CN207941404U - A kind of sterile liquid mixing system - Google Patents
A kind of sterile liquid mixing system Download PDFInfo
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- CN207941404U CN207941404U CN201721897248.8U CN201721897248U CN207941404U CN 207941404 U CN207941404 U CN 207941404U CN 201721897248 U CN201721897248 U CN 201721897248U CN 207941404 U CN207941404 U CN 207941404U
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- Prior art keywords
- pipeline
- tank
- aseptic
- pipe line
- discharge pipe
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- 238000002156 mixing Methods 0.000 title claims abstract description 93
- 239000007788 liquid Substances 0.000 title claims abstract description 26
- 238000001914 filtration Methods 0.000 claims abstract description 28
- 230000001954 sterilising effect Effects 0.000 claims abstract description 27
- 238000005070 sampling Methods 0.000 claims abstract description 18
- 238000003860 storage Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000008215 water for injection Substances 0.000 claims abstract description 8
- 238000002347 injection Methods 0.000 claims description 18
- 239000007924 injection Substances 0.000 claims description 18
- 238000010992 reflux Methods 0.000 claims description 15
- 238000011049 filling Methods 0.000 claims description 14
- 239000000498 cooling water Substances 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- 230000004888 barrier function Effects 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 6
- 238000004140 cleaning Methods 0.000 abstract description 4
- 230000036512 infertility Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 239000000047 product Substances 0.000 description 37
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012865 aseptic processing Methods 0.000 description 1
- 229960002291 clindamycin phosphate Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The utility model discloses a kind of sterile liquid mixing systems, including water for injection pipeline, pure steam pipeline, compressed air line, blending tank, aseptic storage tank, discharge pipe line, water for injection pipeline, pure steam pipeline, compressed air line, discharge pipe line are separately connected blending tank and aseptic storage tank.Compared with prior art, the utility model uses compressed-air line to convey power as material, can ensure that the process for preparation of product carries out under positive pressure environment by pressurization in use；Using explosion-proof diaphragm instead of respirator, entire liquid mixing system is made unanimously to be in closed environment；The effect of aseptic filtration is effectively ensured in three-stage filtration；Steam, the medium pipeline that compressed gas etc. influences product quality are provided with sampling valve, can detect public mass of medium；Whole system is concise, easy to operate, and each section energy on-line cleaning, online to sterilize, sterility barrier is very competent, and the sterile product for that can not carry out terminal sterilization provides a kind of extraordinary sterile liquid mixing system.
Description
Technical field
The utility model is related to a kind of liquid mixing system of injection product, especially a kind of sterile liquid mixing system belongs to medicine
Object preparation equipment technical field.
Background technology
Drug solution preparing is that numerous technology personal care drugs especially sterile preparation produces indispensable process and sterile system
The source of agent production.Particularly with certain sterile products, such as Clindamycin phosphate preparations for injection, because there is height in its active ingredient
The problem of temperature is decomposed, product can not carry out terminal sterilization, it is necessary to just can guarantee product quality using complete aseptic processing.As
The sterility barrier ability in the source of sterile preparation, liquid mixing system is most important, needs liquid mixing system being capable of on-line cleaning and online
Sterilizing, and drug solution preparing process carries out in the gnotobasis of positive-pressure closing, and the liquid mixing system in existing industry is difficult full
The requirement of the foot veriety.
Utility model content
The utility model technical issues that need to address are that in view of the above shortcomings of the prior art, and providing one kind can expire
The sterile preparation of sufficient nonterminal sterilising prods, system is succinctly easy to operate, system can on-line cleaning, online sterilizing, drug solution preparing
Process carries out in the gnotobasis of positive-pressure closing, has the sterile liquid mixing system of extremely strong sterility barrier ability.
In order to solve the above technical problems, the technical solution adopted in the utility model is：
A kind of sterile liquid mixing system, including it is water for injection pipeline, pure steam pipeline, compressed air line, blending tank, sterile
Storage tank, discharge pipe line have the first injection pipeline and the second injection pipeline, the pure steam pipeline on the water for injection pipeline
It is upper that there is the first steam pipe line, the second steam pipe line and third steam pipe line, there is first gas in the compressed air line
Pipeline, second gas pipeline and third gas pipeline, the blending tank are equipped with blending tank moisture ingress, refluxing opening, blending tank
Compressed gas entrance, blending tank products export are equipped with blending tank steam pipeline, blending tank vapour pipe on blending tank moisture ingress
Road is connected to the first injection pipeline or the first steam pipe line, and reflux pipeline is equipped on refluxing opening, and compressed gas entrance connects third
Gas line, the aseptic storage tank are equipped with aseptic tank feed inlet, aseptic tank moisture ingress, aseptic tank compressed gas entrance, nothing
Bacterium tank products export is equipped with aseptic tank steam pipeline, the second injection of aseptic tank steam pipeline connection on aseptic tank moisture ingress
Pipeline or third steam pipe line, aseptic tank compressed gas entrance connect first gas pipeline, are equipped on aseptic tank products export
Outlet conduit, outlet conduit one end connect aseptic tank products export, and the other end is provided with filling supply line, outlet conduit connection
Filling supply line or reflux pipeline are provided with aseptic filtration pipe between the blending tank products export and aseptic tank feed inlet
There is on aseptic filtration pipeline line shunting hose, shunting hose to be connected to the second steam pipe line or second gas pipeline, the discharge
One end of pipeline is connected on first gas pipeline, and the other end is floss hole, has the first discharge pipe line, second on discharge pipe line
Discharge pipe line, third discharge pipe line, the first discharge pipe line connect filling supply line, the second discharge pipe line and third discharge pipe line
It is both connected on aseptic filtration pipeline, exhaust condensate pipeline is communicated between discharge pipe line and pure steam pipeline.
Scheme as a further preference, has the first sterilizing filter at the nozzle of the compressed air line, and first
Sterilizing filter is equipped with compressed gas sampling valve；The first gas pipeline be equipped with the first regulator, first pressure gauge,
One end of second sterilizing filter, discharge pipe line is connected on the second sterilizing filter；It is provided on the third gas pipeline
Second regulator and second pressure gauge.
Scheme as a further preference, the aseptic filtration pipeline is from blending tank products export to aseptic tank feed inlet
Direction is disposed with product sampling valve, first filter, shunting hose, the second filter and third filter before filtering.
Scheme as a further preference, on the discharge pipe line successively from the second sterilizing filter to the first discharge pipe line
It is provided with total temperature sensor, total visor, total ball valve, the both ends of total ball valve have been arranged in parallel total drain valve；Described first
The first temperature sensor, the first visor, the first ball valve are provided on discharge pipe line, the both ends of first ball valve have been arranged in parallel
First drain valve；It is provided with second temperature sensor, the second visor, the second ball valve on second discharge pipe line, described second
The both ends of ball valve have been arranged in parallel the second drain valve, and one end of the second discharge pipe line connection aseptic filtration pipeline is two pieces points
Flow tube line, two bypass lines are separately connected the second filter and third filter；Is provided on the third discharge pipe line
The both ends of three-temperature sensor, third visor, third ball valve, the third ball valve have been arranged in parallel third drain valve.
Scheme as a further preference is additionally provided with blending tank pressure gauge, blending tank feed inlet, mixed on the blending tank
The explosion-proof diaphragm of tank, blending tank magnetic stirrer are closed, blending tank chuck is enclosed with around blending tank, is had on blending tank chuck cold
But water water inlet pipe and cooling water outlet pipe.
Scheme as a further preference is additionally provided with aseptic tank pressure gauge, aseptic tank rupture pressure disc on the aseptic storage tank
Piece, aseptic tank magnetic stirrer.
Scheme as a further preference has on the filling supply line and is produced after product sampling valve and filtering after filtering
Product sterilizing filter.
Scheme as a further preference has on the exhaust condensate pipeline steam sampling valve and exhaust condensate pipe hydrophobic
Valve.
Compared with prior art, a kind of sterile liquid mixing system of the utility model, using compressed-air line as material
Power is conveyed, can ensure that the process for preparation of product carries out under positive pressure environment by pressurization in use；Using explosion-proof
Diaphragm makes entire liquid mixing system unanimously be in closed environment instead of respirator；Aseptic filtration is effectively ensured in three-stage filtration
Effect；Steam, the medium pipeline that compressed gas etc. influences product quality are provided with sampling valve, can detect public medium matter
Amount；Whole system is concise, easy to operate, and each section energy on-line cleaning, online to sterilize, sterility barrier is very competent, is
The sterile product that can not carry out terminal sterilization provides a kind of extraordinary sterile liquid mixing system.
Description of the drawings
Fig. 1 is the structural schematic diagram of the utility model；
Wherein, 1- waters for injection pipeline, the first injection pipelines of 11-, the second injection pipelines of 12-, 13- are vented condensate pipeline,
14- steam sampling valves, 15- are vented condensate pipe drain valve, 2- pure steam pipelines, the first steam pipe lines of 21-, the second steam pipes of 22-
Line, 23- third steam pipe lines, 3- compressed air lines, 31- first gas pipelines, 32- second gas pipelines, 33- third gas
Pipeline, the first sterilizing filters of 34-, 35- compressed gas sampling valves, the first regulators of 311-, 312- first pressure gauges, 313-
Second sterilizing filter, the second regulators of 331-, 332- second pressure gauges, 4- blending tank chucks, 41- cooling water inlet pipes,
42- cooling water outlet pipes, 5- blending tanks, 51- blending tank moisture ingress, 52- refluxing openings, 53- blending tank compressed gas entrances,
54- blending tank products exports, 55- blending tank steam pipelines, 56- blending tank pressure gauges, 57- blending tank feed inlets, 58- blending tanks
Explosion-proof diaphragm, 59- blending tank magnetic stirrers, 6- aseptic storage tanks, 61- aseptic tank feed inlets, 62- aseptic tank moisture ingress, 63-
Aseptic tank compressed gas entrance, 64- aseptic tank products exports, 65- aseptic tank steam pipelines, 66- outlet conduits, 67- aseptic tanks
Pressure gauge, the explosion-proof diaphragm of 68- aseptic tanks, 69- aseptic tank magnetic stirrers, 7- aseptic filtration pipelines, 71- shunt hose, 72- mistakes
Product sampling valve, 73- first filters, the second filters of 74-, 75- third filters, 8- discharge pipe lines, 81- first rows before filter
Put pipeline, the second discharge pipe lines of 82-, 83- third discharge pipe lines, 84- total temperature sensors, the total visors of 85-, the total ball valves of 86-,
The total drain valves of 87-, the first temperature sensors of 811-, the first visors of 812-, the first ball valves of 813-, the first drain valves of 814-, 821-
Second temperature sensor, the second visors of 822-, the second ball valves of 823-, the second drain valves of 824-, 831- third temperature sensors,
832- third visors, 833- third ball valves, 834- third drain valves, the filling supply lines of 9-, product sampling valve after 91- filterings,
Product sterilizing filter after 92- filterings, 10- reflux pipelines.
Specific implementation mode
The optimal technical scheme that according to the present invention will be described in detail below with reference to the accompanying drawings.
As shown in Figure 1, a kind of sterile liquid mixing system of the utility model, one kind is for drug, functional food, health care
The sterile preparation system of the sterile products such as product, nursing product, cosmetics production.The non-final of product may be implemented using this system to go out
Bacterium prevents the use of the chemical addition agents such as preservative, and residual quantity of the material in system is greatly reduced, that is, improves product product
Matter and energy conservation and environmental protection；This system eliminate infusion pump in traditional liquid mixing system, on set agitating paddle, respirator, liquid level gauge etc. no
Easily realize the larger component of CIP/SIP, risk hidden danger.Using closed, positive pressure the method for operation, it can be achieved that truly
CIP/SIP and Preservation in sterile condition.The important parameters such as temperature, pressure, weight, pH, time can realize on-line monitoring in use,
Data are true and reliable.Airtight positive pressure operation, air barrier and elimination back pressure apparatus are that present system provides reliably prevent from polluting
Guarantee；
This system includes process pipelines layout, the configuration of various valve members and mounting means, each container between preparing
Structure and design parameter, air barrier and back pressure cancellation element, this system produce non-final sterilising prods, it is micro- an example do not occur
Biology and the exceeded phenomenon of heat source.This system includes mainly water for injection pipeline 1, pure steam pipeline 2, compressed air line 3, mixing
Tank 5, aseptic storage tank 6, discharge pipe line 8 have the first injection pipeline 11 and the second injection pipeline on the water for injection pipeline 1
12, there is on the pure steam pipeline 2 first steam pipe line 21, the second steam pipe line 22 and third steam pipe line 23, the pressure
There is first gas pipeline 31, second gas pipeline 32 and third gas pipeline 33, on the blending tank 5 on contracting gas line 3
Equipped with blending tank moisture ingress 51, refluxing opening 52, blending tank compressed gas entrance 53, blending tank products export 54, blending tank 5 is
The carrier of product supplementary material mixing, is equipped with blending tank steam pipeline 55, blending tank steam pipeline on blending tank moisture ingress 51
55 the first injection pipelines 11 of connection or the first steam pipe line 21, blending tank steam pipeline 55 can be in the first injection pipelines 11 and first
Switch between steam pipe line 21, reflux pipeline 10 is installed on refluxing opening 52, compressed gas entrance 53 connects third gas pipeline
33, the aseptic storage tank 6 is equipped with aseptic tank feed inlet 61, aseptic tank moisture ingress 62, aseptic tank compressed gas entrance 63, nothing
Bacterium tank products export 64, aseptic tank steam pipeline 65 is equipped on aseptic tank moisture ingress 62, and aseptic storage tank 6 is sterile intermediate production
The carrier of product, aseptic tank steam pipeline 65 are connected to the second injection pipeline 12 or third steam pipe line 23, aseptic tank steam pipeline 65
It can switch between the second injection pipeline 12 and third steam pipe line 23, aseptic tank compressed gas entrance 63 connects first gas pipe
Line 31 is equipped with outlet conduit 66 on aseptic tank products export 64, and 66 one end of outlet conduit connects aseptic tank products export 64, separately
One end is provided with filling supply line 9, and outlet conduit 66 is connected to filling supply line 9 or reflux pipeline 10, and outlet conduit 66 can
Switch between filling supply line 9 and reflux pipeline 10, between the blending tank products export 54 and aseptic tank feed inlet 61
It is provided with aseptic filtration pipeline 7, there is shunting hose 71, shunting hose 71 to be connected to the second steam pipe line on aseptic filtration pipeline 7
22 or second gas pipeline 32, shunting hose 71 can switch between the second steam pipe line 22 and second gas pipeline 32, described
One end of discharge pipe line 8 is connected on first gas pipeline 31, and the other end is floss hole 84, has first row on discharge pipe line 8
Pipeline 81, the second discharge pipe line 82, third discharge pipe line 83 are put, the first discharge pipe line 81 connects filling supply line 9, second row
It puts pipeline 82 and third discharge pipe line 83 is both connected on aseptic filtration pipeline 7, connect between discharge pipe line 8 and pure steam pipeline 2
It is connected with exhaust condensate pipeline 13.
There is the first sterilizing filter 34, the first sterilizing filter 34 to be equipped at the nozzle of the compressed air line 3
Compressed gas sampling valve 35；The first gas pipeline 31 is removed equipped with the first regulator 311, first pressure gauge 312, second
One end of bacterium filter 313, discharge pipe line 8 is connected on the second sterilizing filter 313；It is arranged on the third gas pipeline 33
There are the second regulator 331 and second pressure gauge 332.
The aseptic filtration pipeline 7 was disposed with from blending tank products export 54 to the direction of aseptic tank feed inlet 61
Product sampling valve 72, first filter 73, shunting hose 71, the second filter 74 and third filter 75 before filter.
Total moisture content is disposed on the discharge pipe line 8 from 313 to the first discharge pipe line 81 of the second sterilizing filter to pass
The both ends of sensor 88, total visor 85, total ball valve 86, total ball valve 86 have been arranged in parallel total drain valve 87；First discharge
The first temperature sensor 811, the first visor 812, the first ball valve 813, the both ends of first ball valve 813 are provided on pipeline 81
It has been arranged in parallel the first drain valve 814；Second temperature sensor 821, the second visor are provided on second discharge pipe line 82
822, the both ends of the second ball valve 823, second ball valve 823 have been arranged in parallel the second drain valve 824, second discharge pipe line
One end of 82 connection aseptic filtration pipelines 7 is two bypass lines, and two bypass lines are separately connected the second filter 74 and the
Three filters 75；Third temperature sensor 831, third visor 832, third ball valve are provided on the third discharge pipe line 83
833, the both ends of the third ball valve 833 have been arranged in parallel third drain valve 834.
Be additionally provided on the blending tank 5 the explosion-proof diaphragm 58 of blending tank pressure gauge 56, blending tank feed inlet 57, blending tank,
Blending tank magnetic stirrer 59 is enclosed with blending tank chuck 4 around blending tank 5, has cooling water water inlet on blending tank chuck 4
Pipe 41 and cooling water outlet pipe 42, cooling water enter from 4 bottom of chuck, and top outflow, cooling water inlet pipe 41 is connected to chuck 4
Bottom, cooling water outlet pipe 42 are connected to 4 top of chuck, and the burst pressure of the explosion-proof diaphragm of blending tank 58 is 3bar, under blending tank 5
There is support leg in portion, and weighing system is mounted in the support leg.
The explosion-proof diaphragm 68 of aseptic tank pressure gauge 67, aseptic tank, aseptic tank magnetic agitation are additionally provided on the aseptic storage tank 6
The burst pressure of machine 69, the explosion-proof diaphragm of aseptic tank 68 is 3bar, and there is support leg in 6 lower part of aseptic storage tank, is installed in the support leg
Weighing system.
Product sterilizing filter 92 after there is product sampling valve 91 after filtering on the filling supply line 9 and filter.
There is steam sampling valve 14 and exhaust condensate pipe drain valve 15 on the exhaust condensate pipeline 13.
Above-described specific implementation mode, to the purpose of this utility model, technical solution and advantageous effect carried out into
One step is described in detail, it should be understood that the foregoing is merely specific embodiment of the present utility model, is not used to limit
The utility model processed, within the spirit and principle of the utility model, any modification, equivalent substitution, improvement and etc. done,
It should be included within the scope of protection of this utility model.
Claims (8)
1. a kind of sterile liquid mixing system, it is characterised in that：Including water for injection pipeline（1）, pure steam pipeline（2）, compressed gas
Pipeline（3）, blending tank（5）, aseptic storage tank（6）, discharge pipe line（8）, the water for injection pipeline（1）It is upper that there is the first injection-tube
Line（11）With the second injection pipeline（12）, the pure steam pipeline（2）It is upper that there is the first steam pipe line（21）, the second steam pipe line
（22）With third steam pipe line（23）, the compressed air line（3）It is upper that there is first gas pipeline（31）, second gas pipeline
（32）With third gas pipeline（33）, the blending tank（5）It is equipped with blending tank moisture ingress（51）, refluxing opening（52）, mixing
Tank compressed gas entrance（53）, blending tank products export（54）, blending tank moisture ingress（51）On blending tank vapour pipe is installed
Road（55）, blending tank steam pipeline（55）It is connected to the first injection pipeline（11）Or first steam pipe line（21）, refluxing opening（52）On
Reflux pipeline is installed（10）, compressed gas entrance（53）Connect third gas pipeline（33）, the aseptic storage tank（6）It is equipped with
Aseptic tank feed inlet（61）, aseptic tank moisture ingress（62）, aseptic tank compressed gas entrance（63）, aseptic tank products export
（64）, aseptic tank moisture ingress（62）On aseptic tank steam pipeline is installed（65）, aseptic tank steam pipeline（65）Connection second
Injection pipeline（12）Or third steam pipe line（23）, aseptic tank compressed gas entrance（63）Connect first gas pipeline（31）, nothing
Bacterium tank products export（64）On outlet conduit is installed（66）, outlet conduit（66）One end connects aseptic tank products export（64）,
The other end is provided with filling supply line（9）, outlet conduit（66）It is connected to filling supply line（9）Or reflux pipeline（10）, institute
State blending tank products export（54）With aseptic tank feed inlet（61）Between be provided with aseptic filtration pipeline（7）, aseptic filtration pipeline
（7）It is upper that there is shunting hose（71）, shunt hose（71）It is connected to the second steam pipe line（22）Or second gas pipeline（32）, described
Discharge pipe line（8）One end be connected to first gas pipeline（31）On, the other end is floss hole（84）, discharge pipe line（8）Upper tool
There is the first discharge pipe line（81）, the second discharge pipe line（82）, third discharge pipe line（83）, the first discharge pipe line（81）It connects filling
Supply line（9）, the second discharge pipe line（82）With third discharge pipe line（83）It is both connected to aseptic filtration pipeline（7）On, discharge
Pipeline（8）With pure steam pipeline（2）Between be communicated with exhaust condensate pipeline（13）.
2. a kind of sterile liquid mixing system according to claim 1, it is characterised in that：The compressed air line（3）Pipe
There is the first sterilizing filter at mouthful（34）, the first sterilizing filter（34）It is equipped with compressed gas sampling valve（35）；Described
One gas line（31）It is equipped with the first regulator（311）, first pressure gauge（312）, the second sterilizing filter（313）, row
Put pipeline（8）One end be connected to the second sterilizing filter（313）On；The third gas pipeline（33）On be provided with the second tune
Pressure device（331）And second pressure gauge（332）.
3. a kind of sterile liquid mixing system according to claim 1, it is characterised in that：The aseptic filtration pipeline（7）From mixed
Close tank products export（54）To aseptic tank feed inlet（61）Direction be disposed with product sampling valve before filtering（72）, the first mistake
Filter（73）, shunting hose（71）, the second filter（74）With third filter（75）.
4. a kind of sterile liquid mixing system according to claim 1, it is characterised in that：The discharge pipe line（8）On from second
Sterilizing filter（313）To the first discharge pipe line（81）It is disposed with total temperature sensor（88）, total visor（85）, total ball valve
（86）, total ball valve（86）Both ends be arranged in parallel total drain valve（87）；First discharge pipe line（81）On be provided with
First temperature sensor（811）, the first visor（812）, the first ball valve（813）, first ball valve（813）Both ends parallel connection set
It is equipped with the first drain valve（814）；Second discharge pipe line（82）On be provided with second temperature sensor（821）, the second visor
（822）, the second ball valve（823）, second ball valve（823）Both ends be arranged in parallel the second drain valve（824）, described second
Discharge pipe line（82）Connect aseptic filtration pipeline（7）One end be two bypass lines, two bypass lines are separately connected second
Filter（74）With third filter（75）；The third discharge pipe line（83）On be provided with third temperature sensor（831）,
Triple view mirror（832）, third ball valve（833）, the third ball valve（833）Both ends be arranged in parallel third drain valve（834）.
5. a kind of sterile liquid mixing system according to claim 1, it is characterised in that：The blending tank（5）On be additionally provided with
Blending tank pressure gauge（56）, blending tank feed inlet（57）, the explosion-proof diaphragm of blending tank（58）, blending tank magnetic stirrer（59）, mix
Close tank（5）Around be enclosed with blending tank chuck（4）, blending tank chuck（4）It is upper that there is cooling water inlet pipe（41）And cooling water
Outlet pipe（42）.
6. a kind of sterile liquid mixing system according to claim 1, it is characterised in that：The aseptic storage tank（6）On also set up
There is sterile pressure tank table（67）, the explosion-proof diaphragm of aseptic tank（68）, aseptic tank magnetic stirrer（69）.
7. a kind of sterile liquid mixing system according to claim 1, it is characterised in that：The filling supply line（9）Upper tool
There is product sampling valve after filtering（91）With product sterilizing filter after filtering（92）.
8. a kind of sterile liquid mixing system according to claim 1, it is characterised in that：The exhaust condensate pipeline（13）Upper tool
There is steam sampling valve（14）With exhaust condensate pipe drain valve（15）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721897248.8U CN207941404U (en) | 2017-12-29 | 2017-12-29 | A kind of sterile liquid mixing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721897248.8U CN207941404U (en) | 2017-12-29 | 2017-12-29 | A kind of sterile liquid mixing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207941404U true CN207941404U (en) | 2018-10-09 |
Family
ID=63701071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721897248.8U Expired - Fee Related CN207941404U (en) | 2017-12-29 | 2017-12-29 | A kind of sterile liquid mixing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207941404U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107855012A (en) * | 2017-12-29 | 2018-03-30 | 潘林 | A kind of sterile liquid mixing system |
| CN115318171A (en) * | 2022-07-19 | 2022-11-11 | 江苏谷地机械科技有限公司 | Be used for non-terminal sterilization injection equipment of bio-pharmaceuticals and system |
-
2017
- 2017-12-29 CN CN201721897248.8U patent/CN207941404U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107855012A (en) * | 2017-12-29 | 2018-03-30 | 潘林 | A kind of sterile liquid mixing system |
| CN115318171A (en) * | 2022-07-19 | 2022-11-11 | 江苏谷地机械科技有限公司 | Be used for non-terminal sterilization injection equipment of bio-pharmaceuticals and system |
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