CN105560155A - Cosmetic composition containing goat milk and application thereof - Google Patents
Cosmetic composition containing goat milk and application thereof Download PDFInfo
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- CN105560155A CN105560155A CN201610055800.2A CN201610055800A CN105560155A CN 105560155 A CN105560155 A CN 105560155A CN 201610055800 A CN201610055800 A CN 201610055800A CN 105560155 A CN105560155 A CN 105560155A
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- cosmetic composition
- extract
- goat milk
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- skin
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 91
- 239000000203 mixture Substances 0.000 title claims abstract description 79
- 235000020251 goat milk Nutrition 0.000 title claims abstract description 46
- 239000000284 extract Substances 0.000 claims abstract description 51
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 29
- 201000004624 Dermatitis Diseases 0.000 claims abstract description 20
- 208000010668 atopic eczema Diseases 0.000 claims abstract description 19
- 230000003266 anti-allergic effect Effects 0.000 claims abstract description 15
- 206010016807 Fluid retention Diseases 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 14
- 238000012423 maintenance Methods 0.000 claims description 11
- -1 alkyl androstanediol Chemical compound 0.000 claims description 10
- 208000007502 anemia Diseases 0.000 claims description 9
- 235000013336 milk Nutrition 0.000 claims description 9
- 239000008267 milk Substances 0.000 claims description 9
- 210000004080 milk Anatomy 0.000 claims description 9
- 239000003921 oil Substances 0.000 claims description 9
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 8
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
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- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 claims description 2
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- KRPAJLYSLFNDOA-UHFFFAOYSA-N mephenesin carbamate Chemical compound CC1=CC=CC=C1OCC(O)COC(N)=O KRPAJLYSLFNDOA-UHFFFAOYSA-N 0.000 claims description 2
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
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- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 2
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- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/986—Milk; Derivatives thereof, e.g. butter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a cosmetic composition containing goat milk and the application thereof. The cosmetic composition is prepared from, by weight, 3-25 parts of goat milk extract and 1-15 parts of sweet orange extract. The cosmetic composition is exacted from natural components, does not contain chemical component or essence, is mild and free of irritation to skin, has remarkable moisturizing, anti-allergy and eczema controlling effects, can be added to cosmetics special for people with allergic skin, pregnant women and children, and solves the problem of skin care product selection for people liable to allergy.
Description
Technical field
The present invention relates to cosmetic field, particularly relate to a kind of cosmetic composition and the application thereof that contain Goat Milk.
Background technology
Along with developing rapidly of economy, global environmental pollution is increasingly severe, and skin is as the first line of defence of human immune system, and direct and environmental exposure, comparatively other organs are more easily irritated, and it is reported, the whole world has the crowd of 15% ~ 20% that skin allergy occurred.Cause the factor of skin allergy many, outside the Pass the endogenous factors such as removing and race, age, or sex, heredity, endocrine have, also relevant with extrinsic factors such as the stimulations of environmental pollution, chemicals, the external use skin care kind of nowadays people's use is day by day various, the complicated component of skin care item, containing number of chemical material, as spice, pigment, emulsifying agent, antiseptic, play the additive etc. of nutrition and therapeutical effect, wherein a lot of composition can chafe cause allergy.The incidence rate of skin allergy is in rising trend, especially in some special populations, as anemia of pregnant woman and child, anemia of pregnant woman the pregnancy period due to skin be subject to more being drawn high and the impact of hormone in vivo change etc. more fragile than the skin of normal person, and become more responsive; It is thin that child skin is comparatively grown up, and control soda acid ability, the immune system of skin self is not yet perfect, and resistance is more weak, though more easily absorb foreign object, also therefore more easily causes skin allergy.Therefore, advocate the skin nursing of science, specification, thus the skin allergy reducing or stop because the abuse of chemical substance etc. causes, maintain the health of normal skin, especially special population (as anemia of pregnant woman, child) skin health, is problem demanding prompt solution.
Goat Milk, derives from the milk of milk goat secretion, Goat Milk is nutritious with it, is easy to the fine work that the advantages such as absorption are regarded as in milk, be called as " king in milk ".The Compendium of Material Medica of the Ming Dynasty of China Li Shizhen (1518-1593 A.D.) is also recorded " Lac caprae seu ovis is sweet, warm, nontoxic, can beneficial the five internal organs, the kidney invigorating void, beneficial vital essence, the lung that nourishes heart, sharp skin, profit hair." " book Wei " record: " often drink sheep milk, color is as virgin." as far back as the seventies in last century the United Nations's food and agricultural organization (FAO) just publish and have " goat observations " book; wherein mentioned: " very early, Goat Milk has been widely regarded as the food being particularly suitable for old people, sick people, sick convalescent people and infant use.Under many circumstances, when individuality produces irritated to milk, the use of Goat Milk not only can remove allergic symptom, and the growth of health can be made to grow according to normal speed ".But, the product development of China's Goat Milk is scarcely out of swaddling-clothes, Goat Milk is few by its milk source, resource is unbalanced, have unique local flavor (smell of mutton, soapy flavor etc.), processing and the factor impact such as de-technology of having a strong smell is limited, the application in some field is limited, in addition, Goat Milk, because of the characteristic of some composition contained by the pollution effect of milk goat feeding environment and self, still can cause allergic reaction to some crowds especially child and anemia of pregnant woman.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of cosmetic composition containing Goat Milk, said composition is extracted from natural component, not containing chemical composition, non-stimulated to skin gentleness, and especially applicable allergic skin crowd and anemia of pregnant woman, child use.
The present invention is achieved through the following technical solutions:
The invention discloses a kind of cosmetic composition containing Goat Milk, described cosmetic composition comprises the raw material of following weight portion: Goat Milk extract 3 ~ 25 parts, Fructus Citri sinensis extract 1 ~ 15 part.
Skin Cell Physiologic Studies is pointed out, skin generation anaphylaxis is because Skin Cell is impaired, and make the immunity degradation of skin, if fail to repair these damaged cells in time, just them can be caused constantly to divide the bad and sebum film of immunity and secrete incomplete Skin Cell, thus leave many sequela, such as skin is irritated for a long time, pigementation, redness that skin damage causes is produced, dermatitis, eczema etc. because of irritated.The present inventor studies and finds that cosmetic composition of the present invention is by combining Goat Milk extract and Fructus Citri sinensis extract; be easy to skin absorb; its not only can maintenance skin damage cell, promote cell regeneration; and form one natural protecting film at skin surface; and Fructus Citri sinensis extract can strengthen the ability that Goat Milk extract repairs damaged cell; accelerate reparation speed; the sensitization of Goat Milk and elimination can be reduced further simultaneously or cover the smell of mutton of Goat Milk uniqueness; both share, and can play mutually collaborative effect.This characteristic that Goat Milk extract and Fructus Citri sinensis extract combine makes the present composition have good antiallergic, repairs responsive skin, effect of moisturizing and control allergic eczema, and comparatively speaking, safer, gentle non-stimulated.
Further, described cosmetic composition comprises the raw material of following weight portion: Goat Milk extract 10 ~ 15 parts, Fructus Citri sinensis extract 6 ~ 10 parts.Goat Milk extract and Fructus Citri sinensis extract combine with this proportioning, make its antiallergic, repair responsive skin, effect of moisturizing and control allergic eczema and abnormal smells from the patient and economy ideal.
The cosmetic composition that the invention also discloses containing Goat Milk is preparing the application in cosmetics.
Further, described cosmetics use as child, anemia of pregnant woman's skin protection, give skin moisture-keeping, antiallergic, prevent and treat eczema performance.
Further, the present invention being 1 ~ 21 part containing parts by weight in described cosmetics contains the cosmetic composition of Goat Milk.
Further, the present invention being 8 ~ 15 parts containing parts by weight in described cosmetics contains the cosmetic composition of Goat Milk.This cosmetic composition makes an addition in the middle of cosmetics with this proportioning, makes its antiallergic, repairs responsive skin, effect of moisturizing and control allergic eczema is ideal.
Further, the dosage form of described cosmetics is moisturizing facial milk cleanser, moisture retention water, moisturizing emulsion, elite of compacting, maintenance frost, moisture saver mask, BB frost.
The invention also discloses a kind of maintenance frost, described maintenance frost comprises the component of following portions by weight:
The present invention contains the cosmetic composition of Goat Milk: 1 ~ 21,
Cetearyl alcohol: 1 ~ 2,
Glyceryl stearate: 0.5 ~ 1.5,
Semen Maydis oil: 5 ~ 10,
C14-22 alcohol: 1 ~ 2,
C12-20 alkyl androstanediol: 1 ~ 2,
Ring five polydimethylsiloxane: 2 ~ 5,
Squalane: 2 ~ 5,
Hydrogenated jojoba oil: 1 ~ 3,
Polydimethylsiloxane: 1 ~ 2,
Stearic acid: 0.3 ~ 1,
Lanoline: 0.5 ~ 2,
Butylated hydroxytoluene: 0.01 ~ 0.1,
Propyl hydroxybenzoate: 0.05 ~ 0.15,
Methyl hydroxybenzoate: 0.1 ~ 0.2,
Glycerol: 5 ~ 10,
Propylene glycol: 0.5 ~ 1,
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer: 0.1 ~ 0.2,
Triethanolamine: 0.1 ~ 0.2,
Herba Centellae extract: 0.1 ~ 0.3,
Diazolidinyl urea: 0.1 ~ 0.2,
Iodine propilolic alcohol butyl mephenesin Carbamate: 0.001 ~ 0.005,
Deionized water: 32.15 ~ 78.65.
The invention also discloses a kind of moisturizing emulsion, described moisturizing emulsion comprises the component of following portions by weight:
The present invention contains the cosmetic composition of Goat Milk: 1 ~ 21,
Glyceryl stearate: 0.5 ~ 1,
PEG-100 stearate: 0.5 ~ 1,
Methyl gluceth-20:0.5 ~ 1,
Isosteareth-20:0.5 ~ 1,
Different ceteth-20:0.5 ~ 1,
Caprylic/capric triglyceride: 3 ~ 7,
Ring five polydimethylsiloxane: 2 ~ 5,
Butyrospermum Parkii Oil: 1 ~ 4,
Squalane: 1 ~ 4,
Dormant oils: 1 ~ 4,
Polydimethylsiloxane: 0.5 ~ 1.5,
Cetearyl alcohol: 0.5 ~ 1.6,
Butanediol: 3 ~ 7,
Hydroxyethyl-cellulose: 0.05 ~ 0.2,
Carbomer: 0.05 ~ 0.25,
Xanthan gum: 0.05 ~ 0.15,
Polyacrylamide: 0.1 ~ 0.5,
C13-14 isoparaffin: 0.1 ~ 0.5,
Laureth-7:0.1 ~ 0.5,
Triethanolamine: 0.05 ~ 0.25,
Phenoxyethanol: 0.3 ~ 0.6,
Sensiva SC50: 0.03 ~ 0.06,
Deionized water: 45.3 ~ 70.75.
The invention also discloses a kind of moisture retention water, described moisture retention water comprises the component of following portions by weight:
The present invention contains the cosmetic composition of Goat Milk: 8 ~ 15,
Butyrospermum Parkii Oil: 0.1 ~ 0.5,
Ovshinsky Sargassum extract: 0.1 ~ 0.5,
Hamamelis virginiana extract: 0.1 ~ 0.5,
Fructus Pruni pseudocerasi extract: 0.1 ~ 0.3,
Black tea extract: 0.1 ~ 0.4,
Semen Vitis viniferae extract: 0.1 ~ 0.3,
Beta glucan: 0.1 ~ 0.6,
1,2-hexanediol, caprylyl glycol: 0.1 ~ 0.5,
Deionized water: 75.5 ~ 98.5.
The present invention contains cosmetic composition and the application thereof of Goat Milk, has following beneficial effect:
1, cosmetic composition of the present invention extracts from natural component, does not easily cause the material of allergic symptom containing chemical composition and essence etc., to skin safe, gentle non-stimulated, is easy to skin and absorbs, and is especially applicable to allergic skin crowd and anemia of pregnant woman, child use.
2, Goat Milk extract and Fructus Citri sinensis extract combine with specific proportioning by cosmetic composition of the present invention, both are mutually collaborative, can be strengthened it further repair damaged cell and promote cell regeneration ability, reduce its sensitization and unique smell of mutton simultaneously, there is effect of significant antiallergic, the responsive skin of reparation, moisturizing and control allergic eczema.
3, cosmetic composition of the present invention makes an addition in cosmetics series, can reach good compatibility and stability and soft and moist property while keeping it to skin unique effects with other compositions in formula.
Detailed description of the invention
In order to make those skilled in the art person understand technical scheme of the present invention better, below in conjunction with embodiment, technical scheme of the present invention is described in further detail.
Embodiment 1
Cosmetic composition of the present invention: Goat Milk extract 3 parts, Fructus Citri sinensis extract 1 part.
Embodiment 2
Cosmetic composition of the present invention: Goat Milk extract 10 parts, Fructus Citri sinensis extract 6 parts.
Embodiment 3
Cosmetic composition of the present invention: Goat Milk extract 13 parts, Fructus Citri sinensis extract 8 parts.
Embodiment 4
Cosmetic composition of the present invention: Goat Milk extract 15 parts, Fructus Citri sinensis extract 10 parts.
Embodiment 5
Cosmetic composition of the present invention: Goat Milk extract 25 parts, Fructus Citri sinensis extract 15 parts.
Comparative example 1
Comparative example cosmetic composition: Goat Milk extract 40 parts.
Comparative example 2
Comparative example cosmetic composition: Fructus Citri sinensis extract 40 parts.
The application of embodiment 6 cosmetic composition of the present invention in maintenance frost
Cosmetic composition of the present invention and comparative example cosmetic composition are prepared into maintenance frost, A, B, C, D, component E Han You embodiment 1 ~ 5 cosmetic compositions, E1 group is containing comparative example 1 cosmetic composition, E2 group is containing comparative example 2 cosmetic composition, E0 group is blank group, and the parts by weight of the present composition in maintenance frost see the following form:
Table 1 maintenance frost component and parts by weight thereof
The application of embodiment 7 cosmetic composition of the present invention in moisturizing emulsion
The embodiment of the present invention 4 cosmetic composition is prepared into moisturizing emulsion, is numbered F, G, H, I, J respectively, J0 group is blank group, and the parts by weight of embodiment 4 cosmetic composition in moisturizing emulsion see the following form:
The component of table 2 moisturizer and parts by weight thereof
The application of embodiment 8 cosmetic composition of the present invention in moisture retention water
The embodiment of the present invention 3 cosmetic composition is prepared into moisture retention water, is numbered K, L, M respectively, M0 group is blank group, and the parts by weight of embodiment 3 cosmetic composition in moisture retention water see the following form:
The component of table 3 moisture retention water and parts by weight thereof
Embodiment 9 safety evaluatio
Experiment purpose: by the safety of the cosmetic composition obtained by relative analysis Evaluation operation example.
Experimental technique: with reference to ECVAM-DB-ALM:INVITTOXprotocol:RedBloodCellTestSystemINVI TTOXn
037.The ultimate principle of RBCTestSystem: if raw material has stimulation to erythrocyte cell membrane, can make erythrocyte membranolysis, produces haemolysis to a certain degree.Therefore, under 530nm, measure absorbance, absorbance is larger, and illustrate that cell hemolysis rate is higher, the zest of raw material is stronger.
Experimental result: hemolysis rate (%) calculating=sample absorbance/positive control absorbance × 100, concrete data see the following form 4.
Table 4 embodiment 1 ~ 5 and comparative example 1 ~ 2 cosmetic composition and the absorbance table of control sample under 530nm
| Numbering | Sample name | Absorbance |
| 1 | Embodiment 1 cosmetic composition | 0.061 |
| 2 | Embodiment 2 cosmetic composition | 0.068 |
| 3 | Embodiment 3 cosmetic composition | 0.071 |
| 4 | Embodiment 4 cosmetic composition | 0.075 |
| 5 | Embodiment 5 cosmetic composition | 0.080 |
| 6 | Embodiment 6 cosmetic composition | 0.091 |
| 7 | Embodiment 7 cosmetic composition | 0.087 |
| 8 | Positive control | 1.563 |
Interpretation of result: as can be seen from Table 4, with positive control (975 μ L water+25 μ LRBC) complete hemolysis rate for 100%, embodiment 1 ~ 5 cosmetic composition zest is starkly lower than the zest of comparative example 1 ~ 2 cosmetic composition, and all in safety range (< 10%), visible, cosmetic composition of the present invention is safe, gentle as external preparation for skin raw material, and the combination of Goat Milk extract and Fructus Citri sinensis extract obviously can reduce the zest to skin mutually, and its effect is is not simply added and subtracted mutually.
Embodiment 10 moisture retention effect assessment
Test philosophy: according to the difference of composition moisture absorption, performance of keeping humidity, different wetting agent molecules is different to the active force of hydrone, absorbs moisture different with keeping the ability of moisture.Oil content has sealing process to moisture, can prevent scattering and disappearing of moisture.Hygroscopic effect power is large, strong to water molecules power, and absorb and keep the amount of moisture also larger, closure is good, also lacking of moisture loss.Utilize adhesive tape to imitate the biomaterial of horny layer, epidermis etc., adhesive tape is coated with cosmetics, simulation practical application situation.Sample is placed under the condition of constant humidity after certain hour, and what weigh before and after putting is of poor quality, obtains the loss of sample size, can calculate the effect of moisturizing ingredient moisturizing.
Moisturizing rate computing formula: moisturizing rate=(M2 – M0)/(M1 – M0) × 100%
In formula:
M0: hollow plate quality/g;
M1: glass sheet quality/g after application of sample;
M2: place quality/g after some hours in exsiccator;
Test its moisturizing rate in 4h and 8h when relative humidity is 60%;
Experimental result: result is see table 5 ~ 7.
Table 5 repair cream is in the moisturizing rate of RH60%
Table 6 moisturizer is in the moisturizing rate of RH60%
Table 7 moisture retention water is in the moisturizing rate of RH60%
Interpretation of result: can find out that from table 5 ~ 7 embodiment product and comparative example product and certain are commercially available and declare that the cosmetics containing Goat Milk all have certain moistening effect, but the moisture-keeping efficacy of embodiment product is obviously better than comparative example product and certain commercially available cosmetics declared containing Goat Milk, the moisture-keeping efficacy of product A ~ E is obviously better than the moisture-keeping efficacy of product E 1 (only containing Goat Milk extract), E2 (only containing Fructus Citri sinensis extract) as can be seen from Table 5, illustrates that cosmetic composition of the present invention has mutually collaborative effect thus; Can find out that product F ~ J, product K ~ M moisture-keeping efficacy increases along with the addition increase of cosmetic composition from table 6 and table 7, but be not unconfined growth, but along with addition increasing, growth trend tends towards stability, angularly consider from product effect, safety, economy, the usage ratio of cosmetic composition of the present invention in cosmetics controls 8 ~ 15 ideal.To sum up, cosmetic composition of the present invention and repair cream, moisturizing emulsion, moisture retention water have significant moisture-keeping efficacy.
The evaluation of embodiment 11 clinical efficacy
In order to evaluate cosmetic composition of the present invention and repair cream, moisturizing emulsion, moisture retention water antiallergic, prevent and treat the effect of eczema, respectively from clinical symptoms and sign, comprise pruritus, sensation of pricking, burn feeling, tight sense and dry sensation (are marked by 0-3 level, 0=without, 1=is light, in 2=, 3=is heavy) etc. aspect observe, the therapeutic effect of eczema is according to Efficacy of Traditional Chinese Medicine judgment criteria: " recovery from illness (skin lesion Periostracum Cicadae, gargalesthesia disappears), it is effective that (skin lesion disappears > 60%, occasionally itch), effectively (skin lesion disappears < 60%, gently itch), invalid (skin lesion disappear < 20% or aggravation) is observed.Collection volunteer (anemia of pregnant woman and the length of sensitive skin have the child of eczema) is tested embodiment and comparative example product.Diagnostic criteria is drafted with reference to " the dialectical specification of tcm syndrome ", " People's Republic of China's traditional Chinese medicine industry standard TCM Dermatology disease criterion of therapeutical effect ", " department of dermatologry Chinese traditional medical diagnose ", " clinical dermatology ".Efficacy evaluation: with therapeutic index after medication (namely clinical and somatic feature score decline index) for evaluating basis, total mark × 100% before therapeutic index=(before medication after total mark-medication total mark)/medication.Be final curative effect with the curative effect of 2 weeks after drug withdrawal.Concrete outcome is as following table.
Table 8 repair cream, moisturizing emulsion, moisture retention water antiallergic therapeutic index
Table 9 repair cream, moisturizing emulsion, moisture retention water prevent and treat eczema curative effect
Interpretation of result: can find out that from table 8 ~ 9 embodiment product and comparative example product and certain are commercially available and declare that the cosmetics containing Goat Milk all have certain antiallergic and prevent and treat the effect of eczema, but embodiment product antiallergic is obviously better than comparative example product and certain commercially available cosmetics declared containing Goat Milk with the effect of preventing and treating eczema, namely product A ~ E antiallergic and prevent and treat eczema effect and be obviously better than product E 1 (only containing Goat Milk extract), the antiallergic of E2 (only containing Fructus Citri sinensis extract) and prevent and treat eczema effect, illustrate that cosmetic composition of the present invention has mutually collaborative effect thus, in addition, it can also be seen that from table 8 ~ 9 product F ~ J, product K ~ M antiallergic therapeutic index and prevent and treat eczema cure rate along with cosmetic composition addition increase and increase, but be not unconfined growth, but along with addition increasing, growth trend tends towards stability, angularly consider from product effect, safety, economy, the usage ratio of cosmetic composition of the present invention in cosmetics controls at 8 ~ 15 parts ideal.To sum up, cosmetic composition of the present invention and repair cream, moisturizing emulsion, moisture retention water have significant antiallergic and prevent and treat eczema effect.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. the cosmetic composition containing Goat Milk, is characterized in that, comprise the raw material of following weight portion: Goat Milk extract 3 ~ 25 parts, Fructus Citri sinensis extract 1 ~ 15 part.
2. cosmetic composition according to claim 1, is characterized in that, comprises the raw material of following weight portion: Goat Milk extract 10 ~ 15 parts, Fructus Citri sinensis extract 6 ~ 10 parts.
3. cosmetic composition according to claim 1 and 2 is preparing the application in cosmetics.
4. application according to claim 3, is characterized in that, described cosmetics use as child, anemia of pregnant woman's skin protection, give skin moisture-keeping, antiallergic, prevent and treat eczema performance.
5. the application according to claim 3 or 4, is characterized in that, containing parts by weight in described cosmetics is the cosmetic composition described in the claim 1 or 2 of 1 ~ 21 part.
6. application according to claim 5, is characterized in that, containing parts by weight in described cosmetics is the cosmetic composition described in the claim 1 or 2 of 8 ~ 15 parts.
7. the application according to claim 3 or 4, is characterized in that, the dosage form of described cosmetics is moisturizing facial milk cleanser, moisture retention water, moisturizing emulsion, elite of compacting, maintenance frost, moisture saver mask, BB frost.
8. a maintenance frost, is characterized in that, described maintenance frost comprises the component of following portions by weight:
Cosmetic composition described in claim 1 or 2: 1 ~ 21,
Cetearyl alcohol: 1 ~ 2,
Glyceryl stearate: 0.5 ~ 1.5,
Semen Maydis oil: 5 ~ 10,
C14-22 alcohol: 1 ~ 2,
C12-20 alkyl androstanediol: 1 ~ 2,
Ring five polydimethylsiloxane: 2 ~ 5,
Squalane: 2 ~ 5,
Hydrogenated jojoba oil: 1 ~ 3,
Polydimethylsiloxane: 1 ~ 2,
Stearic acid: 0.3 ~ 1,
Lanoline: 0.5 ~ 2,
Butylated hydroxytoluene: 0.01 ~ 0.1,
Propyl hydroxybenzoate: 0.05 ~ 0.15,
Methyl hydroxybenzoate: 0.1 ~ 0.2,
Glycerol: 5 ~ 10,
Propylene glycol: 0.5 ~ 1,
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer: 0.1 ~ 0.2,
Triethanolamine: 0.1 ~ 0.2,
Herba Centellae extract: 0.1 ~ 0.3,
Diazolidinyl urea: 0.1 ~ 0.2,
Iodine propilolic alcohol butyl mephenesin Carbamate: 0.001 ~ 0.005,
Deionized water: 32.15 ~ 78.65.
9. a moisturizing emulsion, is characterized in that, described moisturizing emulsion comprises the component of following portions by weight:
Cosmetic composition described in claim 1 or 2: 1 ~ 21,
Glyceryl stearate: 0.5 ~ 1,
PEG-100 stearate: 0.5 ~ 1,
Methyl gluceth-20:0.5 ~ 1,
Isosteareth-20:0.5 ~ 1,
Different ceteth-20:0.5 ~ 1,
Caprylic/capric triglyceride: 3 ~ 7,
Ring five polydimethylsiloxane: 2 ~ 5,
Butyrospermum Parkii Oil: 1 ~ 4,
Squalane: 1 ~ 4,
Dormant oils: 1 ~ 4,
Polydimethylsiloxane: 0.5 ~ 1.5,
Cetearyl alcohol: 0.5 ~ 1.6,
Butanediol: 3 ~ 7,
Hydroxyethyl-cellulose: 0.05 ~ 0.2,
Carbomer: 0.05 ~ 0.25,
Xanthan gum: 0.05 ~ 0.15,
Polyacrylamide: 0.1 ~ 0.5,
C13-14 isoparaffin: 0.1 ~ 0.5,
Laureth-7:0.1 ~ 0.5,
Triethanolamine: 0.05 ~ 0.25,
Phenoxyethanol: 0.3 ~ 0.6,
Sensiva SC50: 0.03 ~ 0.06,
Deionized water: 45.3 ~ 70.75.
10. a moisture retention water, is characterized in that, described moisture retention water comprises the component of following portions by weight:
Cosmetic composition described in claim 1 or 2: 8 ~ 15,
Butyrospermum Parkii Oil: 0.1 ~ 0.5,
Ovshinsky Sargassum extract: 0.1 ~ 0.5,
Hamamelis virginiana extract: 0.1 ~ 0.5,
Fructus Pruni pseudocerasi extract: 0.1 ~ 0.3,
Black tea extract: 0.1 ~ 0.4,
Semen Vitis viniferae extract: 0.1 ~ 0.3,
Beta glucan: 0.1 ~ 0.6,
1,2-hexanediol, caprylyl glycol: 0.1 ~ 0.5,
Deionized water: 75.5 ~ 98.5.
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| CN105943481A (en) * | 2016-05-20 | 2016-09-21 | 秦瑜 | Night cream capable of refining pores and calming and soothing nerves |
| CN107049877A (en) * | 2017-06-01 | 2017-08-18 | 四川惠泰农业科技有限公司 | A kind of skin care item containing beta glucan |
| CN107595713A (en) * | 2017-10-27 | 2018-01-19 | 丘少荣 | A kind of great burdock achene acne eliminating cream and preparation method thereof |
| CN109718121A (en) * | 2019-02-13 | 2019-05-07 | 南通柯侎克生物科技有限公司 | A kind of formula and method with pure Goat Milk tunning production facial mask |
| CN111000788A (en) * | 2019-12-19 | 2020-04-14 | 武汉通梁科技有限公司 | Goat milk hand cream and preparation method thereof |
| CN115429737A (en) * | 2022-04-21 | 2022-12-06 | 杨波 | Chinese herbal medicine facial cleanser capable of balancing skin micro-ecology |
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| CN103040702A (en) * | 2012-12-18 | 2013-04-17 | 青岛海诺水务科技股份有限公司 | Goat milk lip balm |
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| CN102470087A (en) * | 2009-06-30 | 2012-05-23 | 考格尼斯知识产权管理有限责任公司 | Ester mixtures and compositions comprising such ester mixtures |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943481A (en) * | 2016-05-20 | 2016-09-21 | 秦瑜 | Night cream capable of refining pores and calming and soothing nerves |
| CN107049877A (en) * | 2017-06-01 | 2017-08-18 | 四川惠泰农业科技有限公司 | A kind of skin care item containing beta glucan |
| CN107595713A (en) * | 2017-10-27 | 2018-01-19 | 丘少荣 | A kind of great burdock achene acne eliminating cream and preparation method thereof |
| CN109718121A (en) * | 2019-02-13 | 2019-05-07 | 南通柯侎克生物科技有限公司 | A kind of formula and method with pure Goat Milk tunning production facial mask |
| CN111000788A (en) * | 2019-12-19 | 2020-04-14 | 武汉通梁科技有限公司 | Goat milk hand cream and preparation method thereof |
| CN115429737A (en) * | 2022-04-21 | 2022-12-06 | 杨波 | Chinese herbal medicine facial cleanser capable of balancing skin micro-ecology |
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