CN105561031A - 一种治疗酒齄鼻的中药组合物 - Google Patents

一种治疗酒齄鼻的中药组合物 Download PDF

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CN105561031A
CN105561031A CN201510989987.9A CN201510989987A CN105561031A CN 105561031 A CN105561031 A CN 105561031A CN 201510989987 A CN201510989987 A CN 201510989987A CN 105561031 A CN105561031 A CN 105561031A
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chinese medicine
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刘晓云
王芳
邢健昆
王燕
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Abstract

本发明涉及一种治疗酒齄鼻的中药组合物，它是由下列重量配比的中药原料组成的：制苍术10-20g、丹参10-20g、何首乌10-25g、茯苓10-25g、蔓荆子10-15g、苦参10-15g、薏苡仁10-25g、防风5-10g、荆芥5-10g、牛蒡子10-15g、赤芍10-15g、黄芩10-15g、桑白皮10-15g、桔梗10-15g、玄参10-15g、牡丹皮10-15g、甘草5-10g。本发明的中药组合物采用天然的中药原料，具有清热燥湿、泻火解毒、养血活血、润肤止痒的功效，其配制简便、药源广、成本低，疗效显著，药性平和，有效率达99.14％，治愈率达67.24％。

Description

一种治疗酒齄鼻的中药组合物
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品，具体地说是一种治疗酒齄鼻的中药组合物。
背景技术
酒齄鼻，又称玫瑰痤疮或酒糟鼻，是一种主要发生于面部中央的红斑和毛细血管扩张的慢性炎症性皮肤病。多见于30～50岁中年人，女性多见。目前，一般的医学书籍认为酒糟鼻的发病原因主要是螨虫感染，又称酒糟鼻为螨虫性皮炎，治疗酒糟鼻以单纯地杀灭螨虫为主。多外用硫磺软膏、甲硝唑软膏、口服甲硝唑、替硝唑等杀螨药。数年临床观察证实，此类疗法对酒糟鼻的疗效不显著。也从侧面说明了酒糟鼻的发病原因绝不仅仅是单纯的螨虫感染，也有可能是因为油性皮肤所引起的，病因尚不十分清楚。可能是在皮脂溢出的基础上，由于体内外各种有害因子的作用，使患部血管舒缩神经功能失调，毛细血管长期扩张所致。毛囊虫及局部反复感染是发病重要因素。传统的中医认为：饮食失调、胃肠功能紊乱、内分泌失调、遗传、冷热不均、以及过食辛辣刺激、茶、酒、咖啡等刺激性食品，可以使颜面部血管运动神经功能失调，毛细血管长期扩张，导致本病。西医则认为：体内性激素偏高、体内缺少微量元素(锌、酮、)等。以上两种治疗酒齄鼻的方法是历来常用的，效果慎微，这也成了(中医、西医)中外医学界的一个医学难题，甚至有些医生说它酒齄鼻是个不死的癌症。这种说法也造成不少的患者丧失了治疗的信心，然而失去了最佳的治疗时期，最终使不死的癌症成为现实。
发明内容
本发明的目的就是为了克服上述现有的技术不足，根据中医理论，通过数年的药物筛选和反复临床验证，提供一种配伍合理，药源广，成本低，疗效显著，无毒副作用的治疗酒齄鼻的中药组合物，具有清热燥湿、泻火解毒、养血活血、润肤止痒的功效，治疗的疗效显著。
本发明解决其技术问题所采用的技术方案是：一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术10-20g、丹参10-20g、何首乌10-25g、茯苓10-25g、蔓荆子10-15g、苦参10-15g、薏苡仁10-25g、防风5-10g、荆芥5-10g、牛蒡子10-15g、赤芍10-15g、黄芩10-15g、桑白皮10-15g、桔梗10-15g、玄参10-15g、牡丹皮10-15g、马齿苋10-15g、蛇床子10-15g、甘草5-10g。
本发明的优选技术方案是：一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术15g、丹参12g、何首乌16g、茯苓15g、蔓荆子12g、苦参10g、薏苡仁15g、防风6g、荆芥5g、牛蒡子12g、赤芍10g、黄芩12g、桑白皮14g、桔梗15g、玄参10g、牡丹皮12g、马齿苋15g、蛇床子10g、甘草5g。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方，其原料成本低，治疗酒齄鼻疗效高，无毒副作用。本发明中药组合物中：制苍术【性味】辛、苦，温【归经】归脾、胃经【功能主治】燥湿健脾、祛湿散寒、明目。用于脘腹胀满、泄泻、水肿、脚气痿璧、风湿痹疼、风寒感冒、夜盲、食欲不振、恶心呕吐。丹参【性味】苦，微寒【归经】归心、肝经【功能主治】祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，瘴瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。何首乌【性味】苦；甘；涩；性微温【归经】肝；肾经【功能主治】养血滋阴；润肠通便；截疟；祛风；解毒。主治血虚头昏目眩；心悸；失眠；肝肾阴虚之腰膝酸软；须发早白；耳鸣；遗精；肠燥便秘；久疟体虚；风疹瘙痒；疮痈；瘰疬；痔疮。茯苓【性味】甘、淡，平【归经】归心、脾、肾经【功能主治】利水消肿，渗湿，健脾，宁心，主治小便不利，水肿胀满，痰饮咳逆，呕逆，恶阻，泄泻，遗精，淋浊，惊悸，健忘等症。蔓荆子【性味】辛、苦，微寒【归经】归膀胱、肝、胃经【功能主治】疏散风热，清利头目。用于风热感冒头痛，齿龈肿痛，目赤多泪，目暗不明，头晕目眩。苦参【性味】苦，寒【归经】归心、肝、胃、大肠、膀胱经【功能主治】清热燥湿，杀虫，利尿。用于热痢，便血，黄疸尿闭，赤白带下，阴肿阴痒，湿疹，湿疮，皮肤瘙痒，疥癣麻风；外治滴虫性阴道炎。薏苡仁【性味】甘、淡，凉【归经】归脾、胃、肺经【功能主治】健脾渗湿，除痹止泻，清热排浓。用于水肿，脚气，小便不利，湿痹拘挛，脾虚泄泻，肺痈，肠痈；扁平疣。防风【性味】辛、甘，温【归经】归膀胱、肝、脾经【功能主治】解表祛风，胜湿，止痉。用于感冒头痛，风湿痹痛，风疹瘙痒，破伤风。荆芥【性味】辛，温【归经】入肺、肝经【功能主治】发表，祛风，理血；炒炭止血。治感冒发热，头痛，咽喉肿痛，中风口噤，吐血，衄血，便血；崩漏，产后血晕；痈肿，疮疥，瘰疬。荆芥穗效用相同，惟发散之力较强。牛蒡子【性味】辛、苦，寒【归经】归肺、胃经【功能主治】疏散风热，宣肺透疹，解毒利咽。用于风热感冒，咳嗽痰多，麻疹，风疹，咽喉肿痛，痄腮丹毒，痈肿疮毒。赤芍【性味】微寒；苦【归经】归肝经【功能主治】清热凉血；活血祛瘀。用于温毒发斑；吐血衄血；肠风下血；目赤肿痛；痈肿疮疡；闭经；痛经；崩带淋浊；瘀滞胁痛；疝瘕积聚；跌扑损伤。黄芩【性味】苦，寒【归经】归肺、胆、脾、大肠、小肠经【功能主治】清热燥湿，泻火解毒，止血，安胎。用于湿温、暑温胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。桑白皮【性味】甘，寒【归经】入肺、脾经【功能主治】泻肺平喘，行水消肿。治肺热喘咳，吐血，水肿，脚气，小便不利。桔梗【性味】苦辛，平【归经】入肺、胃经【功能主治】开宣肺气，祛痰排脓。治外感咳嗽，咽喉肿痛，肺痈吐脓，胸满胁痛，痢疾腹痛。玄参【性味】甘、苦、咸，微寒【归经】归肺、胃、肾经【功能主治】凉血滋阴，泻火解毒。用于热病伤阴，舌绛烦渴，温毒发斑，津伤便秘，骨蒸劳嗽，目赤，咽痛，瘰疠，白喉，痈肿疮毒。牡丹皮【性味】辛苦，凉【归经】入心、肝、肾经【功能主治】清热，凉血，和血，消瘀。治热入血分，发斑，惊痫，吐、衄、便血，骨蒸劳热，经闭，癥瘕，痈疡，扑损。马齿苋【性味】酸，寒【归经】入大肠，肝、脾经【功能主治】清热解毒，散血消肿。治热痢脓血，热淋，血淋，带下，痈肿恶疮，丹毒，痕疬。用于湿热所致的腹泻、痢疾，常配黄连、木香。内服或捣汁外敷，治痈肿。亦用于便血、子宫出血，有止血作用。蛇床子：【性味】味辛；苦；性温【归经】归脾；肾经【功能主治】温肾壮阳；燥湿杀虫；祛风止痒。主治男子阳痿；阴囊湿痒；女子宫寒不孕；寒湿带下；阴痒肿痛；风湿痹痛；湿疮疥癣。甘草【性味】甘，平【归经】归心，脾，肺，胃经【功能主治】有补脾益气，润肺止咳，清热解毒，缓解止痛，缓和药性的功效。上述诸药合用，具有清热燥湿、泻火解毒、养血活血、润肤止痒的功效，对酒齄鼻达到标本兼治的目的。
本发明的组合物遵循中医的处方用药原则，采用天然的中药原料，配制简便、药源广、成本低。其采用水煎服用，经临床应用验证，其疗效显著，作用可靠，药性平和，未出现毒副作用，总有效率99.14％，治愈率达67.24％。
具体实施方式
实施例1：一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术10g、丹参10g、何首乌10g、茯苓12g、蔓荆子10g、苦参12g、薏苡仁10g、防风5g、荆芥5g、牛蒡子10g、赤芍12g、黄芩15g、桑白皮15g、桔梗10g、玄参15g、牡丹皮15g、马齿苋20g、蛇床子10g、甘草6g。
实施例2：一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术15g、丹参12g、何首乌16g、茯苓15g、蔓荆子12g、苦参10g、薏苡仁15g、防风6g、荆芥5g、牛蒡子12g、赤芍10g、黄芩12g、桑白皮14g、桔梗15g、玄参10g、牡丹皮12g、马齿苋15g、蛇床子10g、甘草5g。
实施例3：一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术20g、丹参20g、何首乌20g、茯苓25g、蔓荆子15g、苦参15g、薏苡仁25g、防风10g、荆芥10g、牛蒡子12g、赤芍15g、黄芩10g、桑白皮10g、桔梗10g、玄参15g、牡丹皮10g、马齿苋10g、蛇床子15g、甘草10g。
实施例4：一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术12g、丹参15g、何首乌15g、茯苓20g、蔓荆子10g、苦参15g、薏苡仁20g、防风10g、荆芥5g、牛蒡子15g、赤芍15g、黄芩15g、桑白皮10g、桔梗15g、玄参10g、牡丹皮15g、马齿苋12g、蛇床子12g、甘草10g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：取本发明组方的中药原料药物放入容器中，先加水浸泡，加冷水漫过药面，浸泡20～30分钟，再加水没过药面约12厘米，进行第一次煎煮，先用武火煎煮，煮沸后用文火煎煮20～30分钟，滤出取药液汁200ml；第二煎煮，加水没过药面约10厘米，水沸后煎煮20～25分钟，滤出取药液汁200ml。两次煎煮取得药液汁合并备用。
一种治疗酒齄鼻的中药组合物的临床疗效总结：
一、一般性资料：本中药组合物应用于临床观察病116例，其中男45例，女71例，年龄30～55岁。病程最短者1个月，最长者达10年。
二、诊断标准：
本病好发于颜面中部，以鼻尖、鼻翼为主，其次为颊部、颏部、前额，常对称分布，多发于中年人，妇女较多，患者多并发皮脂溢，颜面犹如涂脂。皮损表现为红斑、毛细血管扩张和有炎症的毛囊丘疹及脓疱等。病程缓慢，可分为三期，但无明显界限。三期为：红斑期、丘疹期、肥大期。酒糟鼻的症状轻重不一，初起为红斑、油腻。若长时间没有治愈，病变会向皮肤的深层进展，鼻部的皮肤就会变得愈加的粗拙、毛孔粗大，皮色呈暗红色。
三、用法用量：临床应用时，组合物中的组分、用量根据患者的体重、年龄及症状酌情增减。7剂为一疗程，一天一剂，水煎两遍取汁约400ml，分早、晚两次饭前半小时温热服用。
四、疗效标准：
完全缓解：临床症状完全消失。
部分缓解：临床症状改善。
无效：临床症状无变化或加重。
五、治疗效果：临床观察病例中，服药1-5个疗程，治愈78例，有效37例，无效1例。治疗期间未发生毒副作用。
六、典型病例：
1、王某，女，30岁，因感冒长时间鼻塞、流鼻涕，摸鼻涕以致鼻尖部组织轻度发炎、红肿、感冒痊愈后鼻尖部组织仍发炎红肿，并逐渐由鼻尖部组织发炎红肿，表浅皮肤充血，毛细血管扩张，组织增厚蔓延至双面部皮肤发炎红肿，毛细血管扩张，组织增厚。鼻及面部时时有虫爬感，痛痒难忍，每食辛辣腥味食物及月经来时，病情加重。服用本发明的中药组合物4个疗程后，病灶皮肤红色褪至肤色，接近正常。
2、张某、男、46岁，患者于2年前开始鼻两侧和两眉之间经常发生粟粒大疖子，有时自行消退，反复不断。其后鼻部毛孔变粗，皮色变红。曾多次治疗，效果不佳。检查：两眉附近有油腻性鳞屑。鼻尖两翼毛细血管扩张，毛孔开大，可挤出油腻性粉汁。服用本发明中药组合物制备的药剂1个疗程，皮损减轻，红色变淡，继续服用2个疗程，所有症状消失，治愈，半年后随访未复发。
3、吕某，女，53岁，初诊时鼻发红，原因不明，后鼻部开始出现粟米样大小皮疹、潮红、有皮脂溢出现象，继则出现脓疮，在精神紧张、情绪激动和进餐时，潮红更加明显，外擦中、西药，都未见明显疗效。于是就服用本发明3个疗程后，病灶明显消退。

Claims (2)

1.一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术10-20g、丹参10-20g、何首乌10-25g、茯苓10-25g、蔓荆子10-15g、苦参10-15g、薏苡仁10-25g、防风5-10g、荆芥5-10g、牛蒡子10-15g、赤芍10-15g、黄芩10-15g、桑白皮10-15g、桔梗10-15g、玄参10-15g、牡丹皮10-15g、马齿苋10-15g、蛇床子10-15g、甘草5-10g。
2.根据权利要求1所述的一种治疗酒齄鼻的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：制苍术15g、丹参12g、何首乌16g、茯苓15g、蔓荆子12g、苦参10g、薏苡仁15g、防风6g、荆芥5g、牛蒡子12g、赤芍10g、黄芩12g、桑白皮14g、桔梗15g、玄参10g、牡丹皮12g、马齿苋15g、蛇床子10g、甘草5g。
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CN101129876A (zh) * 2007-08-29 2008-02-27 北京艺信堂医药研究所 一种治疗酒渣鼻的中药组合物

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CN101129876A (zh) * 2007-08-29 2008-02-27 北京艺信堂医药研究所 一种治疗酒渣鼻的中药组合物

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