CN114618361A - Full-automatic aseptic liquid preparation system - Google Patents
Full-automatic aseptic liquid preparation system Download PDFInfo
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- CN114618361A CN114618361A CN202210256748.2A CN202210256748A CN114618361A CN 114618361 A CN114618361 A CN 114618361A CN 202210256748 A CN202210256748 A CN 202210256748A CN 114618361 A CN114618361 A CN 114618361A
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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Abstract
The invention discloses a full-automatic sterile liquid preparation system, which belongs to the technical field of bioreactors and comprises a concentration preparation tank, a dilution preparation tank and a connecting pipeline for connecting the concentration preparation tank and the dilution preparation tank, wherein the top end of the concentration preparation tank is communicated with a feeding pipeline, the bottom end of the dilution preparation tank is communicated with a discharging pipeline, the top ends of the concentration preparation tank and the dilution preparation tank are communicated with water vapor pipelines, one end of each water vapor pipeline, which is positioned in the concentration preparation tank and the dilution preparation tank, is provided with a cleaning ball, each water vapor pipeline is respectively and sequentially communicated with the same steam pipeline and a circulating injection pipeline, the top ends of the concentration preparation tank and the dilution preparation tank are communicated with a first auxiliary gas pipeline, and the connecting pipeline and the discharging pipeline are communicated with a second auxiliary gas pipeline and a first auxiliary discharging pipeline. So that the preparation process of the liquid medicine is carried out in a positive pressure closed sterile environment.
Description
Technical Field
The invention belongs to the technical field of bioreactors, and particularly relates to a full-automatic sterile liquid preparation system.
Background
The preparation of the liquid medicine is an indispensable process for the production of a plurality of human therapeutic medicines, particularly sterile preparations, and is also the source of the production of the sterile preparations. Especially for some aseptic products, such as clindamycin phosphate injection, the product can not be subjected to terminal sterilization due to the problem of high-temperature decomposition of the active ingredients, and the product quality can be ensured only by using a complete aseptic process. As a source of an aseptic preparation, the aseptic guarantee capability of a liquid preparation system is very important, the liquid preparation system is required to be capable of online cleaning and online sterilization, the liquid medicine preparation process is carried out in a positive pressure closed aseptic environment, and the liquid preparation system in the prior industry is difficult to meet the requirements of the variety.
Disclosure of Invention
The purpose of the invention is as follows: provides a full-automatic sterile liquid distribution system to solve the problems in the prior art.
The technical scheme is as follows: the full-automatic sterile liquid preparation system comprises a concentration preparation tank, a dilution preparation tank and a connecting pipeline for connecting the concentration preparation tank and the dilution preparation tank, wherein the top end of the concentration preparation tank is connected with a feeding pipeline, the bottom end of the dilution preparation tank is connected with a discharging pipeline, the top ends of the concentration preparation tank and the dilution preparation tank are both connected with a water vapor pipeline, one end of each water vapor pipeline, which is positioned inside the concentration preparation tank and the dilution preparation tank, is provided with a cleaning ball, each water vapor pipeline is respectively and sequentially connected with the same steam pipeline and a circulating injection pipeline, the top ends of the concentration preparation tank and the dilution preparation tank are connected with a second auxiliary gas pipeline, the connecting pipeline and the discharging pipeline are connected with a second auxiliary gas pipeline and a first auxiliary discharge pipeline, each first auxiliary gas pipeline and the second auxiliary gas pipeline are both connected with a main gas pipeline, the bottom ends of the concentration preparation tank and the dilution preparation tank are connected with a second auxiliary discharge pipeline, each second auxiliary discharge pipeline and the second auxiliary discharge pipeline are both connected with a main discharge pipeline, each of the first secondary vent lines communicates with a second secondary gas line.
By adopting the technical scheme, the cleaning liquid circularly flows in the circular injection pipeline, enters the water vapor pipeline and is sprayed out by the cleaning ball, cleaning the tank body and the pipelines, then discharging the cleaning liquid into the main discharge pipeline through the first auxiliary discharge pipeline and the second auxiliary discharge pipeline for discharge, introducing high-temperature steam into the steam pipeline, then discharging the steam pipeline and the cleaning balls, sterilizing the tank body and the pipeline, discharging the steam condensate from the first auxiliary discharge pipeline and the second auxiliary discharge pipeline into the main discharge pipeline for discharge, introducing nitrogen into the main gas pipeline, and then discharging the nitrogen from the first auxiliary gas pipeline and the second auxiliary gas pipeline, the tank body and the pipelines are blown and dried, the pipelines are connected in series and in parallel, the number of the pipelines is effectively reduced, the pipeline cleaning and sterilizing are simple and clear, and all parts can be cleaned and sterilized on line, so that the liquid medicine preparation process is carried out in a positive pressure closed sterile environment.
In a further embodiment, a water pump, a check valve and a first liquid filter are sequentially arranged on the circulating injection pipeline in the direction of the water vapor pipeline, the water pump, the check valve and the first liquid filter are all located at the front end of the water vapor pipeline, and a second diaphragm valve is arranged at the connection end of each water vapor pipeline and the connection end of the water vapor pipeline and the water vapor concentration tank and the connection end of each water vapor pipeline and the water vapor dilution tank.
Through adopting above-mentioned technical scheme, the water pump is with washing liquid pump sending circulation flow in the circulation injection pipeline, and the check valve prevents that the washing liquid from flowing backward this moment to further degerming filters the washing liquid through first liquid filter, improves online cleaning effect.
In a further embodiment, the steam pipeline is sequentially provided with a pressure reducing valve and a second steam trap towards the direction of the steam pipeline, and the pressure reducing valve and the second steam trap are both positioned at the front end of the steam pipeline.
Through adopting above-mentioned technical scheme, through the pressure of relief pressure valve control high-temperature steam input, it is stable to maintain jar pressure, and the second trap can in time discharge the steam condensate water in the steam pipe way when reducing steam consumption.
In a further embodiment, the main gas line is provided with an air filter in the direction of the first secondary gas line.
By adopting the technical scheme, the nitrogen gas is filtered and sterilized through the air filter, so that the nitrogen gas entering the tank body and the pipeline is in an aseptic state, and the tank body and the pipeline are prevented from being polluted by the external environment.
In a further embodiment, a gas pressure gauge and a third diaphragm valve are arranged on the first secondary gas pipeline and the second secondary gas pipeline, each gas pressure gauge is located at the front end of the third diaphragm valve, and each third diaphragm valve is located at the connection end of the first secondary gas pipeline and the concentration tank and the dilution tank and the connection end of the second secondary gas pipeline and the connecting pipeline.
Through adopting above-mentioned technical scheme, monitor the nitrogen gas pressure of the input tank body in with the pipeline through gas pressure table, make things convenient for the staff in time to adjust nitrogen gas pressure, it is stable to maintain the jar pressure, and the effective control nitrogen gas of third diaphragm valve advances volume simultaneously, and is simple and convenient.
In a further embodiment, the outside of the concentration tank and the outside of the dilution tank are both provided with jackets, an inlet and an outlet of each jacket are respectively provided with a first secondary injection pipeline and a second secondary injection pipeline, each first secondary injection pipeline is communicated with the circulation injection pipeline, each second secondary injection pipeline is communicated with the main discharge pipeline, and a first diaphragm valve is arranged at a communication end of each first secondary injection pipeline and the circulation injection pipeline and a communication end of the second secondary injection pipeline and the jackets.
By adopting the technical scheme, high-temperature water or cooling water can be injected into the jacket or discharged from the jacket through the circulating injection pipeline, the first auxiliary injection pipeline, the second auxiliary injection pipeline and the main discharge pipeline, so that the cooling or heating function of materials in the tank body is realized, and the temperature control of the material liquid is automatically completed.
In a further embodiment, the connecting pipeline is sequentially provided with a second liquid filter and a magnetic suspension pump in the direction of the diluting preparation tank, the second liquid filter and the magnetic suspension pump are respectively positioned at the front end and the rear end of the second secondary gas pipeline, and the connecting ends of the connecting pipeline and the concentrating preparation tank and the diluting preparation tank are respectively provided with a fourth diaphragm valve.
Through adopting above-mentioned technical scheme, prevent material transfer in-process contamination with bacteria through the second liquid filter, the fourth diaphragm valve adopts the tilting design simultaneously, and furthest reduces the liquid medicine and remains.
In a further embodiment, a third liquid filter is arranged on the discharge pipeline, a sixth diaphragm valve is arranged at the connection end of the discharge pipeline and the diluting and proportioning tank, the sixth diaphragm valve is positioned at the front end of the third liquid filter, and the discharge pipeline is connected with the filling line.
Through adopting above-mentioned technical scheme, prevent through third liquid filter that the material from infecting with bacteria in ejection of compact process, improve the liquid medicine quality.
In a further embodiment, a fifth diaphragm valve and a first steam trap are sequentially arranged on each of the first auxiliary discharge pipeline and the second auxiliary discharge pipeline towards the main discharge pipeline.
Through adopting above-mentioned technical scheme, can in time discharge first pair of discharge pipe way and the vice discharge pipe way of second with steam condensate water and washing liquid through first trap, improve work efficiency.
In a further embodiment, the support legs of the concentrated preparation tank and the diluted preparation tank are respectively provided with a weigher, and each weigher is electrically connected with the PCL control end.
By adopting the technical scheme, the weight of the liquid medicine in the tank body is measured in real time through the weighing device, and the measured value is synchronized to the PCL control end, so that the liquid medicine preparation accuracy is improved.
In conclusion, the invention has the following beneficial effects:
1. the pipelines are connected in series and in parallel, so that the number of the pipelines is effectively reduced, simplicity and clarity are realized, and all parts can be cleaned and sterilized on line, so that the liquid medicine preparation process is carried out in a positive pressure closed sterile environment.
2. First liquid filter further degerming filters the washing liquid, improves online cleaning performance, and air cleaner nitrogen gas filters the bacterium for the nitrogen gas that gets into in jar body and the pipeline is sterile condition, avoids external environment to cause the pollution to jar body and pipeline.
3. The second liquid filter and the third liquid filter are used for preventing the materials from being contaminated in the transferring process, and meanwhile, the fourth diaphragm valve is designed in an inclined mode, so that the liquid medicine residue is reduced to the maximum extent.
Drawings
Fig. 1 is a schematic structural view of the present invention.
The reference signs are: 1. a concentration tank; 11. a jacket; 12. a feed line; 2. a diluting preparation tank; 3. a circulating injection line; 31. a water pump; 32. a non-return valve; 33. a first liquid filter; 4. a first secondary injection line; 41. a second secondary injection line; 42. a first diaphragm valve; 5. a discharge pipeline; 51. a sixth diaphragm valve; 52. a third liquid filter; 6. a water vapor pipeline; 61. a second diaphragm valve; 62. cleaning the ball; 7. a main gas line; 71. an air filter; 72. a first secondary gas line; 73. a third diaphragm valve; 74. a gas pressure gauge; 75. a second secondary gas line; 8. connecting a pipeline; 81. a fourth diaphragm valve; 82. a second liquid filter; 83. a magnetic suspension pump; 84. a first secondary drain line; 85. a fifth diaphragm valve; 86. a first trap; 9. a main discharge line; 91. a second secondary discharge line; 10. a weighing device; 111. a steam line; 112. a pressure reducing valve; 113. a second trap.
Detailed Description
In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the present invention. It will be apparent, however, to one skilled in the art, that the present invention may be practiced without one or more of these specific details. In other instances, well-known features have not been described in order to avoid obscuring the invention.
Referring to fig. 1, a full-automatic sterile liquid preparation system comprises a concentration preparation tank 1, a dilution preparation tank 2 and a connecting pipeline 8 for connecting the concentration preparation tank 1 and the dilution preparation tank 2, wherein the top end of the concentration preparation tank 1 is connected with a feed pipeline 12, the bottom end of the dilution preparation tank is connected with a discharge pipeline 5, the top ends of the concentration preparation tank 1 and the dilution preparation tank 2 are connected with water vapor pipelines 6, one end of each water vapor pipeline 6, which is positioned inside the concentration preparation tank 1 and the dilution preparation tank 2, is provided with a cleaning ball 62, each water vapor pipeline 6 is respectively connected with a same steam pipeline 111 and a circulating injection pipeline 3 in sequence, the top ends of the concentration preparation tank 1 and the dilution preparation tank 2 are connected with a first auxiliary gas pipeline 72, the connecting pipeline 8 and the discharge pipeline 5 are connected with a second auxiliary gas pipeline 75 and a first auxiliary discharge pipeline 84, each first auxiliary gas pipeline 72 and the second auxiliary gas pipeline 75 are connected with a main gas pipeline 7, the bottom end of the concentration preparation tank 1 and the dilution preparation tank 2 are connected with a second auxiliary discharge pipeline 91, each second auxiliary discharge pipeline 91 and each first auxiliary discharge pipeline 84 are communicated with a main discharge pipeline 9, each first auxiliary discharge pipeline 84 and each second auxiliary gas pipeline 75 are communicated, cleaning liquid circularly flows in the circular injection pipeline 3, at the moment, the cleaning liquid enters the steam pipeline 6 and is sprayed out by the cleaning ball 62 to clean the tank body and the pipelines, then the cleaning liquid is discharged into the main discharge pipeline 9 through the first auxiliary discharge pipeline 84 and the second auxiliary discharge pipeline 91 to be discharged, high-temperature steam enters the steam pipeline 111 and then is discharged out through the steam pipeline 6 and the cleaning ball 62 to sterilize the tank body and the pipelines, steam condensate water is discharged into the main discharge pipeline 9 through the first auxiliary discharge pipeline 84 and the second auxiliary discharge pipeline 91 to be discharged, at the moment, nitrogen enters the main gas pipeline 7 and is then discharged out through the first auxiliary gas pipeline 72 and the second auxiliary gas pipeline 75 to purge and dry the tank body and the pipelines, the pipelines are connected in series and in parallel, so that the number of the pipelines is effectively reduced, simplicity and clarity are realized, and all parts can be cleaned and sterilized on line, so that the liquid medicine preparation process is carried out in a positive pressure closed sterile environment.
As shown in fig. 1, a water pump 31, a check valve 32 and a first liquid filter 33 are sequentially arranged in the direction of the water vapor pipeline 6 of the circulation injection pipeline 3, the water pump 31, the check valve 32 and the first liquid filter 33 are all located at the front end of the water vapor pipeline 6, a second diaphragm valve 61 is arranged at the connection end of each water vapor pipeline 6 and the concentrated tank 1 and the diluted tank 2, the water pump 31 pumps the cleaning liquid into the circulation injection pipeline 3 for circulation flow, at this time, the check valve 32 prevents the cleaning liquid from flowing backwards, and the cleaning liquid is further sterilized and filtered through the first liquid filter 33, so that the online cleaning effect is improved.
As shown in fig. 1, a pressure reducing valve 112 and a second steam trap 113 are sequentially disposed in the steam pipeline 111 towards the steam pipeline 6, the pressure reducing valve 112 and the second steam trap 113 are both located at the front end of the steam pipeline 111, the pressure of the high-temperature steam during input is controlled by the pressure reducing valve 112, the tank pressure is maintained stable, and the second steam trap 113 can discharge the steam condensate water out of the steam pipeline 111 in time while reducing the steam consumption.
As shown in fig. 1, the main gas pipeline 7 is provided with an air filter 71 facing the first secondary gas pipeline 72, and nitrogen gas entering the tank and the pipeline is sterilized by filtering through the air filter 71, so that the tank and the pipeline are protected from being polluted by the external environment.
As shown in fig. 1, a gas pressure gauge 74 and a third diaphragm valve 73 are arranged on the first secondary gas pipeline 72 and the second secondary gas pipeline 75, each gas pressure gauge 74 is respectively located at the front end of the third diaphragm valve 73, each third diaphragm valve 73 is respectively located at the connection end of the first secondary gas pipeline 72 and the enrichment tank 1, the connection end of the dilution tank 2, and the connection end of the second secondary gas pipeline 75 and the connection pipeline 8, the nitrogen pressure input into the tank body and the pipeline is monitored through the gas pressure gauge 74, workers can adjust the nitrogen pressure in time conveniently, the tank pressure is maintained to be stable, and meanwhile, the third diaphragm valve 73 effectively controls the nitrogen inflow, and the operation is simple and convenient.
As shown in fig. 1, jackets 11 are respectively arranged on the outer sides of the concentration tank 1 and the dilution tank 2, an inlet and an outlet of each jacket 11 are respectively provided with a first auxiliary injection pipeline 4 and a second auxiliary injection pipeline 41, each first auxiliary injection pipeline 4 is communicated with the circulation injection pipeline 3, each second auxiliary injection pipeline 41 is communicated with the main discharge pipeline 9, a communication end of each first auxiliary injection pipeline 4 and the circulation injection pipeline 3 and a communication end of each second auxiliary injection pipeline 41 and the jacket 11 are respectively provided with a first diaphragm valve 42, and high-temperature water or cooling water can be injected into the jackets 11 or discharged from the jackets 11 through the circulation injection pipelines 3, the first auxiliary injection pipelines 4, the second auxiliary injection pipelines 41 and the main discharge pipeline 9, so that the cooling or heating function of materials in the tank is realized, and the temperature control of the feed liquid is automatically completed.
As shown in fig. 1, the connecting pipeline 8 is sequentially provided with a second liquid filter 82 and a magnetic suspension pump 83 in a direction toward the diluting preparation tank 2, the second liquid filter 82 and the magnetic suspension pump 83 are respectively located at the front end and the rear end of the second secondary gas pipeline 75, fourth diaphragm valves 81 are respectively arranged at the communicating ends of the connecting pipeline 8, the concentrating preparation tank 1 and the diluting preparation tank 2, contamination during material transfer is prevented through the second liquid filter 82, and meanwhile, the fourth diaphragm valves 81 adopt an inclined design, so that liquid medicine residue is reduced to the maximum extent.
As shown in figure 1, a third liquid filter 52 is arranged on the discharging pipeline 5, a sixth diaphragm valve 51 is arranged at the connection end of the discharging pipeline 5 and the diluting preparation tank 2, the sixth diaphragm valve 51 is positioned at the front end of the third liquid filter 52, the discharging pipeline 5 is connected with a filling line, the third liquid filter 52 prevents materials from being contaminated in the discharging process, and the quality of liquid medicine is improved.
As shown in fig. 1, a fifth diaphragm valve 85 and a first steam trap 86 are sequentially disposed in the first sub-discharge line 84 and the second sub-discharge line 91 toward the main discharge line 9, so that the steam condensate and the cleaning liquid can be timely discharged from the first sub-discharge line 84 and the second sub-discharge line 91 through the first steam trap 86, thereby improving the working efficiency.
As shown in figure 1, the support legs of the concentration tank 1 and the dilution tank 2 are respectively provided with a weighing device 10, each weighing device 10 is electrically connected with the PCL control end, the weight of the liquid medicine in the tank body is measured in real time through the weighing devices 10, and the measured value is synchronized to the PCL control end, so that the liquid medicine preparation accuracy is improved.
The working principle is as follows: cleaning liquid circularly flows in the circulating injection pipeline 3, at the moment, the cleaning liquid enters the water vapor pipeline 6 and is sprayed out by the cleaning ball 62 to clean the tank body, the connecting pipeline 8 and the discharging pipeline 5, then the cleaning liquid is discharged into the main discharging pipeline 9 by the first auxiliary discharging pipeline 84 and the second auxiliary discharging pipeline 91 to be discharged, high-temperature steam enters the steam pipeline 111, then the water vapor pipeline 6 and the cleaning ball 62 are discharged to sterilize the tank body, the connecting pipeline 8 and the discharging pipeline 5, steam condensate water is discharged into the main discharging pipeline 9 by the first auxiliary discharging pipeline 84 and the second auxiliary discharging pipeline 91 to be discharged, at the moment, nitrogen enters the main gas pipeline 7 and is then discharged by the first auxiliary gas pipeline 72 and the second auxiliary gas pipeline 75 to purge and dry the tank body, the connecting pipeline 8 and the discharging pipeline 5, after online cleaning and online sterilization are finished, at the moment, liquid medicine is pumped into the concentrated preparation tank 1 through the feeding pipeline 12, after the preparation is completed, the magnetic suspension pump 83 pumps the liquid medicine to the diluting preparation tank 2 through the connecting pipeline 8, and after the preparation is completed, the liquid medicine is pumped to a filling line through the discharging pipeline for filling.
The preferred embodiments of the present invention have been described in detail with reference to the accompanying drawings, however, the present invention is not limited to the specific details of the embodiments, and various equivalent changes can be made to the technical solution of the present invention within the technical idea of the present invention, and these equivalent changes are within the protection scope of the present invention.
Claims (10)
1. The full-automatic sterile liquid distribution system comprises a concentrated distribution tank (1), a diluted distribution tank (2) and a connecting pipeline (8) for connecting the concentrated distribution tank (1) and the diluted distribution tank (2), and is characterized in that the top end of the concentrated distribution tank (1) is connected with a feeding pipeline (12), the bottom end of the diluted distribution tank is connected with a discharging pipeline (5), the top ends of the concentrated distribution tank (1) and the diluted distribution tank (2) are connected with water vapor pipelines (6), one ends of the water vapor pipelines (6) positioned in the concentrated distribution tank (1) and the diluted distribution tank (2) are provided with cleaning balls (62), the water vapor pipelines (6) are respectively connected with a same steam pipeline (111) and a circulating injection pipeline (3) in sequence, the top ends of the concentrated distribution tank (1) and the diluted distribution tank (2) are connected with a first auxiliary gas pipeline (72), the connecting pipeline (8) and the discharging pipeline (5) are connected with a second auxiliary gas pipeline (75) and a second auxiliary discharging pipeline (84), each it has main gas pipeline (7) all to switch on first vice gas pipeline (72) and the vice gas pipeline of second (75), the jar (1) is joined in marriage with the weak point of joining in marriage jar (2) bottom and has the vice discharge line of second (91), each it has main discharge line (9), each all to switch on the vice discharge line of second (91) and the first pair discharge line (84) first pair discharges pipeline (84) and the switch-on of the vice gas pipeline of second (75).
2. The full-automatic sterile liquid dispensing system according to claim 1, wherein the circulating injection pipeline (3) is sequentially provided with a water pump (31), a check valve (32) and a first liquid filter (33) in a direction towards the steam pipeline (6), the water pump (31), the check valve (32) and the first liquid filter (33) are all positioned at the front end of the steam pipeline (6), and the connection ends of the steam pipeline (6) and the concentration and dilution tanks (1, 2) are respectively provided with a second diaphragm valve (61).
3. The full-automatic sterile liquid distribution system according to claim 1, wherein the steam pipeline (111) is provided with a pressure reducing valve (112) and a second steam trap (113) in sequence towards the steam pipeline (6), and the pressure reducing valve (112) and the second steam trap (113) are both positioned at the front end of the steam pipeline (111).
4. Fully automatic aseptic liquid distribution system according to claim 1, characterized in that said main gas line (7) is provided with an air filter (71) in the direction of the first secondary gas line (72).
5. The full-automatic sterile liquid dispensing system according to claim 1, wherein a gas pressure gauge (74) and a third diaphragm valve (73) are arranged on the first secondary gas pipeline (72) and the second secondary gas pipeline (75), each gas pressure gauge (74) is respectively arranged at the front end of the third diaphragm valve (73), and each third diaphragm valve (73) is respectively arranged at the connection end of the first secondary gas pipeline (72) and the concentration dispensing tank (1), the connection end of the dilution dispensing tank (2) and the connection end of the second secondary gas pipeline (75) and the connection pipeline (8).
6. The full-automatic sterile liquid preparation system according to claim 1, wherein jackets (11) are arranged on the outer sides of the concentrated preparation tank (1) and the diluted preparation tank (2), a first auxiliary injection pipeline (4) and a second auxiliary injection pipeline (41) are respectively arranged at an inlet and an outlet of each jacket (11), each first auxiliary injection pipeline (4) is communicated with the circulating injection pipeline (3), each second auxiliary injection pipeline (41) is communicated with the main discharge pipeline (9), and a first diaphragm valve (42) is arranged at the communication end of each first auxiliary injection pipeline (4) and the circulating injection pipeline (3) and the communication end of each second auxiliary injection pipeline (41) and the jacket (11).
7. The full-automatic sterile liquid dispensing system according to claim 1, wherein the connecting pipeline (8) is sequentially provided with a second liquid filter (82) and a magnetic suspension pump (83) in a direction towards the diluting and dispensing tank (2), the second liquid filter (82) and the magnetic suspension pump (83) are respectively positioned at the front end and the rear end of the second secondary gas pipeline (75), and the connecting ends of the connecting pipeline (8) and the diluting and dispensing tank (2) are respectively provided with a fourth diaphragm valve (81).
8. The full-automatic sterile liquid dispensing system according to claim 1, wherein a third liquid filter (52) is arranged on the discharging pipeline (5), a sixth diaphragm valve (51) is arranged at the connection end of the discharging pipeline (5) and the diluting and dispensing tank (2), the sixth diaphragm valve (51) is positioned at the front end of the third liquid filter (52), and the discharging pipeline (5) is connected with a filling line.
9. A fully automatic aseptic liquid dispensing system according to claim 1, wherein each of said first (84) and second (91) secondary discharge lines is provided, in succession, with a fifth diaphragm valve (85) and a first trap (86) towards the main discharge line (9).
10. The full-automatic sterile liquid preparation system according to claim 1, wherein the support legs of the concentrated preparation tank (1) and the diluted preparation tank (2) are respectively provided with a weigher (10), and each weigher (10) is electrically connected with a PCL control end.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210256748.2A CN114618361A (en) | 2022-03-16 | 2022-03-16 | Full-automatic aseptic liquid preparation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210256748.2A CN114618361A (en) | 2022-03-16 | 2022-03-16 | Full-automatic aseptic liquid preparation system |
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| CN114618361A true CN114618361A (en) | 2022-06-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210256748.2A Pending CN114618361A (en) | 2022-03-16 | 2022-03-16 | Full-automatic aseptic liquid preparation system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115253883A (en) * | 2022-07-28 | 2022-11-01 | 大连大特气体有限公司 | Preparation method of trace gas |
| CN115282842A (en) * | 2022-09-29 | 2022-11-04 | 张家港欧思瑞医疗科技有限公司 | Sterile preparation liquid preparation system with good heat dissipation performance |
-
2022
- 2022-03-16 CN CN202210256748.2A patent/CN114618361A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115253883A (en) * | 2022-07-28 | 2022-11-01 | 大连大特气体有限公司 | Preparation method of trace gas |
| CN115253883B (en) * | 2022-07-28 | 2023-10-24 | 大连大特气体有限公司 | Preparation method of trace gas |
| CN115282842A (en) * | 2022-09-29 | 2022-11-04 | 张家港欧思瑞医疗科技有限公司 | Sterile preparation liquid preparation system with good heat dissipation performance |
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