CN105582245A - Preparation for preventing and treating nephritic syndrome and preparation method of preparation - Google Patents

Abstract

The invention discloses a preparation for preventing and treating a nephritic syndrome and a preparation method of the preparation. The preparation is characterized by comprising leeches, hawthorn fruits, grape seeds, astragalus membranaceus, poria cocos, Chinese yams and oysters. The preparation can replenish both qi and blood, realizes astringence during dissipation, has the efficacy of promoting blood circulation, removing stasis, promoting qi circulation and relieving food stagnation, has a remarkable preventive and treatment effect, is suitable for a wide range of people and convenient to use and carry, has the comprehensive advantages of remarkable curative effect, fast effect, complete curative effect, no relapse, no toxic or side effect, low cost and the like, fills the blank of the kinds of Chinese parent medicines on the market and is suitable for treating the nephritic syndrome with a remarkable blood stasis syndrome caused by hematuresis, proteinuria or deterioration of renal functions due to a glomerular disease.

Description

Preparation of a kind of prevention and treatment nephrotic syndrome and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of ephrosis, especially treat the blood urine, albuminuria or the renal function exacerbation that are caused by renal glomerular disease, and there is the Chinese medicine preparation of the nephrotic syndrome that obvious hemostasis disease resembles.

Background technology

Nephrotic syndrome (nephroticsyndrome, NS), be called for short kidney and combine, refer to be caused by Different types of etiopathogenises, increase the glomerulopathies such as companion's glomerular filtration rate(GFR reduction with glomerular basement membrane permeability and become one group of main syndrome that clinical manifestation is similar, instead of disease independently. Typical case shows as High-grade Proteinuria, Hypoproteinemia, treating serious edema caused, hyperlipidemia.

Modern medicine is thought and is caused that the reason of nephrotic syndrome is a lot, sums up and can be divided into primary and the large class of Secondary cases two, wherein taking primary glomerulopathy as main. In Secondary cases nephrotic syndrome, systemic loupus erythematosus, diabetic nephropathy, renal amyloidosis, anaphylactoid purpura are common. Its most basic feature is High-grade Proteinuria, Hypoproteinemia, (highly) oedema and hyperlipidemia, i.e. so-called " three high one low ", and other metabolic disorders one group of clinical syndrome that is feature.

Doctor trained in Western medicine is in the time for the treatment of nephrotic syndrome, tend to adopt hormone (as metacortandracin etc.), cytotoxic drug (endoxan) and immunodepressant are (as Ciclosporin A, tacrolimus etc.) therapeutic modality, although this methods for the treatment of can in the short time be eliminated symptom, but long-term taking easily produces the dependence to this type of medicine, drug susceptibility is reduced, and hormone and immunodepressant can reduce the resistance of body, immunodepressant also can cause leucocyte to decline, patient's resistance is declined, easily cause Relapse rate outbreak, obstinate, patient is also caused to certain infringement.

The traditional Chinese medical science considers that patient is due to illness weakened body resistance for a long time in the time for the treatment of nephrotic syndrome, all there are the deficiency of vital energy, blood stasis performance in various degree, or poor because using bad medicine to cause physique, lower for the resistance, the deficiency of vital energy, if careless being invaded by exogenous pathogen,invasion of exogenous pathogen now is not more easily healed repeatedly, bring out or deepen the state of an illness, controlling taking eliminating pathogen to support vital qi, promoting blood circulation and removing blood stasis, inducing diuresis for removing edema as main. At present, the Chinese medicine preparation for the treatment of nephrotic syndrome mainly contains hundred makes that capsule, paecilomyces hepiall chen, ephritis relax, tonifying speen and tonifying kidney granular, Shenkangning particle, astragalus injection, ginseng aconite injection liquid, Yiqi and vein recovery etc., their advantage is to use simply, easy to carry, but effect is unsatisfactory, and majority need to coordinate Western medicine to use or use in convalescence.

Summary of the invention

The object of this invention is to provide a kind of taking lead to kidney active, promoting blood circulation and removing blood stasis, turbid toxin expelling falls as approach, reach dredging kidney, promote and improve the Renal microcirculation of atrophy necrosis, accelerate the metabolism of pathology kidney, effectively the preparation of prevention and treatment nephrotic syndrome.

Another object of the present invention is to provide the preparation method of the preparation of a kind of prevention and treatment nephrotic syndrome.

For reaching upper art object, technical scheme of the present invention is:

Prevention and a preparation for the treatment of nephrotic syndrome, is characterized in that comprising leech, hawthorn, grape pip, the Radix Astragali, Poria cocos, Chinese yam, oyster.

Weight portion raw material is: 1～3 part of leech, 1～3 part of hawthorn, 2～4 parts of grape pips, 1～3 part of the Radix Astragali, 2～4 parts, Poria cocos, 1～3 part of Chinese yam, 0.5～2 part of oyster.

Preparation method is:

Ratio is got each medicinal material by weight, adds for the first time 10 times of water gagings, decocts 1.5h, filters, and leaches, and liquid is for subsequent use;

Add for the second time 8 times of water gagings, decoct 1h, filter, liquid and decoction liquor merging for the first time;

It is 1.05～1.15 thick paste that amalgamation liquid is concentrated into relative density, and vacuum drying, is ground into fine powder;

Get dry cream fine powder, add 40% sweet mellow wine, 10% microcrystalline cellulose, 3.0% Sodium Hydroxymethyl Stalcs, wet granulation, the whole grain of 14 mesh sieves;

Add 2.0% Sodium Hydroxymethyl Stalcs, 0.5% dolomol again, mix, compacting is heavily the sheet of 0.5g in flakes, packaging, finished product.

The present invention treats nephrotic syndrome Chinese medicine preparation and has promoting blood circulation and removing blood stasis, the promoting the circulation of qi stagnant effect that disappears, prevention, the result for the treatment of of the nephrotic syndrome blood urine being caused by renal glomerular disease, albuminuria or renal function exacerbation to obvious hemostasis disease elephant is remarkable, have no side effect, the crowd of being suitable for is wide, easy to use and carry. Have evident in efficacy, rapid-action, thoroughly, do not recur, have no side effect, the overall merit such as cost is low, this Chinese medicine preparation has been filled up the vacancy of this type of Chinese patent drug on market.

Chinese medicine preparation of the present invention, because comprising leech, the Radix Astragali, grape pip medicinal material, is respectively got a word, is referred to as water stilbene seed nephrotic syndrome sheet, it has promoting blood circulation and removing blood stasis, the promoting the circulation of qi stagnant effect that disappears, and make tablet, so called after " water stilbene seed " nephrotic syndrome sheet in actual applications.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described.

Traditional Chinese medicine thinks that nephrotic syndrome can be divided into six types, all kinds can transform mutually or doublely see in therapeutic process, are now described below: (1) qi-deficiency type: sick position, mainly at kidney, shows as the soreness of waist weak, without obvious oedema, or only having Mild edema, body is sleepy, very tired vertical in row, not durable seat, in urine, have albumen or have red blood cell in various degree, pink tongue, tongue are thin, forceless deep pulse. (2) deficiency of yang type: sick position, mainly at spleen kidney, shows as complexion Anhui white, the cold limb of shape is cold, and time body is known swollen, and finger submerged while pressing, very can accompany chest ascites, and even uncomfortable in chest out of breath, and urine is deficient, and large loose stool is thin, and urine examination has albumen, and tongue is light and fat, and tongue is thin or greasy, deep thready pulse. (3) YIN-deficiency type: sick position is mainly at liver kidney, visible edema not very, but dry, pharyngodynia with dryness, Light-headedness, edgy, urinate redly, in urine, have albumen and red blood cell in various degree, the soreness of waist, night sweat, dysphoria with smothery sensation, tongue is red, the thin string number of arteries and veins. Common this card type after the heavy dose of hormone therapy of application or excessive diuresis. (4) geomantic omen type: accompany due to ailment said due to cold or exposure attacks outward, especially with wind-heat more than chill, also have and begin as chill, then heat-transmission person. This kind of is foreknowledge eyelid and facial edema often, then involves rapidly whole body, and podomere acid is heavy, and difficult urination, if having urine examined visible albumen or with red blood cell in various degree etc. And tool generates heat, dislikes the accompanying symptoms such as wind, headache, pharyngalgia, cough, nasal obstruction. (5) damp-heat type: due to damp and hot heresy invasion and attack, how anxious onset is, edema all over, the moist light of color of the leather, chest abdomen ruffian is vexed, and dysphoria with smothery sensation is thirsty, dry and hard excrement, scanty drak urine, or skin has sore furuncle, urine examination has a large amount of albumen and red blood cell etc., red tongue with yellowish fur or greasy, slippery and rapid pulse. This kind of is more common in after application cortin ephrosis not more and when scabies secondary infection and Ke Xing Shi disease. (6) blood stasis blocking type: how by oedema with the passing of time, by gas and blood and cause. Clinical visible puffiness of the face and limbs, squamous and dry skin, or existing petechia ecchymosis, or pain in the back urine is red, and urine examination has albumen and polymorphy red blood cell, and tongue is light or red, and there is petechia on tongue limit, and hypogloeeis muscle is stasis of blood purple, the thin Huang of tongue or greasy, uneven pulse or knot generation. Also have and only show as oedema delay, obstinate, lacks other obvious hemostasis and does not levy outward person.

In order to prevent and to treat nephrotic syndrome, inventor has adopted and has comprised that the Chinese medicine of leech, hawthorn, grape pip, the Radix Astragali, Poria cocos, Chinese yam, oyster is raw material, wherein

Weight portion raw material is: 1～3 part of leech, 1～3 part of hawthorn, 2～4 parts of grape pips, 1～3 part of the Radix Astragali, 2～4 parts, Poria cocos, 1～3 part of Chinese yam, 0.5～2 part of oyster;

Preparation method is:

Ratio is got each medicinal material by weight, adds for the first time 10 times of water gagings, decocts 1.5h, filters, and leaches, and liquid is for subsequent use;

Add for the second time 8 times of water gagings, decoct 1h, filter, liquid and decoction liquor merging for the first time;

It is 1.05～1.15 thick paste that amalgamation liquid is concentrated into relative density, and vacuum drying, is ground into fine powder;

Get dry cream fine powder, add 40% sweet mellow wine, 10% microcrystalline cellulose, 3.0% Sodium Hydroxymethyl Stalcs, wet granulation, the whole grain of 14 mesh sieves;

Add 2.0% Sodium Hydroxymethyl Stalcs, 0.5% dolomol again, mix, compacting is heavily the sheet of 0.5g in flakes, packaging, finished product.

The quality standard of the present invention's Chinese medicine used and the property of medicine are:

LeechFor Hirudinidae animal whitmaniaWhitmaniapigraWhitman, leechHirudonippponicaWhitman or willow leaf leechWhitmaniaacranulataWhitman's is dry all. Summer, Qiu Erji catch, boiling hot dead with boiling water, dry or low temperature drying. [nature and flavor] are salty, bitter, property flat. [return through] returns Liver Channel. [function cures mainly] breaks blood, by the stasis of blood, stimulates the menstrual flow. Be used for holding blood, abdominal mass, gathers, and women is through closing, and dry blood becomes consumptive disease, injury from falling down, and order is pain also, cloudiness. Quality standard refers to one the 77th page of Chinese pharmacopoeia version in 2010.

HawthornFor rosaceous plant large-fruited Chinese hawthornCrataeguspinnatifidaBge.var.majorOr hawthorn N.E.Br.CrataeguspinnatifidaBge. dry leaf. Summer, Qiu Erji gather, and dry. [nature and flavor] acid, sweet, tepor; [return through] returns spleen, stomach, Liver Channel; [function cures mainly] food digesting stomach fortifying, the promoting the circulation of qi stasis of blood of faling apart, changes turbid lipopenicillinase. For carnivorous stagnant, gastral cavilty turgor, rushes down dysentery stomachache, and hemostasis is through closing, postpartum stasis blocking, trusted subordinate's shouting pain, chest impediment and cardialgia, hernia pain, hyperlipidemia. Charred FRUCTUS CRATAEGI promoting digestion effect strengthens. For carnivorous stagnant, rush down dysentery not well. Quality standard refers to one the 29th page of Chinese pharmacopoeia version in 2010.

Grape pip[nature and flavor] are sweet, sour. [return through] returns liver, kidney, lung channel. [function cures mainly] fill blood liver and kidney benefiting, born fluid strengthening the bones and muscles, relieving restlessness. For ephritis, hypertension, oedema patient, children, pregnant woman, anaemia patient, neurasthenia, overtired, fatigue and asthenia, prematurely senile, cough due to deficiency of the lung, night sweat.

The Radix AstragaliFor legume astragalus mongolicusAstragalusmembranaceus(Fisch)Bge.

var.mongholicus(Bge.) Hsiao or Astragalus membranacusAstragalusmembranaceus

(Fisch.) the dry root of Bge.. Spring, Qiu Erji excavate, and remove fibrous root and root head, dry. [nature and flavor] are sweet, tepor. [return through] returns lung, the spleen channel. [function cures mainly] tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, promotes the production of body fluid and nourishes blood, the stagnant logical numbness of row, pus draining and toxin expelling, expelling pus and promoting granulation. Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, interior heat is quenched one's thirst, and the deficiency of blood is sallow, hemiplegia, numbness pain is numb, and ulcer is difficult bursts, and bursts and does not hold back for a long time. Quality standard refers to one the 283rd page of Chinese pharmacopoeia version in 2010.

Poria cocosFor On Polyporaceae Poria cocos Poriacocos(Schw.) dry sclerotia of Wolf. More than excavating for 7～September, after digging out, remove silt, bank up after " sweating ", spread out and dry in the air to dry tack free, then " sweating ", after extremely now wrinkle, the large portion of internal moisture scatter and disappear for several times repeatedly, dry in the shade, be called " Poria cocos "; Or fresh Poria cocos is pressed to different parts cutting, and dry in the shade, be called " Poria cocos piece " and " Poria cocos sheet ". [nature and flavor] are sweet, light, flat. [return through] liver, spleen, stomach warp. [function cures mainly] clearing damp and promoting diuresis, invigorating the spleen, Ning Xin. For oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, and have loose bowels in loose stool, confused and worried, palpitation with fear insomnia. Quality standard refers to one the 224th page of Chinese pharmacopoeia version in 2010.

Chinese yamFor Dioscoreaceae plant Chinese yamDioscoreaoppositeThunb. dry rhizome. Winter, cauline leaf was excavated after withering, and cut root head, cleaned, and removed crust and fibrous root, dry, or took advantage of fresh-cut sheet, dry; Also have and select loose straight dry Chinese yam, put in clear water, be dipped into without the dry heart, vexed, trim two ends, be twisted into cylindricly with plank, dry polishing, habit title " light yam ". [nature and flavor] are sweet, flat. [return through] returns spleen, lung, kidney channel. [function cures mainly] tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying. Few for insufficiency of the spleen food, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst. Rhizoma Dioscoreae (parched with bran) tonifying spleen stomach invigorating. Few for insufficiency of the spleen food, the loose stool of having loose bowels, leukorrhea. Quality standard refers to one the 27th page of Chinese pharmacopoeia version in 2010.

OysterFor the long oyster of Ostreidae animalOstreagigasThunberg, ostrea talienwhanensis CrosseOstraetalienwhanensisCrosse or Crassostrea rivularisOstraerivularisThe shell of Gould. All can fish for the whole year, and fleshing is cleaned. Dry. [nature and flavor] are salty, are slightly cold. [return through] liver, courage, kidney channel. [function cures mainly] is transquilization with heavy material, checking exuberance of yang tonifying yin, softening and resolving hard mass. The insomnia that is used for palpitating with fear, dizzy ear toot, scrofula subcutaneous nodule, lump in the abdomen lump in the abdomen lump in the abdomen. Calcined oyster shell convergence is astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache. For spontaneous sweating, emission and spermatorrhea, under uterine bleeding band, stomachache acid regurgitation. Quality standard refers to one the 161st page of Chinese pharmacopoeia version in 2010.

Traditional Chinese medical science prescription is thought: nephrotic syndrome is one group of clinical syndrome in renal glomerular disease. Glomerular lesions oedema with the passing of time, gas and blood can make the resistance of kidney network numbness cause the stasis of blood, also can make blood circulating out of vessels not fall apart into the stasis of blood, some clinical manifestations are blood urine, albuminuria obstinate, some appearance renal function exacerbations and resembling without clear and definite hemostasis disease, at the beginning of some morbidities, just can see skin petechia or ecchymosis tongue body livid purple, darkish complexion, squamous and dry skin, pulse condition is puckery, tight, heavy slow etc. Hemostasis is the pathological product forming in renal glomerular disease progress, is again a paathogenic factor simultaneously, and long term, in body, makes interpretation of the cause, onset and process of an illness complexity, and delay is difficult. A large amount of pathology experimental results show that: capillary endothelial cell hyperplasia, platelet aggregation, Fibrin exudation, last diffuse crescent formation is all relevant with hemostasis, uses blood-activating drug really can improve the intraparenchymatous stasis of blood of kidney stagnant, delays disease progression, even ends renal lesions. We disappear stagnant as monarch drug in a prescription taking leech promoting blood circulation and breaking stagnation; Hawthorn, grape pip principal drug assistance promoting blood circulation, be ministerial drug; The gas of the large tonifying lung spleen of the Radix Astragali, the capable blood of gas; The gas of the flat tonifying lung spleen of Chinese yam kidney, helps the Radix Astragali promoting the circulation of qi stasis of blood that disappears; The light spleen that oozes of Poria cocos wets, and helps the strong fortune of Chinese yam, lets out kidney turbid; Oyster is restrained puckery essence, is adjutant altogether, helps the leech powder promoting the circulation of qi stasis of blood of faling apart.

Full side's qi and blood is ruled together, and has receipts in loose, gather altogether promoting blood circulation and removing blood stasis, the promoting the circulation of qi stagnant effect that disappears. Blood urine, albuminuria or the renal function exacerbation that is applicable to be caused by renal glomerular disease and there is the nephrotic syndrome of obvious hemostasis disease elephant.

Embodiment

Ratio is got each medicinal material by weight, 2 parts of leech, 2 parts of hawthorn, 3 parts of grape pips, 2 parts of the Radixs Astragali, 3 parts, Poria cocos, 2 parts of Chinese yams, 1 part of oyster;

Add for the first time 10 times of water gagings, decoct 1.5h, filter, leach, liquid is for subsequent use;

Add for the second time 8 times of water gagings, decoct 1h, filter, liquid and decoction liquor merging for the first time;

Be concentrated into relative density and be 1 thick paste, vacuum drying, is ground into fine powder; Get dried cream powder, add 40% sweet mellow wine, 10% microcrystalline cellulose, 3.0% Sodium Hydroxymethyl Stalcs, wet granulation, the whole grain of 14 mesh sieves, then add 2.0% Sodium Hydroxymethyl Stalcs, 0.5% dolomol, and mixing, compacting is heavily the sheet of 0.5g in flakes, packaging, finished product.

Inventor has done repeatedly various tests in each medicinal material span of technical scheme, taking the property of medicine of embodiment as best.

Using method: oral, every day 3 times, one time 3.

Clinical use many cases patient, effect is remarkable. As:

(1) Nanning Zhu Yuan is bright, man, and 9 years old, blood urine, albuminuria four months, belonged to typical nephrotic syndrome, taken multi-medicament, and poor effect is taken symptom after this product fortnight and is started to take a turn for the better.

(2) Evalution In Duan County Zhu Zhi literary composition, man, 62 years old, nephrotic syndrome medical history 2 years, blood urine, albuminuria, in the recent period renal function exacerbation, take this product after one month symptom be able to good alleviation.

(3) Tiandeng County, Chongzuo City, Guangxi king's prosperity, man, 24 years old, CGN, chronic renal insufficiency, Uremic CKD5 phase, renal hypertension, hypertensive cardiopathy, the nephrotic syndromes such as Medicamentous liver lesion 2 years, hospitalization, RDT, also took multi-medicament simultaneously, but poor effect, take this product after one month, symptom takes an evident turn for the better, and muscle power is recovered gradually.

(4) land, the Nanning pendant people, man, 35 years old, chronic renal failure, the nephrotic syndromes such as chronic nephritis, chronic renal insufficiency Uremic CKD5 phase, renal hypertension, renal anemia 3 years, Multiple Hospitalization treatment, RDT, took multi-medicament, but poor effect, take this product after one month, symptom takes an evident turn for the better, and muscle power is recovered gradually, takes after one month and can normally go to work, and skin is by aterrimus by turning ruddy, glossy, and blood urine, albuminuria obviously decline.

Claims (4)

1. prevention and a preparation for the treatment of nephrotic syndrome, is characterized in that comprising leech, hawthorn, grape pip, the Radix Astragali, Poria cocos, Chinese yam, oyster.

2. prevention according to claim 1 and the preparation for the treatment of nephrotic syndrome, is characterized in that its weight portion raw material is:

1～3 part of leech, 1～3 part of hawthorn, 2～4 parts of grape pips, 1～3 part of the Radix Astragali, 2～4 parts, Poria cocos, 1～3 part of Chinese yam, 0.5～2 part of oyster.

3. prevention according to claim 1 and the preparation for the treatment of nephrotic syndrome, is characterized in that its preparation method is:

Ratio is got each medicinal material by weight, adds for the first time 10 times of water gagings, decocts 1.5h, filters, and leaches, and liquid is for subsequent use;

Add for the second time 8 times of water gagings, decoct 1h, filter, liquid and decoction liquor merging for the first time;

It is 1.05～1.15 thick paste that amalgamation liquid is concentrated into relative density, and vacuum drying, is ground into fine powder;

Get dry cream fine powder, add 40% sweet mellow wine, 10% microcrystalline cellulose, 3.0% Sodium Hydroxymethyl Stalcs, wet granulation, the whole grain of 14 mesh sieves;

Add 2.0% Sodium Hydroxymethyl Stalcs, 0.5% dolomol again, mix, compacting is heavily the sheet of 0.5g in flakes, packaging, finished product.

4. prevention according to claim 1 and 2 and the preparation for the treatment of nephrotic syndrome, is characterized in that its weight portion raw material is:

2 parts of leech, 2 parts of hawthorn, 3 parts of grape pips, 2 parts of the Radixs Astragali, 3 parts, Poria cocos, 2 parts of Chinese yams, 1 part of oyster.