CN105560693A - Medicine composition for treating haemorrhoids - Google Patents
Medicine composition for treating haemorrhoids Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating haemorrhoids and a preparation method of the medicine composition. The medicine composition is prepared from creeping woodsorrel herb, geranium strictipes, rhizoma belamcandae, semen arecae, citrus peel, semen lepidii, medicated leaven, realgar and scorpions, can be prepared into various dosage forms according to a conventional preparation process and has a remarkable treatment effect on treating haemorrhoids.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of hemorrhoid and preparation method thereof.
Background technology
Hemorrhoid are modal anal and intestinal diseases, and the disease of hemorrhoid is sent out, and usually allow patient suffering can't bear, have blood in stool, the symptom such as pain, pruritus, and had a strong impact on the orthobiosis of patient, moreover serious hemorrhoid also can produce harm to patient, can not be ignored.Generally speaking, the harm of hemorrhoid have following some: 1, anal eczema: hemorrhoid middle and advanced stage patient deviates from severity and Sphincter ani chalasia due to hemorrhoid block, mucus flows out and causes moist unclean outside anus, easily causes skin pruritus or anal eczema.2, anemia: Silent Neuritis intermittent hemorrhage be after an action of the bowels the common sympton of hemorrhoid, long-term chronic is lost blood and can be caused anemia, the early stage fatiguability of patient, with anemia increase the weight of engender the performance such as pale complexion, fatigue and weakness, dizziness, cardiopalmus.3, other anal and intestinal diseases: hemorrhoid can cause the various anorectal diseases such as anal fissure, anal fistula, perianal abscess, increase the misery of patient, also add difficulty to clinical treatment simultaneously.4, prolapse, incarceration be even downright bad: internal hemorrhoid middle and advanced stage, external hemorrhoid, mixed hemorrhoid patient all have in various degree deviate from performance, blood stasis emerges in anus and easily incarceration occurs outward, cause local metabolic product accumulation, increase the weight of anus local edema further, can necrose when the incarceration time is longer or degree is heavier.
The medicine of current treatment hemorrhoid mainly contains: anus Thailand, ZHIGENDUAN sheet, YUNNAN BAIYAO ZHICHUANG GAO, Sphallerocarpus gracilis hemorrhoid-eliminating paste etc.Although these medicines have certain curative effect, but still can not be satisfactory.
Herba Oxalidis Corniculatae: the herb of Oxalidaceae plant Herba Oxalidis Corniculatae OxaliscorniculataL..The four seasons can adopt, and have during flowers and fruits with Xia Qiu and gather medicinal herbs effect better, removing silt, dries.[nature and flavor] acid, cool.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For cold, fever, enteritis, urinary tract infection, lithangiuria, neurasthenia; Traumatic injury is controlled in external, venom, carbuncle furuncle, tinea pedis, eczema, burn and scald.[extracts] " national Chinese herbal medicine compilation ".
Radix Geranii Strictipedis: MangNiu Er Seedling section geranium platymiscium Radix Geranii Strictipedis GeraniumstrictipesR.Knuth [G.strigosumauct.nonBurm.f.], is used as medicine with root.Autumn excavates, and clean section is dried.[nature and flavor] are bitter, puckery, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, promoting blood circulation and hemostasis.For enteritis, dysentery, dyspepsia, chronic gastritis, menoxenia, epistaxis; Traumatic injury is controlled in external.[extracts] " national Chinese herbal medicine compilation ".
Rhizoma Belamcandae: this product is irides Rhizoma Belamcandae Belamcandachinensis(L.) dry rhizome of DC..Just germinateed at the beginning of spring or autumn Mo, stem and leaf was withered time excavate, removing fibrous root and silt, drying.[character] this product is irregular nodular pattern, long 3 ~ 10cm, diameter 1 ~ 2cm.Surface yellowish-brown, sepia or pitchy, shrinkage, has closeer ring grain.There is the stem trace of several discoid depression above, occasionally have stem foot remaining; There are residual radicula and root trace below.Matter is hard, and section is yellow, graininess.Feeble QI, bitter in the mouth, micro-pungent.[nature and flavor] are bitter, cold.[return through] returns lung meridian.[function cures mainly] heat-clearing and toxic substances removing, expectorant, sore-throat relieving.For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.[extracts] " Chinese Pharmacopoeia ".
Semen Arecae: this product is the dry mature seed of babassu Semen Arecae ArecacatechuL..Gather at the beginning of spring Mo to autumn mature fruit, after decocting in water, dry, removing peel, takes out seed, dry.[character] this product is oblate spheroid or taper shape, high 1.5 ~ 3.5cm, base diameter 1.5 ~ 3cm.Surface is fallow or light red brown, the netted rill that tool is slightly recessed, and there is the hole of bead of circular depressed in bottom centre, and there is 1 obvious cicatrix shape hilum on its side.Matter is hard, not easily broken, the marble sample decorative pattern that section visible brown color seed coat is alternate with white endosperm.Feeble QI, puckery, micro-hardship.[nature and flavor] are bitter, pungent, temperature.[return through] returns stomach, large intestine channel.[function cures mainly] killing insect and eliminating accumulation, sending down the abnormal ascending QI, row water, preventing the attack (or recurrence) of malaria.For cestode, ascarid, fasciolopsiasis buski, abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, malaria.[extracts] " Chinese Pharmacopoeia ".
Citrus chachiensis Hort. C. Suavissima Tanaka: be the peel of the multiple Citrus chachiensis Hort. classes such as rutaceae Citrus reticulata Blanco cv. Chachiensis or bowl Citrus chachiensis Hort..Pluck into hot fruit 9 ~ November, strip outside rind, dry in the shade or dry.The peel that [character] is complete, cuts open 3 lobes more, every lobe subcircular, and at fruit stem, place connects together, sometimes broken apart one-tenth single-lobe.The multidirectional outer warp of limb, the internal layer of white obviously exposes; Thick about 1 millimeter of peel.Outer surface yellowish orange, to reddish orange, has countless large and recessed oil drop.Inner surface white cotton is cotton-shaped, and oil drop nick enters.Matter is comparatively loose and soft, still not crisp after drying.Give off a strong fragrance, taste is micro-pungent, but very not bitter.Thin with skin, sheet is large, matter is soft.Few scab, the dense person of glossy, fragrance is good.[nature and flavor] are " seven volume cuisine canons " 1.: " little cold." 2. " detailed outline ": " Xin Gan, cold, nontoxic." [function cures mainly] therapeutic method to keep the adverse QI flowing downwards, in tune, reduces phlegm, relieving alcoholic intoxication.Drinking and eating irregularly after curing the disease, upper gas stuffy sensation with restlessness, gets sick from drinking too much wine thirsty.[extracts] " * dictionary ".
Semen Lepidii (Semen Descurainiae): this product is crucifer Lepidium sativum L. LepidiumapetalumWilld. or descurainia sophia (l.) webb ex prantl Descurainiasophia(L.) dry mature seed of Webbexprantl.The former practises title " lepidii,semen ", and the latter practises title " Semen Descurainiae ".Tap plant during fruit maturation in summer, dry, rub seed, removing impurity.[character] lepidii,semen: in flat avette, long 1 ~ 1.5mm, wide 0.5 ~ 1mm.Surface brown or rufous, micro-glossy, tool longitudinal furrow 2, wherein 1 more obvious.The blunt circle in one end, another end point and nick, off-white color, hilum is positioned at recessed end.Odorless, taste is micro-pungent, and stickiness is stronger.[nature and flavor] are pungent, bitter, Great Cold.[return through] returns lung, urinary bladder channel.[function cures mainly] eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.[extracts] " Chinese Pharmacopoeia ".
Massa Medicata Fermentata: for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.[character] is square or rectangular bulk, wide about 3 centimetres, thick about 1 centimetre, and appearance khaki is coarse; Matter is hard crisp easily broken, and section is uneven, off-white color, as seen not pulverized brown residue and the cavity after fermenting.There is old gas, bitter in the mouth.With old for a long time, free from insect pests person is good.[nature and flavor] sweet, acrid, warm.[return through] enters spleen, stomach warp.[function cures mainly] invigorating the spleen and regulating the stomach, helps digestion in adjusting.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.[extracts] " * dictionary ".
Realgar: this product is sulfide-based mineral Realgar race Realgar, main containing realgar (As2S2).After excavating, removing impurity.Or the fine ore to be produced by poor value flotation.[character] this product is block or granular aggregate, in irregular bulk.Peony or orange red, streak light red orange, crystal face has diamond-like gloss.Matter is crisp, frangible, section tool resin-like gloss.Micro-have special foul smell, lightly seasoned.Fine ore is Powdered or powder aggregates, and matter is crisp, hands pinch powder, orange-yellow, matt.[nature and flavor] are pungent, temperature; Poisonous.[return through] returns liver, large intestine channel.[function cures mainly] removing toxic substances parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria.For carbuncle furuncle, snake bite and insect sting, abdominal pain due to worm stagnation, infantile convulsion, malaria.[extracts] " Chinese Pharmacopoeia ".
Scorpio: this product is the dry body of Buthidae animal Scorpio ButhusmartensiiKarsch.Catch at the beginning of spring Mo to autumn, removing silt, puts boiling water or boils in saline, boil to catalepsy, pull out, put ventilation, dry in the shade.[character] this product cephalothorax and preabdomen are flat oblong, and postabdomen is shape of tail, and shrinkage bends, and complete person's body is about 6cm.Cephalothorax is green and brown color, before have 1 to short and small chelicera and 1 to the tong-like foot of comparatively growing up must, likeness in form Eriocheir sinensis chela, the back side is covered with trapezoidal carapace, and the outside of belly has foot 4 right, is 7 joints, end each tool 2 claw hook; Preabdomen is made up of 7 joints, and Section of seven color depth, carapace has 5 chine line.The green and brown color in the back side, postabdomen brown color, 6 joints, joint all has longitudinal furrow, and minor details have sharp hook-shaped telson, without distance below telson.Feeble QI raw meat, salty in the mouth.[nature and flavor] are pungent, flat; Poisonous.[return through] returns Liver Channel.[function cures mainly] endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.[extracts] " Chinese Pharmacopoeia ".
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective treatment hemorrhoid and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of these treatment hemorrhoid are:
Herba Oxalidis Corniculatae 110-130g, Radix Geranii Strictipedis 100-120g, Rhizoma Belamcandae 50-70g, Semen Arecae 50-60g, Citrus chachiensis Hort. C. Suavissima Tanaka 30-50g, Semen Lepidii (Semen Descurainiae) 80-100g, Massa Medicata Fermentata 90-110g, Realgar 60-80g, Scorpio 50-70g.
Preferably be used for the treatment of the pharmaceutical composition of hemorrhoid, be made up of the crude drug of following weight portion:
Herba Oxalidis Corniculatae 120g, Radix Geranii Strictipedis 110g, Rhizoma Belamcandae 60g, Semen Arecae 55g, Citrus chachiensis Hort. C. Suavissima Tanaka 40g, Semen Lepidii (Semen Descurainiae) 90g, Massa Medicata Fermentata 100g, Realgar 70g, Scorpio 60g.
Treat a pharmaceutical composition for hemorrhoid, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule.
Treat a pharmaceutical composition for hemorrhoid, it is characterized in that the medicine for treaching hemorrhoie that pharmaceutical composition and chemical drugs or Chinese medicine form.
Treat a preparation method for the pharmaceutical composition of hemorrhoid, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herba Oxalidis Corniculatae 110-130g, Radix Geranii Strictipedis 100-120g, Rhizoma Belamcandae 50-70g, Semen Arecae 50-60g, Citrus chachiensis Hort. C. Suavissima Tanaka 30-50g, Semen Lepidii (Semen Descurainiae) 80-100g, Massa Medicata Fermentata 90-110g, Realgar 60-80g, Scorpio 50-70g;
Preparation method: get Herba Oxalidis Corniculatae by crude drug proportioning, Radix Geranii Strictipedis, Rhizoma Belamcandae, Semen Arecae, Citrus chachiensis Hort. C. Suavissima Tanaka, Semen Lepidii (Semen Descurainiae), Massa Medicata Fermentata, Realgar, Scorpio, mixing, with weight percent concentration 45% ethanol as solvent, extract at 50 DEG C of warm macerating, extraction time is 3 times, each extraction time is 2 hours, each solvent load is 17 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Preferably treat a preparation method for the pharmaceutical composition of hemorrhoid, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herba Oxalidis Corniculatae 120g, Radix Geranii Strictipedis 110g, Rhizoma Belamcandae 60g, Semen Arecae 55g, Citrus chachiensis Hort. C. Suavissima Tanaka 40g, Semen Lepidii (Semen Descurainiae) 90g, Massa Medicata Fermentata 100g, Realgar 70g, Scorpio 60g;
Preparation method: get Herba Oxalidis Corniculatae by crude drug proportioning, Radix Geranii Strictipedis, Rhizoma Belamcandae, Semen Arecae, Citrus chachiensis Hort. C. Suavissima Tanaka, Semen Lepidii (Semen Descurainiae), Massa Medicata Fermentata, Realgar, Scorpio, mixing, with weight percent concentration 45% ethanol as solvent, extract at 50 DEG C of warm macerating, extraction time is 3 times, each extraction time is 2 hours, each solvent load is 17 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Treat a preparation method for the pharmaceutical composition of hemorrhoid, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule.
Treat a preparation method for the pharmaceutical composition of hemorrhoid, it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form medicine for treaching hemorrhoie.
Detailed description of the invention
Embodiment 1: pharmaceutical composition for the treatment of hemorrhoid and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of hemorrhoid are: Herba Oxalidis Corniculatae 120g, Radix Geranii Strictipedis 110g, Rhizoma Belamcandae 60g, Semen Arecae 55g, Citrus chachiensis Hort. C. Suavissima Tanaka 40g, Semen Lepidii (Semen Descurainiae) 90g, Massa Medicata Fermentata 100g, Realgar 70g, Scorpio 60g;
Preparation method: get Herba Oxalidis Corniculatae by crude drug proportioning, Radix Geranii Strictipedis, Rhizoma Belamcandae, Semen Arecae, Citrus chachiensis Hort. C. Suavissima Tanaka, Semen Lepidii (Semen Descurainiae), Massa Medicata Fermentata, Realgar, Scorpio, mixing, with weight percent concentration 45% ethanol as solvent, extract at 50 DEG C of warm macerating, extraction time is 3 times, each extraction time is 2 hours, each solvent load is 17 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 2: pharmaceutical composition for the treatment of hemorrhoid and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of hemorrhoid are: Herba Oxalidis Corniculatae 110g, Radix Geranii Strictipedis 120g, Rhizoma Belamcandae 50g, Semen Arecae 60g, Citrus chachiensis Hort. C. Suavissima Tanaka 30g, Semen Lepidii (Semen Descurainiae) 100g, Massa Medicata Fermentata 90g, Realgar 80g, Scorpio 50g;
Preparation method: get Herba Oxalidis Corniculatae by crude drug proportioning, Radix Geranii Strictipedis, Rhizoma Belamcandae, Semen Arecae, Citrus chachiensis Hort. C. Suavissima Tanaka, Semen Lepidii (Semen Descurainiae), Massa Medicata Fermentata, Realgar, Scorpio, mixing, with weight percent concentration 45% ethanol as solvent, extract at 50 DEG C of warm macerating, extraction time is 3 times, each extraction time is 2 hours, each solvent load is 17 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 3: pharmaceutical composition for the treatment of hemorrhoid and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of hemorrhoid are: Herba Oxalidis Corniculatae 130g, Radix Geranii Strictipedis 100g, Rhizoma Belamcandae 70g, Semen Arecae 50g, Citrus chachiensis Hort. C. Suavissima Tanaka 50g, Semen Lepidii (Semen Descurainiae) 80g, Massa Medicata Fermentata 110g, Realgar 60g, Scorpio 70g;
Preparation method: get Herba Oxalidis Corniculatae by crude drug proportioning, Radix Geranii Strictipedis, Rhizoma Belamcandae, Semen Arecae, Citrus chachiensis Hort. C. Suavissima Tanaka, Semen Lepidii (Semen Descurainiae), Massa Medicata Fermentata, Realgar, Scorpio, mixing, with weight percent concentration 45% ethanol as solvent, extract at 50 DEG C of warm macerating, extraction time is 3 times, each extraction time is 2 hours, each solvent load is 17 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 90g, adds starch 50g, mixing, granulates, dry, adds microcrystalline Cellulose 10g, magnesium stearate 1g, and mixing, is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 90g, adds starch 60g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains medicament composition capsule by encapsulated 1000.
Embodiment 6: the pharmaceutical composition for the treatment of hemorrhoid
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of hemorrhoid are:
Radix Geranii Strictipedis 120g, Rhizoma Belamcandae 100g, Massa Medicata Fermentata 110g, Realgar 60g, Scorpio 30g.
Embodiment 7: the pharmaceutical composition for the treatment of hemorrhoid
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of hemorrhoid are:
Radix Geranii Strictipedis 150g, Rhizoma Belamcandae 50g, Massa Medicata Fermentata 130g, Realgar 80g, Scorpio 20g.。
Embodiment 8: the pharmaceutical composition for the treatment of hemorrhoid
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of hemorrhoid are:
Radix Geranii Strictipedis 90g, Rhizoma Belamcandae 120g, Massa Medicata Fermentata 90g, Realgar 70g, Scorpio 30g.
experimental example 1: the experimental study for the treatment of hemorrhoid
1 data and method
1.1 physical data
Select hemorrhoid patients 100 example that October 1 year October in 2012, institute of traditional Chinese medicine of Shandong Province anorectum department was accepted for medical treatment, wherein man 55 example, female 45 example; 27 years old ~ 65 years old age, 43.5 years old mean age; Internal hemorrhoid II degree of 35 example, III degree of 35 example, thrombosed external hemorrhoid 15 example, mixed hemorrhoid 15 example.
1.2 case inclusive criterias
1. anus inspection: the predilection site of internal hemorrhoid is calculi position 3,7,11 places, internal hemorrhoid is removed I and is outside one's consideration, and other 3 degree all can be found under anus inspection.2. to the hemorrhoid block person of deviating from, observe immediately after the defecation of crouching position, clearly can see hemorrhoid block size, number and position.3. anoscopy, not only can see hemorrhoid block situation, also can be observed rectal mucosa with or without hyperemia, edema, ulcer, lump etc.4. thrombosed external hemorrhoid shows as the rectangular circle of crissum mulberry and to swell thing, and surface skin edema, matter are hard, tenderness.
1.3 case exclusion standards
1. rectal cancer: Rectal tonch and proctoscopy can be got rid of.Rectal cancer can kowtow rugged lump when digital rectal examination.2. rectal polyp: low level pedicle skin flap polypus deviates from anus.3. proctoptosis: proctoptosis mucosa ringwise, surface smoothing, sphincter dilatation.
1.4 Therapeutic Method
In conjunction with clinical symptoms and diagnostic result after patient admits, whole body assessment is done to patient, formulates the therapeutic scheme being applicable to patient.Adopt pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20111017) 6g every day, point 2 (early, evening) warm water take.7d is 1 course for the treatment of, carries out therapeutic evaluation after being used in conjunction 5 courses for the treatment of.
1.5 the standard of curative effect evaluation
With reference to the evaluation criterion that State Administration of Traditional Chinese Medicine formulates, cure: clinical symptom disappearance, blood stasis disappears or all atrophys, phone or carry out institute's check, and 1 year without recurrence; Take a turn for the better: clinical symptom relief, hemorrhoid reduce or part atrophy, phone or come institute check 6 months without recurrence; Invalid: Clinical symptom and sign is all without change.Total effective rate=(cure+take a turn for the better)/total number of cases x100%.
2 results
100 routine patients of combination of oral medication (embodiment 1 pharmaceutical composition lot number 20111017) treatment hemorrhoid, after treating 5 courses for the treatment of, carry out treatment effectiveness evaluation according to the standard of curative effect evaluation: cure 78 examples, take a turn for the better 19 examples, invalid 3 examples, total efficiently individual quantity 97 example, accounts for 97.0%.
experimental example 2: model case
Zheng XX, female, 41 years old, the symptom of falling ill: little handbag has been grown at initial discovery anus position, does not cause enough attention at that time.Spent a very long time, she finds that the little handbag at anus position becomes and hardens, and all can occur the phenomenon of pain when each defecation, and find that having drop of blood drops on inside toilet after an action of the bowels, also have the vestige of blood above toilet paper, this just causes the attention of Mrs Han simultaneously.Arriving hospital diagnosis is afterwards having blood in stool of causing of hemorrhoid, starts on January 20th, 2014 to adopt pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20111017) 6g every day, and point 2 (early, evening) warm water take.7d is 1 course for the treatment of, thoroughly cures after being used in conjunction 4 courses for the treatment of.
Du XX, female, 35 years old.The state of an illness: suffer from hemorrhoid and anal fissure 1 year.Having a relapse on November 19th, 2013, there is just blood after an action of the bowels greatly, occurring pain when defecation, present spasm, walk and sit all difficulties, having occurred inappetence, YY hemorrhoid of coming examination in hospital: left lateral position: 3,9 position internal hemorrhoid swelling, deviate from as thumb is large, 6, anal canal place, 12 positions has a fusiformis ulcer surface respectively, and surplus color is greyish white, and edge is uneven, the severe pain touched, merges whistle hemorrhoid as chinaberry shape size.Be diagnosed as once hemorrhoid anal fissure.Start on November 22nd, 2013 to adopt pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20111017) 6g every day, point 2 (early, evening) warm water take.7d is 1 course for the treatment of, is used in conjunction the equal nothing of hemorrhoid symptom after 6 courses for the treatment of, 6,12 position anal fissure ulcer surface healings.So far do not recur.
Claims (7)
1. treat a pharmaceutical composition for hemorrhoid, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Herba Oxalidis Corniculatae 110-130g, Radix Geranii Strictipedis 100-120g, Rhizoma Belamcandae 50-70g, Semen Arecae 50-60g, Citrus chachiensis Hort. C. Suavissima Tanaka 30-50g, Semen Lepidii (Semen Descurainiae) 80-100g, Massa Medicata Fermentata 90-110g, Realgar 60-80g, Scorpio 50-70g.
2. a kind of pharmaceutical composition for the treatment of hemorrhoid according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Herba Oxalidis Corniculatae 120g, Radix Geranii Strictipedis 110g, Rhizoma Belamcandae 60g, Semen Arecae 55g, Citrus chachiensis Hort. C. Suavissima Tanaka 40g, Semen Lepidii (Semen Descurainiae) 90g, Massa Medicata Fermentata 100g, Realgar 70g, Scorpio 60g.
3. a kind of pharmaceutical composition for the treatment of hemorrhoid according to claim 1, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule.
4. a kind of pharmaceutical composition for the treatment of hemorrhoid according to claim 1, is characterized in that the medicine for treaching hemorrhoie that pharmaceutical composition and chemical drugs or Chinese medicine form.
5. treat a preparation method for the pharmaceutical composition of hemorrhoid, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herba Oxalidis Corniculatae 110-130g, Radix Geranii Strictipedis 100-120g, Rhizoma Belamcandae 50-70g, Semen Arecae 50-60g, Citrus chachiensis Hort. C. Suavissima Tanaka 30-50g, Semen Lepidii (Semen Descurainiae) 80-100g, Massa Medicata Fermentata 90-110g, Realgar 60-80g, Scorpio 50-70g;
Preparation method: get Herba Oxalidis Corniculatae by crude drug proportioning, Radix Geranii Strictipedis, Rhizoma Belamcandae, Semen Arecae, Citrus chachiensis Hort. C. Suavissima Tanaka, Semen Lepidii (Semen Descurainiae), Massa Medicata Fermentata, Realgar, Scorpio, mixing, with weight percent concentration 45% ethanol as solvent, extract at 50 DEG C of warm macerating, extraction time is 3 times, each extraction time is 2 hours, each solvent load is 17 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
6. a kind of preparation method for the treatment of the pharmaceutical composition of hemorrhoid according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herba Oxalidis Corniculatae 120g, Radix Geranii Strictipedis 110g, Rhizoma Belamcandae 60g, Semen Arecae 55g, Citrus chachiensis Hort. C. Suavissima Tanaka 40g, Semen Lepidii (Semen Descurainiae) 90g, Massa Medicata Fermentata 100g, Realgar 70g, Scorpio 60g;
Preparation method: get Herba Oxalidis Corniculatae by crude drug proportioning, Radix Geranii Strictipedis, Rhizoma Belamcandae, Semen Arecae, Citrus chachiensis Hort. C. Suavissima Tanaka, Semen Lepidii (Semen Descurainiae), Massa Medicata Fermentata, Realgar, Scorpio, mixing, with weight percent concentration 45% ethanol as solvent, extract at 50 DEG C of warm macerating, extraction time is 3 times, each extraction time is 2 hours, each solvent load is 17 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by ADS-8 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting ADS-8 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
7. a kind of preparation method for the treatment of the pharmaceutical composition of hemorrhoid according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule.
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| CN106215048A (en) * | 2016-08-22 | 2016-12-14 | 常德永利盛祥生物科技有限公司 | A kind of Chinese medicine composition treating hemorrhoid and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106215048A (en) * | 2016-08-22 | 2016-12-14 | 常德永利盛祥生物科技有限公司 | A kind of Chinese medicine composition treating hemorrhoid and preparation method thereof |
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