
[0017] -种用于治疗产后抑郁症的药物的制备方法，包括W下工艺步骤：
[001引（1)将南酸要、鸡蛋果、莲子、乌金草、藤根、红口兰、雪茶、巧神和回屯、草放入容器 中，首先加入10-15倍量蒸馈水浸泡4-5小时后，加热煮沸3-4小时，提取;第二次加8-10倍量 蒸馈水加热煮沸2-3小时，提取;第S次加6-8倍量蒸馈水加热煮沸1-2小时，提取;合并提取 液，滤过，得滤液备用；
[0019] (2)将松叶、豆鼓姜、草柏枝、鄉草和长春屯研末后，浸入体积浓度为90%酒精溶 液，静置4小时，取出上层清液，沉淀下来的浸膏备用；
[0020] (3)将谷芽置锅内用文火炒至深黄色并大部爆裂，取出放凉，研末，过200目细粉， 备用；
[0021] (4)将睡菜绞汁，滤杂质，留汁液，备用；
[0022] (5)将步骤（1)-(4)制得的滤液、浸膏、细粉W及汁液混合，制成片剂，即为所述的 用于治疗产后抑郁症的药物。
[0023] 本发明所用中药的药性如下：
[0024] 南酸要:味甘、酸，性平;归脾、肝经。行气活血，养屯、安神，消积，解毒。主气滞血疲， 胸痛，屯、惇气短，神经衰弱，失眠，支气管炎，食滞腹满，腹泻，痛气，烫火伤。《广西中草药》 载："鲜果，消食滞，治食滞腹痛果核，清热毒，杀虫收敛。治汤火伤。"
[0025]松叶：味苦，性溫；归屯、、脾经。桂风燥湿，杀虫止痒，活血安神。主风湿瘦搏，脚气， 湿疮，癖，风疹痊痒，跌打损伤，神经衰弱，慢性肾炎，高血压病。预防乙脑、流感。广州部队 《常用中草药手册》载："治神经衰弱，维生素丙缺乏，营养性水肿;防治流脑，流感。"
[00%]豆鼓姜:味辛、溫，性苦;归肝、脾、胃经。桂风除湿，理气止痛。主感冒，屯、胃冷痛，腹 痛吐泻，脚气，孕妇水肿，风湿搏痛，跌打损伤，脑血栓形成。《南宁市药物志》载："行气止痛， 桂风湿，理筋骨。治胃冷痛，孕妇水肿，跌打宽筋。"
[0027]鸡蛋果:味甘、酸，性平；归屯、、大肠经。清肺润燥，安神止痛，和血止频。主咳嗽，咽 干，声嘶，大便秘结，失眼，痛经，关节痛，频疾。《新华本草纲要》载："果实:味甘，酸、性平。有 安神、宁屯、、和血，止痛的功能。用于频疾，痛经，失眠。"
[002引莲子:味甘、涩，性平；归屯、、脾、肾、胃、肝、膀脫经。补脾止泻，益肾固精，养屯、安神。 主脾虚久泻，泻久频，肾虚遗精，滑泄，小便不禁，妇人崩漏带下，屯、神不宁，惊惇，不眠。《纲 目》载："交屯、肾，厚肠胃，固精气，强筋骨，补虚损，利耳目，除寒湿，止脾泄久频，赤白浊，女 人带下崩中诸血病。"
[0029] 谷芽:味甘，性平;归脾、胃经。消食化积，健脾开胃。主食品店积停滞，胀满泄泻，脾 虚少食，脚气浮肿。《本草经疏》载："葉米即稻葉也。具生化之性，故为消食健脾、开胃和中之 要药，脾胃和则中自攝，气自下，热自除也。"
[0030] 草柏枝：味辛、苦，性平；归屯、经。散疲妥毒，养屯、安神。主骨折肿痛，咳嗽，普中带 血，咽喉肿痛，屯、惇怔神，蛇犬咬伤。
[0031] 睡菜:味甘、微苦，性寒；归屯、、脾经。健脾消食，养屯、安神，清热利尿。主胃炎，消化 不良，屯、惇失眠，湿热黄痘，胆囊炎，水肿，小便不利或赤热涩痛。《北方常用中草药手册》载： "健脾消食，养屯、安神。治胃炎，胃痛，消化不良、屯、惇失眠、屯、神不安。"
[0032] 乌金草:味甘、微苦，性平；归屯、、肝经。平肝阳，养屯、安神，养血调经。主头晕，神经 衰弱，高血压病，贫血，月经不调。
[0033] 藤根:味甘，性寒；归肺、肝、脾、大肠经。清热，利湿，平肝安神，解毒消肿。主发热， 咽喉肿痛，腹泻，频疾，黄痘，白带，高血压，头昏失眠，风湿搏痛，持疮，脱肛，湿疹，烫伤，蛇 虫咬伤。《吉林中草药》载："解热，利尿，益气，养阴。治高热神昏，五脏虚损，气滞经络，筋骨 疼痛。"
[0034] 红口兰：味甘，性平；归屯、、肾、胃经。补肾养阴，健脾益胃。主阴虚瘦热，烦躁口渴， 不思饮食，经不调。《内蒙古中草药》载："强屯、，补肾，生津，止渴，健脾胃，治烦躁口渴，不思 饮食，阴液不足，月经不调。"
[0035] 雪茶:味甘、苦、淡，性凉；归肺、胃、屯、、肝经。清热生津，醒脑安神。主中暑，屯、烦口 渴，肺热咳嗽，阴虚潮热，癒痛，失眠，目疾。《陕西中草药》载："清热解渴，安神养屯、，明目。治 屯、中烦热，虚劳骨蒸，肺炎咳嗽，癒痛狂躁，神经衰弱，目涩，中暑，高血压。"
[0036] 巧神:味甘、淡，性平；归屯、、脾经。宁屯、读神，利水。主惊惇，健忘，健忘失眠，惊痛， 小便不利。《药性论》载："主惊痛，安神定志，补劳乏;主屯、下急痛坚满，小肠不利。"
[0037] 回屯、草:味淡、微苦，性平；归屯、经。养屯、安神，镇静。主屯、脏病，屯、慌，屯、惇怔忡，神 经衰弱。《云南思茅中草药选》载：巧神镇静。治屯、慌、屯、惇、屯、脏病。"
[003引鄉草:味辛、苦，性溫;!I3屯、、肝经。安屯、神。主屯、神不安，屯、惇失眠，癒狂，脏躁，风湿 搏痛，痛经，经闭，跌打损伤。《陕西中草药》载："安神镇静，驱风解疫，生肌止血，止痛。治療 病，克山病，屯、脏病（屯、肌炎、产后屯、脏病、风湿性屯、脏病合并屯、力衰竭），腰腿痛，胃肠疫李， 关节炎，跌打损伤，外伤出血。"现代医学研究证实，鄉草有镇静作用，能加强大脑皮层的抑 制过程，减低反射兴奋性，解除平滑肌疫李。
[0039] 长春屯:味辛、甘，性溫。发表散寒，桂风除湿，消肿止痛。主风寒感冒，头痛，牙痛， 风湿搏痛，风湿搏痛，筋骨麻木，跌打伤肿。《陕西中草药》载："发散风寒，桂风湿，镇痛，健脾 胃，止咳，解毒。治感冒风寒，周身疼痛，咳嗽，头痛，牙痛，关节肿痛，跌打损伤，风湿筋骨疼 痛、麻木，金牛屯中毒
[0040] 本发明与现有技术相比，具有W下有益效果：
[0041] 本发明药物配伍相宜，诸药相合具有行气活血、镇静安神、疏肝解郁、健脾和营、理 气止痛的功效，对于治疗产后抑郁症具有见效快、治愈率高、无毒副作用、安全方便的优点， 有较为显著的作用，同时明显提高了人体的免疫力，可广泛应用于产后抑郁症的临床治疗。
具体实施方式
[0042] 下面结合具体实施例对本发明做进一步阐述。
[0043] 实施例1
[0044] 本发明药物有效成分的原料组成及重量为： 南酸娶57g松叶日6g豆鼓姜53g鸡蛋果53g 莲子51g谷芽49g:草梢拔铅g睡菜44呂
[0045] 乌金草44g藤根41g红广〕兰礼揉雪茶39g' 巧神36g回.也草.说g续男草沉岩'长.春屯2牠6.
[0046] 本发明药物制备方法的工艺步骤为：
[0047] (1)将南酸要、鸡蛋果、莲子、乌金草、藤根、红口兰、雪茶、巧神和回屯、草放入容器 中，首先加入10-15倍量蒸馈水浸泡4-5小时后，加热煮沸3-4小时，提取;第二次加8-10倍量 蒸馈水加热煮沸2-3小时，提取;第S次加6-8倍量蒸馈水加热煮沸1-2小时，提取;合并提取 液，滤过，得滤液备用；
[004引（2)将松叶、豆鼓姜、草柏枝、鄉草和长春屯研末后，浸入体积浓度为90%酒精溶 液，静置4小时，取出上层清液，沉淀下来的浸膏备用；
[0049] (3)将谷芽置锅内用文火炒至深黄色并大部爆裂，取出放凉，研末，过200目细粉， 备用；
[0050] (4)将睡菜绞汁，滤杂质，留汁液，备用；
[0051] (5)将步骤（1)-(4)制得的滤液、浸膏、细粉W及汁液混合，制成片剂，即为所述的 用于治疗产后抑郁症的药物。
[0052] 用法用量：口服，每日3次，每次2片，7天为一疗程，轻者2到4个疗程即可痊愈，病情 严重者遵医嘱酌增用量。
[0化3] 实施例2
[0054]本发明药物有效成分的原料组成及重量为： 南酸专52g松叶日Og豆鼓姜48g鸡蛋果48g 莲子巧g谷芽44g草柏枝44g睡菓40g
[0化5] 乌金草40g厳根37g化口兰舒g雪茶％g 巧神33g回屯、草30g鄉草29g长春韦24g。
[0056]本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
[0化7]实施例3
[005引本发明药物有效成分的原料组成及重量为： 南酸專:46g松叶44:目豆鼓姜42g鸡蛋果42g 莲子39g谷芽38g草柏枝38g睡菜35g
[0化9] 乌金草358藤根33g红口兰33g雪茶31g 巧神3()g回也草27g顯草26g长春屯22g。
[0060]本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
[0061 ] 实施例4
[0062] 本发明药物有效成分的原料组成及重量为： 南酸安40g松叶3始豆鼓姜Wg鸡蛋果Wg 莲乎3始谷芽32g草柏枝32g睡薬撕g
[0063] 乌金草30g藤根29g红口兰29g雪茶27g 巧神巧g回私草鑛草2始长春屯20g。
[0064] 本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
[0065] 临床资料：
[0066] 1、病例选择：
[0067] 作为治疗产后抑郁症的药物，选择我院或外院确诊的产后抑郁症患者100例临床 观察，病人随机分成两组，治疗组50例，女性50例，年龄20-40岁，平均年龄30岁，病程1个月-2年;对照组50例，女性50例，年龄22-36岁，平均年龄28岁，病程病程1个月-2年。两组病例的 病程、症状轻重程度基本一致，无显著差异，具有可比性。
[006引 2、药物选择：
[0069] 治疗组患者服用本发明药物，每日3次，每次2片，饭后半小时内溫开水送服，7天为 一疗程，连续服用2到4个疗程即可痊愈，病情严重者遵医嘱酌增用量。
[0070] 对照组服用赛乐特，按说明书用，病情严重者遵医嘱酌增用量。
[0071] 3、疗效判定：
[0072] (1)治愈：易激惹、恐怖、焦虑、沮丧、失眠、头痛、身痛、头昏等症状消失，身体恢复 正常。
[0073] (2)有效:上述症状有所缓解。
[0074] (3)无效:病症无变化。
[00对 4、结果：
[0076] 服用本发明药物的治疗组中，治愈38例，有效9例，无效3例，治愈率为76%，总有效 率 94 %。
[0077] 对照组中治愈10例，有效19例，无效21例，治愈率为20%，总有效率58%。
[0078] W上结果显示，治疗组治愈率和总有效率明显高于对照组。
[00巧]5、典型病例举例：
[0080] (1)、林某，女，38岁，家庭主妇，浙江湖州人。患者产后因出现易激惹、失眠、头痛等 症状在当地医院就诊，经检查确诊为产后抑郁症，诊治后未有好转，故来我院求治。服用本 发明药物2个疗程后，上述症状好转，继续服用本发明药物2个疗程，上述症状消失，随访未 复发，彻底治愈。
[0081] (2)、张某，女，29岁，银行职员，江苏南通人。患者患产后抑郁症多年，治疗前主要 症状为头痛、暴躁和失眠，经数家医院诊治后，病情不见好转。为进一步诊治，来我院就诊。 服用本发明药物1个疗程后，身体好转，继续服用本发明药物2个疗程，上述症状消失，随访 未复发，彻底治愈。
[0082] (3)、魏某，女，30岁，会计，福建泉州人。患者不准任何人碰她刚满月的儿子，除了 她自己外，其他任何人哪怕是伸手去摸一下儿子的脸，她都会极度不高兴，包括她的丈夫。 她每天都自己24小时看着儿子，甚至不睡觉。脾气也异常暴躁，经常无理由地发脾气。来我 院就诊，确诊为:产后抑郁症。服用本发明药物2个疗程后，上述症状好转，继续服用本发明 药物2个疗程后，身体痊愈，随访未复发。
[0083] (4)、刘某，女，23岁，文员，湖南长沙人。患者产后常常出现情绪紧张、认为"在挣扎 中生活"、"生活布满阴云"、感到悲伤难过、"陷入昏暗之中"、感觉筋疲力尽、感觉麻木不仁 等症状，后来我院就诊。后服用本发明药物1个疗程后，上述症状减轻，继续服用本发明药物 2个疗程，上述症状全部消失，随访未复发，彻底治愈。
[0084] (5)、任某，女，38岁，教师，山东日照人。患者产后出现过度敏感、食欲不振、难W入 眠等症状，后逐渐加重，来我院就诊，确诊为产后抑郁症。后服用本发明药物2个疗程后，上 述症状好转，继续服用本发明药物2个疗程后，身体痊愈，随访未复发。
[0085] (6)、徐某，女，25岁，收银员，广东灿头人。患者因出现情绪不稳、失眠、暗自哭泣、 郁闷、注意力不集中、焦虑等症状来我院就诊，经医生检查诊断为产后抑郁症。后服用本发 明药物1个疗程，上述症状好转，继续服用本发明药物2个疗程后，上述症状消失，身体痊愈， 随访未复发。
Claims (5)
1. 一种用于治疗产后抑郁症的药物，其特征在于：制成所述药物有效成分的原料组成 及重量份数为： 南酸枣34-58份松叶32-57份 豆豉姜30-54份鸡蛋果30-54份 莲子27-52份 谷芽26-50份 草柏枝26-50份睡菜25_45份 乌金草25-45份蕨根24-42份 红门兰24_42份雪茶22-40份 茯神22-37份 回心草21-34份缬草20-32份 长春七17-27份。
2. 根据权利要求1所述的一种用于治疗产后抑郁症的药物，其特征在于:制成所述药物 有效成分的原料组成及重量份数为： 南酸枣52份松叶50份 豆豉姜48份鸡蛋果48份 莲子45份 谷芽44份 草柏枝44份睡菜40份 乌金草40份蕨根37份 红门兰37份雪茶35份 茯神33份 回心草30份缬草29份 长春七24份。
3. 根据权利要求1所述的一种用于治疗产后抑郁症的药物，其特征在于:制成所述药物 有效成分的原料组成及重量份数为： 南酸枣46份松叶44份 豆豉姜42份鸡蛋果42份 莲子39份 谷芽38份 草柏枝38份睡菜35份 乌金草35份蕨根33份 红门兰33份雪茶31份 茯神30份 回心草27份缬草26份 长春七22份。
4. 根据权利要求1所述的一种用于治疗产后抑郁症的药物，其特征在于:制成所述药物 有效成分的原料组成及重量份数为： 南酸枣40份松叶38份 豆豉姜36份鸡蛋果36份 莲子33份 谷芽32份 草柏枝32份睡菜30份 乌金草30份蕨根29份 红门兰29份雪茶27份 茯神27份 回心草24份缬草23份 长春七20份。
5. -种如权利要求1-4任一项所述的用于治疗产后抑郁症的药物的制备方法，其特征 在于:包括以下工艺步骤： ⑴将南酸枣、鸡蛋果、莲子、乌金草、蕨根、红门兰、雪茶、茯神和回心草放入容器中，首 先加入10-15倍量蒸馏水浸泡4-5小时后，加热煮沸3-4小时，提取;第二次加8-10倍量蒸馏 水加热煮沸2-3小时，提取;第三次加6-8倍量蒸馏水加热煮沸1-2小时，提取;合并提取液， 滤过，得滤液备用； (2) 将松叶、豆豉姜、草柏枝、缬草和长春七研末后，浸入体积浓度为90%酒精溶液，静置 4小时，取出上层清液，沉淀下来的浸膏备用； (3) 将谷芽置锅内用文火炒至深黄色并大部爆裂，取出放凉，研末，过200目细粉，备用； (4) 将睡菜绞汁，滤杂质，留汁液，备用； (5) 将步骤（1)-(4)制得的滤液、浸膏、细粉以及汁液混合，制成片剂，即为所述的用于 治疗产后抑郁症的药物。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610094492.4A CN105663828A (zh) | 2016-02-22 | 2016-02-22 | 一种用于治疗产后抑郁症的药物及制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610094492.4A CN105663828A (zh) | 2016-02-22 | 2016-02-22 | 一种用于治疗产后抑郁症的药物及制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105663828A true CN105663828A (zh) | 2016-06-15 |
Family
ID=56304687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610094492.4A Withdrawn CN105663828A (zh) | 2016-02-22 | 2016-02-22 | 一种用于治疗产后抑郁症的药物及制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105663828A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107184832A (zh) * | 2017-04-28 | 2017-09-22 | 华益药业科技(安徽)有限公司 | 一种治疗产后抑郁的中药组合物及其制备方法 |
-
2016
- 2016-02-22 CN CN201610094492.4A patent/CN105663828A/zh not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107184832A (zh) * | 2017-04-28 | 2017-09-22 | 华益药业科技(安徽)有限公司 | 一种治疗产后抑郁的中药组合物及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102205107B (zh) | 一种治疗十二指肠溃疡的中药制剂及其制备方法 | |
| CN103432475B (zh) | 一种治疗过敏性鼻炎的中药组合物及其制备方法 | |
| CN104474471A (zh) | 一种治疗甲状腺的中药组合物 | |
| CN102205108B (zh) | 一种治疗胃溃疡的中药制剂及其制备方法 | |
| CN103638250B (zh) | 一种治疗面神经麻痹的中药制剂及其制备方法 | |
| CN103432559B (zh) | 一种治疗血滞型月经减少及痛经的中药组合物及其制备方法和用途 | |
| CN102772781A (zh) | 一种治疗慢性结肠炎的中药制剂及其制备方法 | |
| CN103181432B (zh) | 一种补肾保健茶及其制备方法 | |
| CN101342331B (zh) | 治疗肺炎和上呼吸道感染的中药喷剂 | |
| CN103463467B (zh) | 一种具有滋补肾阴功效的苗方药酒 | |
| CN105435190A (zh) | 用于治疗寒热错杂型哮病的中药组合物及其制备方法 | |
| CN105663828A (zh) | 一种用于治疗产后抑郁症的药物及制备方法 | |
| CN104971204A (zh) | 一种配合针灸治疗神经性耳鸣的补肾开窍丸及药条 | |
| CN104547384A (zh) | 一种治疗百草枯中毒的口服液及制备方法 | |
| CN103961578A (zh) | 一种治疗神经衰弱的中药药酒 | |
| CN103830579A (zh) | 一种治疗颈椎病的中药药膏及制备方法 | |
| CN103877226B (zh) | 具有滋肝补肾功效的豆腐黄鳝粥品及其制备方法 | |
| CN103585372B (zh) | 一种治疗脑性瘫痪的中药制剂 | |
| CN103520644B (zh) | 用于治疗痰瘀型高脂血症的中药组合物及其制备方法 | |
| CN108607085A (zh) | 安神疏肝汤 | |
| CN105998469A (zh) | 一种用于治疗嗜睡症的中药制剂及制备方法 | |
| CN107536900A (zh) | 一种治疗痛经和经久不孕并具有暖宫和助孕疗效的药物 | |
| CN105497798A (zh) | 一种清肝胆利湿热的中药组合物及其制备方法 | |
| CN105031499A (zh) | 一种治疗十二指肠溃疡的中药组合物 | |
| CN104840794B (zh) | 一种治疗老年性失眠的中药组合物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| C06 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160615 |
|
| WW01 | Invention patent application withdrawn after publication |