CN105616285A - Sterilizing and skin-care liquid soap and preparation method thereof - Google Patents
Sterilizing and skin-care liquid soap and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention relates to sterilizing and skin-care liquid soap, which is prepared from the following components in parts by weight: 40 to 48 parts of lauramidepropyl amine oxide, 4 to 5 parts of chondroitin sulfate, 20 to 30 parts of medical stone powder, 900 to 1200 parts of deionized water, 120 to 150 parts of sodium lauryl ether sulfate, 60 to 70 parts of sodium cocoyl glycinate, 20 to 30 parts of clove oil, 10 to 12 parts of usnic acid, 16 to 18 parts of folium sennae extract, 0.4 to 0.6 part of distannous citrate, 0.4 to 0.6 part of sodium lactate, and 8 to 12 parts of sodium chloride. The sterilizing and skin-care liquid soap is prepared by compounding multiple plant essence and natural skin-care components, as well as a surfactant by a special method, and the components have an outstanding synergistic effect with one another; the liquid soap has good anti-bacteria and sterilizing effect, and by comparison with general pure chemical liquid soap, the sterilizing and skin-care liquid soap has small irritation to the skin, and has the effect of moisturizing the skin and preserving moisture.
Description
Technical field
The invention belongs to articles for washing technical field, be specifically related to a kind of sterilizing skin-protective hand cleanser and preparation method thereof.
Background technology
People's hand-washing article in the past is mainly soap, fancy soap etc., easy landing when they use, and meets water logging, high temperature and can soften and naturally expend again, is especially easily infected with dirt on hand, antibacterial, becomes secondary pollution source. Along with the transformation of growth in the living standard and consumption idea, handwashing liquid has been increasingly becoming the succedaneum of tradition hand-washing article, is widely used at present in various places such as hospital, hotel, food and drink, families. The contact surface typically just bottle pump head of handwashing liquid and hands, it is easy to cleaning, it is to avoid cross infection. By squash type taken amount, only need to gently pressing nozzle, liquid just flows into the palm of the hand, and consumption is grasped by oneself, deposits use and is quite convenient to.
Nowadays, along with the maturation of handwashing liquid production technology and popularizing of market, the special handwashing liquid with various special efficacy also constantly comes out. Such as heavy duty detergent handwashing liquid, paint-removing handwashing liquid, anhydrous washing hand liquid, disinfection handwashing liquid etc. Wherein, disinfection handwashing liquid is the class that in the special handwashing liquid in market, occupancy volume is maximum. It is reported, the disinfection handwashing liquid commonly used currently on the market, the effectiveness comparison in disinfection is desirable. But considering not good enough in the nursing to hand skin, the component of disinfection is relatively big to the zest of skin, life-time service easily cause hand skin dry, coarse, chap and peel. For this, we are necessary research skin-protection type disinfection handwashing liquid, to make up this kind of deficiency of this series products.
Summary of the invention
It is an object of the invention to provide a kind of sterilizing skin-protective hand cleanser with good bactericidal effect and skin effect and preparation method thereof.
Sterilizing skin-protective hand cleanser of the present invention, is made up of the component of following parts by weight: dodecanamide propyl amine oxide 40��48 parts, chondroitin sulfate 4��5 parts, medical stone powder 20��30 parts, deionized water 900��1200 parts, 120��150 parts of polyoxyethylene lauryl ether sodium sulfate, sodium cocoyl glycinate 60��70 parts, Oleum Caryophylli 20��30 parts, usnic acid 10��12 parts, Folium Sennae extract 16��18 parts, distannous citrate 0.4��0.6 part, sodium lactate 0.4��0.6 part, 8��12 parts of sodium chloride.
As optimizing sterilizing skin-protective hand cleanser of the present invention, it is made up of the component of the number of following weight: dodecanamide propyl amine oxide 42 parts, chondroitin sulfate 4.5 parts, the medical stone powder 25 parts of granularity 1250 order, deionized water 1000 parts, 130 parts of polyoxyethylene lauryl ether sodium sulfate, sodium cocoyl glycinate 65 parts, Oleum Caryophylli 25 parts, usnic acid 11 parts, Folium Sennae extract 17 parts, distannous citrate 0.5 part, sodium lactate 0.5 part, 10 parts of sodium chloride.
The method preparing sterilizing skin-protective hand cleanser of the present invention, comprises the following steps:
A, take the dodecanamide propyl amine oxide of described parts by weight, chondroitin sulfate, medical stone powder 1250 order, deionized water, join in homogenizing agitator tank, at 60��65 DEG C, stirring, mix homogeneously;
B, the polyoxyethylene lauryl ether sodium sulfate of described parts by weight, sodium cocoyl glycinate, Oleum Caryophylli are joined in the mixture in step A, at 60��65 DEG C, stir 10 minutes; When temperature is down to 50��55 DEG C, add the usnic acid of described parts by weight, Folium Sennae extract stirring 15 minutes;
C, the mixture treated in step B, when temperature is down to 40��45 DEG C, is sequentially added into the distannous citrate of described parts by weight, sodium lactate, sodium chloride, stirs, discharging.
In prescription of the present invention, Suzhou Yuan Tairun Chemical Co., Ltd. (SLES70%) polyoxyethylene lauryl ether sodium sulfate can be selected as optimizing, Guangzhou Hua Zhiwang Chemical Co., Ltd. (KAOANDCN-30) sodium cocoyl glycinate, Qingdao excellent rope chemistry Science and Technology Ltd. (LAO-30) dodecanamide propyl amine oxide, the natural extractive of usnea usnic acid in Bei La bio tech ltd, Xi'an, Shaanxi Hui Ke plant development corporation, Ltd. Folium Sennae extract, Rui Ying bio tech ltd, Xi'an chondroitin sulfate (CS), Zhejiang oasis Bioisystech Co., Ltd food grade lactic acid sodium, Shijiazhuang tourmaline mineral products company limited 1250 order medical stone powder, Xin Xi bio tech ltd, Shanghai food stage distannous citrate, the natural Oleum Caryophylli CAS:8000-34-8CloveOil of Guangzhou daily use chemicals Chemical Co., Ltd..
Sterilizing skin-protective hand cleanser of the present invention, by multiple plant extract elite and natural skin care composition, and is had the surfactant of good clean effect, is prepared from by specific process compound, and between each component, synergism highlights; There is good bacteriostasis and sterilization effect, relative to the handwashing liquid of general pure chemistry class, sterilizing skin-protective hand cleanser of the present invention, skin irritation is little, also there is the effect of Glycerin moisturizing water conservation.
Related experiment: sterilization experiment; Staphylococcus aureus (ATCC6538), escherichia coli (8099), bacillus pyocyaneus (ATCC15442), bacillus subtilis var (ATCC9372) are cultivated the fresh slant culture of 18h, wash down with the diluent containing tryptone and be configured to test organisms suspension, applying for carrier quantitative germicidal test.
The embodiment of the present invention 1 handwashing liquid (positive controls is PBS) is contained in sterilized petri dishes by the consumption of 5.0ml/ sheet by test, in (20 soil 1) DEG C water-bath, bacterium sheet is completely immersed in handwashing liquid, act on to the scheduled time, take out bacterium sheet, put into and fill in 5.0ml nertralizer test tube, neutralization 10min, wash the bacterium on lower bacterium sheet, carry out count plate, calculate killing rate.
Preserving moisture and protecting skin measure of merit, chooses 96 triers, in the environment that humidity is identical, is divided into three groups, often organizes 50 people, ante cibum of morning, noon and afternoon and be respectively adopted the sterilizing skin-protective hand cleanser of the embodiment of the present invention 1��3 after meal and clean. Then the test of CorneometerCM825 moisture tester is adopted. Its unit used by tolerance expresses (Arbitrarym with A.C.U., its value falls within 30��40CapacitanceUnits), measurement range is from 0 to 120A.C.U., these values are relative to the water content of upper epidermis, it is dry skin that the degree of depth measured is about 20��40A.C.U., and is high-moisture skin at more than 120A.C.U.. After using one month, test result is in Table 2.
Detailed description of the invention
The invention will be further described for example given below plan; but it is not to be construed as limiting the scope of the invention; those skilled in the art, according to some nonessential improvement and adjustment to the present invention of present invention, still fall within protection scope of the present invention.
Embodiment 1:A, take dodecanamide propyl amine oxide 42 kilograms, chondroitin sulfate 4.5 kilograms, the medical stone powder 25 kilograms of granularity 1250 order, deionized water 1000 kilograms, join in homogenizing agitator tank, at 60��65 DEG C, stirring, mix homogeneously;
B, by 130 kilograms of polyoxyethylene lauryl ether sodium sulfate, sodium cocoyl glycinate 65 kilograms, 25 kilograms of mixture joining in step A of Oleum Caryophylli, at 60��65 DEG C, stir 10 minutes; When temperature is down to 50��55 DEG C, add usnic acid 11 kilograms, Folium Sennae extract 17 kilograms stirring 15 minutes;
C, the mixture treated in step B, when temperature is down to 40��45 DEG C, is sequentially added into distannous citrate 0.5 kilogram, sodium lactate 0.5 kilogram, 10 kilograms of sodium chloride, stirs, discharging.
Embodiment 2:A, take dodecanamide propyl amine oxide 40 kilograms, chondroitin sulfate 4 kilograms, the medical stone powder 20 kilograms of granularity 1250 order, deionized water 900 kilograms, join in homogenizing agitator tank, at 60��65 DEG C, stirring, mix homogeneously;
B, by 120 kilograms of polyoxyethylene lauryl ether sodium sulfate, sodium cocoyl glycinate 60 kilograms, 20 kilograms of mixture joining in step A of Oleum Caryophylli, at 60��65 DEG C, stir 10 minutes; When temperature is down to 50��55 DEG C, add usnic acid 10 kilograms, Folium Sennae extract 16 kilograms stirring 15 minutes;
C, the mixture treated in step B, when temperature is down to 40��45 DEG C, is sequentially added into distannous citrate 0.4 kilogram, sodium lactate 0.4 kilogram, 8 kilograms of sodium chloride, stirs, discharging.
Embodiment 3:A, take dodecanamide propyl amine oxide 48 kilograms, chondroitin sulfate 5 kilograms, the medical stone powder 30 kilograms of granularity 1250 order, deionized water 1200 kilograms, join in homogenizing agitator tank, at 60��65 DEG C, stirring, mix homogeneously;
B, by 150 kilograms of polyoxyethylene lauryl ether sodium sulfate, sodium cocoyl glycinate 70 kilograms, 30 kilograms of mixture joining in step A of Oleum Caryophylli, at 60��65 DEG C, stir 10 minutes; When temperature is down to 50��55 DEG C, add usnic acid 12 kilograms, Folium Sennae extract 18 kilograms stirring 15 minutes;
C, the mixture treated in step B, when temperature is down to 40��45 DEG C, is sequentially added into distannous citrate 0.6 kilogram, sodium lactate 0.6 kilogram, 12 kilograms of sodium chloride, stirs, discharging.
Claims (3)
1. sterilizing skin-protective hand cleanser and preparation method thereof; It is characterized in that being made up of the component of following parts by weight: dodecanamide propyl amine oxide 40��48 parts, chondroitin sulfate 4��5 parts, medical stone powder 20��30 parts, deionized water 900��1200 parts, 120��150 parts of polyoxyethylene lauryl ether sodium sulfate, sodium cocoyl glycinate 60��70 parts, Oleum Caryophylli 20��30 parts, usnic acid 10��12 parts, Folium Sennae extract 16��18 parts, distannous citrate 0.4��0.6 part, sodium lactate 0.4��0.6 part, sodium chloride 8��12.
2. sterilizing skin-protective hand cleanser according to claim 1, it is characterised in that be made up of the component of the number of following weight: dodecanamide propyl amine oxide 42 parts, chondroitin sulfate 4.5 parts, the medical stone powder 25 parts of granularity 1250 order, deionized water 1000 parts, 130 parts of polyoxyethylene lauryl ether sodium sulfate, sodium cocoyl glycinate 65 parts, Oleum Caryophylli 25 parts, usnic acid 11 parts, Folium Sennae extract 17 parts, distannous citrate 0.5 part, sodium lactate 0.5 part, 10 parts of sodium chloride.
3. prepare the method for sterilizing skin-protective hand cleanser described in any one of claim 1��2 for one kind, it is characterised in that comprise the following steps:
A, take the dodecanamide propyl amine oxide of described parts by weight, chondroitin sulfate, medical stone powder 1250 order, deionized water, join in homogenizing agitator tank, at 60��65 DEG C, stirring, mix homogeneously;
B, the polyoxyethylene lauryl ether sodium sulfate of described parts by weight, sodium cocoyl glycinate, Oleum Caryophylli are joined in the mixture in step A, at 60��65 DEG C, stir 10 minutes; When temperature is down to 50��55 DEG C, add the usnic acid of described parts by weight, Folium Sennae extract stirring 15 minutes;
C, the mixture treated in step B, when temperature is down to 40��45 DEG C, is sequentially added into the distannous citrate of described parts by weight, sodium lactate, sodium chloride, stirs, discharging.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102140391A (en) * | 2011-02-16 | 2011-08-03 | 张震红 | Medical stone perfumed soap and preparation method thereof |
CN104490653A (en) * | 2014-11-28 | 2015-04-08 | 青岛市市南区隆德中医药研究所 | Face cleansing cream and preparation method thereof |
CN104825356A (en) * | 2015-04-30 | 2015-08-12 | 威莱(广州)日用品有限公司 | Anti-bacterial hand-washing solution and preparation method thereof |
CN104840378A (en) * | 2015-05-28 | 2015-08-19 | 南阳市汇博生物技术有限公司 | Skin-care sterilization hand sanitizer and preparation method thereof |
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- 2016-01-08 CN CN201610011531.XA patent/CN105616285A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102140391A (en) * | 2011-02-16 | 2011-08-03 | 张震红 | Medical stone perfumed soap and preparation method thereof |
CN104490653A (en) * | 2014-11-28 | 2015-04-08 | 青岛市市南区隆德中医药研究所 | Face cleansing cream and preparation method thereof |
CN104825356A (en) * | 2015-04-30 | 2015-08-12 | 威莱(广州)日用品有限公司 | Anti-bacterial hand-washing solution and preparation method thereof |
CN104840378A (en) * | 2015-05-28 | 2015-08-19 | 南阳市汇博生物技术有限公司 | Skin-care sterilization hand sanitizer and preparation method thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
US11517512B2 (en) | 2017-07-19 | 2022-12-06 | Colgate-Palmolive Company | Personal care compositions comprising zinc : usnic acid complexes and methods of use |
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