Summary of the invention
The object of the present invention is to provide a kind of nutrition moist type hand cream, containing natural flowers and fruits plant essence.
A further object of the invention is the preparation method providing a kind of nutrition moist type hand cream.
A kind of nutrition moist type hand cream, with its raw material components of weight parts and content is:
Described Rhizoma Bletillae extraction solution prepares by the following method:
Take the Pseudobulbus Bletillae (Rhizoma Bletillae) appropriate, soak 0.15-1h, be heated to 90-100 DEG C, decoct extraction 3 times, add 6-12 times of water gaging the 1st time, extract 0.5-2h, add 4-10 times of water gaging 2nd time, extract 0.5-1.5h, add 3-8 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, the volume concentration of filtrate is to 3-6 times of g/ml of Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filter, get filtrate, to obtain final product.
Described green tea extractive liquor is prepared by the following method:
Take green tea appropriate, soak 0.15-0.8h, decoct extraction 3 times in 90-100 DEG C of heating, add 6-12 times of water gaging 1st time, extract 0.5-2h, add 4-10 times of water gaging the 2nd time, extract 0.5-1.5h, add 3-8 times of water gaging the 3rd time, extract 0.5-1.5h, each filtration, merging filtrate, the volume concentration of filtrate, to 3-6 times of g/ml of green tea weight, filters, get filtrate, to obtain final product.
Described Fructus actinidiae chinensis juicing is prepared by the following method:
Take fresh Fructus actinidiae chinensis, peeling, stripping and slicing, takes a certain amount of, puts in juice extractor, and adds the distilled water of 8-12 times of g/ml, and gained Fructus actinidiae chinensis juice double gauze filters 3-6 time, filters, gets filtrate, to obtain final product.
Described pyracantha fortuneana juicing is prepared by the following method:
Take fresh pyracantha fortuneana a certain amount of, put in juice extractor, and add the distilled water of 8-12 times of g/ml, gained pyracantha fortuneana juice double gauze filters 3-6 time, filters, gets filtrate, to obtain final product.
Described Flos Rosae Rugosae is soaked oil and prepares by the following method:
Take dry Flos Rosae Rugosae appropriate, be soaked in 10-18 times of g/ml Semen Maydis oil, soak 12-24h, in 30-60 DEG C of supersound extraction 5-6h, filter, get filtrate, to obtain final product.
Described Herba Saussureae Involueratae soaks oil to be prepared by the following method:
Take dry Herba Saussureae Involueratae appropriate, be soaked in 10-18g/ml times of Semen Maydis oil, soak 12-24h, in 30-60 DEG C of supersound extraction 5-6h, filter, get filtrate, to obtain final product.
Described Myosotis sylvatica soaks oil to be prepared by the following method:
Take Myosotis sylvatica appropriate, be soaked in 10-18 times of camellia seed oil, soak 12-24h, in 30-60 DEG C of supersound extraction 5-6h, filter, get filtrate, to obtain final product.
Described essence is the one in rose essence, peach flavor, flavoring pineapple essence, Fructus Citri Limoniae essence, green cucumber essence, jasmin essence, osmanthus flower fragrance.
The preparation method of a kind of nutrition moist type hand cream provided by the invention, comprises the following steps:
A) take sodium alginate 0.01-0.5 part, be dissolved in 1-10 part distilled water, be heated to 60-80 DEG C, heat while stirring, after mix homogeneously, leave standstill and make it fully swelling, obtain sodium alginate soln;
B) take hydroxypropyl emthylcellulose 0.01-0.5 part, be scattered in 5-12 part distilled water, be stirred to rapidly evenly, leave standstill, naturally swelling 5-7h, stand-by;
C) take shea butter 0.5-5.0 part, house oil 0.2-5.0 part, Semen Tritici aestivi germ oil 1.0-5.0 part, Flos Rosae Rugosae soaks oily 1.0-5.0 part, Herba Saussureae Involueratae soaks oily 1.0-5.0 part, Myosotis sylvatica soaks oily 1.0-5.0 part, general-purpose self emulsifying mixed emulsifier AC-4021.0-5.0 part is placed in beaker and on water-bath, keeps temperature 60-90 DEG C of heating in water bath melting, as oil phase;
D) take distilled water 4.0-50.0 part, 25% triethanolamine solution 1.0-5.0 part, be placed in 60-90 DEG C of heating in water bath, obtain aqueous phase;
E) take Liponic EG-11.0-5.0 part, sodium alginate soln, step b that 1-2 propylene glycol 1.0-5.0 part, 2.0 parts-5.0 parts, biological polyoses glue, step a) are prepared) Gonak prepared, be heated to 80-90 DEG C, stir, obtain thickening agent;
F) treat the complete melting of oil phase, poured into by aqueous phase in oil phase, limit edged stirs to same direction, in even milky paste, obtains substrate, substrate is chilled to room temperature;
G) Mel 0.1-2.0 part, trehalose 0.5-5.0 part, nicotiamide 0.01-1.0 part, vitamin E 0.1-1.0 part, 20% urea liquid 1.0-5.0 part, Rhizoma Bletillae extraction solution 0.1-3.0 part, green tea extractive liquor 0.1-3.0 part, pyracantha fortuneana juicing 0.1-3.0 part, Fructus actinidiae chinensis juicing 0.1-3.0 part is taken, be uniformly mixed, add in cooled substrate, obtain cream mastic;
H) to step g) the cream mastic of gained adds step e) made thickening agent, stir 10-15min, mix homogeneously, then add 10% citric acid solution 0.1-5.0 part, regulate pH between 6-7;
I) 1% disodium ethylene diamine tetra-acetic acid solution 0.01-5.0 part, 5% ethyl hydroxybenzoate alcoholic solution 0.01-5.0 part is finally added, wherein concentration of alcohol is 75%, 1% essence 0.01-0.05 part, stirs, and obtains the nutrition moist type hand cream containing natural flowers and fruits plant essence.
Various compositions in the present invention are as follows:
Shea butter is called as " liquid golden ", is a kind of fully natural green plant source solid grease, very easily in absorption of human body; can promote reepithelialization, deep layer is moistened, and prevents season cracking; skin surface formed protecting film, moisturizing, sun-proof, protection effect remarkable.Its phytosterol of containing is for the effect of injured skin possess both anti-inflammatory, antiallergic, and the natural sun-prevention component-cinnamic acid contained has the effect suppressing to form black tryrosinase, has certain insulating effect, brown patch can be made to shoal, even disappear to ultraviolet.Shea butter is because of its superpower antioxidant effect, and gentle non-stimulated, can keep skin natural elasticity, be the desirable feedstock for the protection of both hands, Glycerin, is applicable to sensitivity skin and uses interior all kinds of babies, child's skin, adult.
The key component of house oil is oleic acid, linoleic acid and Palmic acid, and wherein oleic acid and linoleic acid total content are 50%.The nutrient (vitamin e and linolenic acid) contained in house oil can recover human body health and make skin tender, and the immunity can strengthened disease and resistance.A small amount of " satisfied fatty acid " of house oil forms layer protecting film at skin surface, and its a large amount of unsaturated fatty acid is absorbed by the skin, and participates in the metabolic function of human skin tissue, serves very important effect to the reparation of skin damage cell.
Flos Rosae Rugosae contains the composition useful to health such as volatile oil (Oleum Rosae Rugosae), Quercitroside, amaroid, fat, tannin, multivitamin, glucose, fructose, lemon drops, there is effect of defying age, whitening, can scavenging free radicals effectively, eliminate pigmentation, make us calling out and send out youthful vigor, life-time service can make skin moisten and be rich in gloss, long-term taking, and cosmetic result is excellent.Flos Rosae Rugosae extracts effect that oil has moisturizing, nourishing, makes dry responsive skin recover water profit in time tender; There is convergence, effect that antibacterial and calmness is releived, the pore that compacts, suppress too much fat secretion, make skin exquisiteness pure and fresh, not bellding light; Flos Rosae Rugosae fragrance can be releived emotion of compacting, and then loosens mood, feels at ease and happiness to people, eliminates pressure, promotes U.S. flesh effect further.
Myosotis sylvatica has heat-clearing and toxic substances removing, and clear away heart-fire improving eyesight, enriching yin and nourishing kidney, looks improving and the skin nourishing, effect of nourishing blood for regulating menstruation, and can urge through body metabolism, delaying cell aging, improves immunocompetence.Containing vitamin C, beauty treatment is brightened, and avoids the generation of wrinkle and black speck, particularly has certain eliminating effect to freckle, acne.
Herba Saussureae Involueratae is desirable natural antidotal agent, is exactly treat dermopathic good medicine since ancient times.It contains Herba Saussureae Involueratae lactone, Saussurea Polysaccharide, aminoacid, vitamin, sugar, mineral, phytosterin compound, enzyme isoreactivity material.Its SPF (sun protection factor) up to 22SPF, far above the domestic super-strength ultraviolet radiation of 15SPF.Therefore, can effectively protect skin from ultraviolet damage, and to the rising of lipid peroxide in liver caused by vivotoxin and serum, there is obvious inhibitory action.Effect of Herba Saussureae Involueratae tool antiinflammatory, tissue repair and anti-superoxide radical, bringing out the damage of free radical long-term chronic Progressive symmetric erythrokeratodermia to defence by physiology or non-physiologic factor (as disease) has positive effect.This effect, time for oral administration, show as health care and strengthen immunologic function, the outer used time can reach the object of beauty treatment, speckle dispelling, delay skin aging.Herba Saussureae Involueratae grinds soak energy skin nutrition, and epidermophyton can be suppressed, star exerts the dermatophytess such as card bacterium, have good therapeutical effect, can also ultraviolet be blocked.Herba Saussureae Involueratae can accelerate skin metabolism, balance endocrine, naturally except fiery speckle dispelling, reduces wrinkle, make skin maintenance gloss, plentiful, have good curative effect to facial freckle, chloasma hepaticum etc.These good characteristics of Herba Saussureae Involueratae are used for skin protection, hair care, have moist, sterilizing, antiinflammatory, granulation promoting, sun-proof, softening, level and smooth and only to act in vain to skin.
Biological polyoses glue is the linear poly-polysaccharide viscosity solution of a kind of 1%, and ideally have good sensory advantages and moisture-keeping efficacy, be best " active excipient " simultaneously." water suction " ability of sugar strengthens its moisture-keeping efficacy.From for a long time, biological polyoses glue can be the hydration that skin provides stronger.
Vitamin E is an important antioxidant.The protein active structure of vitamin E energy stabilizing cell membrane, promotes the normal development of muscle and keeps the elasticity of skin, making skin and health maintain vigour.Vitamin E has antidotal effect, entering Skin Cell can more directly help skin to the infringement of free radical resisting, ultraviolet and pollutant, prevent skin from following the string until aging because of some chronic or recessive injuries, the deposition of lipofuscin in cell can be eliminated simultaneously, improve the normal function of cell, slow down histiocytic aging course.
Green tea contributes to slow down aging, prevention and therapy radiation injury.The tea polyphenols contributing to beauty and skin care in green tea has very strong non-oxidizability and physiologically active, is the scavenger of human free radical, has blocking-up lipid peroxidation, the effect of scavenging capacity enzyme.Tea polyphenols and oxidation product thereof have the ability absorbing radioactive substance strontium 90 and Co 60 murder by poisoning.Tea polyphenols is water-soluble substances, washes one's face can remove the greasy of face with it, and convergence pore, has sterilization, sterilizing, resisting age of skin, and the ultraviolet radiation in minimizing daylight is to effects such as the damages of skin.
Fructus actinidiae chinensis has effect that is antipyretic, nourishing and fit keeping function of promoting the production of body fluid.It contains hydrolytic enzyme and the superoxide dismutase of thiol proteinase, there is skin care, improve immunity, defying age, vessel softening, anti-swollen, inflammation-diminishing function and blacking hair and beauty, tender and lovely skin effect.Containing abundant vitamin A, vitamin C and vitamin E in Fructus actinidiae chinensis, and there is antioxidation, can effective skin whitening, eliminate freckle and skin sore, strengthen the defying age ability of skin, strengthening immune system, promote wound healing, have suitable curative effect to small pox and pox print.
Firethorn fruit contains abundant organic acid, protein, aminoacid, vitamin and multiple mineral element.Containing biological whitening substance in pyracantha fortuneana, effectively can suppress the vigor of various pigment enzyme in human body, make skin not chromogenesis.The women in some Fructus Pyracanthae producing regions all use Fructus Pyracanthae juice flush coat it is said whitening effect is fine, its extracting solution is widely used in cosmetics.
The Pseudobulbus Bletillae (Rhizoma Bletillae) has astringing to arrest bleeding, detumescence and promoting granulation, promotes epithelial cell reparation, participates in reparation and the metabolic process of damaged tissues and cell directly, therefore has the effect promoting wound healing, defying age, crease-resistant, moisturizing.Pseudobulbus Bletillae (Rhizoma Bletillae) glucomannan is applied to epithelial cell reparation in cosmetic industry and wrinkle removal, defying age field.Beta glucan can cause macrophage activation usually; and macrophage activation can cause a series of reaction; first the activation of fibroblast be can cause, thus epithelical cell growth factor (ECGF) and angiogenesis factor (AF) skin wrinkling to defying age produced.ECGF can promote the generation of collagen protein and elastin laminin, thus improves skin appearance, smoothes away wrinkles.
Sodium alginate plays good thickening power in cosmetics, can improve the moisture retention of skin, is thickening agent common in cosmetics and wetting agent.
A large amount of natural flowers and fruits plant extract component is with the addition of in this hand cream prescription.On the one hand moisten the dry coarse both hands of maintenance by deep layer, regulate water oil balance, thus suppress mottle wrinkle, prevent the generation of cold injury, chilblain and season cracking.Numerous compositions in this prescription have comprehensive nutrient and antioxidant content, if Radix Arnebiae (Radix Lithospermi), pyracantha fortuneana, the Pseudobulbus Bletillae (Rhizoma Bletillae) etc. are containing trace element-selenium, manganese, monounsaturated fatty acid, and vitamin A, C, E.Bletilla glucomannan can participate in reparation and the metabolic process of damaged tissues or cell, promotes epithelial cell reparation, the skin ulcer that disappears speckle dispelling.Radix Arnebiae (Radix Lithospermi) can all have reasonable curative effect to cold injury, chilblain.For another example shea butter, camellia seed oil, Fructus Tritici aestivi wet goods natural oil energy deep layer moistens hand skin, smooth microgroove, for hand skin brings abundant nutrition, the indices that shea butter and human sebaceous secrete oils and fats is the most close, contain abundant non-saponified composition, very easily in absorption of human body, season cracking can not only be prevented, can also recover further and keep the natural elasticity of skin, there is good deep layer and moisten effect, also possess both anti-inflammatory, the effect of antiallergic and anti-ultraviolet, the peeling that special interpolation vitamin E and carbamide effectively prevent both hands from causing because of drying, cracking.
Carry out supplementary sufficient nutrition by whitening skin and preserving moisture again on the other hand, beautify hand skin, make the colour of skin fine and smooth, glossy, tender white, flexible.As the plant mucilage, mineral, polysaccharide, organic acid, vitamin, antioxidant content etc. that are rich in Flos Rosae Rugosae, Herba Saussureae Involueratae, Myosotis sylvatica, Fructus actinidiae chinensis, green tea, can effectively for both hands keep the skin wet, to releive tight, dry skin, softening old useless cutin, while Glycerin, increase effect of moisturizing whitening.
Compare with prior art, the soft cunning of this hand cream quality, temperature fragrance, fine and smooth homogeneous, deep layer can moisten hand skin, tender coarse skin, accelerate wound repair, regulation of skin immunologic function, strengthen skin and resist environmental stimuli, prevent cold injury, chilblain, improve cutaneous circulation, enhance metabolism, skin is made to be full of elasticity, softness have lasting moisturizing power and smooth feeling, effectively can help the sensation solving hand dry and astringent tight discomfort, effectively smooth the injury that various problem is brought, with after feel comfortable moist immediately.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Shea butter of the present invention, the Pseudobulbus Bletillae (Rhizoma Bletillae), green tea, Fructus actinidiae chinensis are commercially available.
Embodiment 1
The preparation of 1.1 bletilla striata extract:
Take Pseudobulbus Bletillae (Rhizoma Bletillae) 50g, soak 1h, be heated to 100 DEG C, decoct extraction 3 times, add 12 times of water gagings the 1st time, extract 2h, add 10 times of water gagings 2nd time, extract 1.5h, add 8 times of water gagings the 3rd time, extract 1h, filter, merging filtrate at every turn, the volume concentration of filtrate is to 6 times of g/ml of Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filter, get filtrate, to obtain final product.
The preparation of 1.2 green tea extractive liquors:
Take green tea 20g, soak 0.8h, decoct extraction 3 times in 100 DEG C of heating, add 12 times of water gagings 1st time, extract 2h, add 10 times of water gagings the 2nd time, extract 1.5h, add 8 times of water gagings the 3rd time, extract 1h, each filtration, merging filtrate, the volume concentration of filtrate, to 6 times of g/ml of green tea weight, filters, get filtrate, to obtain final product.
The preparation of 1.3 Fructus actinidiae chinensis juicings:
Take fresh Fructus actinidiae chinensis, peeling, stripping and slicing, takes 30g, puts in juice extractor, and adds the distilled water of 12 times, and gained Fructus actinidiae chinensis juice double gauze filters 5 times, filters, gets filtrate, to obtain final product.
The preparation of 1.4 pyracantha fortuneana juicings:
Take fresh pyracantha fortuneana 30g, put in juice extractor, and add the distilled water of 12 times, gained pyracantha fortuneana juice double gauze filters 6 times, filters, gets filtrate, to obtain final product.
1.5 Flos Rosae Rugosaes immersion oil are got thing and are prepared by the following method:
Take dry Flos Rosae Rugosae 30g, be soaked in 18 times of g/ml Semen Maydis oil, soak 15h, in 40 DEG C of supersound extraction 5h, filter, get filtrate, to obtain final product.
Herba Saussureae Involueratae described in 1.6 soaks oil to be prepared by the following method:
Take dry Herba Saussureae Involueratae 30g, be soaked in 16 times of g/ml Semen Maydis oil, soak 15h, in 50 DEG C of supersound extraction 6h, filter, get filtrate, to obtain final product.
Myosotis sylvatica described in 1.7 soaks oil to be prepared by the following method:
Take Myosotis sylvatica 40g, be soaked in 16 times of g/ml camellia seed oils, soak 20h, in 30 DEG C of supersound extraction 6h, filter, get filtrate, to obtain final product.
The preparation method of a kind of nutrition moist type hand cream containing natural flowers and fruits plant essence described in 1.8 comprises the following steps:
A) take sodium alginate 0.5g, be dissolved in 10ml water, be heated to 70 DEG C, heat while stirring, after mix homogeneously, leave standstill and make it fully swelling, obtain sodium alginate soln;
B) take hydroxypropyl emthylcellulose 0.5g, be scattered in 12ml distilled water, be stirred to rapidly evenly, leave standstill, naturally swelling 7h, stand-by;
C) take shea butter 3.0g, house oil 2.0g, Semen Tritici aestivi germ oil 2.0g, Flos Rosae Rugosae soaks oily 2g, Herba Saussureae Involueratae soaks oily 2.0g, Myosotis sylvatica soaks oily 1.0g, general-purpose self emulsifying mixed emulsifier AC-4022.0g is placed in beaker and on water-bath, keeps the melting of temperature 70 C heating in water bath, as oil phase;
D) take distilled water 20.0g, 25% triethanolamine solution 2.0g, be placed in 70 DEG C of heating in water bath, obtain aqueous phase;
E) take Liponic EG-12.0g, 1-2 propylene glycol 3.0g, biological polyoses glue 3.0g, sodium alginate soln, step b that step a) is prepared) Gonak prepared, be warming up to 90 DEG C, stir, obtain thickening agent;
F) treat the complete melting of oil phase, poured into by aqueous phase in oil phase, limit edged stirs to same direction, in even milky paste, obtains substrate, substrate is chilled to room temperature;
G) Mel 0.5g, trehalose 0.5g, nicotiamide 0.4g, vitamin E 0.2g, 20% urea liquid 1.0g, Rhizoma Bletillae extraction solution 0.2g, green tea extractive liquor 0.3g, pyracantha fortuneana juicing 1.0g, Fructus actinidiae chinensis juicing 1.0g is taken, be uniformly mixed, add in cooled substrate, obtain cream mastic;
H) by step g) the cream mastic of gained adds step e) made thickening agent, stir 10min, mix homogeneously, then add 10% citric acid solution 0.2g, regulate pH to be 6.9;
I) finally add 1% disodium ethylene diamine tetra-acetic acid solution 0.2g, 5% ethyl hydroxybenzoate alcoholic solution 0.5g, concentration of alcohol used is that 0.02 part, 75%, 1% essence stirs, and obtains the nutrition moist type hand cream containing natural flowers and fruits plant essence.
Embodiment 2
Rhizoma Bletillae extraction solution described in 2.1 prepares by the following method:
Take Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, soak 0.15h, be heated to 90 DEG C, decoct extraction 3 times, add 11 times of water gagings the 1st time, extract 1.5h, add 8 times of water gagings 2nd time, extract 1h, add 5 times of water gagings the 3rd time, extract 1h, filter, merging filtrate at every turn, the volume concentration of filtrate is to 5 times of g/ml of Pseudobulbus Bletillae (Rhizoma Bletillae) weight, filter, get filtrate, to obtain final product.
Green tea extractive liquor described in 2.2 is prepared by the following method:
Take green tea 20g, soak 0.5h, decoct extraction 3 times in 90 DEG C of heating, add 10 times of water gagings 1st time, extract 1.5h, add 8 times of water gagings the 2nd time, extract 1h, add 8 times of water gagings the 3rd time, extract 1h, each filtration, merging filtrate, the volume concentration of filtrate, to 5 times of g/ml of green tea weight, filters, get filtrate, to obtain final product.。
Fructus actinidiae chinensis juicing described in 2.3 is prepared by the following method:
Take fresh Fructus actinidiae chinensis, peeling, stripping and slicing, takes 50g, puts in juice extractor, and adds the distilled water of 8 times, and gained Fructus actinidiae chinensis juice double gauze filters 5 times, gets filtrate, stand-by.
Pyracantha fortuneana juicing described in 2.4 is prepared by the following method:
Take fresh pyracantha fortuneana 50g, put in juice extractor, and add the distilled water of 10 times, gained pyracantha fortuneana juice double gauze filters 5 times, gets filtrate, stand-by.
Flos Rosae Rugosae immersion oil described in 2.5 is got thing and is prepared by the following method:
Take dry Flos Rosae Rugosae 30g, be soaked in 12 times of g/ml Semen Maydis oil, soak 18h, in 50 DEG C of supersound extraction 6h, filter, get filtrate, to obtain final product.
Herba Saussureae Involueratae described in 2.6 soaks oil to be prepared by the following method:
Take dry Herba Saussureae Involueratae 40g, be soaked in 16 times of g/ml Semen Maydis oil, soak 20h, in 50 DEG C of supersound extraction 6h, filter, get filtrate, to obtain final product.
2.7 Myosotis sylvaticas soak the preparation of oil:
Take Myosotis sylvatica 50g, be soaked in 15 times of g/ml camellia seed oils, soak 20h, in 45 DEG C of supersound extraction 5h, filter, get filtrate, to obtain final product.
The preparation method of a kind of nutrition moist type hand cream containing natural flowers and fruits plant essence described in 2.8, draw together following steps:
A) take sodium alginate 0.3g, be dissolved in 8ml water, be heated to 80 DEG C, heat while stirring, after mix homogeneously, leave standstill and make it fully swelling, obtain sodium alginate soln;
B) take hydroxypropyl emthylcellulose 0.3g, be scattered in 9ml water, be stirred to rapidly evenly, leave standstill, naturally swelling 7h, stand-by;
C) take shea butter 1.0g, house oil 1.0g, Semen Tritici aestivi germ oil 1.0g, Flos Rosae Rugosae soaks oily 1.0g, Herba Saussureae Involueratae soaks oily 2.0g, Myosotis sylvatica soaks oily 2.0g, general-purpose self emulsifying mixed emulsifier AC-4022.0g is placed in beaker and on water-bath, keeps temperature 80 DEG C of heating in water bath meltings, as oil phase;
D) take distilled water 25.0g, 25% triethanolamine solution 2.0g, be placed in 80 DEG C of heating in water bath, obtain aqueous phase;
E) take Liponic EG-12.0g, 1-2 propylene glycol 3.0g, biological polyoses glue 5.0g, sodium alginate soln, step b that step a) is prepared) Gonak prepared is warming up to 80 DEG C, stir, obtain thickening agent;
F) treat the complete melting of oil phase, poured into by aqueous phase in oil phase, limit edged stirs to same direction, in even milky paste, obtains substrate, substrate is chilled to room temperature;
G) Mel 0.5g, trehalose 1.0g, nicotiamide 0.2g, vitamin E 0.1g, 20% urea liquid 2.0g, Rhizoma Bletillae extraction solution 0.5g, green tea extractive liquor 0.5g, pyracantha fortuneana juicing 0.5g, Fructus actinidiae chinensis juicing 0.5g is taken, be uniformly mixed, add in cooled substrate, obtain cream mastic;
H) by step g) the cream mastic of gained adds step e) made thickening agent, stir 15min, mix homogeneously, then add 10% citric acid solution 0.2g, regulate pH to be 6.7;
I) finally add 1% disodium ethylene diamine tetra-acetic acid solution 0.5g, 5% ethyl hydroxybenzoate alcoholic solution 0.5g, wherein concentration of alcohol is that 0.01 part, 75%, 1% essence stirs, and obtains the nutrition moist type hand cream containing natural flowers and fruits plant essence.
Embodiment 3
The physical and chemical index of embodiment 1,2 is as follows:
3.1 character
This product is in pale pink, and denseness is suitable for, the soft cunning of quality, fragrant, and fine and smooth homogeneous, stretchability is good, and moisturizing, moistness are good.
3.2pH value checks
Get this product, measure with pH meter, recording pH value is between 6-7.
3.3 caloric test
Hand cream is packaged in transparence cosmetic bottle, within one month, observes without lamination in the refrigerator cold-storage of 4 DEG C.24h in the calorstat of 55 DEG C, hand cream is without the phenomenon such as layering, emulsifying is spoiled.
3.4 centrifugal test
Hand cream is packaged in 3000r/min in tool plug test tube, centrifugal 20min, without lamination.
3.5 room temperatures place experiment
Embodiment 1,2 made hand cream are placed in bottle for cosmetics, and room temperature leaves standstill investigation 6 months, without lamination, with after feel unchanged, abnormal smells from the patient is unchanged, without denaturalization phenomenon.
3.6 irritation tests, anaphylaxis are tested
White mice back cuts off hair, smears the hand cream prepared by embodiment 1,2 respectively in cutting plucked position, and is not coated with position and compares, and result does not have zest and anaphylaxis.
Example 1 gram is applied in volunteer (15-65 year, 80 people) gesture and facial expression, observes, all do not occur rubescent, dermexanthesis, foaming phenomena after spending 30 minutes.
The experiment of tryrosinase vigor in 3.7 suppression mouse melanin cells
The hand cream prepared by embodiment 1,2 gets 1g respectively, respectively adding distil water 40ml, diluted for use.By B
16melanocyte is inoculated in 96 orifice plates, every hole 100 μ l, puts in incubator after cultivating and educating 24h, adds hand cream diluent.After drug effect 3d, discard the liquid that disappears, rinse twice with pH 6.8 poly butylene succinate (PBS), every hole adds the PBS of 90 μ l containing 1% (volume fraction) TritonX-100.Ultrasonication in ice bath, every hole adds the L-3,4 dihydroxyphenylalanine (L-dopa) of 10 μ l 10mmol/L, hatches 60min for 37 DEG C, and in 475nm place colorimetric, blank well returns to zero, and surveys each hole absorbance.
Suppression ratio %=(1-medicine group mean absorbance values ÷ matched group mean absorbance values) × 100%
3.8 suppress B16 cell experiment in mouse melanin cell
The hand cream prepared by embodiment 1,2 gets 1g respectively, respectively adding distil water 40ml, diluted for use.By the B16 melanoma cells from mice with 1x10
5the density of individual/ml is inoculated in culture dish, at 37 DEG C, 5%CO
2condition under cultivate 2d.Abandon supernatant, add hand cream diluent, after drug effect 3d, abandon supernatant, PBS washs, and every hole adds 0.5ml trypsin digestion cell 3min, and every hole adds 2m1 maintenance medium and stops digestion.After piping and druming mixing, often kind of concentration is taken out 0.5ml and is made cell counting.All the other cell suspension, with the centrifugal 5min of 2500r/min, abandon supernatant, in precipitation, add NaOH solution, and heating makes melanin dissolve, and select 490nm wavelength to survey absorbance on enzyme-linked immunosorbent assay instrument.
B16 cell suppression ratio %=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance ÷ control wells cell density)] × 100%
3.7-3.8 experimental result is in table 1:
Table 1 experimental result
|
Embodiment 1 suppression ratio (%) |
Embodiment 2 suppression ratio (%) |
Restraint of tyrosinase vigor |
59.3 |
59.7 |
Check melanin synthesizes |
65.5 |
67.7 |
Experiment shows, this hand cream has restraint of tyrosinase vigor, the synthesis of check melanin, also illustrates that this hand cream has whitening function.
Embodiment 4:
Moisten maintenance effect experimental
The moist maintenance effect of Evaluation operation example 1,2 is carried out by experiment on probation.The hand cream utilizing embodiment 1,2 to produce and commercially available moist hand cream carry out contrast experiment.Choose the women 120 that 25-45 year hand is coarse.They are divided into arbitrarily three groups.Every day puts both hands on the skin with hand cream each twice sooner or later, the embodiment 1 group hand cream prepared by embodiment 1, the embodiment 2 groups hand cream prepared by embodiment 2, and matched group smears commercially available moist hand cream, uses two months continuously.The improvement detected by an unaided eye on hand is to evaluate moist maintenance effect.This results are shown in Table 2:
Table 2 moistens maintenance effect experimental result
|
Effectively (people) |
A little effectively (people) |
Invalid (people) |
Total effective rate (%) |
Embodiment 1 |
32 |
5 |
3 |
92.45 |
Embodiment 2 |
34 |
4 |
2 |
95.0 |
Matched group |
23 |
10 |
7 |
82.5 |
Embodiment 5:
This hand cream resultant effect is investigated
Below utilize to try out and feel the effect carrying out the hand cream that Evaluation operation example 1,2 produces.Adopt public-opinion poll point system, choose 80 20-50 year age bracket women as object on probation, be divided into arbitrarily two groups, put hand on the skin with the hand cream of embodiment 1,2 preparation respectively.Every day uses twice, two months service time.Every result of use total score is 5 points: five be divided into best result, represents very well, very satisfaction; 4 are divided into better; 3 are divided into and can accept; Less than 3 points is bad, can not accept.It is below every average.The results are shown in 3 tables:
Table 3 resultant effect is investigated
Result of use |
The every average of embodiment 1 |
The every average of embodiment 2 |
Maintenance |
4.8 |
4.9 |
Alimentary |
4.8 |
4.8 |
Whitening |
4.5 |
4.6 |
Moisture retention |
4.8 |
4.7 |
In sum, made this hand cream of the present invention has good maintenance, moistens, whitening and softening skin, moisturizing moisturizing effect, have with rear skin and recover natural elasticity, pale glossy.