CN105641467A - 一种治疗再生障碍性贫血的中药组合物 - Google Patents

一种治疗再生障碍性贫血的中药组合物 Download PDF

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CN105641467A
CN105641467A CN201610131884.3A CN201610131884A CN105641467A CN 105641467 A CN105641467 A CN 105641467A CN 201610131884 A CN201610131884 A CN 201610131884A CN 105641467 A CN105641467 A CN 105641467A
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刘连强
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Abstract

本发明涉及一种治疗再生障碍性贫血的中药组合物，其中药原料及重量份配比为：旱莲草10-30份、侧柏叶5-25份、乌金草5-20份、锁阳5-25份、马勃5-20份、大蓟5-20份、刺五加10-30份、黄精5-25份、胡黄连5-20份、熟地黄10-30份、凤尾草5-25份、槐花5-20份、鹿角霜5-25份、楮实5-25份、石斛5-20份、茜草5-25份、白花蛇舌草5-25份、红参5-20份、仙茅5-25份、赭石5-25份、石龙刍5-20份、大青叶5-25份、鳖甲5-25份、淡菜5-25份、甘草5-15份。本发明的中药组合物具有养肝益肾、益气健脾、滋阴补血、清热解毒、填精益髓、收敛止血的功效，其治疗再生障碍性贫血疗效显著，作用可靠。

Description

一种治疗再生障碍性贫血的中药组合物
技术领域
本发明涉及一种传统草药的未确定结构的医药配制品，尤其是一种治疗再生障碍性贫血的中药组合物。
背景技术
再生障碍性贫血简称再障，是一种由生物、化学、物理等因素引起的骨髓造血功能减退或衰竭，以造血干细胞损伤、外周血全血细胞减少为特征的难治性血液病，是造血系统比较常见的疾病。其主要表现为骨髓造血功能低下、全血细胞减少和贫血、出血、感染。虽然各年龄组均可发病，但以青壮年多见，且男性多于女性，北方多于南方。目前治疗再生障碍性贫血西医以免疫抑制剂、糖皮质激素、雄性激素和输血等治疗，部分患者虽然能暂时缓解症状，但易反复，治疗效果不理想。而且所用药物价格高，副作用大，长期服用免疫抑制剂可造成肝、肾功能损害以及消化道的不良反应。
中医将再生障碍性贫血归属“虚劳”、“血证”范畴。认为劳倦内伤，感受邪气，或毒物戕伤气血，是导致本病的主要病因。如脾虚不能统血，心虚不能主血，肝虚不能藏血，肾虚则精血亏损，内不能调和脏腑，外不能护卫营卫，卫外不因则易罹外感为热。五脏之中，尤以脾肾二脏最为重要，若脾虚及肾，因虚致损，因损成劳，精血不充而为虚劳。
根据中医理论，针对再生障碍性贫血的发病机理，采用养肝益肾、益气健脾、滋阴补血、清热解毒、填精益髓、收敛止血的治法，进行辩证的组方配伍，以达到标本兼治的目的。
发明内容
为了克服现有技术中治疗再生障碍性贫血存在虽然能暂时缓解症状，但易反复，治疗效果不理想的不足，本发明提供一种配制简便、成本低、疗效显著、无副作用的治疗再生障碍性贫血的中药组合物。
本发明解决其技术问题所采用的技术方案是：一种治疗再生障碍性贫血的中药组合物，其特征在于：其中药原料及重量份配比为：旱莲草10-30份、侧柏叶5-25份、乌金草5-20份、锁阳5-25份、马勃5-20份、大蓟5-20份、刺五加10-30份、黄精5-25份、胡黄连5-20份、熟地黄10-30份、凤尾草5-25份、槐花5-20份、鹿角霜5-25份、楮实5-25份、石斛5-20份、茜草5-25份、白花蛇舌草5-25份、红参5-20份、仙茅5-25份、赭石5-25份、石龙刍5-20份、大青叶5-25份、鳖甲5-25份、淡菜5-25份、甘草5-15份。
本发明的优选技术方案是：一种治疗再生障碍性贫血的中药组合物，其特征在于：其中药原料及重量份配比为：旱莲草20份、侧柏叶15份、乌金草10份、锁阳15份、马勃10份、大蓟10份、刺五加20份、黄精15份、胡黄连10份、熟地黄20份、凤尾草15份、槐花10份、鹿角霜15份、楮实15份、石斛10份、茜草15份、白花蛇舌草15份、红参10份、仙茅15份、赭石15份、石龙刍10份、大青叶15份、鳖甲15份、淡菜15份、甘草10份。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方。本发明中药组合物中：旱莲草具有养肝益肾、凉血止血的功效；侧柏叶具有凉血止血、止咳祛痰、祛风湿、散肿毒的功效；乌金草具有平肝阳、养心安神、养血调经的功效；锁阳具有补肾阳、益精血、润肠通便的功效；马勃具有清肺利咽、解毒止血的功效；大蓟具有凉血止血、祛瘀消肿的功效；刺五加具有益气健脾、补肾安神的功效；黄精具有滋肾润肺、补脾益气、养阴生津的功效；胡黄连具有退虚热、消疳热、清热燥湿、泻火解毒的功效；熟地黄具有滋阴补血、益精填髓的功效；凤尾草具有清热利湿、凉血止血、消肿解毒的功效；槐花具有凉血止血、清肝泻火的功效；鹿角霜具有温肾助阳、收敛止血的功效；木耳具有补气养血、润肺止咳的功效；楮实具有补肾清肝、明目、利尿的功效；石斛具有益胃生津、滋阴清热的功效；茜草具有凉血止血、祛瘀通经的功效；白花蛇舌草具有清热解毒、利尿消肿、活血止痛的功效；红参具有大补元气、复脉固脱、益气摄血的功效；仙茅具有补肾助阳、益精血、强筋骨、行血消肿的功效；赭石具有平肝潜阳、降逆止血的功效；石龙刍具有利水通淋、泄热、安神、凉血止血的功效；大青叶具有清热解毒、凉血消斑的功效；鳖甲具有滋阴潜阳、软坚散结、退热除蒸的功效；淡菜具有补肝肾、益精血、消瘿瘤的功效；甘草具有补脾益气、清热解毒、祛痰止咳、调和诸药的功效。本发明精选药物组方，其药物组分经辩证配伍，在作用上相互佐助，共奏养肝益肾、益气健脾、滋阴补血、清热解毒、填精益髓、收敛止血的功效，对再生障碍性贫血的治疗达到标本兼治。
本发明组合物的组分均采用天然的中药原料，其配制简便、药源广、成本低。本发明遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证，其疗效显著可靠，药性平和，未出现毒副作用，有效率达94%，治愈率73%。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1
一种治疗再生障碍性贫血的中药组合物，其中药原料及重量配比为：旱莲草20g、侧柏叶15g、乌金草10g、锁阳15g、马勃10g、大蓟10g、刺五加20g、黄精15g、胡黄连10g、熟地黄20g、凤尾草15g、槐花10g、鹿角霜15g、楮实15g、石斛10g、茜草15g、白花蛇舌草15g、红参10g、仙茅15g、赭石15g、石龙刍10g、大青叶15g、鳖甲15g、淡菜15g、甘草10g。
实施例2
一种治疗再生障碍性贫血的中药组合物，其中药原料及重量配比为：旱莲草15g、侧柏叶25g、乌金草12g、锁阳20g、马勃5g、大蓟15g、刺五加10g、黄精20g、胡黄连5g、熟地黄30g、凤尾草10g、槐花20g、鹿角霜5g、楮实25g、石斛12g、茜草20g、白花蛇舌草10g、红参15g、仙茅5g、赭石20g、石龙刍12g、大青叶25g、鳖甲5g、淡菜20g、甘草8g。
实施例3
一种治疗再生障碍性贫血的中药组合物，其中药原料及重量配比为：旱莲草25g、侧柏叶5g、乌金草5g、锁阳10g、马勃20g、大蓟5g、刺五加25g、黄精10g、胡黄连15g、熟地黄10g、凤尾草20g、槐花5g、鹿角霜25g、楮实10g、石斛20g、茜草5g、白花蛇舌草25g、红参12g、仙茅20g、赭石5g、石龙刍15g、大青叶10g、鳖20g、淡菜5g、甘草12g。
实施例4
一种治疗再生障碍性贫血的中药组合物，其中药原料及重量配比为：旱莲草10g、侧柏20g、乌金草5g、锁阳25g、马勃12g、大蓟20g、刺五加15g、黄精25g、胡黄连12g、熟地黄25g、凤尾草5g、槐花15g、鹿角霜10g、楮实20g、石斛5g、茜草25g、白花蛇舌草5g、红参20g、仙茅10g、赭石25g、石龙刍5g、大青叶20g、鳖甲0g、淡菜25g、甘草5g。
实施例5
一种治疗再生障碍性贫血的中药组合物，其中药原料及重量配比为：旱莲草30g、侧柏叶10g、乌金草20g、锁阳5g、马勃15g、大蓟12g、刺五加30g、黄精5g、胡黄连20g、熟地黄15g、凤尾草25g、槐花12g、鹿角霜20g、楮实5g、石斛15g、茜草10g、白花蛇舌草20g、红参5g、仙茅25g、赭石10g、石龙刍20g、大青叶5g、鳖甲25g、淡菜10g、甘草15g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：将组方的中药原料放入容器中，加冷水漫过药面，浸泡15～20分钟，再加水没过药面约6厘米，进行第一次煎煮，未沸前采用武火煎煮，沸后用文火煎煮20～30分钟；第二次煎煮，加水没过药面约4厘米，水沸后煎煮15～20分钟。两次煎煮取汁，合并。
本发明以实施例1所给出的一种治疗再生障碍性贫血的中药组合物，做临床疗效总结如下：
一、一般性资料：本中药组合物应用于临床观察病例100例，男54例，女46例，年龄25～65岁。
二、诊断标准：
1、中医诊断标准：症见面色白，头晕头痛，目糊耳鸣，心跳气短，神疲乏力，腰膝酸痛，寐艰多梦，健忘，五心烦热，小便黄，下肢轻度浮肿，四肢皮肤有瘀点，舌质淡，苔白腻，脉弦细数无力等临床表现。
2、西医诊断标准：全血细胞减少，网织红细胞百分数＜0.01，淋巴细胞比例增高；一般见肝、脾大；骨髓多部位增生减低(＜正常50％)或重度减低(＜正常25％)，造血细胞减少，非造血细胞比例增高，骨髓小粒空虚(有条件者作骨髓活检可见造血组织均匀减少)；能除外引起全血细胞减少的其他疾病如阵发性睡眠性血红蛋白尿症、骨髓增生异常综合征中的难治性贫血、急性造血功能停滞、骨髓纤维化、急性白血病、恶性组织细胞病等；一般抗贫血药物治疗无效。
三、用法用量：临床应用时，一日一剂，水煎两遍取汁约400ml，分早、晚两次空腹温服。六天为一疗程。治疗期间忌生冷辛辣刺激之物。
四、疗效标准：
(1)痊愈：治疗后临床症状完全消失，经骨髓穿刺检查一切正常，经观察3～5个月一切正常；
(2)显效：治疗后主要症状基本消失，连续观察3～5个月，不再复发，经骨穿刺检查基本正常；
(3)有效：经治疗后症状有所改善，连续观察3～5个月不再复发，经骨髓穿刺检查基本正常；
(4)无效：经治疗后症状无改善或有改善，经3～5个月观察，症状同前，经骨髓穿刺检查无变化。
五、治疗效果：该临床观察病例中，服药2-10个疗程，痊愈73例，随访未见复发；显效13例，有效8例，无效6例。治疗期间未发生毒副作用。
六、典型病例：
病例1：
殷某，男，42岁。患有再生障碍性贫血2余年，心悸气短，头晕失眠，并伴有面色苍白、全身疲倦无力、食欲下降。服用本发明中药组合物制备的药剂3个疗程，精神转好，夜能安寐；继续服用5个疗程，诸症消失，痊愈。半年后随访未见复发。
病例2：
杜某，女，29岁。因心跳、气短、头晕、食欲不振，倦怠无力，面色苍白，下肢轻度浮肿，唇淡红等症状前往医院诊治，经骨髓穿刺检查，确诊为再生障碍性贫血。服用本发明中药组合物制备的药剂3个疗程，病情大有好转；继续服用2个疗程，诸症消失，血色化验已正常，治愈。
病例3：
韩某，男，57岁。确诊为再生障碍性贫血半年，全身无力，头晕头痛，心悸气短、纳呆，面色无华，舌燥、苔薄白，全身出现出血点。口服康力龙、氨肽素等药物治疗，效果不理想。服用本发明中药组合物制备的药剂3个疗程，病情明显好转；继续服用3个疗程，诸症消失，血常规检查正常，治愈。随访半年无复发。

Claims (2)

1.一种治疗再生障碍性贫血的中药组合物，其特征在于：其中药原料及重量份配比为：旱莲草10-30份、侧柏叶5-25份、乌金草5-20份、锁阳5-25份、马勃5-20份、大蓟5-20份、刺五加10-30份、黄精5-25份、胡黄连5-20份、熟地黄10-30份、凤尾草5-25份、槐花5-20份、鹿角霜5-25份、楮实5-25份、石斛5-20份、茜草5-25份、白花蛇舌草5-25份、红参5-20份、仙茅5-25份、赭石5-25份、石龙刍5-20份、大青叶5-25份、鳖甲5-25份、淡菜5-25份、甘草5-15份。
2.根据权利要求1所述一种治疗再生障碍性贫血的中药组合物，其特征在于：其中药原料及重量份配比为：旱莲草20份、侧柏叶15份、乌金草10份、锁阳15份、马勃10份、大蓟10份、刺五加20份、黄精15份、胡黄连10份、熟地黄20份、凤尾草15份、槐花10份、鹿角霜15份、楮实15份、石斛10份、茜草15份、白花蛇舌草15份、红参10份、仙茅15份、赭石15份、石龙刍10份、大青叶15份、鳖甲15份、淡菜15份、甘草10份。
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