CN209253673U - A kind of sterile switching device of biological products liquid mixing system - Google Patents
A kind of sterile switching device of biological products liquid mixing system Download PDFInfo
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- CN209253673U CN209253673U CN201820821317.5U CN201820821317U CN209253673U CN 209253673 U CN209253673 U CN 209253673U CN 201820821317 U CN201820821317 U CN 201820821317U CN 209253673 U CN209253673 U CN 209253673U
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Abstract
The utility model discloses a kind of sterile switching device of biological products liquid mixing system, the sterile switching device of biological products liquid mixing system constitutes as follows: Agitation Tank (1), pure steam pipeline (2), supplementary material pipeline (3), first pressure gauge (4), compressed air line (5), second pressure gauge (6), transfer tube (7), laminar flow protective device (9), the first hose (10), sewage pipe (11), drainage (12), quickly jointed tubular workpieces (13), diaphragm valve (14) and the second hose (15)；Wherein, the first pressure gauge (4) is connected on pure steam pipeline (2), the sterile switching device of the biological products liquid mixing system effectively realizes the online sterilizing and closed conveying of biological products liquid mixing system, greatly reduce pollution risk point and examines, verifying cost, reduce material pollution rate, reducing container transfer, bring is cumbersome and work load, improves production efficiency.
Description
Technical field
The utility model relates to biological products with the design of liquid switching device structure and applied technical field, specifically provide one
The sterile switching device of kind biological products liquid mixing system.
Background technique
Bio-pharmaceuticals be using biotechnology exploitation, research, production drug process, be the except chemical drugs, Chinese medicine
Three big mold of drug development are the development fields that country promotes emphasis.Bio-pharmaceuticals, especially biological products are thin using biology
Born of the same parents, microculture are prepared with the biological products of medical usage, and the outstanding feature of production process and production management is: production ring
Border purity requirements are high, with the presence of virus, germ, biological cell isoreactivity biology, are subject to pollute in process of production, due to
Added value of product is high, if will cause serious economic loss by pollution, so producing each ring to control and reduce as far as possible
Save issuable pollution loss, the production of each process be usually divided into several small control units, with liquid unit also mostly with
Based on small volume receptacle, the disadvantage is that large labor intensity, production efficiency is low, and all kinds of sterilizer configuration scales are big, and face is taken up an area in workshop
Product is big, and energy consumption is high, and operational safety is low.And in biological products production process, raw material prepares workshop and ensures drug quality
First key post is the important control point of quality management, is the material risk source that quality accident occurs.Improve liquid mixing system and
On-line cleaning, sterilizing are horizontal, are the important upgradings of biological products production technology.
A kind of highly desirable sterile switching device for obtaining biological products liquid mixing system that technical effect is excellent of people.
Utility model content
The purpose of the utility model is to provide a kind of sterile switching devices of biological products liquid mixing system.
The sterile switching device of the biological products liquid mixing system constitutes as follows: Agitation Tank 1, pure steam pipeline 2, supplementary material
Pipeline 3, first pressure gauge 4, compressed air line 5, second pressure gauge 6, transfer tube 7, laminar flow protective device 9, the first hose 10,
Sewage pipe 11, drainage 12, quickly jointed tubular workpieces 13, diaphragm valve 14 and the second hose 15；Wherein, the first pressure gauge 4 connects
On pure steam pipeline 2, one end of pure steam pipeline 2 is connected with Agitation Tank 1, one end of supplementary material pipeline 3 and pure steam pipe
Road 2 is connected, and is respectively arranged with diaphragm valve 14 on pure steam pipeline 2 and supplementary material pipeline 3, one end of compressed air line 5 with
Agitation Tank 1 is connected, and is respectively arranged with second pressure gauge 6 and diaphragm valve 14 on compressed air line 5, one end of transfer tube 7 with
Agitation Tank 1 is connected, and the both ends of the first hose 10 pass through quickly jointed tubular workpieces 13 respectively and are connected with transfer tube 7, the first 10 liang of hose
It is respectively arranged with diaphragm valve 14 on the transfer tube 7 at end, when the sterile switching device of biological products liquid mixing system carries out transmission material
When mode works, transfer tube 7 is connected using the first hose 10, qualified preparation liquid is fed to each nothing using pipeline positive pressure
Bacterium operating room point of use, at this point, what is transmitted in transfer tube 7 is qualified preparation liquid.After qualified preparation liquid is transmitted,
It is filled with pure steam by pure steam pipeline 2, after a certain period of time using pure steam pressurization, pressure maintaining, has the function that disinfection.Two rows
Diaphragm valve 14 is respectively arranged on dirty pipe 11, one end of sewage pipe 11 is connected with drainage 12, the other end of sewage pipe 11
It is connected in laminar flow protective device 9 and respectively through quickly jointed tubular workpieces 13 and the second hose 15 with transfer tube 7.The biology
The sterile switching device of product liquid mixing system sterilize online exhaust mode work when, using the second hose 15 connect fastly by two switch
Exhaust pipe of the end respectively with sterilizing pure steam system connects fastly, and check (non-return) valve is arranged on gas exhaust piping, prevents extraneous non-pure air
Flow backward.
The sterile switching device of the biological products liquid mixing system is that the supplementary material between being exclusively used in biological products liquid distributing vehicle is matched
The sterile switching of liquid system feed mode and online sterilizing mode.If guaranteeing the Agitation Tank 1 and feed lines system of liquid mixing system
Reach sterilizing without dead angle, pure steam needs to go out full of whole liquid equipments and material conveying pipe to pressure maintaining when Agitation Tank 1 sterilizes
Pure steam in liquid mixing system is thrown into outdoor after bacterium is up to standard, avoids causing secondary pollution to the environment purification in workshop.Also
It is that the exhaust system to sterilize online is required not only can also thoroughly to disconnect with the seamless sterile docking of liquid mixing system.The biology
The sterile switching device of product liquid mixing system is protected using purification lamina air flow, and hose connects switching fastly, realizes that supplementary material matches liquid system
The material transport model of system is sterile to be switched to online disinfection system exhaust mode, really realizes online sterilizing, improves biological system
Product liquid mixing system and the technical level to sterilize online.
The sterile switching device of the biological products liquid mixing system is arranged suitable volume according to production capacity and process requirements and matches liquid
Tank 1, pure steam pipeline 2, supplementary material pipeline 3, compressed air line 5, transfer tube 7, the first hose 10 and second hose 15 etc. are pure
Steam pressurization, pressure maintaining, exhaust select to determine dwell pressure, time according to verify data, and material is added after steriling test is qualified
It is prepared, then the qualified preparation liquid of real tank sterilizing, inspection is fed to each sterile room using pipeline positive pressure and uses
Point.
The sterile switching of sterile switching device of the biological products liquid mixing system has technical point that Agitation Tank 1 and with liquid
Between fixed -piping sterilized using online pure steam, in the case where A grade laminar flows are protected, the sterile switching of progress transfer tube 7, transfer tube 7 divide
It can not play the role of focusing on washroom washing and sterilizing, package as sterilizing exhaust line and charging line, hose used
It re-uses well.The 316L stainless steel pipe-line system of liquid mixing system and conveying material based on Agitation Tank is arranged in switch terminal
The connection of sanitation-grade hose forms closure feed liquid transportation system using the first hose 10 in feeding.And sterilize exhaust when, disconnect the
One hose 10 is connect fastly using the exhaust pipe that the second hose 15 is connect fastly by two switch terminals respectively with sterilizing pure steam system, is arranged
Check (non-return) valve is set on air pipe, prevents extraneous non-pure air from flowing backward.After sterilizing, hose and gas exhaust piping are disconnected, it is extensive
Multiple first hose 10 forms charging line closure connection, guarantees that system is closed and sterile.
The sterile switching device of the biological products liquid mixing system effectively realizes the online sterilizing of biological products liquid mixing system
And closed conveying, greatly reduce pollution risk point and examine, verifying cost, reduce material pollution rate, reduces container transfer band
The cumbersome and work load come improves production efficiency, improves product quality and controlled level.With more huge economic value
And social value.
Detailed description of the invention
Fig. 1 is that the sterile switching device of biological products liquid mixing system transmits material pattern diagram.
Fig. 2 is that the sterile switching device of biological products liquid mixing system sterilizes exhaust mode schematic diagram online.
Specific embodiment
Embodiment 1
The sterile switching device of the biological products liquid mixing system constitutes as follows: Agitation Tank 1, pure steam pipeline 2, supplementary material
Pipeline 3, first pressure gauge 4, compressed air line 5, second pressure gauge 6, transfer tube 7, laminar flow protective device 9, the first hose 10,
Sewage pipe 11, drainage 12, quickly jointed tubular workpieces 13, diaphragm valve 14 and the second hose 15；Wherein, the first pressure gauge 4 connects
On pure steam pipeline 2, one end of pure steam pipeline 2 is connected with Agitation Tank 1, one end of supplementary material pipeline 3 and pure steam pipe
Road 2 is connected, and is respectively arranged with diaphragm valve 14 on pure steam pipeline 2 and supplementary material pipeline 3, one end of compressed air line 5 with
Agitation Tank 1 is connected, and is respectively arranged with second pressure gauge 6 and diaphragm valve 14 on compressed air line 5, one end of transfer tube 7 with
Agitation Tank 1 is connected, and the both ends of the first hose 10 pass through quickly jointed tubular workpieces 13 respectively and are connected with transfer tube 7, the first 10 liang of hose
It is respectively arranged with diaphragm valve 14 on the transfer tube 7 at end, when the sterile switching device of biological products liquid mixing system carries out transmission material
When mode works, transfer tube 7 is connected using the first hose 10, qualified preparation liquid is fed to each nothing using pipeline positive pressure
Bacterium operating room point of use, at this point, what is transmitted in transfer tube 7 is qualified preparation liquid.After qualified preparation liquid is transmitted,
It is filled with pure steam by pure steam pipeline 2, after a certain period of time using pure steam pressurization, pressure maintaining, has the function that disinfection.Two rows
Diaphragm valve 14 is respectively arranged on dirty pipe 11, one end of sewage pipe 11 is connected with drainage 12, the other end of sewage pipe 11
It is connected in laminar flow protective device 9 and respectively through quickly jointed tubular workpieces 13 and the second hose 15 with transfer tube 7.The biology
The sterile switching device of product liquid mixing system sterilize online exhaust mode work when, using the second hose 15 connect fastly by two switch
Exhaust pipe of the end respectively with sterilizing pure steam system connects fastly, and check (non-return) valve is arranged on gas exhaust piping, prevents extraneous non-pure air
Flow backward.
The sterile switching device of the biological products liquid mixing system is that the supplementary material between being exclusively used in biological products liquid distributing vehicle is matched
The sterile switching of liquid system feed mode and online sterilizing mode.If guaranteeing the Agitation Tank 1 and feed lines system of liquid mixing system
Reach sterilizing without dead angle, pure steam needs to go out full of whole liquid equipments and material conveying pipe to pressure maintaining when Agitation Tank 1 sterilizes
Pure steam in liquid mixing system is thrown into outdoor after bacterium is up to standard, avoids causing secondary pollution to the environment purification in workshop.Also
It is that the exhaust system to sterilize online is required not only can also thoroughly to disconnect with the seamless sterile docking of liquid mixing system.The biology
The sterile switching device of product liquid mixing system is protected using purification lamina air flow, and hose connects switching fastly, realizes that supplementary material matches liquid system
The material transport model of system is sterile to be switched to online disinfection system exhaust mode, really realizes online sterilizing, improves biological system
Product liquid mixing system and the technical level to sterilize online.
The sterile switching device of the biological products liquid mixing system is arranged suitable volume according to production capacity and process requirements and matches liquid
Tank 1, pure steam pipeline 2, supplementary material pipeline 3, compressed air line 5, transfer tube 7, the first hose 10 and second hose 15 etc. are pure
Steam pressurization, pressure maintaining, exhaust select to determine dwell pressure, time according to verify data, and material is added after steriling test is qualified
It is prepared, then the qualified preparation liquid of real tank sterilizing, inspection is fed to each sterile room using pipeline positive pressure and uses
Point.
The sterile switching of sterile switching device of the biological products liquid mixing system has technical point that Agitation Tank 1 and with liquid
Between fixed -piping sterilized using online pure steam, in the case where A grade laminar flows are protected, the sterile switching of progress transfer tube 7, transfer tube 7 divide
It can not play the role of focusing on washroom washing and sterilizing, package as sterilizing exhaust line and charging line, hose used
It re-uses well.The 316L stainless steel pipe-line system of liquid mixing system and conveying material based on Agitation Tank is arranged in switch terminal
The connection of sanitation-grade hose forms closure feed liquid transportation system using the first hose 10 in feeding.And sterilize exhaust when, disconnect the
One hose 10 is connect fastly using the exhaust pipe that the second hose 15 is connect fastly by two switch terminals respectively with sterilizing pure steam system, is arranged
Check (non-return) valve is set on air pipe, prevents extraneous non-pure air from flowing backward.After sterilizing, hose and gas exhaust piping are disconnected, it is extensive
Multiple first hose 10 forms charging line closure connection, guarantees that system is closed and sterile.
The sterile switching device of the biological products liquid mixing system effectively realizes the online sterilizing of biological products liquid mixing system
And closed conveying, greatly reduce pollution risk point and examine, verifying cost, reduce material pollution rate, reduces container transfer band
The cumbersome and work load come improves production efficiency, improves product quality and controlled level.With more huge economic value
And social value.
The sterile switching device of the biological products liquid mixing system, should in certain pharmaceutical factory production of vaccine workshop practical application
The Agitation Tank that 31 cubic metre of item setup, the liquid materials such as preparing normal saline, culture solution are sent to C+B grades of clear production areas
Sterile room, provide safely and effectively process liquid for vaccinogen liquid workshop, and realize the online sterilizing of liquid mixing system.It should
Project operation significant effect, production efficiency are significantly improved, and reduce largely with container, reduce setting for sterilizer
It sets, reduces that container is temporary, cleaning area, the energy consumption of workshop sterilizing, purification air-conditioning is effectively reduced, reduces and matches liquid, cleaning, sterilizing
The personnel in post prepare.While improving the production efficiency, the anti-pollution level for effectively increasing system, reduces systemic contamination
Risk passes through the GMP certification of country.
Claims (1)
1. a kind of sterile switching device of biological products liquid mixing system, it is characterised in that: the sterile of biological products liquid mixing system cuts
Changing device constitutes as follows: Agitation Tank (1), pure steam pipeline (2), supplementary material pipeline (3), first pressure gauge (4), compressed air hose
Road (5), second pressure gauge (6), transfer tube (7), laminar flow protective device (9), the first hose (10), sewage pipe (11), blowdown system
System (12), quickly jointed tubular workpieces (13), diaphragm valve (14) and the second hose (15)；Wherein, the first pressure gauge (4) is connected to pure steaming
On vapor pipeline (2), one end of pure steam pipeline (2) is connected with Agitation Tank (1), one end of supplementary material pipeline (3) and pure steam
Pipeline (2) is connected, and is respectively arranged with diaphragm valve (14), compressed air line on pure steam pipeline (2) and supplementary material pipeline (3)
(5) one end is connected with Agitation Tank (1), and second pressure gauge (6) and diaphragm valve are respectively arranged on compressed air line (5)
(14), one end of transfer tube (7) is connected with Agitation Tank (1), and the both ends of the first hose (10) pass through quickly jointed tubular workpieces (13) respectively
It is connected with transfer tube (7), is respectively arranged with diaphragm valve (14) on the transfer tube (7) at the first hose (10) both ends, two blowdowns
It is respectively arranged with diaphragm valve (14) on pipe (11), one end of sewage pipe (11) is connected with drainage (12), sewage pipe (11)
The other end be located in laminar flow protective device (9) and respectively by quickly jointed tubular workpieces (13) and the second hose (15) and transfer tube (7)
It is connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820821317.5U CN209253673U (en) | 2018-05-30 | 2018-05-30 | A kind of sterile switching device of biological products liquid mixing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820821317.5U CN209253673U (en) | 2018-05-30 | 2018-05-30 | A kind of sterile switching device of biological products liquid mixing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209253673U true CN209253673U (en) | 2019-08-16 |
Family
ID=67555992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820821317.5U Active CN209253673U (en) | 2018-05-30 | 2018-05-30 | A kind of sterile switching device of biological products liquid mixing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209253673U (en) |
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2018
- 2018-05-30 CN CN201820821317.5U patent/CN209253673U/en active Active
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