CN105646530A - 苯基吡唑类化合物及其制备方法与用途 - Google Patents
苯基吡唑类化合物及其制备方法与用途 Download PDFInfo
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- CN105646530A CN105646530A CN201410725327.5A CN201410725327A CN105646530A CN 105646530 A CN105646530 A CN 105646530A CN 201410725327 A CN201410725327 A CN 201410725327A CN 105646530 A CN105646530 A CN 105646530A
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- edaravone
- preparation
- compound
- propylene glycol
- sodium pyrosulfite
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- YAWIITSUNKRQLT-UHFFFAOYSA-N CC(C)(c(c(C)n[n]1-c2ccccc2)c1O1)S1(=O)=O Chemical compound CC(C)(c(c(C)n[n]1-c2ccccc2)c1O1)S1(=O)=O YAWIITSUNKRQLT-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
序号 | 13C-NMR | 1H-NMR |
3 | 141.21 | - |
4 | 115.45 | - |
5 | 149.06 | - |
6 | 138.56 | - |
7 | 120.66 | 7.95 |
8 | 128.67 | 7.44 |
9 | 125.04 | 7.23 |
10 | 128.67 | 7.44 |
11 | 120.66 | 7.95 |
12 | 57.54 | - |
13 | 18.10 | 2.13 |
14 | 18.10 | 2.13 |
15 | 11.57 | 2.32 |
Claims (10)
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CN201410725327.5A CN105646530B (zh) | 2014-12-03 | 2014-12-03 | 苯基吡唑类化合物及其制备方法与用途 |
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CN105646530A true CN105646530A (zh) | 2016-06-08 |
CN105646530B CN105646530B (zh) | 2020-05-12 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108072710A (zh) * | 2016-11-14 | 2018-05-25 | 江苏正大丰海制药有限公司 | 一种依达拉奉氯化钠注射液有关物质检测方法 |
Citations (7)
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JP2008201740A (ja) * | 2007-02-21 | 2008-09-04 | Ohara Yakuhin Kogyo Kk | エダラボンの精製方法及び高純度エダラボン |
CN101288650A (zh) * | 2008-06-04 | 2008-10-22 | 江苏先声药物研究有限公司 | 一种依达拉奉的冻干制剂及其制备工艺 |
CN101732247A (zh) * | 2010-01-06 | 2010-06-16 | 长沙易睿医药科技有限公司 | 一种含有依达拉奉的注射液 |
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CN101933899A (zh) * | 2010-08-26 | 2011-01-05 | 南京先声东元制药有限公司 | 一种依达拉奉注射液及其制备方法 |
CN102887857A (zh) * | 2011-07-21 | 2013-01-23 | 南京争锋信息科技有限公司 | 吡唑啉酮衍生物,用途及其制备方法 |
CN104098512A (zh) * | 2013-04-03 | 2014-10-15 | 江苏先声药物研究有限公司 | 依达拉奉衍生物及其制备方法、检测方法和用途 |
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2014
- 2014-12-03 CN CN201410725327.5A patent/CN105646530B/zh active Active
Patent Citations (7)
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JP2008201740A (ja) * | 2007-02-21 | 2008-09-04 | Ohara Yakuhin Kogyo Kk | エダラボンの精製方法及び高純度エダラボン |
CN101288650A (zh) * | 2008-06-04 | 2008-10-22 | 江苏先声药物研究有限公司 | 一种依达拉奉的冻干制剂及其制备工艺 |
CN101732247A (zh) * | 2010-01-06 | 2010-06-16 | 长沙易睿医药科技有限公司 | 一种含有依达拉奉的注射液 |
CN101805292A (zh) * | 2010-04-27 | 2010-08-18 | 江苏先声药物研究有限公司 | 吡唑啉类化合物、用途及其制备方法 |
CN101933899A (zh) * | 2010-08-26 | 2011-01-05 | 南京先声东元制药有限公司 | 一种依达拉奉注射液及其制备方法 |
CN102887857A (zh) * | 2011-07-21 | 2013-01-23 | 南京争锋信息科技有限公司 | 吡唑啉酮衍生物,用途及其制备方法 |
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Non-Patent Citations (2)
Title |
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林冠雄等: "依达拉奉注射液制剂处方及工艺的研究", 《海峡药学》 * |
许真玉: "依达拉奉注射液杂质谱分析", 《中国执业药师》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108072710A (zh) * | 2016-11-14 | 2018-05-25 | 江苏正大丰海制药有限公司 | 一种依达拉奉氯化钠注射液有关物质检测方法 |
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Effective date of registration: 20180607 Address after: 211800 8 Xing Long Road, Pukou Economic Development Zone, Nanjing, Jiangsu. Applicant after: Nanjing Simcere Dongyuan Pharmaceutical Co., Ltd. Applicant after: Jiangsu Simcere Pharmaceutical Co., Ltd. Address before: 210042 699 Xuanwu Road, Xuanwu District, Nanjing, Jiangsu -18 Applicant before: Jiangsu Simcere Pharmaceutical Co., Ltd. |
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Address after: No.99, Huakang Road, Jiangbei new district, Nanjing, Jiangsu Province, 210032 Patentee after: SIMCERE PHARMACEUTICAL Group Patentee after: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd. Address before: 211800 Nanjing, Pukou Economic Development Zone, Jiangsu Road, No. 8 Patentee before: NANJING SIMCERE DONGYUAN PHARMACEUTICA Co.,Ltd. Patentee before: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd. |