CN105596610A - Traditional Chinese medicine for treating gastric ulcer caused by hyperactive liver-qi attacking stomach and preparation method - Google Patents

Abstract

The invention provides traditional Chinese medicine for treating gastric ulcer caused by hyperactive liver-qi attacking the stomach and a preparation method. The traditional Chinese medicine comprises Hance Rosewood Stem, Cordia Dichotoma, Podocarpus Macrophyllus, Pothos Chinensis, Chinese Osbeckia Herb, Indian Epimeredi Herb, Porana Racemosa, Cortex Illicii, Schisandraceae Kadsura Oblongifolia, Root-bark of Lokao Buckthorn, Rostellularia Procumbens, Zanthoxylum Ailanthoides and Eruca Sativa. The traditional Chinese medicine has the advantages that the traditional Chinese medicine is highly targeted to the gastric ulcer caused by hyperactive liver-qi attacking the stomach, has exact curative effect and has no toxic or side effect and adverse effect.

Description

A kind of Chinese medicine and preparation method who treats hyperactive liver-qi attacking the stomach gastric ulcer

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, relate in particular toA kind of Chinese medicine and preparation method who treats hyperactive liver-qi attacking the stomach gastric ulcer.

Background technology

Be referred to as gastric ulcer (gastriculcer, GU) in orifice of the stomach to the chronic ulcer between pylorus, beThe one of peptic ulcer. Peptic ulcer can occur in Stomach duodenum, also can occur under oesophagusNear end, stomach-intestinal anastomosis mouth and on the interior Ectopic Gastric Mucosa of your diverticulum of Meike. The formation of these ulcer is equalRelevant with pepsic digestion with hydrochloric acid in gastric juice, therefore be called peptic ulcer. This sick overwhelming majority is positioned atStomach and duodenum (98%～99%). In crowd, approximately there is 10% people may suffer from this disease in the middle of all one's life,Therefore be a frequently-occurring disease and common disease, in digestive surgery, occupy an important position.

Gastric ulcer is a kind of multi-factor disease, and cause of disease complexity is completely unclear so far, is a composite factorDue to. 1. inherent cause: gastric ulcer has family history sometimes, especially children's ulcer patient has the family history person canAccount for 25%～60%. The people of A type blood easily suffers from this disease than the people of other blood groups in addition. 2. chemical factor: long-termThe medicines such as potable spirit or long-term taking aspirin, corticosteroid easily cause this sick generation, long-term in additionSmoking and drink strong tea like also there being certain relation. 3. life factor: canker patient is in some occupation as departmentIn the middle of the people such as machine and doctor, seem more common, may to owe rule relevant with diet. Work overstrain alsoCan bring out this disease occurs. 4. mental element: nervous or worried, sentimental, mental labour is too muchAlso be this sick risk factor. May be because of vagal excitation, gastroxia and causing. Infect because ofElement: the effect that helicobacter pylori (HP) occurs gastric ulcer is still difficult to explain, because of in a lot of HP the infecteds onlyMinority generation gastric ulcer. But almost gastric ulcer person merge chronic active gastritis. HP is gastritisMorbidity and the Etiological spreading. HP is eliminated gastritis and disappears. The quantitative study that HP infects shows, stomachUlcer is especially positioned at the ulcer of the stomach first half, often merges serious HP and infects. 6. other factors: differenceCountry, this sick incidence of different regions are not quite similar, and the different incidences of disease in season is also different, explanationGeographical environment and weather are also key factors. This disease also can be in other protopathy as burn, severe brain in additionOn the basis of wound, gastrinoma, hyperparathyroidism, pulmonary emphysema, cirrhosis, renal failure, fall ill, what is called continuesSend out ulcer. This may be overexcited relevant with gastrin, hypercalcinemia and vagus nerve.

The clinical manifestation of gastric ulcer and duodenal ulcer are a bit similar, but have self particularity. 1, stomachThe clinical manifestation of ulcer has 3 features: 1. chronic process. Several years at least, more than 10 years or longer at most.2. periodically. In the course of disease, often occur that stage of attack and paracmasis alternately occur. 3. rhythmicity: pain shows asPain after the meal, half an hour, pain started after the meal, to disappear before the meal next time, went round and began again. The disease of gastric ulcerShape main manifestations is stomachache; Companion or do not accompany the symptoms such as vomiting, nauseating, sour regurgitation, belch. But also there are many diseasesPeople taking the various complication of gastric ulcer as perforation, hemorrhage, pyloric stenosis and as onset symptoms. 2, upper abdomenSecret anguish discomfort: the pain of gastric ulcer is a kind of pain of internal organ character, body surface location is imprecise, simultaneously painPain is how inviolent, can stand, and shows as and burns sample pain, secret anguish discomfort etc. Active stage, has rhythmicity,Show as pain after the meal, along with the development of pathology has periodically and seasonal feature. Near ulcer orifice of the stomachAlso can show as burn feeling and left chest pain after breastbone. When ulcer penetrates, show as pain degreeIncrease the weight of, to back radiation or backache, have the performances such as hypnalgia simultaneously, when characteristic of pain and rhythmicity generationWhen change, also should watch out for the possibility cancerating. 3, feel sick, vomit: vomiting occurs without pyloric stenosis and carry moreShow that ulcer is in active stage, vomit for intermittence. The many promptings of frequent vomiting pyloric stenosis. 4, sour regurgitation,Gas, diarrhoea: sour regurgitation also points out the ulcer may be in active stage. 5, hemorrhage, perforation: occur hemorrhage, wearBehind hole, there is its special clinical manifestation, see complication one joint.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of treat hyperactive liver-qi attacking the stomach gastric ulcer inMedicine and preparation method, have definite curative effect to hyperactive liver-qi attacking the stomach gastric ulcer, and toxic and side effect is little.

In order to solve the problems of the technologies described above, the invention provides a kind of treat hyperactive liver-qi attacking the stomach gastric ulcer inMedicine, its raw medicinal material comprises: hance rosewood stem or root, rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb,Snowcreeper porana herb, anisetree bark, scarlet kadsura stem and leaf, lokao buckthorn leaf and root-bark, justicia, ailanthus prickly ash and rocket salad.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows: red perfume (or spice)10～20 parts, rattan, 5～15 parts, rag wood, 15～25 parts of podocarpus, 25～35 parts of Chinese pothos herbs, day perfume25～40 parts, stove, 10～20 parts of Indian Epimeredi Herbs, 25～35 parts of snowcreeper porana herbs, 10～30 parts of anisetree barks, meal15～30 parts, group rattan, 30～40 parts of lokao buckthorn leaf and root-barks, 10～20 parts of justicias, 20～30 parts of ailanthus prickly ash and sesame30～45 parts of fiber crops dishes.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably as follows: red10～15 parts, fragrant rattan, 10～15 parts, rag wood, 17～25 parts of podocarpus, 25～30 parts of Chinese pothos herbs,30～40 parts of osbeckia chinensis, 17～20 parts of Indian Epimeredi Herbs, 25～30 parts of snowcreeper porana herbs, 16～25 parts of anisetree barks,18～25 parts of scarlet kadsura stem and leafs, 30～35 parts of lokao buckthorn leaf and root-barks, 15～18 parts of justicias, 20～28 parts of ailanthus prickly ash and35～45 parts of rocket salad.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: red13 parts, fragrant rattan, 14 parts, rag wood, 20 parts of podocarpus, 30 parts of Chinese pothos herbs, 37 parts of osbeckia chinensis, windproof20 parts of grass, 26 parts of snowcreeper porana herbs, 18 parts of anisetree barks, 24 parts of scarlet kadsura stem and leafs, 32 parts of lokao buckthorn leaf and root-barks, justicia15 parts, 42 parts of 27 parts of ailanthus prickly ash and rocket salad.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: red15 parts, fragrant rattan, 20 parts, rag wood, 25 parts of podocarpus, 28 parts of Chinese pothos herbs, 32 parts of osbeckia chinensis, windproof17 parts of grass, 30 parts of snowcreeper porana herbs, 22 parts of anisetree barks, 18 parts of scarlet kadsura stem and leafs, 35 parts of lokao buckthorn leaf and root-barks, justicia18 parts, 35 parts of 20 parts of ailanthus prickly ash and rocket salad.

The present invention also provides the preparation method of above-mentioned Chinese medicine, in the time that the formulation of described Chinese medicine is oral liquid,Its preparation method comprises the following steps:

The first step, by hance rosewood stem or root, rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb and beat meterFlower mixes, and adds with respect to 3 times～5 times, mixture and measures the alcohol reflux extraction 2 that determining alcohols are 55%～65%Inferior～4 time, each 2 hours～3 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into 70 DEG CRelative density is 1.30～1.32 lotion, for subsequent use;

Second step, mixes surplus stock medicinal material in proportion, adds with respect to 3～5 times of water gagings of mixture, boilsBoil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29;

The 3rd step, the described lotion that the first step, second step are obtained mixes, 55 DEG C～65 DEG C reduced vacuumDry, powder gets dry extract;

The 4th step, adds ethanol in the described dried cream powder that the 3rd step is obtained, obtains containing alcohol lotion, described inIs 65%～70% containing alcohol lotion containing alcohol amount; Refrigerate successively processing, precipitation by described containing alcohol lotionProcessing, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis lotion, and wherein, the refrigeration processing time is 30～40 hours, 3～6 DEG C of refrigerated storage temperatures;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis lotion, carry out successively heat treated,Filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis lotion and described cane sugar powder is1: 0.1～0.3; The weight ratio of described dealcoholysis lotion and described active carbon is 1: 0.001～0.002; InstituteThe time of stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product that the 5th step is obtained carry out successively filtration treatment, embedding processing,Sterilization treatment, obtains described traditional Chinese medicine oral liquid finished product.

The present invention also provides the preparation method of above-mentioned Chinese medicine, when the formulation of described Chinese medicine is decoction, and its systemPreparation Method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicine to clear waterMaterial upper surface 2-5cm, soaks 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 30-50 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate a, for subsequent use;

Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 2-3cm to clear water, soakBubble 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 25-35 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

Beneficial effect of the present invention: Chinese medicine of the present invention is to hyperactive liver-qi attacking the stomach gastric ulcer, with strong points, has reallyCut curative effect, have no side effect and bad reaction.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of hyperactive liver-qi attacking the stomach gastric ulcer, its raw medicinal material comprises: redFragrant rattan, rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb, snowcreeper porana herb, anisetree bark, rice dumplingRattan, lokao buckthorn leaf and root-bark, justicia, ailanthus prickly ash and rocket salad.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Hance rosewood stem or root: [another name] rattan perfume (or spice), chicken play perfume (or spice), dalbergia wood (" Luchuan book on Chinese herbal medicine "), large fragrant rattan, in the wrongYe Teng, Cold boiled chicken thorn rattan, Huanglong's undress (" Guangxi medicine is planted register "). [source] is legume rattanThe stem of yellow wingceltis or root. Summer, Qiu Cai. [nature and flavor] " this leather of Luchuan ": " pungent puckery, temperature ". [function masterControl] 1. " Luchuan book on Chinese herbal medicine ": " stem: promoting the circulation of qi, pain relieving, broken long-pending. Control heart peratodynia, for a long time the long-pending pain of wound. GasBreathe heavily bleeding from five sense organs or subcutaneous tissue ". " Guangxi medicine is planted register ": " root: strengthening the bones and muscles, wide muscle, active. Resin: hemostasis. ControlCollywobbles, motive pain ". [extracts] " Chinese medicine voluminous dictionary "

Rag wood: [another name] blue or green paulownia wood, dichotomous cordia root, kite Gao Shu. [source] Boraginaceae ragWood, is used as medicine with root, fruit. [nature and flavor] are micro-sweet, flat. [function cures mainly] promoting qi circulation and relieving pain, preventing phlegm from forming and stopping coughing.[extracts] " national Chinese herbal medicine compilation "

Podocarpus: [another name] native China fir, arhat China fir [source] Podocarpaceae podocarpus nagi platymiscium podocarpus, withRoot skin and cone are used as medicine. The root four seasons can adopt, and adopt cone autumn. [nature and flavor] are sweet, tepor. [function masterControl] really: beneficial gas bowl spares. For heart peratodynia, deficiency of blood sallow complexion. Root skin: promoting blood circulation and stopping pain, desinsection.For traumatic injury, tinea. [extracts] " national Chinese herbal medicine compilation "

Chinese pothos herb: [another name] stone gas mandarin orange, mandarin orange bacterium taro (" classification herbal medicine "), Shi Puteng (" ridgeCampus, south plant register "), CAULIS PIPER WALLICHII, blue or green Pu Lu tea, stone cucurbit (" Guangxi Chinese medicinal herbal ").[source] is the herb of aroid rattan tangerine. 3～April or 9～October gather. [nature and flavor] " fourRiver Chinese medicinal herbal ": " slightly warm in nature, bitter is pungent, nontoxic ". [function cures mainly] regulating qi-flowing for relieving pain, wines used as antirheumatic.Control heart peratodynia, hernia beriberi, treating rheumatic ostealgia. [extracts] " Chinese medicine voluminous dictionary "

Osbeckia chinensis: [another name] large incense burner (" the sward property of medicine is standby to be wanted "), sky hangs perfume (or spice), and (" gather medicinal herbs in the south of the Five RidgesRecord "), the cup of looking up to heaven (" Luchuan book on Chinese herbal medicine "), thin golden incense burner, little Jin clock (" Nanning City's medicine will "),Ceylon leucas herb (" Traditional Chinese Medicine in Sichuan will "), seguin argyreia herb, gold pomegranate, seven-star born (" Quanzhou book on Chinese herbal medicine "),Reduce phlegm grass, golden cup grass, Zijin clock, willow leaf flower, to sky pomegranate, nine lamps (" Hunan medicine will "),Cucurbit grass, thin frame gold pomegranate (" east, Fujian book on Chinese herbal medicine "). [source] is Melastomateae plants osbeckiaWhole herb with root or root. Summer, autumn gather. [nature and flavor] are pungent, flat. [return through] enters lung, large intestine, Liver Channel.[function cures mainly] dampness elimination of dispeling the wind, the hemostasis stasis of blood that disappears. Control cough, asthma, dysentery, has loose bowels; Spit blood, cough upBlood, has blood in stool, through closing, and infantile malnutrition due to digestive disturbances or intestinalparasites, treating rheumatic ostealgia, traumatic injury. [extracts] " Chinese medicine voluminous dictionary "

Indian Epimeredi Herb: [another name] fail clothing, false purple perilla, horsecloth leaf (" the sward property of medicine is standby to be wanted ") is rareXian grass, soil windproof (" south of the Five Ridges gather medicinal herbs record "), cubic stem, stinkweed (" Guangxi Chinese veterinarian's medicine is planted "),Smelly Soviet Union head, duck are slightd (" Luchuan book on Chinese herbal medicine "), dirty grass (" Nanning City's medicine will "), large thin bamboo strip grass,Llama Gu is disturbed (" Guangxi Chinese medicinal herbal "), air draft grass (Guangzhou army " conventional Chinese herbal medicine handbook "),Smelly Soviet Union (" Fujian Chinese herbal medicine "). [source] is the herb of labiate Indian Epimeredi Herb. Summer, Qiu JianExtract herb, clean, dry or using fresh herb. [nature and flavor] are arduous, temperature. [function cures mainly] dispels the wind, and removesWet, removing toxic substances. The body heat that cures cold, vomiting, stomachache, arthralgia and myalgia, sore, eczema, haemorrhoids. [pluckRecord] " Chinese medicine voluminous dictionary "

Snowcreeper porana herb: [another name] Ma Langhua, trachelospermum jasminoides (" Guizhou folk medicine "), little ingot is (" wideWestern medicine is planted register "). [source] is root or the herb of convolvulaceous plant buccae rattan. Gather autumn. [propertyTaste] warm in nature, taste is pungent. [function cures mainly] breaks blood, promoting the circulation of qi, detumescence poison. [extracts] " large diction of Chinese medicineAllusion quotation "

Anisetree bark: [another name] Cortex schizophragmatis integrifolii radicis, Chinese hydrangeavine root-bark, Nanning anisetree bark, wind. [source] this productFor the dry bark of Magnoliaceae Chinese anise platymiscium anisetree bark. Spring, Qiu Erji strip, and dry or low temperatureDry. [nature and flavor] are micro-pungent, puckery, temperature; Slightly poisonous. [return through] returns bladder, kidney channel. [function masterControl] dispel rheumatism, promoting qi circulation and relieving pain. For arthralgia due to wind-dampness, lumbar muscle strain. [extracts] " Chinese pharmacopoeia "

Scarlet kadsura stem and leaf: [another name] goto sand, cross mountain breeze, black tiger (" south of the Five Ridges gather medicinal herbs record "), 18Disease (" Luchuan book on Chinese herbal medicine "), smelly rice dumpling, siphon rattan (" Hainan flora "), large scarlet kadsura stem and leaf,Blood rattan, great Ye ZUANGUFENG, chicken intestines wind (" Guangxi medicine is planted register "), K. Cocciniea (Jiangxi " grassMedicine handbook "), food and drink group (" rural area Chinese herbal and crude drugs preparations technology "). [source] is Magnoliacea plantThe stem of kadsurae coccineae, leaf. Can adopt the whole year. [nature and flavor] " Luchuan book on Chinese herbal medicine ": " acid is sweet, tepor ". [meritCan cure mainly] 1. " Luchuan book on Chinese herbal medicine ": " synthetism, the loose stasis of blood, detumescence, removing toxic substances. Control injury and bone fracture, rheumatic boneBitterly, sore furuncle, wound infection ". 2. " Guangxi medicine is planted register ": " promoting the circulation of qi, pain relieving. Control stomachache, fall and beatDamage ". [extracts] " Chinese medicine voluminous dictionary "

Lokao buckthorn leaf and root-bark: [another name] duck dung tree, wild chinaberry, Dong Pishu, smelly plum, old crane eye. [comeSource] be cauline leaf, the root skin of Rhamnaceae plant Rhamnus globosus. Summer, autumn gather. Dry. [nature and flavor] hardshipPuckery, be slightly cold, nontoxic. [function cures mainly] desinsection, lower gas, eliminates the phlegm, and helps digestion. [extracts] " Chinese medicineVoluminous dictionary "

Justicia: [another name] little green grass, hexagonal English, cute conjunctivitis one's old mother grass, wheat head Huang, mouse tail Huang, my childGrass, wild evergreen, Herba Rostellulariae, large duck grass, hair Herba Lycopi [Sichuan]. [source] this product is the Acanthaceae rank of nobilityThe herb of bed platymiscium justicia. Xia Qiu gathers, using fresh herb or dry. [nature and flavor] micro-hardship, cold. [functionCure mainly] clearing heat and detoxicating, inducing diuresis to reduce edema, preventing malaria. For cold, fever, malaria, abscess of throat, children'sInfantile malnutrition due to digestive disturbances or intestinalparasites, dysentery, enteritis, nephritic dropsy, urinary infection, chyluria; Carbuncle sore furuncle is controlled in external application, fallsPlay damage. [extracts] " national Chinese herbal medicine compilation "

Ailanthus prickly ash: [another name] Yueshu (" extensively refined ") ， File (supplement to the Herbal), argy wormwood (" thisSketch warp "), spicy (" detailed outline "). [source] is the fruit of rutaceae Zanthoxylum ailanthoides.Gather when fruit maturation for 10～November, dries. [nature and flavor] are arduous, and temperature is poisonous. [function cures mainly]Wen Zhong, eliminating dampness, desinsection, pain relieving. Control trusted subordinate's crymodynia, cold drink, has loose bowels, cold dysentery, arthritis with fixed pain caused by dampness, red leukorrheaUnder, dentalgia. [extracts] " Chinese medicine voluminous dictionary "

Rocket salad: [another name] Jintang Roripa montana, lepidium seed, bitter draba. [source] medicinal material Ji Yuan: forThe seed of crucifer rocket salad. [nature and flavor] are pungent; Bitter; Cold. [return through] lung; Urinary bladder channel.[function cures mainly] lower capable water of gas; Eliminating phlegm relieving asthma. Main phlegm heap soil or fertilizer over and around the roots is breathed with cough; Oedema; Ascites. [extracts] " inChina's book on Chinese herbal medicine "

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows: red perfume (or spice)10～20 parts, rattan, 5～15 parts, rag wood, 15～25 parts of podocarpus, 25～35 parts of Chinese pothos herbs, day perfume25～40 parts, stove, 10～20 parts of Indian Epimeredi Herbs, 25～35 parts of snowcreeper porana herbs, 10～30 parts of anisetree barks, meal15～30 parts, group rattan, 30～40 parts of lokao buckthorn leaf and root-barks, 10～20 parts of justicias, 20～30 parts of ailanthus prickly ash and sesame30～45 parts of fiber crops dishes.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably as follows: red10～15 parts, fragrant rattan, 10～15 parts, rag wood, 17～25 parts of podocarpus, 25～30 parts of Chinese pothos herbs,30～40 parts of osbeckia chinensis, 17～20 parts of Indian Epimeredi Herbs, 25～30 parts of snowcreeper porana herbs, 16～25 parts of anisetree barks,18～25 parts of scarlet kadsura stem and leafs, 30～35 parts of lokao buckthorn leaf and root-barks, 15～18 parts of justicias, 20～28 parts of ailanthus prickly ash and35～45 parts of rocket salad.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: red13 parts, fragrant rattan, 14 parts, rag wood, 20 parts of podocarpus, 30 parts of Chinese pothos herbs, 37 parts of osbeckia chinensis, windproof20 parts of grass, 26 parts of snowcreeper porana herbs, 18 parts of anisetree barks, 24 parts of scarlet kadsura stem and leafs, 32 parts of lokao buckthorn leaf and root-barks, justicia15 parts, 42 parts of 27 parts of ailanthus prickly ash and rocket salad.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: red15 parts, fragrant rattan, 20 parts, rag wood, 25 parts of podocarpus, 28 parts of Chinese pothos herbs, 32 parts of osbeckia chinensis, windproof17 parts of grass, 30 parts of snowcreeper porana herbs, 22 parts of anisetree barks, 18 parts of scarlet kadsura stem and leafs, 35 parts of lokao buckthorn leaf and root-barks, justicia18 parts, 35 parts of 20 parts of ailanthus prickly ash and rocket salad.

The present invention also provides the preparation method of above-mentioned Chinese medicine, in the time that the formulation of described Chinese medicine is oral liquid,Its preparation method comprises the following steps:

The first step, by hance rosewood stem or root, rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb and beat meterFlower mixes, and adds with respect to 3 times～5 times, mixture and measures the alcohol reflux extraction 2 that determining alcohols are 55%～65%Inferior～4 time, each 2 hours～3 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into 70 DEG CRelative density is 1.30～1.32 lotion, for subsequent use;

Second step, mixes surplus stock medicinal material in proportion, adds with respect to 3～5 times of water gagings of mixture, boilsBoil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29;

The 3rd step, the described lotion that the first step, second step are obtained mixes, 55 DEG C～65 DEG C reduced vacuumDry, powder gets dry extract;

The 4th step, adds ethanol in the described dried cream powder that the 3rd step is obtained, obtains containing alcohol lotion, described inIs 65%～70% containing alcohol lotion containing alcohol amount; Refrigerate successively processing, precipitation by described containing alcohol lotionProcessing, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis lotion, and wherein, the refrigeration processing time is 30～40 hours, 3～6 DEG C of refrigerated storage temperatures;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis lotion, carry out successively heat treated,Filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis lotion and described cane sugar powder is1: 0.1～0.3; The weight ratio of described dealcoholysis lotion and described active carbon is 1: 0.001～0.002; InstituteThe time of stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product that the 5th step is obtained carry out successively filtration treatment, embedding processing,Sterilization treatment, obtains described traditional Chinese medicine oral liquid finished product.

The present invention also provides the preparation method of above-mentioned Chinese medicine, when the formulation of described Chinese medicine is decoction, and its systemPreparation Method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicine to clear waterMaterial upper surface 2-5cm, soaks 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 30-50 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate a, for subsequent use;

Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 2-3cm to clear water, soakBubble 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 25-35 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand whereby the present invention asWhat application technology means solves technical problem, reaches technique effect and implements according to this.

Embodiment 1: oral liquid

Get hance rosewood stem or root 130g, rag wood 140g, podocarpus 200g, Chinese pothos herb 300g, osbeckia chinensis 370g,Indian Epimeredi Herb 200g, snowcreeper porana herb 260g, anisetree bark 180g, scarlet kadsura stem and leaf 240g, lokao buckthorn leaf and root-bark 320g, justicia150g, ailanthus prickly ash 270g and rocket salad 420g.

Preparation according to the following steps:

The first step, by hance rosewood stem or root, rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb and beat meterFlower mixes, and the alcohol reflux that to add with respect to 5 times, mixture amount determining alcohols be 65% extracts 3 times, and each 3Hour, to filter, filtrate merges, and reclaims ethanol, is concentrated into the lotion that 70 DEG C of relative densities are 1.32,For subsequent use;

Second step, mixes surplus stock medicinal material in proportion, adds with respect to 5 times of water gagings of mixture, boils4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.29;

The 3rd step, the described lotion that the first step, second step are obtained mixes, and 65 DEG C of reduced vacuum are dry,Powder gets dry extract;

The 4th step, adds ethanol in the described dried cream powder that the 3rd step is obtained, obtains containing alcohol lotion, described inIs 70% containing alcohol lotion containing alcohol amount; By described containing alcohol lotion refrigerate successively processing, precipitation process,Filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis lotion, and wherein, the refrigeration processing time is 40 hours,4 DEG C of refrigerated storage temperatures;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis lotion, carry out successively heat treated,Filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis lotion and described cane sugar powder is1: 0.3; The weight ratio of described dealcoholysis lotion and described active carbon is 1: 0.002; Described heat treatedTime is 40 minutes, and temperature is 110 DEG C;

The 6th step, the more described semi-finished product that the 5th step is obtained carry out successively filtration treatment, embedding processing,Sterilization treatment, obtains described traditional Chinese medicine oral liquid finished product.

Embodiment 2: decoction

Get hance rosewood stem or root 15g, rag wood 20g, podocarpus 25g, Chinese pothos herb 28g, osbeckia chinensis 32g, anti-Wind grass 17g, snowcreeper porana herb 30g, anisetree bark 22g, scarlet kadsura stem and leaf 18g, lokao buckthorn leaf and root-bark 35g, justicia 18g, foodFruit of medicinal cornel 20g and rocket salad 35g.

Preparation according to the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicine to clear waterMaterial upper surface 5cm, soaks 10 hours;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 50 minutes to liquidDosage be 300ml, filter, obtain filtrate a, for subsequent use;

Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 3cm to clear water, soak 5Hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 35 minutes to liquidDosage be 300ml, filter, obtain filtrate b, filtrate a and filtrate b are mixed.

Toxicity test:

Acute toxicity testing: 60 of application mouse, male and female half and half, body weight 20-30g, carries out acute poisonProperty is tested. Mouse is divided into two groups at random, i.e. control group and administration group, and fasting 12 hours before experiment, incite somebody to action thisExtract oral liquor prepared by inventive embodiment 1 is dissolved in water, (concentration is 8.96g crude drug/ml,Maximum concentration) gavage, gavage volume is 5ml/kg (being that single-dose dosage is 44.8 crude drugs/kg),Control group gives equivalent physiological saline, administration in a day 2 times, and delivery time 6 hours, connects after administrationContinuous observation 14 days, and record mouse toxic reaction and death toll. Experimental result shows: with control groupRelatively, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, mouse overall health of patients, diet,Drinking-water, body weight gain is all normal. Mouse oral administration gavage oral solutions LD50 of the present invention > 44.8 crude drugs/kg,Every day, maximum dosage-feeding was 89.6 crude drugs/kg/ day. Chinese medicine clinical application amount of the present invention be 8.6g crude drug/Day/people, becomes body weight for humans in 60KG, and average dosage is 0.143g crude drug/kg/ day. Press batheroom scale:The dosis tolerata of mouse (average weight is taking 25g) oral administration gavage Chinese medicine of the present invention is 626 of quantityDoubly. Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 oral solutions of the present invention is to three groups of mouse (20 every group)By 15.82,23.66 and 15 weeks (1.0ml/100g body weight, every days of 45.86g crude drug/kg continuous use2 times) and drug withdrawal after 3 weeks, result shows: the hair of Chinese medicine of the present invention to mouse, behavior, stool and urine,The indexs such as body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat all have no significant effect, internal organsNaked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, littleThe each internal organs of mouse are all without obviously changing. Illustrate that toxicity is little after Chinese medicine of the present invention is to mouse long-term prescription, after drug withdrawalThere is no difference reaction, application safety yet.

Clinical data:

Case selection: this is organized 120 examples and is the out-patient of the court, male 65 examples, female's 55 examples; Age 18-60Year; The course of disease 1 month-10 years. Be divided at random treatment group and control group. Wherein, treatment group 60 examples, man33 examples, female's 27 examples; Age 18-60 year; The course of disease 1 month-10 years. Control group 60 examples, male 32 examples,Female's 28 examples; Age 18-58 year; The course of disease 1 month-9 years. Two groups of patients are in sex, age, the course of diseaseEtc. aspect data through statistical procedures, difference there are no significant meaning (p > 0.05), has comparativity.

Diagnostic criteria: " clinical disease diagnosis and the curative effect judging standard " write according to hospital associate of Hunan ProvinceGastroduodenal ulcer diagnostic criteria formulate. 1, the chronic course of disease, periodical attack, become normal and seasonChange, mental element, improper diet relevant, or have long-term taking can cause the pharmacohistory of ulcer. 2, upper abdomen is hiddenCusalgia or dull pain bitterly. Pain has rhythmicity more, often in empty stomach or generation in 1-2 hour after the meal. Pain is normalAcid, belch and Abdeminal pain occur together. Note whether having spitting blood, melena history. 3, secrete on patients w ith peptic ulcer disease basisAcid amount, maximum are secreted acid and are measured normal or on the low side. Acid amount is secreted on duodenal ulcer basis, maximum is secreted acid amount and often increased.The fecal occult blood positive. 4, gastroscope or x-ray barium meal examination result can be made a definite diagnosis. Discovery gastric ulcer should be done live body groupKnit inspection, particularly ulcer diameter is greater than 2.5cm and should gets rid of malignant change.

Chinese medical discrimination: hyperactive liver-qi attacking the stomach: stomachache is indistinct, desire for warm and being pressed, pain of empty stomach very, obtains food slow,Time hydroptysis, receive poor abdominal distension, spiritlessness and weakness, the hands and feet being not warm, large loose stool is thin. Tongue nature is light, and tongue is thin white,Arteries and veins is thin and delicate.

Methods for the treatment of:

Control group: the each 0.4g of oral bismuth citrate ranitidine, every twice-daily, 4 weeks courses for the treatment of; PylorusHelicobacter positive the last fortnight adds CLA each 0.25 or 0.5g, twice of every day.

Treatment group: oral Chinese medicine embodiment 1 oral liquid of the present invention, each 10ml, every day 3 times, the course for the treatment of4 weeks.

Period in a medicine is avoided tobacco and wine, the irritable food such as pungent, should have more meals a day but less food at each, and avoids and eats and drinks immoderately.

Curative effect judging standard: cure: epigastric pain and other clinical symptoms all disappear, gastrocopy ulcerHealing, HP detects negative. Effective: epigastric pain disappears, and other clinical symptoms disappear substantially, gastrocopyUlcer heals substantially, and HP detects negative. Effective: epigastric pain obviously alleviates, other clinical symptoms are improved,Gastrocopy ulcer scope is dwindled more than 50%, and HP detects weak positive. Invalid: epigastric pain, other are clinicalSymptom, gastrocopy, HP detect all without changing.

Treatment results: see the following form.

Group	n	Cure	Effective	Effectively	Invalid	Effectively total
							Treatment group	60	35	16	7	2	58(96.7％)
Control group	60	20	17	11	12	48(80％)

Note: treatment group and control group comparison, treatment group curative effect is better than control group (P < 0.05).

Bad reaction: two groups of patients are showed no liver and kidney dysfunction or other bad reactions.

Concrete case: ox, man, 45 years old. Gastric ulcer case history is more than 4 years, and stomachache is indistinct, desire for warm and being pressed,Pain of empty stomach very, obtains food slow, time hydroptysis, receive poor abdominal distension, spiritlessness and weakness, the hands and feet being not warm, large loose stoolThin. Tongue nature is light, and tongue is thin white, and arteries and veins is thin and delicate, diagnoses also somatotype to be through the clinical examinations such as gastroscope and tcm symptomHyperactive liver-qi attacking the stomach gastric ulcer. Take the oral liquid of the embodiment of the present invention 1, each 10ml, every day 3 times,Treat 4 weeks, epigastric pain and other clinical symptoms all disappear, gastrocopy ulcer healing, and HP detects cloudyProperty, cure, follow up a case by regular visits to and do not recur half a year.

The above, be only preferred embodiment of the present invention, is not that the present invention is made to other formRestriction, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changedOr be modified as the equivalent embodiment of equivalent variations. But every technical solution of the present invention content that do not depart from, complies withAny simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention,Still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. a Chinese medicine for the treatment of hyperactive liver-qi attacking the stomach gastric ulcer, is characterized in that, each raw material in described Chinese medicineMedicinal material comprises: hance rosewood stem or root, and rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb, snowcreeper porana herb,Anisetree bark, scarlet kadsura stem and leaf, lokao buckthorn leaf and root-bark, justicia, ailanthus prickly ash and rocket salad.

2. Chinese medicine as claimed in claim 1, is characterized in that, the weight of each raw medicinal material in described Chinese medicineAmount portion rate is as follows: 10～20 parts of hance rosewood stem or roots, 5～15 parts, rag wood, 15～25 parts of podocarpus, stone25～35 parts of mandarin oranges, 25～40 parts of osbeckia chinensis, 10～20 parts of Indian Epimeredi Herbs, 25～35 parts of snowcreeper porana herbs,10～30 parts of anisetree barks, 15～30 parts of scarlet kadsura stem and leafs, 30～40 parts of lokao buckthorn leaf and root-barks, 10～20 parts of justicias,30～45 parts of 20～30 parts of ailanthus prickly ash and rocket salad.

3. Chinese medicine as claimed in claim 1 or 2, is characterized in that, each raw medicinal material in described Chinese medicineRatio of weight and number as follows: 10～15 parts of hance rosewood stem or roots, 10～15 parts, rag wood, podocarpus 17～25Part, 25～30 parts of Chinese pothos herbs, 30～40 parts of osbeckia chinensis, 17～20 parts of Indian Epimeredi Herbs, snowcreeper porana herb 25～30 parts, 16～25 parts of anisetree barks, 18～25 parts of scarlet kadsura stem and leafs, 30～35 parts of lokao buckthorn leaf and root-barks, justicia 15～18 parts, 35～45 parts of 20～28 parts of ailanthus prickly ash and rocket salad.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, each raw medicinal material in described Chinese medicineRatio of weight and number as follows: 13 parts of hance rosewood stem or roots, 14 parts, rag wood, 20 parts of podocarpus, Chinese pothos herb 30Part, 37 parts of osbeckia chinensis, 20 parts of Indian Epimeredi Herbs, 26 parts of snowcreeper porana herbs, 18 parts of anisetree barks, scarlet kadsura stem and leaf 24Part, 32 parts of lokao buckthorn leaf and root-barks, 15 parts of justicias, 42 parts of 27 parts of ailanthus prickly ash and rocket salad.

5. the Chinese medicine as described in claim 1 to 4, is characterized in that, each raw medicinal material in described Chinese medicineRatio of weight and number as follows: 15 parts of hance rosewood stem or roots, 20 parts, rag wood, 25 parts of podocarpus, Chinese pothos herb 28Part, 32 parts of osbeckia chinensis, 17 parts of Indian Epimeredi Herbs, 30 parts of snowcreeper porana herbs, 22 parts of anisetree barks, scarlet kadsura stem and leaf 18Part, 35 parts of lokao buckthorn leaf and root-barks, 18 parts of justicias, 35 parts of 20 parts of ailanthus prickly ash and rocket salad.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the formulation of described Chinese medicine is oralLiquid, its preparation method comprises the following steps:

The first step, by hance rosewood stem or root, rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb and beat meterFlower mixes, and adds with respect to 3 times～5 times, mixture and measures the alcohol reflux extraction 2 that determining alcohols are 55%～65%Inferior～4 time, each 2 hours～3 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into 70 DEG CRelative density is 1.30～1.32 lotion, for subsequent use;

Second step, mixes surplus stock medicinal material in proportion, adds with respect to 3～5 times of water gagings of mixture, boilsBoil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29;

The 3rd step, the described lotion that the first step, second step are obtained mixes, 55 DEG C～65 DEG C reduced vacuumDry, powder gets dry extract;

The 4th step, adds ethanol in the described dried cream powder that the 3rd step is obtained, obtains containing alcohol lotion, described inIs 65%～70% containing alcohol lotion containing alcohol amount; Refrigerate successively processing, precipitation by described containing alcohol lotionProcessing, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis lotion, and wherein, the refrigeration processing time is 30～40 hours, 3～6 DEG C of refrigerated storage temperatures;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis lotion, carry out successively heat treated,Filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis lotion and described cane sugar powder is1: 0.1～0.3; The weight ratio of described dealcoholysis lotion and described active carbon is 1: 0.001～0.002; InstituteThe time of stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product that the 5th step is obtained carry out successively filtration treatment, embedding processing,Sterilization treatment, obtains described traditional Chinese medicine oral liquid finished product.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the formulation of described Chinese medicine is decoction,Its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicine to clear waterMaterial upper surface 2-5cm, soaks 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 30-50 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate a, for subsequent use;

Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 2-3cm to clear water, soakBubble 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 25-35 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, described Chinese medicineFormulation is oral liquid, and its preparation method comprises the following steps:

The first step, by hance rosewood stem or root, rag wood, podocarpus, Chinese pothos herb, osbeckia chinensis, Indian Epimeredi Herb and beat meterFlower mixes, and adds with respect to 3 times～5 times, mixture and measures the alcohol reflux extraction 2 that determining alcohols are 55%～65%Inferior～4 time, each 2 hours～3 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into 70 DEG CRelative density is 1.30～1.32 lotion, for subsequent use;

Second step, mixes surplus stock medicinal material in proportion, adds with respect to 3～5 times of water gagings of mixture, boilsBoil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29;

The 3rd step, the described lotion that the first step, second step are obtained mixes, 55 DEG C～65 DEG C reduced vacuumDry, powder gets dry extract;

The 4th step, adds ethanol in the described dried cream powder that the 3rd step is obtained, obtains containing alcohol lotion, described inIs 65%～70% containing alcohol lotion containing alcohol amount; Refrigerate successively processing, precipitation by described containing alcohol lotionProcessing, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis lotion, and wherein, the refrigeration processing time is 30～40 hours, 3～6 DEG C of refrigerated storage temperatures;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis lotion, carry out successively heat treated,Filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis lotion and described cane sugar powder is1: 0.1～0.3; The weight ratio of described dealcoholysis lotion and described active carbon is 1: 0.001～0.002; InstituteThe time of stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product that the 5th step is obtained carry out successively filtration treatment, embedding processing,Sterilization treatment, obtains described traditional Chinese medicine oral liquid finished product.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, described Chinese medicineFormulation is decoction, and its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicine to clear waterMaterial upper surface 2-5cm, soaks 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 30-50 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate a, for subsequent use;

Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 2-3cm to clear water, soakBubble 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 25-35 minute extremelyThe dosage of liquid is 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.