CN105536011A - Liquid mixing system and full-automatic online sterilization control method based on same - Google Patents
Liquid mixing system and full-automatic online sterilization control method based on same Download PDFInfo
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- CN105536011A CN105536011A CN201610143120.6A CN201610143120A CN105536011A CN 105536011 A CN105536011 A CN 105536011A CN 201610143120 A CN201610143120 A CN 201610143120A CN 105536011 A CN105536011 A CN 105536011A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/23—Containers, e.g. vials, bottles, syringes, mail
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
Abstract
The invention discloses a liquid mixing system. The liquid mixing system comprises a liquid mixing tank, an air filter, a breather, a first filter, a second filter, a first pressure meter, a second pressure meter, a third pressure meter, a first thermometer, a second thermometer, a third thermometer, a fourth thermometer and peripheral pipelines, wherein the peripheral pipelines comprise an air supply pipeline, a pure steam supply pipeline, a first delivery pipeline, a second delivery pipeline and a third delivery pipeline, and online sterilization can be realized. The invention further discloses a full-automatic online sterilization control method based on the liquid mixing system. The problem of sterilization cold spots and the problem about sterile docking are solved.
Description
Technical field
The present invention relates to pharmaceutical field and dosing control technology field.
Background technology
Pharmaceutical industry liquid mixing system valve is many, pipeline is complicated, easily produces cold spot and an aseptic docking difficult problem during sterilizing.Its sterilization method of the structures shape that liquid mixing system is traditional manually adds off-line, i.e. jar and the online sterilizing of part pipeline, and respiratory organ and surge tank off-line are by the sterilizing of moist heat sterilization cabinet.The shortcoming of this manual sterilization method is: if occur abnormal in sterilization process, can not Timeliness coverage and correction; Higher to the environmental requirement of aseptic docking, the completeness of sterilizing and repeatability can not meet the demand of increasing pharmaceutical industry producer.
Summary of the invention
An object of the present invention is the liquid mixing system providing a kind of advantages of simple, can sterilizing online.
Two of object of the present invention is to provide a kind of online sterilizing control method coordinating liquid mixing system, avoids sterilizing cold spot and an aseptic docking difficult problem.
The technical scheme realizing above-mentioned purpose is:
The liquid mixing system of one of the present invention, comprising: Agitation Tank, air filter, respiratory organ, the first filter, the second filter, the first piezometer, the second piezometer, the 3rd piezometer, the first thermometer, the second thermometer, the 3rd thermometer, the 4th thermometer and peripheral pipeline; Described peripheral pipeline comprises: air feed conduit, pure steam supply pipeline, the first transmission pipeline, the second transmission pipeline and the 3rd transmission pipeline, wherein,
Described air feed conduit is communicated with described first transmission pipeline by described air filter;
Described pure steam supply pipeline is communicated with described first transmission pipeline;
Described first transmission pipeline is communicated with injection water entrance and the mouth spray of described Agitation Tank by described second transmission pipeline;
Row's mouth of described respiratory organ is communicated with described Agitation Tank; Row's mouth of described respiratory organ is all communicated with described first transmission pipeline with outlet;
The outlet of described Agitation Tank is communicated with described first filter by described 3rd transmission pipeline;
The respective outlet of described first filter and described second filter and row's mouth are all communicated with described first transmission pipeline;
Row's mouth of described first filter is communicated with described second filter;
Described air feed conduit is located at by described first piezometer;
Described pure steam supply pipeline is located at by described second piezometer;
Described Agitation Tank is located at by described 3rd piezometer;
Described first thermometer is located at described first transmission pipeline;
Described second thermometer is located at described Agitation Tank;
Described 3rd thermometer is located at row's mouth of described first filter;
Described 4th thermometer is located at row's mouth of described second filter.
A kind of full-automatic online sterilizing control method based on above-mentioned liquid mixing system of the present invention two, comprising:
Step S1, confirms that the state of liquid mixing system is intact;
Step S2, peripheral pipeline heats up in advance;
Step S3, respiratory organ heats up;
Step S4, Agitation Tank heats up;
Step S5, the first filter heats up;
Step S6, the second filter heats up;
Step S7, liquid mixing system entirety heats up;
Step S8, liquid mixing system whole constant temperature;
Step S9, sterilizing;
Step S10, the first filter is dry in advance;
Step S11, respiratory organ is dry;
Step S12, the first filter is dry;
Step S13, the second filter is dry;
Step S14, Agitation Tank cool drying;
Step S15, liquid mixing system keeps malleation;
Step S16, terminates.
In above-mentioned full-automatic online sterilizing control method,
In described step S1, institute's acknowledgement state comprises:
First manometric pressure >=0.5Mpa;
Second manometric pressure >=0.2Mpa;
Agitation Tank on-line cleaning terminates and enters auto state;
Liquid mixing system pressure discharges;
First filter and the second filter are installed;
Liquid mixing system air tightness test is qualified;
Described step S2 comprises: carry out pure steam circulation to peripheral tube net, temperature >=pre-warming temperature the P1 of the first thermometer enters next step and heats up, if the pre-warming temperature P1 of the temperature < of temperature first thermometer in 3min, sterilizing runs time-out simultaneity factor and reports to the police;
Described step S3 comprises: the injection water entrance of Agitation Tank enters pure steam, after row's mouth circulation 1min of respiratory organ, then penetrates filter element circulation 1min;
Described step S4 comprises: the injection water entrance of Agitation Tank and mouth spray enter pure steam, temperature >=pre-warming temperature the P1 of the second thermometer enters next step and heats up, if the pre-warming temperature P1 of the temperature < of the second thermometer in 10min, sterilizing runs time-out simultaneity factor and reports to the police;
Described step S5 comprises: row's mouth of the first filter heats up, pure steam circulation 3min; Pure steam penetrates filter element, and the temperature of the 3rd thermometer >=pre-warming temperature P1 enters next step and heats up, if in 5min the pre-warming temperature P1 of the temperature < of the 3rd thermometer, sterilizing runs and suspends simultaneity factor and report to the police;
Described step S6 comprises: row's mouth of the second filter heats up, pure steam circulation 3min; Pure steam penetrates filter element, and the temperature of the 4th thermometer >=pre-warming temperature P1 enters next step and heats up, if in 5min the pre-warming temperature P1 of the temperature < of the 4th thermometer, sterilizing runs and suspends simultaneity factor and report to the police;
Described step S7 comprises: whole system entirety heats up, heat up so the temperature of the 4th thermometer >=sterilising temp P2 enters next step, if the temperature < sterilising temp P2 of temperature control four thermometer in 10min, sterilizing runs time-out simultaneity factor and reports to the police;
Described step S8 comprises: whole system is in temperature constant state, allows the temperature forward bias of all thermometeies from sterilising temp P2 critical state, constant temperature 3min;
Described step S9 comprises: whole system keeps the temperature >=sterilising temp P2 of all thermometeies, keep sterilizing 30min, if there is the temperature < sterilising temp P2 of a thermometer in the process, system can accumulate once the frequency of failure, frequency of failure < sterilizing number of times P3 turns back to step S8, if the frequency of failure >=sterilizing number of times P3 sterilizing runs time-out, simultaneity factor is reported to the police, continue operation and jump to step S8, remain on this sterilization process and keep 30min;
Described step S10 comprises: pass into clean compressed air after air filter filters, carry out air displacement to entrained steam in the worry shell of the first filter;
Described step S11 comprises: pass into clean compressed air after air filter filters, and arranges mouth and discharges, also to the row mouth of respiratory organ carry out cool drying while carrying out air displacement to Agitation Tank entrained steam by injection water entrance and mouth spray through respiratory organ; Pass into clean compressed air after air filter filters, export discharge by injection water entrance and mouth spray through respiratory organ, while air displacement is carried out to Agitation Tank entrained steam, also cool drying is carried out to the outlet of respiratory organ;
Described step S12 comprises: pass into clean compressed air after air filter filters, and carries out drying purge filter row's P4 time dry mouth time to the first filter row mouth; Pass into clean compressed air after air filter filters, drying is carried out to the first filter outlet and purges a filter outlet P5 drying time time;
Described step S13 comprises: pass into clean compressed air after air filter filters, and carries out filter row's P4 time dry mouth time of drying purging divide a word with a hyphen at the end of a line next step to the second filter row mouth; Pass into clean compressed air after air filter filters, drying is carried out to the second filter outlet and purges a filter outlet P5 drying time time;
Described step S14 comprises: pass into clean compressed air after air filter filters, and carries out dry cooling purge until the temperature≤tank body of the second thermometer is lowered the temperature in advance temperature P6 to Agitation Tank; Pass into clean compressed air after air filter filters, while purging Agitation Tank, chuck enters cooling water until the final baking temperature P7 of the temperature≤tank body of the second thermometer;
Described step S15 comprises: pass into clean compressed air after air filter filters, and protects malleation, the 3rd manometric pressure >=dwell pressure value P8 to system inflation.
The invention has the beneficial effects as follows: the present invention by the rational liquid mixing system of simplicity of design, makes it can sterilizing online, the sterilization method manually adding off-line of abandoning tradition.Meanwhile, by the online sterilizing control method of design coupling, avoid that liquid mixing system valve is many, pipeline is complicated, easily produce cold spot and an aseptic docking difficult problem during sterilizing, make sterilization effect meet the demand of pharmaceutical industry producer.
Accompanying drawing explanation
Fig. 1 is the structure chart of the liquid mixing system of one of the present invention;
Fig. 2 is the flow chart of the full-automatic online sterilizing control method of the present invention two.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described.
Refer to Fig. 1, the liquid mixing system of one of the present invention, comprising: Agitation Tank 1, air filter 2, respiratory organ 3, first filter 4, second filter 5, first piezometer 6, second piezometer 7, the 3rd piezometer 8, first thermometer 9, second thermometer 10, the 3rd thermometer 11, the 4th thermometer 12 and peripheral pipeline.Peripheral pipeline comprises: air feed conduit 13, pure steam supply pipeline 14, first transmission pipeline 15, second transmission pipeline 16 and the 3rd transmission pipeline 17.
Air feed conduit 13 is communicated with the first transmission pipeline 15 by air filter 2.Pure steam supply pipeline 14 is communicated with the first transmission pipeline 15.First transmission pipeline 15 is communicated with injection water entrance 101 and the mouth spray 102 of Agitation Tank 1 by the second transmission pipeline 16.
Row's mouth of respiratory organ 3 is communicated with Agitation Tank 1.Row's mouth of respiratory organ 3 is all communicated with the first transmission pipeline 15 with outlet.
The outlet of Agitation Tank 1 is communicated with the first filter 4 by the 3rd transmission pipeline 17.The outlet that first filter 4 is respective with the second filter 5 and row's mouth are all communicated with the first transmission pipeline 15.Row's mouth of the first filter 4 is communicated with the second filter 5.
Air feed conduit 13 is located at by first piezometer 6, display air supply pressure.
Pure steam supply pipeline 14 is located at by second piezometer 7, shows pure steam supply pressure.
Agitation Tank 1 is located at by 3rd piezometer 8, pressure in display Agitation Tank.
First thermometer 9 is located at the first transmission pipeline 15, temperature in display tube.
Second thermometer 10 is located at Agitation Tank 1, temperature in display tank.
3rd thermometer 11 is located at row's mouth of the first filter 4, display row mouth temperature.
4th thermometer 12 is located at row's mouth of the second filter 5, display row mouth temperature.
Refer to Fig. 2, the full-automatic online sterilizing control method based on liquid mixing system of the present invention two, comprises the following steps:
Step S1, confirms that the state of liquid mixing system is intact, comprising:
Pressure >=the 0.5Mpa of the first piezometer 6;
Pressure >=the 0.2Mpa of the second piezometer 7;
Agitation Tank on-line cleaning terminates and enters auto state;
Liquid mixing system pressure discharges;
First filter 4 and the second filter 5 are installed;
Liquid mixing system air tightness test is qualified.
Step S2, peripheral pipeline heats up in advance, that is: pure steam circulation is carried out to peripheral tube net, temperature >=pre-warming temperature the P1 of the first thermometer 9 enters next step and heats up, if the pre-warming temperature P1 of the temperature < of temperature first thermometer in 3min, sterilizing runs time-out simultaneity factor and reports to the police, and button click continues operational system and can continue to run sterilizing program.
Step S3, respiratory organ 3 heats up, that is: the injection water entrance 101 of Agitation Tank 1 enters pure steam, and after row's mouth circulation 1min of respiratory organ 3, then penetrate filter element circulation 1min, button click continues operational system and can continue to run sterilizing program.
Step S4, Agitation Tank 1 heats up, that is: the injection water entrance 101 of Agitation Tank and mouth spray 102 enter pure steam, temperature >=pre-warming temperature the P1 of the second thermometer 10 enters next step and heats up, if the pre-warming temperature P1 of the temperature < of the second thermometer 10 in 10min, sterilizing runs time-out simultaneity factor and reports to the police, and button click continues operational system and can continue to run sterilizing program.
Step S5, the first filter 4 heats up, and comprising: row's mouth of the first filter 4 heats up, pure steam circulation 3min; Pure steam penetrates filter element, temperature >=pre-warming temperature the P1 of the 3rd thermometer 11 enters next step and heats up, if the pre-warming temperature P1 of the temperature < of the 3rd thermometer 11 in 5min, sterilizing runs time-out simultaneity factor and reports to the police, and button click continues operational system and can continue to run sterilizing program.
Step S6, the second filter 5 heats up, and comprising: row's mouth of the second filter 5 heats up, pure steam circulation 3min; Pure steam penetrates filter element, temperature >=pre-warming temperature the P1 of the 4th thermometer 12 enters next step and heats up, if the pre-warming temperature P1 of the temperature < of the 4th thermometer 12 in 5min, sterilizing runs time-out simultaneity factor and reports to the police, and button click continues operational system and can continue to run sterilizing program.
Step S7, liquid mixing system entirety heats up, that is: whole system entirety heats up, temperature >=sterilising temp the P2 of the 4th thermometer 12 enters next step and heats up, if the temperature < sterilising temp P2 of the 4th thermometer 12 in 10min, sterilizing runs time-out simultaneity factor and reports to the police, and button click continues operational system and can continue to run sterilizing program.
Step S8, liquid mixing system whole constant temperature, that is: whole system is in temperature constant state, allows the temperature forward bias of all thermometeies from sterilising temp P2 critical state, constant temperature 3min.
Step S9, sterilizing, that is: whole system keeps the temperature >=sterilising temp P2 of all thermometeies, keep sterilizing 30min, if there is the temperature < sterilising temp P2 of a thermometer in the process, system can accumulate once the frequency of failure, frequency of failure < sterilizing number of times P3 turns back to step S8, if the frequency of failure >=sterilizing number of times P3 sterilizing runs time-out, simultaneity factor is reported to the police, continue operation and jump to step S8, remain on this sterilization process and keep 30min.
Step S10, the first filter 4 is dry in advance, that is: pass into clean compressed air after air filter 2 filters, carry out air displacement to entrained steam in the worry shell of the first filter 4.
Step S11, respiratory organ 3 is dry, that is: pass into clean compressed air after air filter 2 filters, arrange mouth by injection water entrance 101 and mouth spray 102 through respiratory organ 3 and discharge, while air displacement is carried out to Agitation Tank 1 entrained steam, also cool drying is carried out to row's mouth of respiratory organ 3; Pass into clean compressed air after air filter 2 filters, export discharge by injection water entrance 101 and mouth spray 102 through respiratory organ 3, while air displacement is carried out to Agitation Tank 1 entrained steam, also cool drying is carried out to the outlet of respiratory organ 3.
Step S12, the first filter 4 is dry, that is: pass into clean compressed air after air filter 2 filters, and arranges mouth carry out filter row's P4 time dry mouth time of drying purging to the first filter 4; Pass into clean compressed air after air filter 2 filters, drying is carried out to the first filter 4 outlet and purges a filter outlet P5 drying time time.
Step S13, the second filter 5 is dry, that is: pass into clean compressed air after air filter 2 filters, and arranges mouth carry out drying and purge a filter and arrange P4 time dry mouth time and divide a word with a hyphen at the end of a line next step the second filter 5; Pass into clean compressed air after air filter 2 filters, drying is carried out to the second filter 5 outlet and purges a filter outlet P5 drying time time.
Step S14, Agitation Tank 1 cool drying, that is: pass into clean compressed air after air filter 2 filters, and carries out dry cooling purge until the temperature≤tank body of the second thermometer 10 is lowered the temperature in advance temperature P6 to Agitation Tank 1; Pass into clean compressed air after air filter 2 filters, while purging Agitation Tank 1, chuck enters cooling water until the final baking temperature P7 of the temperature≤tank body of the second thermometer 10;
Step S15, liquid mixing system keeps malleation, that is: pass into clean compressed air after air filter 2 filters, and protects malleation, the pressure >=dwell pressure value P8 of the 3rd piezometer 8 to system inflation.
Step S16, terminates.
Above embodiment is used for illustrative purposes only, but not limitation of the present invention, person skilled in the relevant technique, without departing from the spirit and scope of the present invention, various conversion or modification can also be made, therefore all equivalent technical schemes also should belong to category of the present invention, should be limited by each claim.
Claims (3)
1. a liquid mixing system, it is characterized in that, comprising: Agitation Tank, air filter, respiratory organ, the first filter, the second filter, the first piezometer, the second piezometer, the 3rd piezometer, the first thermometer, the second thermometer, the 3rd thermometer, the 4th thermometer and peripheral pipeline; Described peripheral pipeline comprises: air feed conduit, pure steam supply pipeline, the first transmission pipeline, the second transmission pipeline and the 3rd transmission pipeline, wherein,
Described air feed conduit is communicated with described first transmission pipeline by described air filter;
Described pure steam supply pipeline is communicated with described first transmission pipeline;
Described first transmission pipeline is communicated with injection water entrance and the mouth spray of described Agitation Tank by described second transmission pipeline;
Row's mouth of described respiratory organ is communicated with described Agitation Tank; Row's mouth of described respiratory organ is all communicated with described first transmission pipeline with outlet;
The outlet of described Agitation Tank is communicated with described first filter by described 3rd transmission pipeline;
The respective outlet of described first filter and described second filter and row's mouth are all communicated with described first transmission pipeline;
Row's mouth of described first filter is communicated with described second filter;
Described air feed conduit is located at by described first piezometer;
Described pure steam supply pipeline is located at by described second piezometer;
Described Agitation Tank is located at by described 3rd piezometer;
Described first thermometer is located at described first transmission pipeline;
Described second thermometer is located at described Agitation Tank;
Described 3rd thermometer is located at row's mouth of described first filter;
Described 4th thermometer is located at row's mouth of described second filter.
2., based on a full-automatic online sterilizing control method for liquid mixing system described in claim 1, it is characterized in that, comprising:
Step S1, confirms that the state of liquid mixing system is intact;
Step S2, peripheral pipeline heats up in advance;
Step S3, respiratory organ heats up;
Step S4, Agitation Tank heats up;
Step S5, the first filter heats up;
Step S6, the second filter heats up;
Step S7, liquid mixing system entirety heats up;
Step S8, liquid mixing system whole constant temperature;
Step S9, sterilizing;
Step S10, the first filter is dry in advance;
Step S11, respiratory organ is dry;
Step S12, the first filter is dry;
Step S13, the second filter is dry;
Step S14, Agitation Tank cool drying;
Step S15, liquid mixing system keeps malleation;
Step S16, terminates.
3. full-automatic online sterilizing control method according to claim 2, is characterized in that,
In described step S1, institute's acknowledgement state comprises:
First manometric pressure >=0.5Mpa;
Second manometric pressure >=0.2Mpa;
Agitation Tank on-line cleaning terminates and enters auto state;
Liquid mixing system pressure discharges;
First filter and the second filter are installed;
Liquid mixing system air tightness test is qualified;
Described step S2 comprises: carry out pure steam circulation to peripheral tube net, temperature >=pre-warming temperature the P1 of the first thermometer enters next step and heats up, if the pre-warming temperature P1 of the temperature < of temperature first thermometer in 3min, sterilizing runs time-out simultaneity factor and reports to the police;
Described step S3 comprises: the injection water entrance of Agitation Tank enters pure steam, after row's mouth circulation 1min of respiratory organ, then penetrates filter element circulation 1min;
Described step S4 comprises: the injection water entrance of Agitation Tank and mouth spray enter pure steam, temperature >=pre-warming temperature the P1 of the second thermometer enters next step and heats up, if the pre-warming temperature P1 of the temperature < of the second thermometer in 10min, sterilizing runs time-out simultaneity factor and reports to the police;
Described step S5 comprises: row's mouth of the first filter heats up, pure steam circulation 3min; Pure steam penetrates filter element, and the temperature of the 3rd thermometer >=pre-warming temperature P1 enters next step and heats up, if in 5min the pre-warming temperature P1 of the temperature < of the 3rd thermometer, sterilizing runs and suspends simultaneity factor and report to the police;
Described step S6 comprises: row's mouth of the second filter heats up, pure steam circulation 3min; Pure steam penetrates filter element, and the temperature of the 4th thermometer >=pre-warming temperature P1 enters next step and heats up, if in 5min the pre-warming temperature P1 of the temperature < of the 4th thermometer, sterilizing runs and suspends simultaneity factor and report to the police;
Described step S7 comprises: whole system entirety heats up, heat up so the temperature of the 4th thermometer >=sterilising temp P2 enters next step, if the temperature < sterilising temp P2 of temperature control four thermometer in 10min, sterilizing runs time-out simultaneity factor and reports to the police;
Described step S8 comprises: whole system is in temperature constant state, allows the temperature forward bias of all thermometeies from sterilising temp P2 critical state, constant temperature 3min;
Described step S9 comprises: whole system keeps the temperature >=sterilising temp P2 of all thermometeies, keep sterilizing 30min, if there is the temperature < sterilising temp P2 of a thermometer in the process, system can accumulate once the frequency of failure, frequency of failure < sterilizing number of times P3 turns back to step S8, if the frequency of failure >=sterilizing number of times P3 sterilizing runs time-out, simultaneity factor is reported to the police, continue operation and jump to step S8, remain on this sterilization process and keep 30min;
Described step S10 comprises: pass into clean compressed air after air filter filters, carry out air displacement to entrained steam in the worry shell of the first filter;
Described step S11 comprises: pass into clean compressed air after air filter filters, and arranges mouth and discharges, also to the row mouth of respiratory organ carry out cool drying while carrying out air displacement to Agitation Tank entrained steam by injection water entrance and mouth spray through respiratory organ; Pass into clean compressed air after air filter filters, export discharge by injection water entrance and mouth spray through respiratory organ, while air displacement is carried out to Agitation Tank entrained steam, also cool drying is carried out to the outlet of respiratory organ;
Described step S12 comprises: pass into clean compressed air after air filter filters, and carries out drying purge filter row's P4 time dry mouth time to the first filter row mouth; Pass into clean compressed air after air filter filters, drying is carried out to the first filter outlet and purges a filter outlet P5 drying time time;
Described step S13 comprises: pass into clean compressed air after air filter filters, and carries out filter row's P4 time dry mouth time of drying purging divide a word with a hyphen at the end of a line next step to the second filter row mouth; Pass into clean compressed air after air filter filters, drying is carried out to the second filter outlet and purges a filter outlet P5 drying time time;
Described step S14 comprises: pass into clean compressed air after air filter filters, and carries out dry cooling purge until the temperature≤tank body of the second thermometer is lowered the temperature in advance temperature P6 to Agitation Tank; Pass into clean compressed air after air filter filters, while purging Agitation Tank, chuck enters cooling water until the final baking temperature P7 of the temperature≤tank body of the second thermometer;
Described step S15 comprises: pass into clean compressed air after air filter filters, and protects malleation, the 3rd manometric pressure >=dwell pressure value P8 to system inflation.
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| CN201610143120.6A CN105536011B (en) | 2016-03-14 | 2016-03-14 | Liquid mixing system and its full-automatic online sterilizing control method |
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| CN201610143120.6A CN105536011B (en) | 2016-03-14 | 2016-03-14 | Liquid mixing system and its full-automatic online sterilizing control method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875407A (en) * | 2017-12-15 | 2018-04-06 | 天津梅花生物医药科技有限公司 | A kind of new bulk drug sterile processing systems |
| CN109364279A (en) * | 2018-09-06 | 2019-02-22 | 丽珠集团利民制药厂 | It is a kind of can online CIP/SIP thimerosal filtration sterilization and cleaning system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107875407A (en) * | 2017-12-15 | 2018-04-06 | 天津梅花生物医药科技有限公司 | A kind of new bulk drug sterile processing systems |
| CN109364279A (en) * | 2018-09-06 | 2019-02-22 | 丽珠集团利民制药厂 | It is a kind of can online CIP/SIP thimerosal filtration sterilization and cleaning system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105536011B (en) | 2017-12-08 |
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