CN105596599A - Pharmaceutical composition for treating tympanitis and preparation method thereof - Google Patents
Pharmaceutical composition for treating tympanitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating tympanitis and a preparation method thereof. The pharmaceutical composition is prepared by taking herb of lepidium virginicum L., Chinese galls, honeycombs, herba taraxaci, rhizoma alismatis, herba periliae, aucubin and platycodin D as bulk pharmaceuticals in proportion and can be prepared into preparations of various forms according to a conventional preparation technology, and the tympanitis treating effect is significant.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, relate in particular to a kind of pharmaceutical composition and preparation side thereof for the treatment of tympanitisMethod.
Background technology
Tympanitis refers to the inflammatory that involves all or part of structure of middle ear (comprising tubotympanum, tympanic antrum and mastoid air cell)The pathology overwhelming majority is non-specific arrangement inflammation, is especially apt to occur in children, can be divided into apyetous and suppurative two large classes. OftenSee have secretory otitis media, acute suppurative otitis media and Cholesteatomatous Tympanitis and barotraumatic otitis media. Tympanitis is existingThe incidence of disease still higher, now a lot of people especially young man all there is no rational habits and customs, add at ordinary timesDo not note individual ear health, these have all aggravated the possibility that tympanitis occurs. Only in children, nearly 75% suffered from oneInferior or repeatedly fall ill. So tympanitis more and more affects and has endangered our life.
The general medicine of tympanitis has 3% hydrogen peroxide or drips with " neomycinsulphate [Dan " " hundred inflammation that oral medicine has nowOnly " and " sodium acid carbonate " sheet, " phenergan sheet ", " Amoxicillin " etc. Although these medicines have certain curative effect, but still can not make usSatisfied.
The fragrant shepherd's purse of great Ye: be the herb of crucifer qin leaf Roripa scrofula LepidiumvirginicumL.. [nature and flavor]Sweet; Flat, [function cures mainly] expelling parasites and food tagnancy. Main children's's enterozoic abdominal distention, [extracts] " China's book on Chinese herbal medicine ".
Chinese gall: this product is Anacardiaceae plant Chinese sumac RhuschinensisMill., blue or green bran poplar RhusPotaniniiMaxim. or redpunjab sumac root Rhuspun-jabensisStew.var.sinica(Diels) Rehd.etWils. the insect gall on leaf, mainly by melaphis chinensis Baker Melaphischinensis(Bell) Baker is parasitic and form. Adopt autumnPluck, put and in boiling water, slightly boil or steam to surperficial gray, kill aphid, take out, dry. By profile difference, be divided into " tripe doubly " and " angleDoubly ". [proterties] tripe times: be Long Circle or spindle cryptomere, long 2.5～9cm, diameter 1.5～4cm. Surface taupe or greyish brownLook, micro-have a pubescence. Matter is hard and crisp, easily broken, and section cutin sample is glossy, wall thickness 0.2～0.3cm, and inwall is level and smooth, has dark brownLook dead aphid and grey powdery excreta. Gas is special, puckery. [nature and flavor] acid, puckery, cold. [return through] returns lung, large intestine, kidney channel.[function cures mainly] astringed the lung and fallen fire, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic sore. For chronic cough of deficiency lung, lung feverish cough, rush down for a long time for a long timeDysentery, night sweat, quenches one's thirst, the hemorrhoid of having blood in stool blood, traumatism and bleeding, carbuncle sore tumefacting virus, skin moisture fester. [extracts] " Chinese pharmacopoeia ".
Honeycomb: this product is Vespidae insect fruit hornet Polistesolivaceous(DeGeer), the long pin wasp of JapanThe nest of PolistesjaponicusSaussure or different abdomen wasp ParapolybiavariaFabricius. Autumn, winter twoJi Caishou, dries, or slightly steams, and removes the dead pupa of dead honeybee, dries. In the form of annular discs or the irregular flat bulk of [proterties] this product, hasLike lotus pod shape, not of uniform size. Surface canescence or taupe. The outside of belly has most neat holes, hexagon room, aperture 3～4mm or 6～8mm; There are 1 or several black short handle in the back side. Body is light, and matter is tough, slightly flexible. Gas is micro-, and taste is pungent light. Crisp or the hard person of matter is notCan hyoscine. [nature and flavor] are sweet, flat. [return through] returns stomach warp. [function cures mainly] dispels the wind, merit poison, desinsection, pain relieving. For carious tooth toothBitterly, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, the fungal infection of the hand. [extracts] " Chinese pharmacopoeia ".
Dandelion: this product is feverfew dandelion TaraxacummongolicumHand.-Mazz., alkali ground Pu public affairsEnglish TaraxacumsinicumKitag. or belong to the dry herbs of several plants together. Spend spring to autumn while just opening and excavate, removeImpurity, cleans, and dries. [proterties] this product is the curling agglomerate of shrinkage. It is conical that root is, how bending, long 3～7cm; Surface palm fibreBrown, shirring; Root head has the fine hair of sepia or yellow-white, and what have comes off. Phyllopodium is raw, many shrinkages fragmentation, intact leafBe down lanceolar, green and brown look or lead, tip point or blunt, edge is shallow to be split or pinnation, and base portion is gradually narrow, the downward handle shape that is,Lower surface master pulse is obvious. Scape 1 is to several, every top repiece locusta, and phyllary multilayer, inner face one deck is longer, and corolla is yellowish-brownLook or yellowish white. The oblong achene of the visible most tool white pappus that have. Gas is micro-, mildly bitter flavor. [nature and flavor] are bitter, sweet,Cold. [return through] returns liver, stomach warp. [function cures mainly] is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia. For furuncle swelling toxin, acute mastitis,Scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, heat is drenched puckery pain. [extracts] " Chinese pharmacopoeia ".
Rhizoma alismatis: [herbal classic] taste is sweet cold. Main wind-cold-dampness arthralgia, the newborn difficulty water that disappears, supports the five internal organs, and beneficial strength is fertile strong. Take for a long time knowledge acute hearingBright, not hungry, to prolong life and make light of one's life by commiting suicide, the light of looking unfamiliar, can manage it waterborne. A watery diarrhea, an awns taro, a swan rushes down. Raw Chi Ze. Taste is salty, is slightly cold,Enter kidney meridian, the urinary bladder channel of foot-Taiyang. Dry soil rushes down wet, and promoting diuresis for stranguria, except patient suffering from fluid-retention syndrome's vertigo, is treated the dry thirsty of diseases caused by dampness, enraged water swellingAll spirits, the diaphragm gastric disorder causing nausea of choking is all imitated. [extracts] " Changsha medicine solution " volume four.
Su Ye: [herbal classic] nothing. Taste is pungent, enter lung meridian. Fall punching contrary and drive turbidly, disappear and stagnate and dissipating bind. Su Yexin falls apart itProperty, kind broken solidifying cold and undershoot is contrary, chest expanding abdomen and dissipate-swelling is full, therefore can control the card of stasis in pharynx, reaches arteries and veins and stimulate the menstrual flow, and sends out and rushes down chill, twoSeparate the medicine of China and foreign countries also. Its all curing mainly, table chill, relievings asthma and coughs, subduing inflammation, peace damage, only loses blood, and separates crab poison. [extracts] " Changsha medicineSeparate " volume three.
Aucubin (aucubin): No. CAS: 479-98-1, molecular formula C15H22O9, molecular weight 346.33, peach leaf coralCoral glycosides is a kind of important bioactivator, has clearing away damp-heat, diuresis, analgesia, step-down, liver protecting, the work such as antitumorWith. It can promote stem cell regenerating, obviously suppresses copying of hepatitis B virus DNA, and its aglycon and effectively polymer are a kind ofAntibiotic. It is one of active ingredient of the Chinese medicines such as the bark of eucommia, Asiatic plantain, glutinous rehmannia, is again the quality index of some patent medicine.
Platycodin D (platycodinD): No. CAS: 58479-68-8, molecular formula: C57H92O28, molecular weight1225.32358. To the direct stimulation of oral cavity, throat, gastric mucosa, reflectivity ground increase tunica mucosa bronchiorum hypersecretion fromAnd make sputum dilution, be easy to discharge.
The chemical constitution of 2 bulk drugs:
Aucubin (aucubin)
Platycodin D (platycodinD).
Summary of the invention
The object of the invention is to overcome the deficiency of background technology, provide a kind of effective treatment tympanitis pharmaceutical composition andIts preparation method.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the bulk drug of the pharmaceutical composition of this treatment tympanitis are:
The fragrant shepherd's purse 80-100 of great Ye weight portion, Chinese gall 70-90 weight portion, honeycomb 80-90 weight portion, dandelion 80-100 weightPart, rhizoma alismatis 50-70 weight portion, Su Ye 50-70 weight portion, aucubin 3-5 weight portion, Platycodin D 2-3 weight portion.
Preferably be used for the treatment of the pharmaceutical composition of tympanitis, formed by the bulk drug of following weight portion:
Fragrant shepherd's purse 90 weight portions of great Ye, Chinese gall 80 weight portions, honeycomb 85 weight portions, dandelion 90 weight portions, rhizoma alismatis 60 weightPart, Su Ye 60 weight portions, aucubin 4 weight portions, Platycodin D 2.5 weight portions.
Treat a pharmaceutical composition for tympanitis, it is characterized in that pharmaceutical composition can adopt the routine side of galenic pharmacyLegal system standby one-tenth tablet or capsule or dripping pill.
Treat a pharmaceutical composition for tympanitis, it is characterized in that controlling of pharmaceutical composition and chemical drugs or Chinese medicine compositionTreat tympanitis medicine.
Treat a preparation method for the pharmaceutical composition of tympanitis, it is characterized in that preparing as follows:
The composition of bulk drug and weight portion are: the fragrant shepherd's purse 80-100 of great Ye weight portion, Chinese gall 70-90 weight portion, honeycomb 80-90Weight portion, dandelion 80-100 weight portion, rhizoma alismatis 50-70 weight portion, Su Ye 50-70 weight portion, aucubin 3-5 weightPart, Platycodin D 2-3 weight portion;
Preparation method: get the fragrant shepherd's purse of great Ye, Chinese gall, honeycomb, dandelion, rhizoma alismatis, Su Ye, peach jaurel by bulk drug proportioningGlycosides, Platycodin D, mix, and, gets 55 DEG C of warm lixiviates as solvent with weight percent concentration 50% ethanol, and extraction time is 4Inferior, each extraction time is 1.5 hours, and each solvent load is 15 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extractionLiquid, extract reclaims ethanol, is concentrated into relative density 1.13, filters, and liquid is by LS-300 large pore resin absorption column, first waterWash-out, then use the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, collect percentage by weight denseSpend 65% ethanol eluate, reclaim ethanol, concentrate drying, obtains pharmaceutical composition.
The preparation method of preferred a kind of pharmaceutical composition for the treatment of tympanitis, is characterized in that preparing as follows:
The composition of bulk drug and weight portion are: fragrant shepherd's purse 90 weight portions of great Ye, Chinese gall 80 weight portions, honeycomb 85 weight portions, PuPublic English 90 weight portions, rhizoma alismatis 60 weight portions, Su Ye 60 weight portions, aucubin 4 weight portions, Platycodin D 2.5 weight portions;
Preparation method: get the fragrant shepherd's purse of great Ye, Chinese gall, honeycomb, dandelion, rhizoma alismatis, Su Ye, peach jaurel by bulk drug proportioningGlycosides, Platycodin D, mix, and, gets 55 DEG C of warm lixiviates as solvent with weight percent concentration 50% ethanol, and extraction time is 4Inferior, each extraction time is 1.5 hours, and each solvent load is 15 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extractionLiquid, extract reclaims ethanol, is concentrated into relative density 1.13, filters, and liquid is by LS-300 large pore resin absorption column, first waterWash-out, then use the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, collect percentage by weight denseSpend 65% ethanol eluate, reclaim ethanol, concentrate drying, obtains pharmaceutical composition.
Treat a preparation method for the pharmaceutical composition of tympanitis, it is characterized in that pharmaceutical composition can adopt preparationThe conventional method of learning is prepared into tablet or capsule or dripping pill.
Treat a preparation method for the pharmaceutical composition of tympanitis, it is characterized in that pharmaceutical composition and chemical drugs or inMedicine composition treatment tympanitis medicine.
Detailed description of the invention
Embodiment 1: pharmaceutical composition for the treatment of tympanitis and preparation method thereof
Composition and the weight portion of the bulk drug of the pharmaceutical composition for the treatment of tympanitis are: fragrant shepherd's purse 90 weight portions of great Ye, Chinese gall80 weight portions, honeycomb 85 weight portions, dandelion 90 weight portions, rhizoma alismatis 60 weight portions, Su Ye 60 weight portions, aucubin 4 weightsAmount part, Platycodin D 2.5 weight portions;
Preparation method: get the fragrant shepherd's purse of great Ye, Chinese gall, honeycomb, dandelion, rhizoma alismatis, Su Ye, peach jaurel by bulk drug proportioningGlycosides, Platycodin D, mix, and, gets 55 DEG C of warm lixiviates as solvent with weight percent concentration 50% ethanol, and extraction time is 4Inferior, each extraction time is 1.5 hours, and each solvent load is 15 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extractionLiquid, extract reclaims ethanol, is concentrated into relative density 1.13, filters, and liquid is by LS-300 large pore resin absorption column, first waterWash-out, then use the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, collect percentage by weight denseSpend 65% ethanol eluate, reclaim ethanol, concentrate drying, obtains pharmaceutical composition.
Embodiment 2: pharmaceutical composition for the treatment of tympanitis and preparation method thereof
Composition and the weight portion of the bulk drug of the pharmaceutical composition for the treatment of tympanitis are: fragrant shepherd's purse 80 weight portions of great Ye, Chinese gall90 weight portions, honeycomb 80 weight portions, dandelion 100 weight portions, rhizoma alismatis 50 weight portions, Su Ye 70 weight portions, aucubin 3 weightsAmount part, Platycodin D 3 weight portions;
Preparation method: get the fragrant shepherd's purse of great Ye, Chinese gall, honeycomb, dandelion, rhizoma alismatis, Su Ye, peach jaurel by bulk drug proportioningGlycosides, Platycodin D, mix, and, gets 55 DEG C of warm lixiviates as solvent with weight percent concentration 50% ethanol, and extraction time is 4Inferior, each extraction time is 1.5 hours, and each solvent load is 15 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extractionLiquid, extract reclaims ethanol, is concentrated into relative density 1.13, filters, and liquid is by LS-300 large pore resin absorption column, first waterWash-out, then use the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, collect percentage by weight denseSpend 65% ethanol eluate, reclaim ethanol, concentrate drying, obtains pharmaceutical composition.
Embodiment 3: pharmaceutical composition for the treatment of tympanitis and preparation method thereof
Composition and the weight portion of the bulk drug of the pharmaceutical composition for the treatment of tympanitis are: fragrant shepherd's purse 100 weight portions of great Ye, Chinese gall70 weight portions, honeycomb 90 weight portions, dandelion 80 weight portions, rhizoma alismatis 70 weight portions, Su Ye 50 weight portions, aucubin 5 weightsAmount part, Platycodin D 2 weight portions;
Preparation method: get the fragrant shepherd's purse of great Ye, Chinese gall, honeycomb, dandelion, rhizoma alismatis, Su Ye, peach jaurel by bulk drug proportioningGlycosides, Platycodin D, mix, and, gets 55 DEG C of warm lixiviates as solvent with weight percent concentration 50% ethanol, and extraction time is 4Inferior, each extraction time is 1.5 hours, and each solvent load is 15 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extractionLiquid, extract reclaims ethanol, is concentrated into relative density 1.13, filters, and liquid is by LS-300 large pore resin absorption column, first waterWash-out, then use the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, collect percentage by weight denseSpend 65% ethanol eluate, reclaim ethanol, concentrate drying, obtains pharmaceutical composition.
Embodiment 4: the preparation of tablet
Get embodiment 1 pharmaceutical composition 85g, add starch 55g, mix, granulate, dry, add microcrystalline cellulose 10g, stearic acidMagnesium 1g, mixes, and is pressed into 100, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Get embodiment 2 pharmaceutical composition 85g, add starch 65g, mix, granulate, dry, whole grain, adds appropriate dolomol,Mix, encapsulated 100, obtain medicament composition capsule.
Embodiment 6: the preparation of dripping pill
Take Macrogol 6000 180g water-bath (80 DEG C) heating and boil moltenly, add embodiment 3 pharmaceutical composition 30g, fully stirMix evenly, taking atoleine as cooling agent, put in glass tube (4*80cm), chilling temperature is 4 DEG C, and drip internal-and external diameter is 7.0/2.0 (mm/mm), drip is 1.5cm apart from liquid level, drips speed taking 45 of per minutes as optimum condition, blots the cold of dripping pill surface with cottonSolidifying agent, obtains medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition for the treatment of tympanitis
Composition and the weight portion of the bulk drug of the pharmaceutical composition for the treatment of tympanitis are:
Dandelion 80 weight portions, rhizoma alismatis 70 weight portions, aucubin 2 weight portions, Platycodin D 2 weight portions.
Embodiment 8: the pharmaceutical composition for the treatment of tympanitis
Composition and the weight portion of the bulk drug of the pharmaceutical composition for the treatment of tympanitis are:
Dandelion 40 weight portions, rhizoma alismatis 70 weight portions, aucubin 0.5 weight portion, Platycodin D 3 weight portions.
Embodiment 9: the pharmaceutical composition for the treatment of tympanitis
Composition and the weight portion of the bulk drug of the pharmaceutical composition for the treatment of tympanitis are:
Dandelion 110 weight portions, rhizoma alismatis 40 weight portions, aucubin 4 weight portions, Platycodin D 1 weight portion.
Experimental example 1: the experimental study for the treatment of tympanitis
1 data and method
1.1 physical data
Select the medical treatment of the 2012-2013 of institute of traditional Chinese medicine of Shandong Province otitis media suppurative patient 80 examples, wherein male 42 examples, female 38Example. 8O example patient is divided into control group (40 example) and observation group's (40 example) at random. Control group the range of age is 20～51 years old, average38 years old age; In the range of age 18-49 of observation group year, 37.2 years old mean age, all patients are all diagnosed as in chronic purulentOtitis, two groups of sex, age, disease character and course of disease difference all do not have statistical significance (P > 0.05), have comparativity.
1.2 method
Control group: first rinse external auditory meatus with 3% hydrogen peroxide, then process fester with attractor, advise after complete patient askew to strongSide makes Ipsilateral upward, splashes into 5～8 [Dans, keeps posture 10min, and 2 times/d, ear fluid is selected ofloxacin ear drops. ObserveGroup: washing external auditory meatus and to splash into ear fluid method identical with control group, and add pharmaceutical composition (embodiment 1 medicine group simultaneouslyCompound lot number 20110316), each 1.5g, take every day for 2 times.
All after 14 days, observe patient's symptom and curative effect for two groups.
1.3 criterion of therapeutical effect
Cure: in ear, flow out without fester, and ear inner drying is clean, mucous membrane is without oedema and congested phenomenon; Effective: in ear, fester dividesSecrete minimizing, still have humidity in ear, but also not serious, mucous membrane still has oedema or hyperemia, but is slight; Invalid: in ear, fester dividesSecrete there is no and reduce or increase, moist in duct, mucous membrane hyperemia or oedema.
1.4 statistical method
Adopt SPSS10.0 statistical software to carry out data processing, represent that with P < 0.05 difference has statistical significance.
2 results
Control group is cured 19 examples, effective 16 examples, invalid 5 examples, cure rate 47.5%, total effective rate 87.5%; Observation group cures30 examples, effective 8 examples, invalid 2 examples, cure rate 75.0%, total effective rate 95.0%, in table 1.
Table 1 liang group patient's result for the treatment of comparison [example (%)]
| Group | Number of cases | Recovery from illness | Effectively | Invalid | Cure rate | Total effective rate |
| Observation group | 40 | 30* | 8 | 2 | 75.0 ％ | 95.0%* |
| Control group | 40 | 19 | 16 | 5 | 47.5％ | 87.5% |
Note: with control group comparison, * P < 0.05.
Experimental example 2: model case
Week XX, man, 31 years old, tympanitis patient, cardinal symptom: occurred before half a year that auris dextra suppurates repeatedly, companion's Hearing. Subsequently,Left ear also occurs repeatedly suppurating (companion's Hearing), is yellow-white thickness sample, measures mediumly, has a little peculiar smell. After the treatment of locality,Have no improvement. Patient starts to take this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number on July 9th, 201320110316), each 1.5g, every day 2 times, 7d is 1 course for the treatment of, after continuous 2 courses for the treatment of, all shapes disappear, and thoroughly cure.
Lee XX, female, 40 years old, otitis media acuta patient, cardinal symptom: feel that ear is vexed, hearing is gradually fallen, companion's tinnitus. Otalgia playStrong, also with chilly, heating etc. Occur once in a while the symptom that ear is suppurated, patient started to take this medicine on June 2nd, 2013Composition (embodiment 1 pharmaceutical composition lot number 20110316), each 1.5g, every day 2 times, 7d is 1 course for the treatment of, continuous 2After the individual course for the treatment of, all shapes disappear, and thoroughly cure.
King XX, man, 32 years old, tympanitis patient, cardinal symptom: have a small amount of mucus in duct, often with buzz and streamThe underwater sound. Patient starts to take this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20110316) on April 2nd, 2013, everyInferior 1.5g, every day 2 times, 7d is 1 course for the treatment of, after continuous 2 courses for the treatment of, all shapes disappear, and thoroughly cure.
Claims (8)
1. treat a pharmaceutical composition for tympanitis, it is characterized in that the composition of the bulk drug of making this pharmaceutical composition and weighAmount part is:
The fragrant shepherd's purse 80-100 of great Ye weight portion, Chinese gall 70-90 weight portion, honeycomb 80-90 weight portion, dandelion 80-100 weightPart, rhizoma alismatis 50-70 weight portion, Su Ye 50-70 weight portion, aucubin 3-5 weight portion, Platycodin D 2-3 weight portion.
2. a kind of pharmaceutical composition for the treatment of tympanitis according to claim 1, is characterized in that making this pharmaceutical compositionComposition and the weight portion of bulk drug be:
Fragrant shepherd's purse 90 weight portions of great Ye, Chinese gall 80 weight portions, honeycomb 85 weight portions, dandelion 90 weight portions, rhizoma alismatis 60 weightPart, Su Ye 60 weight portions, aucubin 4 weight portions, Platycodin D 2.5 weight portions.
3. a kind of pharmaceutical composition for the treatment of tympanitis according to claim 1, is characterized in that pharmaceutical composition can adoptBe prepared into tablet or capsule or dripping pill by the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for the treatment of tympanitis according to claim 1, is characterized in that pharmaceutical composition and chemistryThe treatment tympanitis medicine of medicine or Chinese medicine composition.
5. treat a preparation method for the pharmaceutical composition of tympanitis, it is characterized in that preparing as follows:
The composition of bulk drug and weight portion are: the fragrant shepherd's purse 80-100 of great Ye weight portion, Chinese gall 70-90 weight portion, honeycomb 80-90Weight portion, dandelion 80-100 weight portion, rhizoma alismatis 50-70 weight portion, Su Ye 50-70 weight portion, aucubin 3-5 weightPart, Platycodin D 2-3 weight portion;
Preparation method: get the fragrant shepherd's purse of great Ye, Chinese gall, honeycomb, dandelion, rhizoma alismatis, Su Ye, peach jaurel by bulk drug proportioningGlycosides, Platycodin D, mix, and, gets 55 DEG C of warm lixiviates as solvent with weight percent concentration 50% ethanol, and extraction time is 4Inferior, each extraction time is 1.5 hours, and each solvent load is 15 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extractionLiquid, extract reclaims ethanol, is concentrated into relative density 1.13, filters, and liquid is by LS-300 large pore resin absorption column, first waterWash-out, then use the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, collect percentage by weight denseSpend 65% ethanol eluate, reclaim ethanol, concentrate drying, obtains pharmaceutical composition.
6. a kind of preparation method of pharmaceutical composition for the treatment of tympanitis according to claim 5, is characterized in that by as followsStep preparation:
The composition of bulk drug and weight portion are: fragrant shepherd's purse 90 weight portions of great Ye, Chinese gall 80 weight portions, honeycomb 85 weight portions, PuPublic English 90 weight portions, rhizoma alismatis 60 weight portions, Su Ye 60 weight portions, aucubin 4 weight portions, Platycodin D 2.5 weight portions;
Preparation method: get the fragrant shepherd's purse of great Ye, Chinese gall, honeycomb, dandelion, rhizoma alismatis, Su Ye, peach jaurel by bulk drug proportioningGlycosides, Platycodin D, mix, and, gets 55 DEG C of warm lixiviates as solvent with weight percent concentration 50% ethanol, and extraction time is 4Inferior, each extraction time is 1.5 hours, and each solvent load is 15 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extractionLiquid, extract reclaims ethanol, is concentrated into relative density 1.13, filters, and liquid is by LS-300 large pore resin absorption column, first waterWash-out, then use the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, collect percentage by weight denseSpend 65% ethanol eluate, reclaim ethanol, concentrate drying, obtains pharmaceutical composition.
7. a kind of preparation method of pharmaceutical composition for the treatment of tympanitis according to claim 5, is characterized in that medicine groupCompound can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or dripping pill.
8. a kind of preparation method of pharmaceutical composition for the treatment of tympanitis according to claim 5, is characterized in that medicine groupCompound and chemical drugs or Chinese medicine composition treatment tympanitis medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511768A (en) * | 2016-12-10 | 2017-03-22 | 济南昊雨青田医药技术有限公司 | Pharmaceutical composition for preventing and treating tympanitis and preparation method thereof |
| CN106619790A (en) * | 2016-12-10 | 2017-05-10 | 济南昊雨青田医药技术有限公司 | Pharmaceutical composition for preventing and treating otitis media and preparation method of pharmaceutical composition |
| CN108938673A (en) * | 2018-08-22 | 2018-12-07 | 赵丽静 | A kind of drug and preparation method thereof for treating otitis media suppurative |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705802A (en) * | 2014-01-02 | 2014-04-09 | 王雪雁 | Medicine composition for curing otitis media and application thereof |
| CN103784640A (en) * | 2014-01-15 | 2014-05-14 | 纪晓青 | Traditional Chinese medicinal herbal preparation and preparation method thereof |
| CN104873836A (en) * | 2015-06-02 | 2015-09-02 | 岳兵兵 | Otitis media suppurativa treatment external use medicine and preparation method |
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705802A (en) * | 2014-01-02 | 2014-04-09 | 王雪雁 | Medicine composition for curing otitis media and application thereof |
| CN103784640A (en) * | 2014-01-15 | 2014-05-14 | 纪晓青 | Traditional Chinese medicinal herbal preparation and preparation method thereof |
| CN104873836A (en) * | 2015-06-02 | 2015-09-02 | 岳兵兵 | Otitis media suppurativa treatment external use medicine and preparation method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511768A (en) * | 2016-12-10 | 2017-03-22 | 济南昊雨青田医药技术有限公司 | Pharmaceutical composition for preventing and treating tympanitis and preparation method thereof |
| CN106619790A (en) * | 2016-12-10 | 2017-05-10 | 济南昊雨青田医药技术有限公司 | Pharmaceutical composition for preventing and treating otitis media and preparation method of pharmaceutical composition |
| CN108938673A (en) * | 2018-08-22 | 2018-12-07 | 赵丽静 | A kind of drug and preparation method thereof for treating otitis media suppurative |
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