CN204988705U - That uses isolation tank joins in marriage online integrality test system of liquid system filter core - Google Patents

That uses isolation tank joins in marriage online integrality test system of liquid system filter core Download PDF

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Publication number
CN204988705U
CN204988705U CN201520704466.XU CN201520704466U CN204988705U CN 204988705 U CN204988705 U CN 204988705U CN 201520704466 U CN201520704466 U CN 201520704466U CN 204988705 U CN204988705 U CN 204988705U
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CN
China
Prior art keywords
valve
filtrator
filter core
outlet
mouth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn - After Issue
Application number
CN201520704466.XU
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Chinese (zh)
Inventor
郑效东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGHAI TOFFLON TAPU TECHNOLOGY Co Ltd
Shanghai Tofflon Science and Technology Co Ltd
Original Assignee
SHANGHAI TOFFLON TAPU TECHNOLOGY Co Ltd
Shanghai Tofflon Science and Technology Co Ltd
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Publication date
Application filed by SHANGHAI TOFFLON TAPU TECHNOLOGY Co Ltd, Shanghai Tofflon Science and Technology Co Ltd filed Critical SHANGHAI TOFFLON TAPU TECHNOLOGY Co Ltd
Priority to CN201520704466.XU priority Critical patent/CN204988705U/en
Application granted granted Critical
Publication of CN204988705U publication Critical patent/CN204988705U/en
Withdrawn - After Issue legal-status Critical Current
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Abstract

The utility model provides a that uses isolation tank joins in marriage online integrality test system of liquid system filter core. The utility model provides a not enough of current scheme has been overcome to the method, realized joining in marriage after the sterilization of liquid system filter core online integrality testing capabilities and to sterile environment's protection, avoided the sterilization to cause the problem of damaging and can not in time discovering to the filter core, can not destroy the sterile environment of system simultaneously again. The utility model discloses a method and effect satisfy the demand of more and more pharmacy trade producers.

Description

A kind of online integrity testing system of liquid mixing system filter core applying sealing chamber
Technical field
The utility model relates to the application system of a kind of gas sealing chamber in the online integrity test of liquid mixing system filter core, for ensureing aseptic during the online integrity test of the filter core of pharmaceutical industry fully-automatic liquid make-up system, belongs to dosing control technology field.
Background technology
Pharmaceutical industry liquid mixing system valve is many, pipeline is complicated, requires high to system gnotobasis, must ensure that the integrality of filter core before liquor charging is good, do online integrity test to these needs before liquor charging to filter core.
During traditional filter core online integrity detection, the outlet of filtrator is connected with the comb of liquid mixing system, and comb is connected with total row in whole workshop, certain pressure can be there is in total row in workshop, gas in total row or liquid can pour in down a chimney in liquid mixing system, and then pollute the gnotobasis of liquid mixing system, the gnotobasis of the outlet of filtrator and filter core rear end is destroyed.
Summary of the invention
The technical problems to be solved in the utility model is: isolation when realizing filter core online integrity test between filtrator rear end and liquid mixing system comb, ensures aseptic during the online integrity test of filter core.
In order to solve the problems of the technologies described above, the technical solution of the utility model there is provided a kind of online integrity testing system of liquid mixing system filter core applying sealing chamber, it is characterized in that: comprise filtrator, pressurized air is via electro connecting pressure gauge, integrity tester and valve two are arranged mouth with the gas of filtrator and are connected, the gas row mouth of filtrator also via valve one with always arrange mouth and be connected, liquid is successively via valve three, valve four and pressure transducer one connect the import of filtrator, water for injection/pressurized air/pure steam connects the import of filtrator via valve four and pressure transducer one, the outlet of filtrator connects valve five, valve aspect on May Day connects medicine liquid outlet via valve six, connect via valve seven on the other hand and always arrange mouth, pipeline between valve five and the outlet of filtrator is provided with pressure transducer two, pipeline between valve five and valve seven is provided with temperature sensor, one end of valve eight is connected with the pipeline between temperature sensor with valve seven, the other end of valve eight connects the import of sealing chamber, the outlet of sealing chamber via valve nine with always arrange mouth and be connected, the gas vent of sealing chamber connects the gas feed of respirator, the outlet of respirator is connected with gas outlet via valve ten on the one hand, on the other hand via valve 11 with always arrange mouth and be connected, the freeing port of respirator via valve 12 with always arrange mouth and be connected,
Valve one, valve two, valve three, valve four, valve five, valve six, valve seven, valve eight, valve nine, valve ten, valve 11, valve 12 are connected with valve island, valve island connects PLC, PLC and is also connected with pressure transducer one, pressure transducer two, temperature sensor and electro connecting pressure gauge.
The utility model overcomes the deficiency of existing scheme; achieve the online integrity test function of the filter core after liquid mixing system sterilizing and the protection to gnotobasis; avoid sterilizing to cause filter core and to damage and can not the problem of Timeliness coverage, the gnotobasis of system can not be destroyed again simultaneously.Method of the present utility model and effect meet the demand of increasing pharmaceutical industry producer.
Accompanying drawing explanation
Fig. 1 is online integrity testing system schematic diagram;
The online integrity test control flow chart that Fig. 2 provides for the utility model.
Embodiment
For making the utility model become apparent, hereby with preferred embodiment, and accompanying drawing is coordinated to be described in detail below.
As shown in Figure 1, a kind of online integrity testing system of liquid mixing system filter core applying sealing chamber that the utility model provides, comprise filtrator 1, pressurized air is via electro connecting pressure gauge 7, integrity tester and valve two B arrange mouth with the gas of filtrator 1 and are connected, the gas row mouth of filtrator 1 also via valve one A with always arrange mouth and be connected, liquid is successively via valve three C, valve four D and pressure transducer 1 connect the import of filtrator 1, water for injection/pressurized air/pure steam connects the import of filtrator 1 via valve four D and pressure transducer 1, the outlet of filtrator 1 connects valve five E, valve five E mono-aspect connects medicine liquid outlet via valve six F, connect via valve seven G on the other hand and always arrange mouth, pipeline between valve five E and the outlet of filtrator 1 is provided with pressure transducer 25, pipeline between valve five E and valve seven G is provided with temperature sensor 6, one end of valve eight H is connected with the pipeline between temperature sensor 6 with valve seven G, the other end of valve eight H connects the import of sealing chamber 2, the outlet of sealing chamber 2 via valve nine I with always arrange mouth and be connected, the gas vent of sealing chamber 2 connects the gas feed of respirator 3, the outlet of respirator 3 is connected with gas outlet via valve ten J on the one hand, on the other hand via valve 11 K with always arrange mouth and be connected, the freeing port of respirator 3 via valve 12 L with always arrange mouth and be connected,
Valve one A, valve two B, valve three C, valve four D, valve five E, valve six F, valve seven G, valve eight H, valve nine I, valve ten J, valve 11 K, valve 12 L are connected with valve island, valve island connects PLC, PLC and is also connected with pressure transducer 1, pressure transducer 25, temperature sensor 6 and electro connecting pressure gauge 7.
Composition graphs 2, based on the online Integrity Testing of liquid mixing system filter core of application sealing chamber of the present utility model, comprises the following steps:
Confirm before the first step, integrity test
1 air supply pressure is normal, the reading >=0.5MPa of electro connecting pressure gauge 7;
2 system sterilizings terminate, and comprise filtrator 1, sealing chamber 2 and respirator 3, and enter auto state;
3 associated pipe and cartridge pressure discharge;
4 integrity testers access and are ready to;
Second step, filter core are wetting:
1 release filtrator 1 filter core and associated conduit, sealing chamber 2 pressure;
The water for injection of 2 coolings passes in filtrator 1 via valve four D, first discharge from total row's mouth after gas row's mouth and valve one A of filter 1, after keeping water for injection to be circulated to 30s, discharge from total row's mouth after the outlet, valve five E and valve seven G of filter 1 again, after being circulated to the 30s of setting, stop passing into water for injection;
3 pressurized air pass in filtrator 1 via valve four D, discharge from total row's mouth after gas row's mouth and valve one A of filter 1 on the one hand and purge, discharge from total row's mouth after the outlet, valve five E and valve seven G of filter 1 on the other hand and purge, to remove the water for injection of pipeline residual, meanwhile, the residual water for injection of filtrator 1 rear end enters in sealing chamber 2 via valve eight H;
3rd step, to be tested by integrity tester, valve seven G is closed, valve eight H is opened, valve ten J is opened, pressurized air enters filtrator 1 via valve two B, pass in respirator 3 after entering sealing chamber 2 via valve five E and valve eight H again, communicated with room by respirator 3 filter core, keep with no pressure;
If the test result of the 4th step integrity tester is qualified, then enter the 6th step, if the test result of integrity tester is defective, then select again to soak, retest or more renew cartridge, select again wetting after, jump to second step, after selection retests, jump to the 3rd step, select, more after renew cartridge, to jump to the 5th step;
5th step, sterilizing is carried out to filter core
Pressurized air passes in filtrator 1 via valve four D by 1, discharge from total row's mouth after gas row's mouth and valve one A of filter 1 on the one hand and purge, discharge from total row's mouth after the outlet, valve five E and valve seven G of filter 1 on the other hand and purge, purge after continuing 30s, residual water for injection is drained;
The pressure of 2 release filtrators 1 and associated pipe, until obtain force value≤0.02MPa by pressure transducer 1 and pressure transducer 25, changes the filter core of filtrator 1 after time delay 20s;
Pure steam passes in filtrator 1 via valve four D by 3, carries out sterilizing to the filter core in filtrator 1, continues 30min;
Pressurized air passes in filtrator 1 via valve four D by 4, utilizes the filter core of the purged filter 1 of pressurized air, and by after steam discharging, jumps to second step;
6th step, pressurized air is passed in filtrator 1 via valve four D, after utilizing pressurized air to purge 30s to filtrator 1, by emptying for residual water for injection, again pressurising protection is carried out to filtrator 1 and associated pipe, make to obtain force value >=0.15MPa by pressure transducer 1 and pressure transducer 25;
7th step, end test.
In whole liquid mixing system operational process, if the pressure < 0.5MPa that electro connecting pressure gauge 7 obtains, then after time delay 30s, system can run time-out automatically, guarantees that starting valve normally opens; After control power supply sky holds escape, system can run time-out automatically, and after above-mentioned several heavy warning is got rid of, system can recover normal operation again.

Claims (1)

1. apply the online integrity testing system of liquid mixing system filter core of sealing chamber for one kind, it is characterized in that: comprise filtrator (1), pressurized air is via electro connecting pressure gauge (7), integrity tester and valve two (B) are arranged mouth with the gas of filtrator (1) and are connected, the gas row mouth of filtrator (1) also via valve one (A) with always arrange mouth and be connected, liquid is successively via valve three (C), valve four (D) and pressure transducer one (4) connect the import of filtrator (1), water for injection/pressurized air/pure steam connects the import of filtrator (1) via valve four (D) and pressure transducer one (4), the outlet of filtrator (1) connects valve five (E), valve five (E) connects medicine liquid outlet via valve six (F) on the one hand, connect via valve seven (G) on the other hand and always arrange mouth, pipeline between valve five (E) and the outlet of filtrator (1) is provided with pressure transducer two (5), pipeline between valve five (E) and valve seven (G) is provided with temperature sensor (6), one end of valve eight (H) is connected with the pipeline between temperature sensor (6) with valve seven (G), the other end of valve eight (H) connects the import of sealing chamber (2), the outlet of sealing chamber (2) via valve nine (I) with always arrange mouth and be connected, the gas vent of sealing chamber (2) connects the gas feed of respirator (3), the outlet of respirator (3) is connected with gas outlet via valve ten (J) on the one hand, on the other hand via valve 11 (K) with always arrange mouth and be connected, the freeing port of respirator (3) via valve 12 (L) with always arrange mouth and be connected,
Valve one (A), valve two (B), valve three (C), valve four (D), valve five (E), valve six (F), valve seven (G), valve eight (H), valve nine (I), valve ten (J), valve 11 (K), valve 12 (L) are connected with valve island, valve island connects PLC, PLC and is also connected with pressure transducer one (4), pressure transducer two (5), temperature sensor (6) and electro connecting pressure gauge (7).
CN201520704466.XU 2015-09-11 2015-09-11 That uses isolation tank joins in marriage online integrality test system of liquid system filter core Withdrawn - After Issue CN204988705U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201520704466.XU CN204988705U (en) 2015-09-11 2015-09-11 That uses isolation tank joins in marriage online integrality test system of liquid system filter core

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201520704466.XU CN204988705U (en) 2015-09-11 2015-09-11 That uses isolation tank joins in marriage online integrality test system of liquid system filter core

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105092234A (en) * 2015-09-11 2015-11-25 上海东富龙拓溥科技有限公司 System and method applying isolation tank for liquid dosing system filter core on-line integrity tests
US10617603B2 (en) 2016-01-22 2020-04-14 Baxter International Inc. Sterile solutions product bag
US11021275B2 (en) 2016-01-22 2021-06-01 Baxter International Inc. Method and machine for producing sterile solution product bags

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105092234A (en) * 2015-09-11 2015-11-25 上海东富龙拓溥科技有限公司 System and method applying isolation tank for liquid dosing system filter core on-line integrity tests
CN105092234B (en) * 2015-09-11 2017-11-03 上海东富龙拓溥科技有限公司 Using the online integrity testing system of liquid mixing system filter core and method of sealing chamber
US10617603B2 (en) 2016-01-22 2020-04-14 Baxter International Inc. Sterile solutions product bag
US11021275B2 (en) 2016-01-22 2021-06-01 Baxter International Inc. Method and machine for producing sterile solution product bags

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AV01 Patent right actively abandoned

Granted publication date: 20160120

Effective date of abandoning: 20171103

AV01 Patent right actively abandoned