CN105536011B - Liquid mixing system and its full-automatic online sterilizing control method - Google Patents

Liquid mixing system and its full-automatic online sterilizing control method Download PDF

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Publication number
CN105536011B
CN105536011B CN201610143120.6A CN201610143120A CN105536011B CN 105536011 B CN105536011 B CN 105536011B CN 201610143120 A CN201610143120 A CN 201610143120A CN 105536011 B CN105536011 B CN 105536011B
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temperature
filter
mouth
row
thermometer
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CN105536011A (en
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郑效东
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SHANGHAI TOFFLON TAPU TECHNOLOGY Co Ltd
Shanghai Tofflon Science and Technology Co Ltd
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SHANGHAI TOFFLON TAPU TECHNOLOGY Co Ltd
Shanghai Tofflon Science and Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/24—Apparatus using programmed or automatic operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/23—Containers, e.g. vials, bottles, syringes, mail
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)

Abstract

The invention discloses a kind of liquid mixing system, including：Agitation Tank, air cleaner, respirator, first filter, the second filter, first pressure meter, second pressure meter, the 3rd pressure gauge, the first thermometer, second temperature meter, the 3rd thermometer, the 4th thermometer and peripheral pipeline；The peripheral pipeline includes:Air feed conduit, pure steam service, the first transmission pipeline, the second transmission pipeline and the 3rd transmission pipeline, can sterilize online.The invention also discloses the full-automatic online sterilizing control method based on liquid mixing system, sterilize cold spot and sterile docking problem are avoided.

Description

Liquid mixing system and its full-automatic online sterilizing control method
Technical field
The present invention relates to pharmaceutical field and with liquid control technology field.
Background technology
Pharmaceutical industry liquid mixing system valve is more, pipeline is complicated, easily produces cold spot and sterile docking problem during sterilizing.With liquid Its sterilization method of the structures shape of system conventional is manually plus offline, i.e. jar and part pipeline sterilize online, respirator and Surge tank is sterilized by moist heat sterilization cabinet offline.The shortcomings that this manual sterilization method is：If occur in sterilization process different Often, it is impossible to find and correct in time；Environmental requirement to sterile docking is higher, and the completeness and reappearance of sterilizing can not meet to get over Carry out the demand of more pharmaceutical industry producers.
The content of the invention
An object of the present invention is to provide a kind of liquid mixing system of advantages of simple, can sterilized online.
The second object of the present invention is to provide a kind of online sterilizing control method for coordinating liquid mixing system, avoids sterilizing cold Point and sterile docking problem.
Realizing the technical scheme of above-mentioned purpose is：
The liquid mixing system of one of the present invention, including：Agitation Tank, air cleaner, respirator, first filter, the second mistake Filter, first pressure meter, second pressure meter, the 3rd pressure gauge, the first thermometer, second temperature meter, the 3rd thermometer, the 4th temperature Degree meter and peripheral pipeline；The peripheral pipeline includes:Air feed conduit, pure steam service, the first transmission pipeline, second Transmission pipeline and the 3rd transmission pipeline, wherein,
The air feed conduit connects first transmission pipeline by the air cleaner；
The pure steam service connects first transmission pipeline；
First transmission pipeline connects the injection water inlet and spray of the Agitation Tank by second transmission pipeline Mouthful；
Row's mouth of the respirator connects the Agitation Tank；Row's mouth of the respirator connects described first with outlet and passed Defeated pipeline；
The outlet of the Agitation Tank connects the first filter by the 3rd transmission pipeline；
First filter outlet respective with second filter and row's mouth connect first transmission pipeline；
Row's mouth of the first filter connects second filter；
The first pressure meter is located at the air feed conduit；
The second pressure meter is located at the pure steam service；
3rd pressure gauge is located at the Agitation Tank；
First thermometer is located at first transmission pipeline；
The second temperature meter is located at the Agitation Tank；
3rd thermometer is located at row's mouth of the first filter；
4th thermometer is located at row's mouth of second filter.
A kind of full-automatic online sterilizing control method based on above-mentioned liquid mixing system of the two of the present invention, including：
Step S1, confirm that the state of liquid mixing system is intact；
Step S2, peripheral pipeline heat up in advance；
Step S3, respirator heating；
Step S4, Agitation Tank heating；
Step S5, first filter heating；
Step S6, the heating of the second filter；
Step S7, liquid mixing system integrally heat up；
Step S8, liquid mixing system whole constant temperature；
Step S9, sterilizing；
Step S10, first filter are pre-dried；
Step S11, respirator are dried；
Step S12, first filter are dried；
Step S13, the second filter are dried；
Step S14, Agitation Tank cool drying；
Step S15, liquid mixing system keep malleation；
Step S16, terminate.
In above-mentioned full-automatic online sterilizing control method,
Institute's acknowledgement state includes in the step S1：
Pressure >=0.5Mpa of first pressure meter；
Pressure >=0.2Mpa of second pressure meter；
Agitation Tank on-line cleaning terminates and enters auto state；
Liquid mixing system pressure has discharged；
First filter and the second filter have been installed；
Liquid mixing system air tightness test is qualified；
The step S2 includes：Pure steam circulation, temperature >=pre- warming temperature of the first thermometer are carried out to peripheral tube net P1 enters to heat up in next step, if the pre- warming temperature P1 of the temperature ＜ of the thermometer of temperature control one in 3min, sterilizing operation pause Simultaneity factor is alarmed；
The step S3 includes：The injection water inlet of Agitation Tank enters pure steam, after row's mouth circulation 1min of respirator, then wears Filter core circulation 1min；
The step S4 includes：The injection water inlet and mouth spray of Agitation Tank enter pure steam, and the temperature of second temperature meter >= Pre- warming temperature P1 enters to heat up in next step, if the pre- warming temperature P1 of the temperature ＜ of second temperature meter in 10min, sterilizing fortune Row pause simultaneity factor is alarmed；
The step S5 includes：Row's mouth heating of first filter, pure steam circulation 3min；Pure steam penetrates filter core, the The temperature of three thermometers >=pre- warming temperature P1 enters to heat up in next step, if in 5min the 3rd thermometer temperature ＜ lockups Temperature P1, sterilizing operation pause simultaneity factor are alarmed；
The step S6 includes：Row's mouth heating of second filter, pure steam circulation 3min；Pure steam penetrates filter core, the The temperature of four thermometers >=pre- warming temperature P1 enters to heat up in next step, if in 5min the 4th thermometer temperature ＜ lockups Temperature P1, sterilizing operation pause simultaneity factor are alarmed；
The step S7 includes：Whole system integrally heats up, so the temperature of the 4th thermometer >=sterilising temp P2 enters In next step heat up, if in 10min the thermometer of temperature control four temperature ＜ sterilising temp P2, sterilizing operation pause simultaneity factor Alarm；
The step S8 includes：Whole system is in temperature constant state, allows the temperature of all thermometers is positive to deviate sterilizing temperature Spend P2 critical conditions, constant temperature 3min；
The step S9 includes：Whole system keeps temperature >=sterilising temp P2 of all thermometers, keeps sterilizing 30min, if there is the temperature ＜ sterilising temp P2 of a thermometer in the process, system can accumulate once the frequency of failure, lose Lose number ＜ sterilizings number P3 and return to step S8, if the frequency of failure >=sterilizing number P3 sterilizing operation pause simultaneity factor hairs Raw alarm, continues to run with and jumps to step S8, keeps keeping 30min in this sterilization process；
The step S10 includes：Clean compressed air is passed through after air cleaner filters, the worry to first filter Entrained steam carries out air displacement in shell；
The step S11 includes：Clean compressed air is passed through after air cleaner filters, by injection water inlet and spray Mouth is drenched through respirator row's mouth discharge, also row's mouth of respirator is carried out while air displacement is carried out to Agitation Tank entrained steam cold But dry；Clean compressed air is passed through after air cleaner filters, is exported by injection water inlet and mouth spray through respirator Discharge, also the outlet to respirator carries out cool drying while air displacement is carried out to Agitation Tank entrained steam；
The step S12 includes：Clean compressed air is passed through after air cleaner filters, mouth is arranged to first filter One filter row's P4 time dry mouth time of purging is dried；Clean compressed air is passed through to filter by air cleaner Afterwards, one filter outlet drying time P5 time of purging is dried to first filter outlet；
The step S13 includes：Clean compressed air is passed through after air cleaner filters, mouth is arranged to the second filter Being dried purging one filter row's P4 times dry mouth time divides a word with a hyphen at the end of a line in next step；It is passed through clean compressed air and passes through air mistake After filter filtering, the second filter outlet is dried one filter outlet drying time P5 time of purging；
The step S14 includes：Clean compressed air is passed through after air cleaner filters, Agitation Tank is dried Cooling purging cools temperature P6 in advance until temperature≤tank body of second temperature meter；It is passed through clean compressed air and passes through air cleaner After filtering, chuck enters cooling water until the final drying temperature of temperature≤tank body of second temperature meter while purging to Agitation Tank P7；
The step S15 includes：Clean compressed air is passed through after air cleaner filters, system inflation is protected just Pressure, pressure >=dwell pressure value P8 of the 3rd pressure gauge.
The beneficial effects of the invention are as follows：Liquid mixing system of the invention by designing advantages of simple, it is set to sterilize online, The manual plus offline sterilization method of abandoning tradition.Meanwhile by designing the online sterilizing control method of matching, avoid with liquid System valve is more, pipeline is complicated, easily produces cold spot and sterile docking problem during sterilizing so that sterilization effect meets pharmaceutical industry The demand of producer.
Brief description of the drawings
Fig. 1 is the structure chart of the liquid mixing system of one of the present invention；
Fig. 2 is the flow chart of the full-automatic online sterilizing control method of the two of the present invention.
Embodiment
Below in conjunction with accompanying drawing, the invention will be further described.
Referring to Fig. 1, the liquid mixing system of one of present invention, including：Agitation Tank 1, air cleaner 2, respirator 3, first Filter 4, the second filter 5, first pressure meter 6, second pressure meter 7, the 3rd pressure gauge 8, the first thermometer 9, second temperature Count the 10, the 3rd thermometer 11, the 4th thermometer 12 and peripheral pipeline.Peripheral pipeline includes:Air feed conduit 13, pure steam supply To pipeline 14, the first transmission pipeline 15, the second transmission pipeline 16 and the 3rd transmission pipeline 17.
Air feed conduit 13 connects the first transmission pipeline 15 by air cleaner 2.Pure steam service 14 connects First transmission pipeline 15.First transmission pipeline 15 connects injection water inlet 101 and the spray of Agitation Tank 1 by the second transmission pipeline 16 Drench mouth 102.
Row's mouth connection Agitation Tank 1 of respirator 3.Row's mouth of respirator 3 connects the first transmission pipeline 15 with outlet.
The outlet of Agitation Tank 1 connects first filter 4 by the 3rd transmission pipeline 17.First filter 4 and second filters The respective outlet of device 5 and row's mouth connect the first transmission pipeline 15.Row's mouth of first filter 4 connects the second filter 5.
First pressure meter 6 is located at air feed conduit 13, shows air supply pressure.
Second pressure meter 7 is located at pure steam service 14, shows pure steam supply pressure.
3rd pressure gauge 8 is located at Agitation Tank 1, shows pressure in Agitation Tank.
First thermometer 9 is located at the first transmission pipeline 15, temperature in display tube.
Second temperature meter 10 is located at Agitation Tank 1, shows temperature in tank.
3rd thermometer 11 is located at row's mouth of first filter 4, display row's mouth temperature.
4th thermometer 12 is located at row's mouth of the second filter 5, display row's mouth temperature.
Referring to Fig. 2, the two of the present invention full-automatic online sterilizing control method based on liquid mixing system, including following step Suddenly：
Step S1, confirm that the state of liquid mixing system is intact, including：
Pressure >=0.5Mpa of first pressure meter 6；
Pressure >=0.2Mpa of second pressure meter 7；
Agitation Tank on-line cleaning terminates and enters auto state；
Liquid mixing system pressure has discharged；
The filter 5 of first filter 4 and second has been installed；
Liquid mixing system air tightness test is qualified.
Step S2, peripheral pipeline heat up in advance, i.e.,：Pure steam circulation, the temperature of the first thermometer 9 are carried out to peripheral tube net >=pre- warming temperature P1 enters to heat up in next step, if the pre- warming temperature P1 of the temperature ＜ of the thermometer of temperature control one in 3min, Sterilizing operation pause simultaneity factor is alarmed, and click button continues to run with system and may proceed to run sterilizing program.
Step S3, respirator 3 heat up, i.e.,：The injection water inlet 101 of Agitation Tank 1 enters pure steam, row's mouth stream of respirator 3 After logical 1min, then filter core circulation 1min is penetrated, click button continues to run with system and may proceed to run sterilizing program.
Step S4, Agitation Tank 1 heat up, i.e.,：The injection water inlet 101 and mouth spray 102 of Agitation Tank enter pure steam, the second temperature Temperature >=pre- warming temperature P1 of degree meter 10 enters to heat up in next step, if the temperature ＜ of second temperature meter 10 is pre- in 10min Warming temperature P1, sterilizing operation pause simultaneity factor are alarmed, and click button continues to run with system and may proceed to operation sterilizing journey Sequence.
Step S5, first filter 4 heat up, including：Row's mouth heating of first filter 4, pure steam circulation 3min；Pure steaming Vapour penetrates filter core, and temperature >=pre- warming temperature P1 of the 3rd thermometer 11 enters to heat up in next step, if the 3rd temperature in 5min The pre- warming temperature P1 of temperature ＜ of degree meter 11, sterilizing operation pause simultaneity factor are alarmed, click on button and continue to run with system It may proceed to run sterilizing program.
Step S6, the second filter 5 heat up, including：Row's mouth heating of second filter 5, pure steam circulation 3min；Pure steaming Vapour penetrates filter core, and temperature >=pre- warming temperature P1 of the 4th thermometer 12 enters to heat up in next step, if the 4th temperature in 5min The pre- warming temperature P1 of temperature ＜ of degree meter 12, sterilizing operation pause simultaneity factor are alarmed, click on button and continue to run with system It may proceed to run sterilizing program.
Step S7, liquid mixing system integrally heat up, i.e.,：Whole system integrally heats up, temperature >=sterilizing of the 4th thermometer 12 Temperature P2 enter in next step heat up, if in 10min the 4th thermometer 12 temperature ＜ sterilising temp P2, sterilizing operation pause Simultaneity factor is alarmed, and click button continues to run with system and may proceed to run sterilizing program.
Step S8, liquid mixing system whole constant temperature, i.e.,：Whole system is in temperature constant state, allow all thermometers temperature just To deviation sterilising temp P2 critical conditions, constant temperature 3min.
Step S9, sterilizing, i.e.,：Whole system keeps temperature >=sterilising temp P2 of all thermometers, keeps sterilizing 30min, if there is the temperature ＜ sterilising temp P2 of a thermometer in the process, system can accumulate once the frequency of failure, lose Lose number ＜ sterilizings number P3 and return to step S8, if the frequency of failure >=sterilizing number P3 sterilizing operation pause simultaneity factor hairs Raw alarm, continues to run with and jumps to step S8, keeps keeping 30min in this sterilization process.
Step S10, first filter 4 are pre-dried, i.e.,：Clean compressed air is passed through after the filtering of air cleaner 2, Entrained steam carries out air displacement in worry shell to first filter 4.
Step S11, respirator 3 are dried, i.e.,：Clean compressed air is passed through after the filtering of air cleaner 2, by injection water Entrance 101 and mouth spray 102 are discharged through the row's mouth of respirator 3, also to exhaling while carrying out air displacement to the entrained steam of Agitation Tank 1 Row's mouth of haustorium 3 carries out cool drying；Clean compressed air is passed through after the filtering of air cleaner 2, by injection water inlet 101 With mouth spray 102 through respirator 3 export discharge, to the entrained steam of Agitation Tank 1 carry out air displacement while also to respirator 3 Outlet carries out cool drying.
Step S12, first filter 4 are dried, i.e.,：Clean compressed air is passed through after the filtering of air cleaner 2, to the One filter row's P4 time dry mouth time of purging is dried in the row's mouth of one filter 4；Clean compressed air is passed through by empty After air filter 2 filters, one filter outlet drying time P5 time of purging is dried to the outlet of first filter 4.
Step S13, the second filter 5 are dried, i.e.,：Clean compressed air is passed through after the filtering of air cleaner 2, to the The row's mouth of tow filtrator 5 is dried purging one filter row's P4 times dry mouth time and divided a word with a hyphen at the end of a line in next step；It is passed through clean compression One filter outlet drying time of purging is dried after the filtering of air cleaner 2, to the outlet of the second filter 5 in air The P5 times.
Step S14, the cool drying of Agitation Tank 1, i.e.,：Be passed through clean compressed air by air cleaner 2 filtering after, to Cooling purging is dried until temperature≤tank body of second temperature meter 10 cools temperature P6 in advance in flow container 1；It is empty to be passed through clean compression Gas is after the filtering of air cleaner 2, and chuck enters cooling water until the temperature of second temperature meter 10 while purging to Agitation Tank 1 The final drying temperature P7 of≤tank body；
Step S15, liquid mixing system keep malleation, i.e.,：Clean compressed air is passed through after the filtering of air cleaner 2, it is right Malleation, pressure >=dwell pressure value P8 of the 3rd pressure gauge 8 are protected in system inflation.
Step S16, terminate.
Above example is used for illustrative purposes only, rather than limitation of the present invention, the technology people about technical field Member, without departing from the spirit and scope of the present invention, can also make various conversion or modification, therefore all equivalent Technical scheme should also belong to scope of the invention, should be limited by each claim.

Claims (3)

  1. A kind of 1. liquid mixing system, it is characterised in that including：Agitation Tank, air cleaner, respirator, first filter, the second mistake Filter, first pressure meter, second pressure meter, the 3rd pressure gauge, the first thermometer, second temperature meter, the 3rd thermometer, the 4th temperature Degree meter and peripheral pipeline；The peripheral pipeline includes:Air feed conduit, pure steam service, the first transmission pipeline, second Transmission pipeline and the 3rd transmission pipeline, wherein,
    The air feed conduit connects first transmission pipeline by the air cleaner；
    The pure steam service connects first transmission pipeline；
    First transmission pipeline connects the injection water inlet and mouth spray of the Agitation Tank by second transmission pipeline；
    Row's mouth of the respirator connects the Agitation Tank；Row's mouth of the respirator connects first transfer tube with outlet Road；
    The outlet of the Agitation Tank connects the first filter by the 3rd transmission pipeline；
    First filter outlet respective with second filter and row's mouth connect first transmission pipeline；
    Row's mouth of the first filter connects second filter；
    The first pressure meter is located at the air feed conduit；
    The second pressure meter is located at the pure steam service；
    3rd pressure gauge is located at the Agitation Tank；
    First thermometer is located at first transmission pipeline；
    The second temperature meter is located at the Agitation Tank；
    3rd thermometer is located at row's mouth of the first filter；
    4th thermometer is located at row's mouth of second filter.
  2. A kind of 2. full-automatic online sterilizing control method based on liquid mixing system described in claim 1, it is characterised in that including：
    Step S1, confirm that the state of liquid mixing system is intact；
    Step S2, peripheral pipeline heat up in advance；
    Step S3, respirator heating；
    Step S4, Agitation Tank heating；
    Step S5, first filter heating；
    Step S6, the heating of the second filter；
    Step S7, liquid mixing system integrally heat up；
    Step S8, liquid mixing system whole constant temperature；
    Step S9, sterilizing；
    Step S10, first filter are pre-dried；
    Step S11, respirator are dried；
    Step S12, first filter are dried；
    Step S13, the second filter are dried；
    Step S14, Agitation Tank cool drying；
    Step S15, liquid mixing system keep malleation；
    Step S16, terminate.
  3. 3. full-automatic online sterilizing control method according to claim 2, it is characterised in that
    Institute's acknowledgement state includes in the step S1：
    Pressure >=0.5Mpa of first pressure meter；
    Pressure >=0.2Mpa of second pressure meter；
    Agitation Tank on-line cleaning terminates and enters auto state；
    Liquid mixing system pressure has discharged；
    First filter and the second filter have been installed；
    Liquid mixing system air tightness test is qualified；
    The step S2 includes：Pure steam circulation is carried out to peripheral tube net, temperature >=pre- warming temperature P1 of the first thermometer enters Enter and heat up in next step, if the pre- warming temperature P1 of the temperature ＜ of the thermometer of temperature control one in 3min, sterilizing operation pause is simultaneously System is alarmed；
    The step S3 includes：The injection water inlet of Agitation Tank enters pure steam, after row's mouth circulation 1min of respirator, then penetrates filter Core circulation 1min；
    The step S4 includes：The injection water inlet and mouth spray of Agitation Tank enter pure steam, temperature >=lockup of second temperature meter Temperature P1 enters to heat up in next step, if the pre- warming temperature P1 of the temperature ＜ of second temperature meter in 10min, sterilizing operation is temporary Stop simultaneity factor to alarm；
    The step S5 includes：Row's mouth heating of first filter, pure steam circulation 3min；Pure steam penetrates filter core, the 3rd temperature The temperature >=pre- warming temperature P1 for spending meter enters and heated up in next step, if the temperature ＜ of the 3rd thermometer heats up temperature in advance in 5min P1 is spent, sterilizing operation pause simultaneity factor is alarmed；
    The step S6 includes：Row's mouth heating of second filter, pure steam circulation 3min；Pure steam penetrates filter core, the 4th temperature The temperature >=pre- warming temperature P1 for spending meter enters and heated up in next step, if the temperature ＜ of the 4th thermometer heats up temperature in advance in 5min P1 is spent, sterilizing operation pause simultaneity factor is alarmed；
    The step S7 includes：Whole system integrally heats up, thus the temperature of the 4th thermometer >=sterilising temp P2 enter it is next Step heating, if in 10min the thermometer of temperature control four temperature ＜ sterilising temp P2, sterilizing operation suspends simultaneity factor Alarm；
    The step S8 includes：Whole system is in temperature constant state, allows the temperature of all thermometers is positive to deviate sterilising temp P2 Critical condition, constant temperature 3min；
    The step S9 includes：Whole system keeps temperature >=sterilising temp P2 of all thermometers, keeps sterilizing 30min, such as Fruit has the temperature ＜ sterilising temp P2 of a thermometer in the process, and system can accumulate once the frequency of failure, frequency of failure ＜ Sterilizing number P3 returns to step S8, if the frequency of failure >=sterilizing number P3 sterilizing operation pause simultaneity factors are alarmed, Continue to run with and jump to step S8, keep keeping 30min in this sterilization process；
    The step S10 includes：Clean compressed air is passed through after air cleaner filters, in the worry shell to first filter Entrained steam carries out air displacement；
    The step S11 includes：Clean compressed air is passed through after air cleaner filters, by injection water inlet and mouth spray Through respirator row's mouth discharge, it is dry that cooling is also carried out while carrying out air displacement to Agitation Tank entrained steam to row's mouth of respirator It is dry；Clean compressed air is passed through after air cleaner filters, is exported and discharged through respirator by injection water inlet and mouth spray, Also the outlet to respirator carries out cool drying while air displacement is carried out to Agitation Tank entrained steam；
    The step S12 includes：Clean compressed air is passed through after air cleaner filters, first filter row's mouth is carried out Dry and purge filter row's P4 times dry mouth time；Clean compressed air is passed through after air cleaner filters, it is right One filter outlet drying time P5 time of purging is dried in first filter outlet；
    The step S13 includes：Clean compressed air is passed through after air cleaner filters, the second filter row's mouth is carried out One filter row's P4 time dry mouth time of purging is dried to divide a word with a hyphen at the end of a line in next step；It is passed through clean compressed air and passes through air cleaner After filtering, the second filter outlet is dried one filter outlet drying time P5 time of purging；
    The step S14 includes：Clean compressed air is passed through after air cleaner filters, Agitation Tank is dried cooling Purging cools temperature P6 in advance until temperature≤tank body of second temperature meter；Clean compressed air is passed through to filter by air cleaner Afterwards, chuck enters cooling water until the final drying temperature P7 of temperature≤tank body of second temperature meter while purging to Agitation Tank；
    The step S15 includes：Clean compressed air is passed through after air cleaner filters, system is inflated and protects malleation, the The pressure of three pressure gauges >=dwell pressure value P8.
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CN107875407A (en) * 2017-12-15 2018-04-06 天津梅花生物医药科技有限公司 A kind of new bulk drug sterile processing systems
CN109364279A (en) * 2018-09-06 2019-02-22 丽珠集团利民制药厂 It is a kind of can online CIP/SIP thimerosal filtration sterilization and cleaning system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN203493950U (en) * 2013-09-28 2014-03-26 大理药业股份有限公司 Sterilization tank for sterilization of astragalus injection intermediate goods
CN204798414U (en) * 2015-06-03 2015-11-25 上海至纯洁净系统科技股份有限公司 Liquid device is joined in marriage in sterilization
CN205549051U (en) * 2016-03-14 2016-09-07 上海东富龙拓溥科技有限公司 Solution preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080006159U (en) * 2007-06-08 2008-12-11 손준영 Reprocessing-Tank affixed Steam Sterilizer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN203493950U (en) * 2013-09-28 2014-03-26 大理药业股份有限公司 Sterilization tank for sterilization of astragalus injection intermediate goods
CN204798414U (en) * 2015-06-03 2015-11-25 上海至纯洁净系统科技股份有限公司 Liquid device is joined in marriage in sterilization
CN205549051U (en) * 2016-03-14 2016-09-07 上海东富龙拓溥科技有限公司 Solution preparation

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