CN105561380A - 一种医用凝胶及其制备方法 - Google Patents

一种医用凝胶及其制备方法 Download PDF

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CN105561380A
CN105561380A CN201511015299.9A CN201511015299A CN105561380A CN 105561380 A CN105561380 A CN 105561380A CN 201511015299 A CN201511015299 A CN 201511015299A CN 105561380 A CN105561380 A CN 105561380A
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黄朝阳
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Foshan Ming Qian Science And Technology Ltd
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Abstract

本发明公开了一种医用凝胶及其制备方法。该医用凝胶由以下透明质酸钠份的原料制备：透明质酸钠80～180份、纳米级可溶性银盐5～10份、芦荟纳米微粉5～24份、大豆蛋白粉20~55份、壳聚糖10~44份、醋酸1~5份、聚乙烯醇8~18份。本发明的凝胶具有良好的吸液性、生物相容性、抗菌性，可快速促进细胞生长加速创口愈合；固化速度适中，粘合强度高，粘接时放热低，粘接薄膜韧性好，对皮肤刺激性小，对各种创伤、手术切口具有高强度快速粘合作用，固化后无疤痕。

Description

一种医用凝胶及其制备方法
技术领域
本发明涉及一种医用新材料，具体是一种医用凝胶及其制备方法，属于医疗辅助用品技术领域。
背景技术
医用胶水是代替缝针用的新兴医用产品，医用胶水在创面血液和组织液中阴离子的作用下，能快速聚合固化成膜并与创面镶嵌紧密，可牢固地保持伤口的对合状态，且胶膜可阻止血球、血小板通过，在凝血酶和纤维蛋白原的共同作用下，封闭创面断裂的小血管可以有效止血，同时胶膜将组织和细菌隔离，还具有抗感染和保护创面的作用。聚合物中的醚链还具有止痛作用，因此医用胶水具有粘和、止血、止痛、消炎、护创、促进愈合等综合功效。
医用胶粘和法与传统的缝合法相比具有以下优点：1、快速止血，粘和过程没有痛苦，不需要麻醉。2、伤口呈线性愈合，无缝针缝线等异物对皮肤的刺激，减少炎症的发生，形成的瘢痕很小，具有良好的美容效果。3、不用拆线，大大缩短就医时间，节省就医费用。4、在腹股沟疝平片无张力修补术中应用化学性医用胶黏合固定补片和创面止血的效果良好，不增加术后复发率，可节省手术时间和减轻术后疼痛，还可减少术后慢性疼痛和局部血肿的发生。
医用凝胶也主要用作术后创口创伤敷料，其吸液性、生物相容性、抗菌性、促进细胞生长加速创口愈合方面的要求较高。
发明内容
本发明的目的是提供一种医用凝胶及其制备方法。
本发明的技术方案如下：一种医用凝胶，由以下透明质酸钠份的原料制备：透明质酸钠80～180份、纳米级可溶性银盐5～10份、芦荟纳米微粉5～24份、大豆蛋白粉20~55份、壳聚糖10~44份、醋酸1~5份、聚乙烯醇8~18份。
所述芦荟纳米微粉的制备方法是：取新鲜芦荟，干燥至水分含量10~20%，粉碎至粒径300~500nm。
本发明的医用凝胶的制备方法是：
（1）大豆蛋白粉以50-60℃的去离子水溶解，得大豆蛋白溶液；将透明质酸钠及其质量8倍的去离子水溶解，得胶液；将纳米级可溶性银盐配置成；将大豆蛋白溶液、胶液、银盐溶液混合均匀，得混合胶液；
（2）壳聚糖和醋酸溶解，加入适量去离子水，得壳聚糖溶液；将壳聚糖溶液与步骤（1）的混合胶液混合均匀，加入聚乙烯醇、芦荟纳米微粉，混合均匀，调节pH为6.5~8，经过交联固化后制得。
可进一步制备成符合医用要求的膜、片等不同形态的材料。
本发明的凝胶具有良好的吸液性、生物相容性、抗菌性，可快速促进细胞生长加速创口愈合；固化速度适中，粘合强度高，粘接时放热低，粘接薄膜韧性好，对皮肤刺激性小，对各种创伤、手术切口具有高强度快速粘合作用，固化后无疤痕。
具体实施方式
下面通过实施例对本发明做进一步详细说明，这些实施例仅用来说明本发明，并不限制本发明的范围。
实施例1由以下透明质酸钠份的原料制备：透明质酸钠100份、纳米级可溶性银盐6份、芦荟纳米微粉20份、大豆蛋白粉20份、壳聚糖24份、醋酸2份、聚乙烯醇8份。制备方法如下：
（1）大豆蛋白粉以50-60℃的去离子水溶解，得大豆蛋白溶液；将透明质酸钠及其质量8倍的去离子水溶解，得胶液；将纳米级可溶性银盐配置成；将大豆蛋白溶液、胶液、银盐溶液混合均匀，得混合胶液；
（2）壳聚糖和醋酸溶解，加入适量去离子水，得壳聚糖溶液；将壳聚糖溶液与步骤（1）的混合胶液混合均匀，加入聚乙烯醇、芦荟纳米微粉，调节pH为6.9，经过交联固化后制得。
实施例2由以下透明质酸钠份的原料制备：透明质酸钠80份、纳米级可溶性银盐5份、芦荟纳米微粉15份、大豆蛋白粉35份、壳聚糖44份、醋酸5份、聚乙烯醇18份。制备方法如下：
（1）大豆蛋白粉以50-60℃的去离子水溶解，得大豆蛋白溶液；将透明质酸钠及其质量8倍的去离子水溶解，得胶液；将纳米级可溶性银盐配置成；将大豆蛋白溶液、胶液、银盐溶液混合均匀，得混合胶液；
（2）壳聚糖和醋酸溶解，加入适量去离子水，得壳聚糖溶液；将壳聚糖溶液与步骤（1）的混合胶液混合均匀，加入聚乙烯醇、芦荟纳米微粉，调节pH为6.5，经过交联固化后制得。
实施例3由以下透明质酸钠份的原料制备：透明质酸钠180份、纳米级可溶性银盐10份、芦荟纳米微粉24份、大豆蛋白粉55份、壳聚糖10份、醋酸1份、聚乙烯醇10份。制备方法如下：
（1）大豆蛋白粉以50-60℃的去离子水溶解，得大豆蛋白溶液；将透明质酸钠及其质量8倍的去离子水溶解，得胶液；将纳米级可溶性银盐配置成；将大豆蛋白溶液、胶液、银盐溶液混合均匀，得混合胶液；
（2）壳聚糖和醋酸溶解，加入适量去离子水，得壳聚糖溶液；将壳聚糖溶液与步骤（1）的混合胶液混合均匀，加入聚乙烯醇、芦荟纳米微粉，调节pH为8，经过交联固化后制得。

Claims (3)

1.一种医用凝胶，其特征在于：由以下透明质酸钠份的原料制备：透明质酸钠80～180份、纳米级可溶性银盐5～10份、芦荟纳米微粉5～24份、大豆蛋白粉20~55份、壳聚糖10~44份、醋酸1~5份、聚乙烯醇8~18份。
2.根据权利要求1所述的医用凝胶，其特征在于：所述芦荟纳米微粉的制备方法是：取新鲜芦荟，干燥至水分含量10~20%，粉碎至粒径300~500nm。
3.根据权利要求1所述的医用凝胶，其特征在于：其制备步骤如下：
（1）大豆蛋白粉以50-60℃的去离子水溶解，得大豆蛋白溶液；将透明质酸钠及其质量8倍的去离子水溶解，得胶液；将纳米级可溶性银盐配置成；将大豆蛋白溶液、胶液、银盐溶液混合均匀，得混合胶液；
（2）壳聚糖和醋酸溶解，加入适量去离子水，得壳聚糖溶液；将壳聚糖溶液与步骤（1）的混合胶液混合均匀，加入聚乙烯醇、芦荟纳米微粉，混合均匀，调节pH为6.5~8，经过交联固化后制得。
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CN106421886A (zh) * 2016-08-17 2017-02-22 倪娟形 一种创面修复水凝胶敷料及其制备方法
CN109700741A (zh) * 2019-03-06 2019-05-03 桂林电子科技大学 一种柿子单宁复合材料及其在抗电离辐射中的应用
CN110124116A (zh) * 2019-07-02 2019-08-16 淄博鲁泰正隆医疗器械有限公司 一种皮肤亲和电极片覆膜材料
CN111000796A (zh) * 2019-12-31 2020-04-14 瑞希(重庆)生物科技有限公司 一种透明质酸钠凝胶及其制备方法和应用
CN112316210A (zh) * 2020-11-09 2021-02-05 上海大学 一种含大豆蛋白的混合水凝胶及其制备方法和应用、血管化网络支架及其制备方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106421886A (zh) * 2016-08-17 2017-02-22 倪娟形 一种创面修复水凝胶敷料及其制备方法
CN109700741A (zh) * 2019-03-06 2019-05-03 桂林电子科技大学 一种柿子单宁复合材料及其在抗电离辐射中的应用
CN110124116A (zh) * 2019-07-02 2019-08-16 淄博鲁泰正隆医疗器械有限公司 一种皮肤亲和电极片覆膜材料
CN111000796A (zh) * 2019-12-31 2020-04-14 瑞希(重庆)生物科技有限公司 一种透明质酸钠凝胶及其制备方法和应用
CN112316210A (zh) * 2020-11-09 2021-02-05 上海大学 一种含大豆蛋白的混合水凝胶及其制备方法和应用、血管化网络支架及其制备方法
CN112316210B (zh) * 2020-11-09 2021-10-12 上海大学 一种含大豆蛋白的混合水凝胶及其制备方法和应用、血管化网络支架及其制备方法

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