CN105595337B - A kind of auxiliary hyperglycemic algin soft capsule and preparation method thereof - Google Patents
A kind of auxiliary hyperglycemic algin soft capsule and preparation method thereof Download PDFInfo
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- 230000003345 hyperglycaemic effect Effects 0.000 title claims abstract description 13
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to health product technology field, specially a kind of auxiliary hyperglycemic algin soft capsule and preparation method thereof.The soft capsule fill material is seaweed, edible and medical fungi blood-sugar decreasing active compound preparation, and group is divided into sargassum, kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, coprinus comatus, black fungus, Agricus blazei, Chinese yam, guava, soybean oil, highly basic water, pure water.Preparation method includes prepared by the extraction of raw material functional component and algin soft capsule.Manufactured algin soft capsule shell itself can avoid worry of the people to edible gelatin product, while reducing the pollution to environment containing a variety of hypoglycemic active ingredients such as algal polysaccharides with replacing whole animal origin Gelatin production soft capsule.The algin soft capsule shell and its filling liquid have improvement result to hyperglycemia caused by diabetes patient, insulin resistance, are widely used in diabetes and have no toxic side effect.
Description
Technical field
The present invention relates to health product technology field, specially a kind of auxiliary hyperglycemic algin soft capsule and its preparation side
Method.
Background technology
Diabetes are a kind of metabolic diseases characterized by hyperglycemia, hyperglycemia be then due to defect of insulin secretion or
Its biological effect is impaired, or both have concurrently and cause.Algin is the general designation of algin, agar, carragheen and its derivative.Horse hair
Algae, kelp are the main sources of algin, and algin generally exists with the sodium-salt form of alginic acid, and sodium alginate is a kind of monovalence
Water soluble algae hydrochlorate has good filming performance.Sargassum is resourceful in China, has about 60 kinds of sargassum, is mainly to produce
One of ground, Guangdong and ALONG GUANGXI COAST, especially Hainan Island and continent island and Weizhou Island are widely distributed.Fat content is relatively low in sargassum
And contain abundant minerals and vitamins, wherein B family vitamin content highest.Sargassan is proved it with hypoglycemic
Activity, the present invention have carried out hypoglycemic activity research on this basis, to sargassum oligosaccharides：Using alpha-amylase, phlorose
Glycosides enzyme and HepG2 cells study the blood sugar decreasing effect of sargassum oligosaccharides as extracorporeal receptor model, the results showed that：It is arranged with Roger
As positive drug, sargassum oligosaccharides there is preferable inhibitory activity, IC50 values to be alpha-glucosidase for ketone and acarbose
4.82mg/ml, and dose dependent is presented, while having to the glucose consumption of insulin resistance HepG2 cells apparent
Facilitation.Modern pharmacological studies have shown that laminarin has hypoglycemic, reducing blood lipid, immunological regulation, antitumor, anti-oxidant, anti-
The various biologicals effect such as virus, anticoagulation, antiatherosclerosis.Oval centipede algae is mainly distributed on the Zhejiang of China, rich
Containing a kind of bromophenol, there is apparent inhibition alpha-glucosidase and the active effect of Protein-tyrosine-phosphatase.Fragrant plant mentioned in ancient texts dish, Qi
Unicorn dish is the main source of carragheen and agaropectin, and Eucheuma is rich in polysaccharide and cellulose, belongs to high dietary-fiber food, diet
Fiber accounts for 70% of frond or more, is the suitable good merchantable brand of diabetes patient.
Coprinus comatus, black fungus, Agricus blazei are all edible mushrooms full of nutrition, and are the traditional health foods in China, are rich in
Polysaccharide, it is high that the poly sugared content of wherein Agricus blazei, which is in all known health care fungies, and content is up to 6.55g/100g, is spirit
5 times of sesame.It is many it is demonstrated experimentally that when the effect of some edible and medicinal fungi polysaccharide composites is hypoglycemic, effect more preferably than single polysaccharide, and
Concertedness is presented in pharmacological action between them.Chinese yam, guava are full of nutrition, have drug effect well to treatment diabetes,
There is auxiliary therapeutic action for the mitigation of illness.In addition " rabid ox diseases " in some areas Eurasian in recent years, " aftosa ' ' etc. animals
The outburst of sexually transmitted disease epidemic situation and prevalence, to bringing punching by the biological safety of the gelatin capsule formulation of raw material of animal sebum
It hits, animal product faces the serious problems checked again.The algin soft capsule can be with replacing whole animal origin gelatin system
Soft capsule is made, avoids worry of the people to edible gelatin product, while reducing the pollution to environment.
Invention content
The purpose of the present invention is to provide a kind of auxiliary hyperglycemic algin soft capsules and preparation method thereof.The soft capsule is filled out
It is seaweed, edible and medical fungi blood-sugar decreasing active compound preparation to fill material, and group is divided into sargassum, kelp, oval centipede algae, Qi
Unicorn dish, fragrant plant mentioned in ancient texts dish, coprinus comatus, black fungus, Agricus blazei, Chinese yam, guava, soybean oil.Preparation method includes raw material functional component
Prepared by extraction and algin soft capsule, wherein the extraction of hypoglycemic active ingredient uses heating and refluxing extraction technique, obtain sargassum
Oligosaccharides, composite fungi amylose；Algin soft capsule moulding process includes the procedures such as glue, suspension liquid processed, glue capsule.It is made
Algin soft capsule shell itself containing a variety of hypoglycemic active ingredients such as algal polysaccharides, and can be with replacing whole animal origin
Gelatin production soft capsule avoids worry of the people to edible gelatin product, while reducing the pollution to environment.The algin
Soft capsule shell and its filling liquid have improvement result to hyperglycemia caused by diabetes patient, insulin resistance, generally applicable
In diabetes and have no toxic side effect.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of auxiliary hyperglycemic algin soft capsule, primary raw material used include by weight：Sargassum 60-100
Part, 5-12 parts of kelp, oval 10-15 parts of centipede algae, 7-10 parts of Eucheuma, 5-15 parts of fragrant plant mentioned in ancient texts dish, 3-6 parts of coprinus comatus, black fungus
4-7 parts, it is 2-4 parts of Agricus blazei, 1-3 parts of Chinese yam, 8-15 parts of guava, 0.4-1.6 parts of soybean oil, 0.05-0.2 parts of highly basic water, pure
2200-3800 parts of water purification.
The processing method of the auxiliary hyperglycemic algin soft capsule includes that blood-sugar decreasing active extraction and algin are soft
It is prepared by capsule：
1. raw material preparation：Weigh sargassum, kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, coprinus comatus, black fungus, a Ji
Matsutake, Chinese yam, guava, clear water wash 3-5 times.By kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, sargassum, coprinus comatus,
Black fungus, Agricus blazei, Chinese yam, 45-60 DEG C drying, be respectively fed to micronizer crushing, guava with beater be beaten kind
Juice of my pomegranate, 80-100 mesh fine filters net filtration 2-3 times, for use.
2. blood-sugar decreasing active extracts
1）1500-2500 parts of pure water are added into 45-80 parts of sargassum powder, are extracted using water extraction at 85-92 DEG C
It 2-2.5 hours, after extraction, is filtered, filter residue is repeated the above steps and carries out 2-3 extraction, the filtrate of acquisition is mixed
It is concentrated after conjunction, 3-4 times of 95% ethyl alcohol of volume is added, ethanol precipitation is after 8-12 hours, by the ethyl alcohol in sediment in 50-65
It DEG C volatilizes, and is freeze-dried, is crushed to get sargassum oligosaccharides powder；
2）The coprinus comatus of crushing, black fungus, Agricus blazei powder are added 300-600 parts of pure water after mixing, 80-86 DEG C
Hot water extracts 2.5-3 hours, after extraction, is filtered, and filter residue is repeated the above steps and carries out 2-3 extraction, will be obtained
Filtrate mixing after concentrated, be added 3-4 times of 95% ethyl alcohol of volume, ethanol precipitation is after 8-12 hours, by the ethyl alcohol in sediment
It volatilizes at 50-65 DEG C and is freeze-dried, crushed to get composite fungi amylose powder.
3. prepared by algin soft capsule
1）Prepare colloidal sol：400-700 parts of pure water are heated to 50-60 DEG C, highly basic water is added, is slowly added to 15-20 parts
Sargassum powder and the constantly stirring of 5-12 kelps powder are warming up to 72-80 DEG C, addition 0.2-0.6 until formation clear solution
Soybean oil adds 5-15 parts of 10-15 parts of oval centipede algae, 7-10 parts of Eucheuma, fragrant plant mentioned in ancient texts dish powder and mixes and be stirred continuously straight
To clear solution is formed, constant temperature handles 30-45min, is allowed to dissolve into uniform glue, with 100-150 mesh filtered through gauze, filtrate
Water-bath keeps the temperature 45-60 minutes at 50-60 DEG C, removes liquid level foam, and guava juice seasoning is added, it is standby that algin glue is made
With；
2）Prepare suspension liquid：0.1-0.8 portions of soybean oils are heated to 40-50 DEG C, by sargassum oligosaccharides powder, compound true
Granulose powder, Chinese yam dry powder blend are added in oil and constantly stir evenly, and suspension is made, and 40-50 DEG C of heat preservation storage is standby
With；
3）Die pressing prepares soft capsule：The algin glue made is uniformly applied on steel mould, with 85-90 DEG C of temperature
So that surface moisture is evaporated, it is spare that the suitable film of toughness, elasticity is made；The two sides of punching block is heated, first takes film one to open, Xiang Gang
It is anti-sticking that template die face first applies 0.05-0.1 soybean oil lubrications, then falls above-mentioned suspension liquid on film, making uniformly thin
Layer, then take film one to open and be placed on liquid, 0.05-0.1 portions of soybean oils are also applied at its back side, cope plate is covered, is placed in hydraulic press
Middle pressurization, film is cut off, and the film of packaging medicine is pressed into pelletization in die hole up and down, pill is taken out, 20-25 DEG C puts
It sets, whole grain packaging,；Automatic rotation pellet press continuous operation can be used when big production.
The advantage of the invention is that：
1. algin soft capsule shell itself made of, and can be with containing a variety of hypoglycemic active ingredients such as algal polysaccharides
Replacing whole animal origin Gelatin production soft capsule；
2. raw material selected by the present invention all is from wholefood, any unknown substance is not added, and have no toxic side effect；
3. the algin soft capsule shell and its filling liquid are equal to hyperglycemia caused by diabetes patient, insulin resistance
There is improvement result.
Specific implementation mode
Embodiment 1
A kind of auxiliary hyperglycemic algin soft capsule, primary raw material used are calculated as by weight：60 parts of sargassum, kelp
5 parts, oval 10 parts of centipede algae, 7 parts of Eucheuma, 5 parts of fragrant plant mentioned in ancient texts dish, 3 parts of coprinus comatus, 4 parts of black fungus, 2 parts of Agricus blazei, 1 part of Chinese yam,
8 parts of guava, 0.6 part of soybean oil, 0.05 part of highly basic water, 2200 parts of pure water.
The processing method of the auxiliary hyperglycemic algin soft capsule includes that blood-sugar decreasing active extraction and algin are soft
It is prepared by capsule：
1. raw material preparation：Sargassum, kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, coprinus comatus, black wood are weighed in proportion
Ear, Agricus blazei, Chinese yam, guava, clear water wash 5 times, 60 DEG C of drying.By kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish,
Sargassum, black fungus, Agricus blazei, Chinese yam, is respectively fed to micronizer crushing at coprinus comatus, and guava is beaten with beater
Guava juice, 100 mesh fine filter net filtrations 2 times, for use.
2. blood-sugar decreasing active extracts
3）1500 parts of pure water are added into 45 parts of sargassum powder, are extracted 2 hours using water extraction at 85 DEG C, extraction knot
Shu Hou is filtered, and filter residue is repeated the above steps and carries out 3 extractions, will be concentrated after the filtrate mixing of acquisition, and will be added 3
Times 95% ethyl alcohol of volume, ethanol precipitation volatilizes after 8 hours, by the ethyl alcohol in sediment at 50 DEG C, and is freeze-dried, is crushed,
Up to sargassum oligosaccharides powder；
4）300 parts of pure water are added in the coprinus comatus of crushing, black fungus, Agricus blazei powder after mixing, and 80 DEG C of hot water carry
It takes 2.5 hours, after extraction, is filtered, filter residue is repeated the above steps and carries out 2 extractions, the filtrate of acquisition is mixed
After concentrated, 3 times of 95% ethyl alcohol of volume are added, the ethyl alcohol in sediment volatilizes and gone forward side by side at 50 DEG C after 8 hours by ethanol precipitation
Row freeze-drying crushes to get composite fungi amylose powder.
3. prepared by algin soft capsule
1）Prepare colloidal sol：400 parts of pure water are heated to 50 DEG C, highly basic water is added, is slowly added to 15 parts of sargassum powder
With the constantly stirring of kelp powder until forming clear solution, 72 DEG C are warming up to, 0.4 soybean oil is added, adds oval centipede
Algae, Eucheuma, fragrant plant mentioned in ancient texts vegetable powder end mix and are stirred continuously until forming clear solution, and constant temperature handles 30min, is allowed to dissolve into equal
Even glue, with 100 mesh filtered through gauze, filtrate water-bath at 50 DEG C keeps the temperature 45 minutes, removes liquid level foam, guava juice is added
It is spare that algin glue is made in seasoning；
2）Prepare suspension liquid：0.1 portion of soybean oil is heated to 40 DEG C, by sargassum oligosaccharides powder, composite fungi amylose
Powder, Chinese yam dry powder blend are added in oil and constantly stir evenly, and suspension is made, and 40 DEG C of heat preservation storages are spare；
3）Die pressing prepares soft capsule：The algin glue made is uniformly applied on steel mould, is made with 85 DEG C of temperature
Surface moisture evaporates, and it is spare that the suitable film of toughness, elasticity is made；The two sides of punching block is heated, first takes film one to open, to steel plate
It is anti-sticking that die face first applies 0.05 soybean oil lubrication, then falls above-mentioned suspension liquid on film, making thin uniform layer, then take
Film one, which is opened, to be placed on liquid, is also applied 0.05 portion of soybean oil at its back side, is covered cope plate, be placed in hydraulic press and pressurize, by glue
Piece is cut off, and the film of packaging medicine is pressed into pelletization in die hole up and down, and pill is taken out, 20 DEG C of placements, whole grain packaging, i.e.,
At；Automatic rotation pellet press continuous operation can be used when big production.
Embodiment 2
A kind of auxiliary hyperglycemic algin soft capsule, primary raw material used are calculated as by weight：100 parts of sargassum, sea
12 parts of band, oval 15 parts of centipede algae, 10 parts of Eucheuma, 15 parts of fragrant plant mentioned in ancient texts dish, 6 parts of coprinus comatus, 7 parts of black fungus, 4 parts of Agricus blazei, mountain
3 parts of medicine, 15 parts of guava, 1.6 parts of soybean oil, 0.2 part of highly basic water, 3800 parts of pure water.
1. raw material preparation：Sargassum, kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, coprinus comatus, black is weighed in proportion
Agaric, Agricus blazei, Chinese yam, guava, clear water wash 4 times, 50 DEG C of drying.By kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish,
Sargassum, black fungus, Agricus blazei, Chinese yam, is respectively fed to micronizer crushing at coprinus comatus, and guava is beaten with beater
Guava juice, 100 mesh fine filter net filtrations 3 times, for use.
2. blood-sugar decreasing active extracts
1）It is added into 80 parts of sargassum powder at 2500 parts of 92 DEG C of pure water and is extracted 2.5 hours using water extraction, extraction
After, it is filtered, filter residue is repeated the above steps and carries out 3 extractions, will concentrate, and be added after the filtrate mixing of acquisition
4 times of 95% ethyl alcohol of volume, ethanol precipitation volatilizes after 10 hours, by the ethyl alcohol in sediment at 60 DEG C, and is freeze-dried, powder
It is broken to get sargassum oligosaccharides powder；
2）600 parts of pure water are added in the coprinus comatus of crushing, black fungus, Agricus blazei powder after mixing, and 83 DEG C of hot water carry
It takes 3 hours, after extraction, is filtered, filter residue is repeated the above steps and carries out 3 extractions, after the filtrate of acquisition is mixed
It is concentrated, 4 times of 95% ethyl alcohol of volume is added, ethanol precipitation is volatilized at 60 DEG C and carried out after 10 hours, by the ethyl alcohol in sediment
Freeze-drying crushes to get composite fungi amylose powder.
3. prepared by algin soft capsule
1）Prepare colloidal sol：600 parts of pure water are heated to 55 DEG C, highly basic water is added, is slowly added to 20 parts of sargassum powder
With the constantly stirring of kelp powder until forming clear solution, 76 DEG C are warming up to, 0.6 soybean oil is added, adds oval centipede
Algae, Eucheuma, fragrant plant mentioned in ancient texts vegetable powder end mix and are stirred continuously until forming clear solution, and constant temperature handles 40min, is allowed to dissolve into equal
Even glue, with 120 mesh filtered through gauze, filtrate water-bath at 55 DEG C keeps the temperature 55 minutes, removes liquid level foam, guava juice is added
It is spare that algin glue is made in seasoning；
2）Prepare suspension liquid：0.8 portion of soybean oil is heated to 50 DEG C, by sargassum oligosaccharides powder, composite fungi amylose
Powder, Chinese yam dry powder blend are added in oil and constantly stir evenly, and suspension is made, and 45 DEG C of heat preservation storages are spare；
3）Die pressing prepares soft capsule：The algin glue made is uniformly applied on steel mould, is made with 85 DEG C of temperature
Surface moisture evaporates, and it is spare that the suitable film of toughness, elasticity is made；The two sides of punching block is heated, first takes film one to open, to steel plate
It is anti-sticking that die face first applies 0.1 soybean oil lubrication, then falls above-mentioned suspension liquid on film, making thin uniform layer, then take
Film one, which is opened, to be placed on liquid, is also applied 0.1 portion of soybean oil at its back side, is covered cope plate, be placed in hydraulic press and pressurize, by film
The film of cut-out, packaging medicine is pressed into pelletization in die hole up and down, and pill is taken out, 25 DEG C of placements, whole grain packaging,；
Automatic rotation pellet press continuous operation can be used when big production.
Embodiment 3
A kind of auxiliary hyperglycemic algin soft capsule, primary raw material used are calculated as by weight：80 parts of sargassum, kelp
10 parts, oval 12 parts of centipede algae, 9 parts of Eucheuma, 10 parts of fragrant plant mentioned in ancient texts dish, 5 parts of coprinus comatus, 5 parts of black fungus, 3 parts of Agricus blazei, Chinese yam 2
Part, 12 parts of guava, 0.8 part of soybean oil, 0.1 part of highly basic water, 3000 parts of pure water.
The processing method of the auxiliary hyperglycemic algin soft capsule includes that blood-sugar decreasing active extraction and algin are soft
It is prepared by capsule：
1. raw material preparation：Weigh sargassum, kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, coprinus comatus, black fungus, a Ji
Matsutake, Chinese yam, guava, clear water wash 3 times, 45 DEG C of drying.By kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, sargassum,
Coprinus comatus, Agricus blazei, Chinese yam, is respectively fed to micronizer crushing at black fungus, and guava is beaten to obtain guava with beater
Juice, 80 mesh fine filter net filtrations 2 times, for use.
2. blood-sugar decreasing active extracts
1) 2000 parts of pure water are added into 65 parts of sargassum powder, is extracted 2.5 hours, is carried using water extraction at 92 DEG C
It after taking, is filtered, filter residue is repeated the above steps and carries out 3 extractions, will concentrate, and add after the filtrate mixing of acquisition
Entering 4 times of 95% ethyl alcohol of volume, ethanol precipitation volatilizes after 12 hours, by the ethyl alcohol in sediment at 65 DEG C, and be freeze-dried,
It crushes to get sargassum oligosaccharides powder；
2) 500 parts of pure water are added in the coprinus comatus of crushing, black fungus, Agricus blazei powder after mixing, and 86 DEG C of hot water carry
It takes 3 hours, after extraction, is filtered, filter residue is repeated the above steps and carries out 3 extractions, after the filtrate of acquisition is mixed
It is concentrated, 4 times of 95% ethyl alcohol of volume is added, ethanol precipitation volatilized the ethyl alcohol in sediment at 50-65 DEG C simultaneously after 12 hours
It is freeze-dried, crushed to get composite fungi amylose powder.
3. prepared by algin soft capsule
1）Prepare colloidal sol：500 parts of pure water are heated to 60 DEG C, highly basic water is added, is slowly added to 15 parts of sargassum powder
With the constantly stirring of kelp powder until forming clear solution, 80 DEG C are warming up to, 0.3 soybean oil is added, adds oval centipede
Algae, Eucheuma, fragrant plant mentioned in ancient texts vegetable powder end mix and are stirred continuously until forming clear solution, and constant temperature handles 45min, is allowed to dissolve into equal
Even glue, with 150 mesh filtered through gauze, filtrate water-bath at 60 DEG C keeps the temperature 60 minutes, removes liquid level foam, guava juice is added
It is spare that algin glue is made in seasoning；
2）Prepare suspension liquid：0.3 portion of soybean oil is heated to 50 DEG C, by sargassum oligosaccharides powder, composite fungi amylose
Powder, Chinese yam dry powder blend are added in oil and constantly stir evenly, and suspension is made, and 50 DEG C of heat preservation storages are spare；
3）Die pressing prepares soft capsule：The algin glue made is uniformly applied on steel mould, is made with 90 DEG C of temperature
Surface moisture evaporates, and it is spare that the suitable film of toughness, elasticity is made；The two sides of punching block is heated, first takes film one to open, to steel plate
It is anti-sticking that die face first applies 0.1 soybean oil lubrication, then falls above-mentioned suspension liquid on film, making thin uniform layer, then take
Film one, which is opened, to be placed on liquid, is also applied 0.1 portion of soybean oil at its back side, is covered cope plate, be placed in hydraulic press and pressurize, by film
The film of cut-out, packaging medicine is pressed into pelletization in die hole up and down, and pill is taken out, 25 DEG C of placements, whole grain packaging,；
Automatic rotation pellet press continuous operation can be used when big production.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification should all belong to the covering scope of the present invention.
Claims (1)
1. a kind of preparation method of auxiliary hyperglycemic algin soft capsule, it is characterised in that：
Its primary raw material is calculated as by weight：60-100 parts of sargassum, 5-12 parts of kelp, oval 10-15 parts of centipede algae, Eucheuma
7-10 parts, 5-15 parts of fragrant plant mentioned in ancient texts dish, 3-6 parts of coprinus comatus, 4-7 parts of black fungus, 2-4 parts of Agricus blazei, 1-3 parts of Chinese yam, guava 8-15
Part, 0.4-1.6 parts of soybean oil, 0.05-0.2 parts of highly basic water, 2200-3800 parts of pure water；
The raw material preparation step is：Weigh in proportion sargassum, kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, coprinus comatus,
Black fungus, Agricus blazei, Chinese yam, guava, clear water wash 3-5 times；By kelp, oval centipede algae, Eucheuma, fragrant plant mentioned in ancient texts dish, horse hair
Algae, coprinus comatus, black fungus, Agricus blazei, Chinese yam, 45-60 DEG C of drying are respectively fed to micronizer crushing, guava mashing
Machine is beaten to obtain guava juice, 80-100 mesh fine filters net filtration 2-3 times, for use；
Blood-sugar decreasing active extracting method is：
1）1500-2500 parts of pure water are added into 45-80 parts of sargassum powder, water extraction extraction 2-2.5 is used at 85-92 DEG C
Hour, it after extraction, is filtered, filter residue is repeated the above steps and carries out 2-3 extraction, the filtrate of acquisition is mixed laggard
Row concentration, is added 3-4 times of 95% ethyl alcohol of volume, and ethanol precipitation volatilized the ethyl alcohol in sediment at 50-65 DEG C after 8-12 hours,
And it is freeze-dried, crushed to get sargassum oligosaccharides powder；
2）300-600 parts of pure water, 80-86 DEG C of hot water is added in the coprinus comatus of crushing, black fungus, Agricus blazei powder after mixing
Extraction 2.5-3 hours, after extraction, is filtered, and filter residue is repeated the above steps and carries out 2-3 extraction, by the filter of acquisition
It is concentrated after liquid mixing, 3-4 times of 95% ethyl alcohol of volume is added, ethanol precipitation volatilized the ethyl alcohol in sediment after 8-12 hours
At 50-65 DEG C and it is freeze-dried, is crushed to get composite fungi amylose powder；
Algin soft capsule preparation method is：
1）Prepare colloidal sol：400-700 parts of pure water are heated to 50-60 DEG C, highly basic water is added, is slowly added to 15-20 parts of horse hairs
Algae powder and the constantly stirring of 5-12 kelps powder are warming up to 72-80 DEG C, addition is 0.2-0.6 parts big until formation clear solution
Soya-bean oil, add 5-15 parts of 10-15 parts of oval centipede algae, 7-10 parts of Eucheuma, fragrant plant mentioned in ancient texts dish powder mix and be stirred continuously until
Form clear solution, constant temperature handles 30-45min, is allowed to dissolve into uniform glue, with 100-150 mesh filtered through gauze, filtrate in
Water-bath keeps the temperature 45-60 minutes at 50-60 DEG C, removes liquid level foam, and guava juice seasoning is added, it is spare that algin glue is made；
2）Prepare suspension liquid：0.1-0.8 portions of soybean oils are heated to 40-50 DEG C, by the sargassum oligosaccharides powder of acquisition, compound
Fungi polysaccharide powder, Chinese yam dry powder blend are added in soybean oil and constantly stir evenly, and suspension is made, and 40-50 DEG C of heat preservation is deposited
It puts, it is spare；
3）Die pressing prepares soft capsule：The algin glue made is uniformly applied on steel mould, table is made with 85-90 DEG C of temperature
It is spare that the suitable film of toughness, elasticity is made in face moisture evaporation；The two sides of punching block is heated, first takes film one to open, to steel mould
It is anti-sticking that face first applies 0.05-0.1 parts of soybean oil lubrications, then falls above-mentioned suspension liquid on film, makes thin uniform layer,
It takes film one to open again to be placed on liquid, also applies 0.05-0.1 portions of soybean oils at its back side, cover cope plate, be placed in hydraulic press and add
Pressure, film is cut off, and the film of packaging medicine is pressed into pelletization in die hole up and down, and pill is taken out, and 20-25 DEG C of placement is whole
Grain packaging,；Automatic rotation pellet press continuous operation can be used when big production.
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| CN107440124A (en) * | 2017-10-11 | 2017-12-08 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material |
| CN107495375A (en) * | 2017-10-11 | 2017-12-22 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the preventing and treating cardiovascular and cerebrovascular disease soft capsule preparation of capsule material |
| CN107485026A (en) * | 2017-10-11 | 2017-12-19 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the enhancing memory soft capsule preparation of capsule material |
| CN110192650A (en) * | 2019-06-21 | 2019-09-03 | 福建农林大学 | A kind of hypoglycemic light black bulk kelp water proposes the preparation method and applications of compound |
| CN115490780B (en) * | 2022-10-12 | 2023-10-20 | 广东海洋大学 | Extraction method and application of crude extract of gulfweed fucoidin |
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