CN105596567A - Traditional Chinese medicine composition for treating bone fracture and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating bone fracture and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating bone fracture and a preparation method thereof. The traditional Chinese medicine composition is prepared from, by weight, 10-22 parts of Vitex negundo L., 12-24 parts of fructus psoraleae, 12-22 parts of air plant herb, 10-22 parts of radix astragali, 8-20 parts of leaves of Clematis filamentosa Dunn, 8-18 parts of moutan bark, 6-18 parts of ground beetles, 6-18 parts of poria cocos, 6-18 parts of szechwan lovage rhizome, 8-16 parts of radix angelica sinensis and 6-14 parts of liquorice roots. The medicine composition is reasonable in formula and strong in synergistic effect, has functions, is remarkable in treatment effect and high in cure rate, and has remarkable clinical popularization value.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, particularly relate to Chinese medicine composition and the preparation side thereof for the treatment of fractureMethod.
Background technology
Fracture has destroyed continuity and the integrality of bone due to the effect of external force, cause bone portion or completely disconnectedSplit. Fracture can cause because of direct violence, again can be because indirect violence is as lever violence, torsion violence or longitudinally conductionViolence and causing; Muscles shrinks hurriedly or tractive, bone are given a shock for a long time or be out of shape and also can cause fracture. ThisOutward, External Force Acting is in human body, also can because of age, health status (as the elderly easily suffers from osteoporosis etc.),Whether the region of anatomy, structure, injured posture, bone have the former difference of sending out the factors such as pathology inherent, produce differentThe damage of type.
The traditional Chinese medical science, taking diagnosis and treatment as basis, is implemented " be association of activity and inertia, muscles and bones is laid equal stress on, internal and external application, cooperation between the doctors and patients "Principle of reatment, emphasize organic conception, internal and external application. Handle well dialectically reset in fractures, fixing,The do exercises relation of activity and medicine treatment. Accomplish that as far as possible the reduction of the fracture does not increase local soft tissue damage, fixingFracture and do not hinder limb activity, thereby can promote whole body qi-blood circulating, enhancing metabolism, unionAdvance side by side with functional rehabilitation. Meanwhile, the traditional Chinese medical science thinks that for oral administration and external used medicine is two important sides for the treatment of fractureMethod. Traumatology has accumulated many secret recipes, proved recipe, all has his own strong points, but always with " traumatic injury, all hemostasisAlso the blood stasis of blood of not living can not be gone interior and loose, and the stasis of blood is not gone to roll over and can not be continued " and " stasis of blood is gone, new life, bone and "As theoretical background. Take orally and external used medicine, to correcting the internal organs, channels and collaterals, the qi and blood merit that cause because of damageCan be disorderly, promote the healing of fracture all to have good action.
Chinese patent application 201410243537.0 discloses a kind of Chinese medicine composition for the treatment of fracture, this Chinese medicineComposition is made by following raw material: Cordyceps sinensis, Moschus, safflower, leech, frankincense, myrrh, dragon's blood,The rhizome of davallia, teasel root, sea crab shell, Radix Angelicae Sinensis, cortex acanthopanacis, stir-baked SQUAMA MANITIS, ground bettle, the red sage root, bush, peach kernel,Rhizoma cibotii etc. The Chinese medicine composition preparation technology that this kind treated bone fracture bone fracture disease is simple, taking convenience, but medicament categoriesNumerous, complicated component, the cost of the medicines such as while Cordyceps sinensis, Moschus is higher, is unfavorable for promoting.
Summary of the invention
The technical problem to be solved in the present invention is to provide the Chinese medicine composition for the treatment of fracture, and this Chinese medicine composition hasRemove obstruction in channels to relieve pain, promoting blood circulation and removing blood stasis, reunion of fractured tendons and bones, effect of the peaceful heart of invigorating the spleen, possesses that result for the treatment of is remarkable, drug effect is steadyThe advantages such as calmly, preparation technology is simple, medicine cost is low and be easy to apply. In addition, the present invention also provides phaseThe manufacturing process of answering is made this pharmaceutical composition to facilitate easy-to-use preparation under the prerequisite that ensures curative effect.
The Chinese medicine composition that the present invention treats fracture is made up of the medicinal material of following parts by weight:
Vitex negundo var cannabifolia 10-22 part, Psoralea corylifolia 12-24 part, the 12-22 part of taking root, Radix Astragali 10-22 part, Gan MuLogical 8-20 part, moutan bark 8-18 part, ground bettle 6-18 part, Poria cocos 6-18 part, Ligusticum wallichii 6-18 part, Radix Angelicae Sinensis8-16 part and Radix Glycyrrhizae 6-14 part.
Preferably, described Chinese medicine composition is made up of the medicinal material of following parts by weight:
10 parts of Vitex negundo var cannabifolias, 12 parts of Psoralea corylifolias, 12 parts, 10 parts of the Radixs Astragali, 8 parts of sweet akebis, tree peony take root6 parts, 8 parts of skins, 6 parts of ground bettles, 6 parts, Poria cocos, 6 parts of Ligusticum wallichiis, 8 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.
Further preferably, described Chinese medicine composition is made up of the medicinal material of following parts by weight:
22 parts of Vitex negundo var cannabifolias, 24 parts of Psoralea corylifolias, 22 parts, 22 parts of the Radixs Astragali, 20 parts of sweet akebis, male take root14 parts, 18 parts of the root barks of tree peony, 18 parts of ground bettles, 18 parts, Poria cocos, 18 parts of Ligusticum wallichiis, 16 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.
Still more preferably, described Chinese medicine composition is made up of the medicinal material of following parts by weight:
16 parts of Vitex negundo var cannabifolias, 18 parts of Psoralea corylifolias, 17 parts, 16 parts of the Radixs Astragali, 14 parts of sweet akebis, male take root10 parts, 13 parts of the root barks of tree peony, 12 parts of ground bettles, 12 parts, Poria cocos, 12 parts of Ligusticum wallichiis, 12 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.
Further, the present invention treats the Chinese medicine composition of fracture, can granulation agent, tablet, capsule,The multiple formulations such as pill, oral liquid, powder.
The preparation method that the present invention treats the Chinese medicine composition of fracture comprises following steps:
S1: take respectively ingredients, wash away impurity, pulverize respectively after being dried, cross 60-80 mesh sieve, obtain slightlyPowder, for subsequent use;
S2: get Vitex negundo var cannabifolia, Psoralea corylifolia, take root, the Radix Astragali, sweet akebi, moutan bark, ground bettle, Poria cocos,Ligusticum wallichii, Radix Angelicae Sinensis and Radix Glycyrrhizae meal mix, and adding medicinal material coarse powder gross weight 10-16 doubly to measure volume fraction is 60-80%Ethanol, Microwave Extraction 20-30 minute, microwave power is 400-600W, extraction temperature is 40-60 DEG C, mistakeFilter and retain filter residue, filtrate decompression is concentrated into the medicinal extract that at 60 DEG C, relative density is 1.10-1.20, makes extractionThing A;
S3: toward the water soaking 30-60 minute that adds filter residue gross weight 8-12 doubly to measure in the filter residue of S2 gained, returnStream extracts 2-3 time, and each 3-5 hour, filters, merging filtrate, and filtrate decompression is concentrated at 60 DEG C relatively closeDegree, for the medicinal extract of 1.10-1.20, makes extract B;
S4: merge extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
Source, the nature and flavor of the present invention's Chinese medicine used, return through and effect:
Schizonepeta: this product is the dry aerial parts of labiate schizonepeta; Taste is pungent, slightly warm in nature; Return lung, Liver Channel;The loose wind that induces sweat, promoting eruption.
Psoralea corylifolia: the dry mature fruit that this product is legumes psoraleae; Taste is pungent, bitter, warm in nature; Return kidney,The spleen channel; Warming kidney and enhancing yang, receives gas, antidiarrheal.
Take root: the Crassulaceae platymiscium that takes root takes root, with all herbal medicine; Lightly seasoned, micro-acid, puckery,Cool in nature; Return lung, kidney channel; Removing toxicity for detumescence, promoting blood circulation and stopping pain, removing toxic substances and promoting tissue regeneration.
The Radix Astragali: this product is the root of legume Radix Hedysari multijugi; Taste is sweet, warm in nature; The thoughts of returning home, lung, spleen, kidney channel;Invigorating qi for strengthening superficies, diuresis, pus draining and toxin expelling, regenerating tissue to heal wond.
Sweet akebi: this product is the sweet akebi of Ranunculaceae, is used as medicine with leaf. Taste is sweet, slightly cool in nature; The thoughts of returning home, Liver Channel; ClearlyIrascibility, the peaceful mind, hypotensive, remove obstruction in channels to relieve pain.
Moutan bark: the dry root skin that this product is ranunculaceae peony. Bitter, pungent, cold nature; The thoughts of returning home, liver,Kidney channel; Clearing heat and cooling blood, promoting blood circulation and removing blood stasis.
Ground bettle: this product is the dry body of the female worm of Corydiidae insect eupolyphoge sinensis or Ji eupolyphoge sinensis; Taste is salty, cold in nature; Return liverWarp; Dissipating blood stasis with potent drugs, reunion of fractured tendons and bones.
Poria cocos: this product is the dry sclerotia of On Polyporaceae Poria cocos; Taste is sweet, light, and property is flat; The thoughts of returning home, lung,Spleen, kidney channel; Clearing damp and promoting diuresis, the peaceful heart of invigorating the spleen.
Ligusticum wallichii: this product is the rhizome of Umbelliferae herbaceous plant Ligusticum wallichii; Taste is pungent, warm in nature; Return liver, gallbladder channel; Promoting the circulation of qiOpen strongly fragrantly, dispel pathogenic wind and remove dampness, promoting blood circulation and stopping pain.
Radix Angelicae Sinensis: the dry root that this product is umbelliferae angelica; Taste is sweet, pungent, warm in nature; Return liver, the heart, the spleen channel;Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, glycyrrhiza inflate bat or glycyrrhiza glabra. Taste is sweet, and property is flat;The thoughts of returning home, lung, spleen, stomach warp; Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
The prescription analysis of Chinese prescription of the present invention:
The Chinese medicine composition that the present invention treats fracture is taking Vitex negundo var cannabifolia, Psoralea corylifolia and takes root as monarch drug in a prescription, induces sweat looseWind, warming kidney and enhancing yang, removing toxicity for detumescence; Taking the Radix Astragali, sweet akebi and moutan bark as ministerial drug, invigorating qi for strengthening superficies, dredging collateral is onlyBitterly, promoting blood circulation and removing blood stasis; With ground bettle, Poria cocos, Ligusticum wallichii with when being classified as adjutant, reunion of fractured tendons and bones, the peaceful heart of invigorating the spleen, livesBlood and relieving pain, enriches blood and invigorates blood circulation; Radix Glycyrrhizae, for making medicine, is invigorated the spleen and benefited qi, clearing heat and detoxicating, coordinating the drug actions of a prescription. Jointly reach logicalNetwork pain relieving, promoting blood circulation and removing blood stasis, reunion of fractured tendons and bones, the effects such as invigorating the spleen Ning Xin, have very significantly and control fracture patientTherapeutic effect.
Compared with prior art, the Chinese medicine composition that the present invention treats fracture has following advantage:
(1) Chinese medicine composition of the present invention has good curative effect to fracture rat, particularly uses senior amount group to enterRow treatment, its result for the treatment of is better than positive control drug. The clinical test of pesticide effectiveness shows, clinical fracture aspiration patient clothesWith the Chinese medicinal capsule of the embodiment of the present invention, fracture cure rate reaches more than 65%, and total effective rate reaches more than 90%,Be better than taking cure rate and the total effective rate of positive control drug.
(2) Chinese medicine composition of the present invention is natural Chinese traditional medicines prescription, has and removes obstruction in channels to relieve pain, promoting blood circulation and removing blood stasis, continuous muscleSynthetism, effect of the peaceful heart of invigorating the spleen, and also Chinese prescription is simple, and treatment cycle is short, toxic and side effect is little.
Detailed description of the invention
Further describe the present invention by specific embodiment below, the present invention is not limited only to following examples. ?In scope of the present invention or not departing from content of the present invention, spirit and scope, the change that the present invention is carried outMore, combination or replace, be apparent for a person skilled in the art, and be included in of the present inventionWithin scope.
EXAMPLE l:
The present embodiment Chinese medicine composition is made up of the medicinal material of following parts by weight:
10 parts of Vitex negundo var cannabifolias, 12 parts of Psoralea corylifolias, 12 parts, 10 parts of the Radixs Astragali, 8 parts of sweet akebis, tree peony take root6 parts, 8 parts of skins, 6 parts of ground bettles, 6 parts, Poria cocos, 6 parts of Ligusticum wallichiis, 8 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.
Preparation method is as follows:
S1: take respectively ingredients, wash away impurity, after being dried, pulverize respectively, cross 80 mesh sieves, obtain meal,For subsequent use;
S2: get Vitex negundo var cannabifolia, Psoralea corylifolia, take root, the Radix Astragali, sweet akebi, moutan bark, ground bettle, Poria cocos,Ligusticum wallichii, Radix Angelicae Sinensis and Radix Glycyrrhizae meal mix, and add the second that 16 times of amount volume fractions of medicinal material coarse powder gross weight are 80%Alcohol, Microwave Extraction 30 minutes, microwave power is 600W, extracting temperature is 60 DEG C, filter and retain filter residue,Filtrate decompression is concentrated into the medicinal extract that at 60 DEG C, relative density is 1.10, makes extract A;
S3: toward the water soaking 60 minutes that adds 12 times of amounts of filter residue gross weight in the filter residue of S2 gained, backflow is carriedGet 3 times, each 5 hours, filter, merging filtrate, it is 1.10 that filtrate decompression is concentrated into relative density at 60 DEG CMedicinal extract, make extract B;
S4: merge extract A and extract B, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, obtains Chinese medicineFine powder;
S5: be prepared into tablet after the Chinese medicine fine powder making toward S4 adds suitable auxiliary material.
Embodiment 2:
The present embodiment Chinese medicine composition is made up of the medicinal material of following parts by weight:
22 parts of Vitex negundo var cannabifolias, 24 parts of Psoralea corylifolias, 22 parts, 22 parts of the Radixs Astragali, 20 parts of sweet akebis, male take root14 parts, 18 parts of the root barks of tree peony, 18 parts of ground bettles, 18 parts, Poria cocos, 18 parts of Ligusticum wallichiis, 16 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3:
The present embodiment Chinese medicine composition is made up of the medicinal material of following parts by weight:
16 parts of Vitex negundo var cannabifolias, 18 parts of Psoralea corylifolias, 17 parts, 16 parts of the Radixs Astragali, 14 parts of sweet akebis, male take root10 parts, 13 parts of the root barks of tree peony, 12 parts of ground bettles, 12 parts, Poria cocos, 12 parts of Ligusticum wallichiis, 12 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Pharmacodynamics test:
One, the research experiment of Chinese medicine composition of the present invention to fracture rat
1. animal used as test: 40 of healthy SPF level male Wistar rats, 3 monthly ages, body weight 320 ± 20g (byGuangdong Medical Lab Animal Center provides).
2. model is set up: rat is weighed, 10% chloraldurate solution 0.3ml/100g intraperitoneal injection of anesthesia, green grass or young cropsMould essence injecta 50mg.kg-1Intramuscular injection, preserved skin before right thigh lateral and knee, left lateral position is fixed on operating table,0.5% iodophor disinfection drape. Enuflex position lower edge in right knee kneecap, with sharp knife prick skin, is 2mm long verticalOtch, with the needle for trephination of diameter 1mm in the inner side of kneecap tendon and the intersection of kneecap lower edge is oblique thrusts above outerArticular cavity, needle point reaches to be pulled positive needle for trephination while being equivalent to the recessed inner vertex of femoral intercondylar place and makes it parallel with femoral shaft,Vertically thrust pulp cavity and reach femur total length, take out needle for trephination by long the 3.8cm that gets ready, diameter 1mm Kirschner wire byNeedle track inserts DF. The skin outside femur stage casing that continues does the long longitudinal incision of 1cm, cuts skin and subcutaneousTissue, is entered and is appeared femoral shaft by musculus lateralis externi gap, (is equivalent to section in femoral shaft in third trochanter lower edgePut) walk crosswise sawed-off femur with hand surgical saw (tread 1mm), normal saline flushing visual area, reseting fracture is disconnectedEnd, inserts by DF Kirschner wire to near-end, end is embedded under femoral intercondylar cortex of bone, checks that fracture is rightPosition is good, after fixation, and 4-0 suture layer-by-layer suture manadesma and skin incision. Postoperative intramuscular injection green grass or young crops50mg.(kg.d)-1, inject continuously 3 days.
3. test method: get 40 rats and be divided at random 5 groups, 8 every group; Be respectively model group, the positiveThe high, medium and low dosage group of tablet that control group, embodiment 3 make. Wherein, model group gavage is given isopyknicPhysiological saline; Positive controls gavage is to bone setting tablet (the accurate word Z21021461 of traditional Chinese medicines, Dalian Metro Chinese medicineCo., Ltd., Factory) suspension made, its concentration is 8mg/kg; Tablet that embodiment 3 makes is high, in,Low dose group respectively gavage is given the suspension of being made up of tablet, and dosage is respectively: 8mg/kg, 4mg/kg,2mg/kg, successive administration 30d. During treatment, each group rat is often daily raised with normal diet, ad lib, drinkWater.
4. experimental result: in table 1.
Table 1. orthopaedics x-ray evaluation criteria
The x-ray evaluation result of the each phase union of table 2. situation
5. experiment conclusion: the x-ray evaluation result of the each phase union of table 2 situation shows, is using the present inventionTraditional Chinese medicine composition for treating after, fracture has an obvious improvement. The high agent of the tablet that the embodiment of the present invention 3 makesAmount group, using the 6th week, has 7 rat fracture sites to disappear completely, periosteal reaction density in 8 ratsApproximate bone shadow, poroma is filled up damaged, identical with cortex of bone density and be connected to each other, and is better than positive controlsResult for the treatment of, meanwhile, the low dose group of Chinese medicine composition of the present invention and positive controls have suitable curative effect.Above result shows, Chinese medicine composition of the present invention has the effect that promotes union.
Two, the clinical fracture patient volunteer of the traditional Chinese medicine composition for treating of the present invention test of pesticide effectiveness
1. physical data
Screen the clinical volunteer of 320 routine fracture of rib, wherein male 200 examples, female's 120 examples, mean age 35In year, be simple fracture of rib, course of disease 2-6d. All cases all meets " practical combination of Chinese tradiational and Western medicine diagnoses and treatmentLearn " in the criterion of fracture of rib. Be divided into 4 groups, be respectively treatment A, B, C group and control group, everyOrganize 80 examples, Epidemiological Analysis by statistics, without difference, has comparativity between each group.
2. methods for the treatment of
Treatment A, B, C group: the aspiration patient tablet that oral embodiment of the present invention 1-3 makes respectively, every day2 times, each 2 20 days is a course for the treatment of.
Control group: the oral bone setting tablet of aspiration patient (the accurate word Z21021461 of traditional Chinese medicines, the Dalian Metro pharmaceutical factory of traditional Chinese medicineCo., Ltd), every day 2 times, each 4 20 days is a course for the treatment of.
3. criterion of therapeutical effect
Curative effect determinate standard: with reference to People's Republic of China's traditional Chinese medical science professional standard " disease of tcm diagnosis curative effect markAccurate ".
Recovery from illness: fracture reduction is satisfied to heal, and partial gall disappears, and cough and deep breathing are without pain;
Effective: fracture reduction is good, healing substantially, there are mild pain and tenderness in part, thorax extruding (scholar);
Invalid: fracture is healing not, and partial gall is not improved, the positive is levied in thorax extruding.
4. result
The efficacy result of the each group treatment of table 3. fracture
As shown in Table 3, clinical aspiration patient takes the tablet that embodiment of the present invention 1-3 makes, and cure rate reaches 65%Above, total effective rate reaches more than 90%, higher than cure rate and the total effective rate of taking bone setting tablet, wherein withTreatment C group is result for the treatment of the best of 3 groups of embodiment, and above result shows, Chinese medicine composition of the present invention facesBed result for the treatment of is obvious, has very much the meaning of clinical expansion.
Owing to having described the present invention by above preferred embodiment, in spirit of the present invention and/or scope,Any for replacement of the present invention/or combination implement the present invention, be all for a person skilled in the artApparent, and be included among the present invention.
Claims (7)
1. the Chinese medicine composition for the treatment of fracture, is characterized in that, described Chinese medicine composition is by the medicinal material of following parts by weightComposition: Vitex negundo var cannabifolia 10-22 part, Psoralea corylifolia 12-24 part, the 12-22 part of taking root, Radix Astragali 10-22 part, sweet akebi 8-20Part, moutan bark 8-18 part, ground bettle 6-18 part, Poria cocos 6-18 part, Ligusticum wallichii 6-18 part, Radix Angelicae Sinensis 8-16 part and Radix Glycyrrhizae6-14 part.
2. the Chinese medicine composition for the treatment of fracture according to claim 1, is characterized in that described Chinese medicine compositionMedicinal material by following parts by weight forms: 10 parts of Vitex negundo var cannabifolias, 12 parts of Psoralea corylifolias, take root 12 parts, 10 parts of the Radixs Astragali,6 parts, 8 parts of sweet akebis, 8 parts of moutan barks, 6 parts of ground bettles, 6 parts, Poria cocos, 6 parts of Ligusticum wallichiis, 8 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of fracture according to claim 1, is characterized in that described Chinese medicine compositionMedicinal material by following parts by weight forms: 22 parts of Vitex negundo var cannabifolias, 24 parts of Psoralea corylifolias, take root 22 parts, 22 parts of the Radixs Astragali,20 parts of sweet akebis, 18 parts of moutan barks, 18 parts of ground bettles, 18 parts, Poria cocos, 18 parts of Ligusticum wallichiis, 16 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae14 parts.
4. the Chinese medicine composition for the treatment of fracture according to claim 1, is characterized in that described Chinese medicine compositionMedicinal material by following parts by weight forms: 16 parts of Vitex negundo var cannabifolias, 18 parts of Psoralea corylifolias, take root 17 parts, 16 parts of the Radixs Astragali,14 parts of sweet akebis, 13 parts of moutan barks, 12 parts of ground bettles, 12 parts, Poria cocos, 12 parts of Ligusticum wallichiis, 12 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae10 parts.
5. according to the Chinese medicine composition of the treatment fracture described in claim 1-4 any one, it is characterized in that, described inThe preparation method of drug composition comprises the following steps:
S1: take respectively ingredients, wash away impurity, after being dried, pulverize respectively, cross 60-80 mesh sieve, obtain meal, standbyWith;
S2: get Vitex negundo var cannabifolia, Psoralea corylifolia, take root, the Radix Astragali, sweet akebi, moutan bark, ground bettle, Poria cocos, Ligusticum wallichii,Radix Angelicae Sinensis and Radix Glycyrrhizae meal mix, and add medicinal material coarse powder gross weight 10-16 doubly to measure the ethanol that volume fraction is 60-80%, micro-Ripple extracts 20-30 minute, and microwave power is 400-600W, and extraction temperature is 40-60 DEG C, filters and retains filter residue, filtersLiquid is evaporated to the medicinal extract that at 60 DEG C, relative density is 1.10-1.20, makes extract A;
S3: toward the water soaking 30-60 minute that adds filter residue gross weight 8-12 doubly to measure in the filter residue of S2 gained, refluxing extraction2-3 time, each 3-5 hour, filters, merging filtrate, and it is 1.10-1.20 that filtrate decompression is concentrated into relative density at 60 DEG CMedicinal extract, make extract B;
S4: merge extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
6. according to the Chinese medicine composition of the treatment fracture described in claim 1-4 any one, it is characterized in that, described inThe preparation of drug composition is granule, tablet, capsule, pill, oral liquid or powder.
7. a preparation method for the Chinese medicine composition of the fracture of the treatment as described in claim 1-6 any one, its featureBe, described preparation method comprises the following steps:
S1: take respectively ingredients, wash away impurity, after being dried, pulverize respectively, cross 60-80 mesh sieve, obtain meal, standbyWith;
S2: get Vitex negundo var cannabifolia, Psoralea corylifolia, take root, the Radix Astragali, sweet akebi, moutan bark, ground bettle, Poria cocos, Ligusticum wallichii,Radix Angelicae Sinensis and Radix Glycyrrhizae meal mix, and add medicinal material coarse powder gross weight 10-16 doubly to measure the ethanol that volume fraction is 60-80%, micro-Ripple extracts 20-30 minute, and microwave power is 400-600W, and extraction temperature is 40-60 DEG C, filters and retains filter residue, filtersLiquid is evaporated to the medicinal extract that at 60 DEG C, relative density is 1.10-1.20, makes extract A;
S3: toward the water soaking 30-60 minute that adds filter residue gross weight 8-12 doubly to measure in the filter residue of S2 gained, refluxing extraction2-3 time, each 3-5 hour, filters, merging filtrate, and it is 1.10-1.20 that filtrate decompression is concentrated into relative density at 60 DEG CMedicinal extract, make extract B;
S4: merge extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
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| CN101716266A (en) * | 2010-01-13 | 2010-06-02 | 孟照明 | Medicaments for treating fractures and preparation method thereof |
| CN102406766A (en) * | 2011-12-04 | 2012-04-11 | 许从玉 | Traditional Chinese medicine composition for treating bone fracture and application thereof |
| CN102429973A (en) * | 2011-11-28 | 2012-05-02 | 海南医学院 | Preparation method of traditional Chinese medicinal extract with effect of enhancing fracture healing |
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| CN101716266A (en) * | 2010-01-13 | 2010-06-02 | 孟照明 | Medicaments for treating fractures and preparation method thereof |
| CN102429973A (en) * | 2011-11-28 | 2012-05-02 | 海南医学院 | Preparation method of traditional Chinese medicinal extract with effect of enhancing fracture healing |
| CN102406766A (en) * | 2011-12-04 | 2012-04-11 | 许从玉 | Traditional Chinese medicine composition for treating bone fracture and application thereof |
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