CN206298582U - A kind of liquid mixing system of continuous liquid supply - Google Patents
A kind of liquid mixing system of continuous liquid supply Download PDFInfo
- Publication number
- CN206298582U CN206298582U CN201621455783.3U CN201621455783U CN206298582U CN 206298582 U CN206298582 U CN 206298582U CN 201621455783 U CN201621455783 U CN 201621455783U CN 206298582 U CN206298582 U CN 206298582U
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- China
- Prior art keywords
- liquid
- agitation tank
- mixing system
- control valve
- continuous
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Abstract
The utility model provides a kind of liquid mixing system of continuous liquid supply, including the first Agitation Tank, the second Agitation Tank, three-way change-over valve, on first Agitation Tank and second Agitation Tank liquid outlet and leakage fluid dram are provided near bottom, connecting tube is installed on the liquid outlet, discharging tube is installed on the leakage fluid dram, two connecting tubes are separately mounted to two entrance points of the three-way change-over valve, the port of export of the three-way change-over valve is provided with drain pipe, and discharge opeing control valve is mounted on two discharging tubes；Feed tube and air filter are mounted on first Agitation Tank and near top on the second described Agitation Tank, liquid inlet control valve and filter are sequentially installed with along liquid flow direction on two feed tubes；By the above-mentioned setting system can on-line cleaning, sterilization, and can be continuous continual to liquid needed for every bioreactor supply.
Description
Technical field
The utility model is related to bio-pharmaceuticals equipment technical field, more particularly to a kind of liquid mixing system of continuous liquid supply.
Background technology
In bio-pharmaceuticals industry, the traditional spinner culture technique of bioreactor culture technique substitution will be as future vaccines
Industry development certainty.The culture feed liquid supplied needed for bioreactor in large-scale production is different from spinner culture, and it needs
Reduction of feed volume it is big, and need to continuously supply, cultivated in supply process the classification of feed liquid, storage, it is aseptic the problems such as all need
Careful research and planning.
In the prior art, traditional operating method by Agitation Tank to bioreactor supply nutrient solution is：With liquid by
The operating personnel of bioreactor each complete, and after liquid is prepared through Stainless Steel tank, bioreactor are directly pushed by handcart
Operation room, then aseptic filtration is in the sterile buffer tank being connected with bioreactor.Each aseptic filtration is required for carrying out
The aseptic connection of pipeline filter, therefore directly increase sterile working risk, the number of times to reduce aseptic filtration then needs to increase number
Individual sterile buffer tank, but larger space can be taken, and because the space of operation room is limited, it is very inconvenient；It is such
It is with liquid, feed liquid way both labor intensive and time and more with liquid batch, also it is unfavorable for aseptic controlling；Giving in addition should match somebody with somebody liquid system
All it is offline during system sterilizing, occurs in sterilization process abnormal, it is impossible to finds in time and correct.
The patent of application number 201620193164.5 discloses a kind of liquid mixing system, including：Agitation Tank, air cleaner, exhale
Haustorium, the first filter, the second filter, first pressure meter, second pressure meter, the 3rd pressure gauge, the first thermometer, the second temperature
Degree meter, the 3rd thermometer, the 4th thermometer and peripheral pipeline；The peripheral pipeline includes:Air feed conduit, pure steam supply
Pipeline, the first transmission pipeline, the second transmission pipeline and the 3rd transmission pipeline, can sterilize online；Above-mentioned patent is only realized
Online sterilizing, and continuous liquid supply can not be realized.
Utility model content
(1) technical problem to be solved
Problem to be solved in the utility model is to provide a kind of liquid mixing system of continuous liquid supply, and the system can be clear online
Wash, sterilization, and can be continuous continual to liquid needed for every bioreactor supply.
(2) technical scheme
To reach above-mentioned purpose, the utility model provides a kind of liquid mixing system of continuous liquid supply, including the first Agitation Tank, the
On two Agitation Tanks, three-way change-over valve, first Agitation Tank and second Agitation Tank liquid outlet and row are provided near bottom
Liquid mouthful, is provided with connecting tube on the liquid outlet, discharging tube is provided with the leakage fluid dram, and two connecting tubes are respectively mounted
In two entrance points of the three-way change-over valve, the port of export of the three-way change-over valve is provided with drain pipe, two discharge opeings
Discharge opeing control valve is mounted on pipe；
Feed tube and air filter are mounted on first Agitation Tank and near top on the second described Agitation Tank,
On two feed tubes liquid inlet control valve and filter are sequentially installed with along liquid flow direction；By the above-mentioned setting system both
Energy on-line cleaning, sterilization, and can be continuous continual to liquid needed for every bioreactor supply.
In further technical scheme, the leakage fluid dram is located at the liquid outlet bottom；The setting can be prevented effectively with liquid
The deposit of pot bottom flows into bioreactor.
In further technical scheme, the filter is twin strainer；This is arranged on when changing clothes filter can be with continuous liquid supply.
In further technical scheme, first Agitation Tank and the second Agitation Tank side are vertically provided with
Liquid level display；The setting can facilitate liquid level inside real time inspection Agitation Tank highly.
In further technical scheme, the three-way change-over valve, discharge opeing control valve, liquid inlet control valve are control manually
Valve.
In further technical scheme, first Agitation Tank and second Agitation Tank are size identical cylinder,
And be made by stainless steel material；Using stainless steel can effectively prevent corrosion prevent pollution.
In further technical scheme, the feed tube, drain pipe, discharging tube, connecting tube are stainless-steel pipe.
(3) beneficial effect
Compared with prior art, the technical solution of the utility model has advantages below：By setting three-way change-over valve, should
System can on-line cleaning, sterilization, and can be continuous continual to liquid needed for every bioreactor supply；Using double
Connection filter, ensure that can be with continuous liquid supply when filter is changed clothes.
Brief description of the drawings
Fig. 1 is a kind of structural representation of the liquid mixing system of continuous liquid supply in the present embodiment 1；
Fig. 2 is a kind of structural representation of the liquid mixing system of continuous liquid supply in the present embodiment 2.
The corresponding component names of each reference are：1. the first Agitation Tank；2. the second Agitation Tank；3. three-way change-over valve；
4. connecting tube；5. discharging tube；6. drain pipe；7. discharge opeing control valve；8. feed tube；9. air filter；10. liquid inlet control valve；11.
Twin strainer；12. liquid level displays；13. integrated manipulators.
Specific embodiment
Embodiment 1
Present embodiment discloses a kind of liquid mixing system of continuous liquid supply, including manual 3, two cylinders of three-way change-over valve
Size is identical, and the first Agitation Tank 1 and the second Agitation Tank 2 being made by stainless steel material, first Agitation Tank 1 and described
Liquid outlet and leakage fluid dram are provided near bottom on second Agitation Tank 2, by being installed by welding with stainless steel on the liquid outlet
The connecting tube 4 of matter, by being installed by welding with the discharging tube 5 of stainless steel on the leakage fluid dram, two connecting tubes 4 are distinguished
Two entrance points of the three-way change-over valve 3 are arranged on by flange, the port of export of the three-way change-over valve 3 is installed by flange
There is the drain pipe 6 of stainless steel, manual discharge opeing control valve 7 is mounted on by flange on two discharging tubes 5；
Stainless steel is mounted on first Agitation Tank 1 and on the second described Agitation Tank 2 in upper end
Feed tube 8 and air filter 9, pass sequentially through flange and are provided with manual to enter on two feed tubes 8 along liquid flow direction
Hydraulic control valve 10 and twin strainer 11.
In order to the deposit for effectively preventing Agitation Tank bottom flows into bioreactor, the leakage fluid dram is located at the liquid outlet
Bottom.
For convenience of the liquid level inside real time inspection Agitation Tank highly, first Agitation Tank 1 and described second matches somebody with somebody liquid
The side of tank 2 is vertically provided with liquid level display 12.
Concrete operations application method is：The liquid mixing system of continuous liquid supply carries out sterilization through pure steam, is turned by threeway
Valve 3 is changed to be isolated the first Agitation Tank 1 and the second Agitation Tank 2.The nutrient solution that will be prepared is through the feed liquor on the first Agitation Tank 1
To in the first Agitation Tank 1, while the second Agitation Tank 2 also make full liquid, startup refrigeration system is to tank body for the control aseptic filtration of valve 10
Insulation, the connection bioreactor of drain pipe 6.After the nutrient solution in the first Agitation Tank 1 has been used, three-way change-over valve is adjusted manually
3 the first Agitation Tanks 1 of isolation, use the liquid in the second Agitation Tank 2.On-line cleaning is carried out to the first Agitation Tank 1, then through first
The discharge opeing control valve 7 of Agitation Tank bottom drains rinse water in tank, therefore can independent online sterilization.So repeatedly, can be continuous
To nutrient solution needed for bioreactor supply.
Embodiment 2
The present embodiment is substantially the same manner as Example 1, as shown in Fig. 2 its difference is described three-way change-over valve 3, discharge opeing
Control valve 7, liquid inlet control valve 10 are motor-operated control valve, concrete mode described three-way change-over valve 3, discharge opeing control valve 7, enter
Hydraulic control valve 10 is all connected to an integrated manipulator 13, and then carrys out the keying of integrated each valve of control.
The above is only preferred embodiment of the present utility model, it is noted that for the common skill of the art
For art personnel, on the premise of the utility model know-why is not departed from, some improvements and modifications can also be made, these change
Enter and retouch also to should be regarded as protection domain of the present utility model.
Claims (7)
1. a kind of liquid mixing system of continuous liquid supply, it is characterised in that：Including the first Agitation Tank (1), the second Agitation Tank (2), threeway
Switching valve (3), liquid outlet and leakage fluid dram are provided with first Agitation Tank (1) and second Agitation Tank (2) near bottom,
Connecting tube (4) is installed on the liquid outlet, discharging tube (5) is installed on the leakage fluid dram, two connecting tubes (4) are respectively
Installed in two entrance points of the three-way change-over valve (3), the port of export of the three-way change-over valve (3) is provided with drain pipe (6),
Discharge opeing control valve (7) is mounted on two discharging tubes (5)；
Feed tube (8) and air are mounted on first Agitation Tank (1) and near top on described the second Agitation Tank (2)
Filter (9), liquid inlet control valve (10) and filter are sequentially installed with two feed tubes (8) along liquid flow direction.
2. the liquid mixing system of continuous liquid supply as claimed in claim 1, it is characterised in that：The leakage fluid dram is located under the liquid outlet
Portion.
3. the liquid mixing system of continuous liquid supply as claimed in claim 1, it is characterised in that：The filter is twin strainer (11).
4. the liquid mixing system of continuous liquid supply as claimed in claim 1, it is characterised in that：First Agitation Tank (1) and described
Two Agitation Tanks (2) side is vertically provided with liquid level display (12).
5. the liquid mixing system of continuous liquid supply as claimed in claim 1, it is characterised in that：The three-way change-over valve (3), discharge opeing control
Valve (7), liquid inlet control valve (10) are hand control valve.
6. the liquid mixing system of continuous liquid supply as claimed in claim 1, it is characterised in that：First Agitation Tank (1) and described
Two Agitation Tanks (2) are size identical cylinder, and are made by stainless steel material.
7. the liquid mixing system of continuous liquid supply as claimed in claim 1, it is characterised in that：The feed tube (8), drain pipe (6), row
Liquid pipe (5), connecting tube are stainless-steel pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621455783.3U CN206298582U (en) | 2016-12-28 | 2016-12-28 | A kind of liquid mixing system of continuous liquid supply |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621455783.3U CN206298582U (en) | 2016-12-28 | 2016-12-28 | A kind of liquid mixing system of continuous liquid supply |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206298582U true CN206298582U (en) | 2017-07-04 |
Family
ID=59205650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621455783.3U Expired - Fee Related CN206298582U (en) | 2016-12-28 | 2016-12-28 | A kind of liquid mixing system of continuous liquid supply |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206298582U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114951193A (en) * | 2022-07-29 | 2022-08-30 | 常州捷佳创精密机械有限公司 | Wafer cleaning equipment and liquid supply method |
-
2016
- 2016-12-28 CN CN201621455783.3U patent/CN206298582U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114951193A (en) * | 2022-07-29 | 2022-08-30 | 常州捷佳创精密机械有限公司 | Wafer cleaning equipment and liquid supply method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yu Zhiyuan Inventor after: Wu Jinan Inventor before: Yu Zhiyuan Inventor before: Wu Xiunan |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170704 Termination date: 20201228 |