CN105535606A - 一种治疗慢性锰中毒植物神经紊乱的药物 - Google Patents
一种治疗慢性锰中毒植物神经紊乱的药物 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性锰中毒植物神经紊乱的药物,其中,包括以下原来药材:枸杞子、山茶花、芜菁花、何首乌、穞豆、八月札、虎尾轮根、苎麻根、羊红膻、黑种草、狮子七、一把伞、广枣、太白参、草苁蓉、地蚕、石斛、蜜环菌、桑椹、长梗排草、黄精、牛尾菜、一点血、黄背草果、防风和黄芪。本发明的有益效果是:本发明治疗慢性锰中毒植物神经紊乱,治疗效果好,通过对基体的调节,达到标本兼治的目的,且安全无毒,预后不具有反复性。
Description
技术领域
本发明涉及中医药领域,尤其涉及一种治疗慢性锰中毒植物神经紊乱的药物。
背景技术
随着我国工业的发展,焊接工艺迅猛发展,焊接种类和焊接技术在不断更新,但在工业生产中电弧焊接仍最为广泛。在电弧焊接时,电焊条和金属母材在3000~6000℃电弧高温下产生大量金属氧化物,以气溶胶状态散发到空气中,经迅速冷凝而形成电焊烟尘。电焊烟尘中含有多种元素,主要有锰、铁等。电焊烟尘的分散度很高,粒径<5μm的呼吸性粉尘占94.2%。电焊烟尘可通过呼吸道等途径进入人体,对健康造成损害。电焊作业场所的电焊尘浓度、锰烟浓度超标现象较为严重,由于电焊作业时作业人员相对不固定,不易安装通风排毒设施,因此电焊烟尘易长时间聚集在作业点环境中,电焊作业人员健康状况令人担忧。电焊工人头昏、头痛、失眠、多梦等神经衰弱症候群的发生率高,其原因可能与锰烟进入人体后对神经系统的影响有关。电焊工的尿锰超标率高。锰在体内排泄较快,生物半减期为40d左右。虽然脱离锰作业,体内已吸收的锰便随之减少,但锰在脑中时间较长,锰可穿透血脑屏障,在脑组织豆状核和小脑中储存量最多。锰中毒主要表现为锥体外系神经障碍,锰对线粒体有特殊亲和力,能大量蓄积在富有线粒体的组织中。锰还使皮质突触、脊髓神经元、周围神经的突触与肌纤维产生不同程度的变性,特别是对大脑皮层下结构,主要是基底节和小脑有选择性作用,使基底神经节的纹状体等组织中儿茶酚胺和5一轻色胺的含量明显降低,从而导致肌张力增加和锰毒性震颤麻痹。
职业性慢性锰中毒是长期接触锰的烟尘所引起的以神经系统改变为主的疾病。早期表现为神经衰弱综合征和植物神经功能紊乱。中毒较明显时,出现锥体外系损害,并可伴有精神症状。严重时可表现为帕金森氏综合征和中毒性精神病。患者表现为头晕、头痛、容易疲乏、睡眠障碍、健忘等神经衰弱综合征的表现,以及肢体疼痛、下肢无力和沉重感,多汗、心悸等植物神经功能紊乱的表现;肌张力增高;肌张力增高虽不肯定,但手指有明显震颤,腱反射亢进;并有容易兴奋、情绪不稳定、对周围事物缺乏兴趣等精神情绪改变。重度中毒表现为:a)明显的锥体外系损害,表现为帕金森氏综合征:四肢肌张力增高,伴有静止性震颤,可引发出齿轮样强直;并可出现对指或轮替试验不灵活、不准确,闭目难立征阳性,言语障碍,或步态异常、后退困难等运动障碍。b)中毒性精神病:有显著的精神情绪改变,如感情淡漠、反应迟钝、不自主哭笑、强迫观念、冲动行为等。等症状。尿锰或发锰超过本地区正常值上限。治疗原则:早期可用金属络合剂如依地酸二钠钙等治疗,并适当给予对症治疗。出现明显的锥体外系损害或中毒性精神病时,治疗原则与神经一精神科相同。
中医慢性锰中毒植物神经紊乱证候情绪不宁、心悸、健忘、失眠、多梦、头晕、头痛、容易疲乏、五心烦热、盗汗、口咽干燥、肢体疼痛、下肢无力和沉重感,舌红少津,脉细数。
西医虽有治疗方法,但是与中医比较,有很多的不足。
发明内容
为了达到上述目的,本发明提供了一种治疗慢性锰中毒植物神经紊乱的药物。
为了达到上述目的,本发明提供了一种治疗慢性锰中毒植物神经紊乱的药物,其中,包括以下原来药材:枸杞子、山茶花、芜菁花、何首乌、穞豆、八月札、虎尾轮根、苎麻根、羊红膻、黑种草、狮子七、一把伞、广枣、太白参、草苁蓉、地蚕、石斛、蜜环菌、桑椹、长梗排草、黄精、牛尾菜、一点血、黄背草果、防风和黄芪。
其中,包括以下质量份数的原料药材:枸杞子10-20重量份、山茶花5-9重量份、芜菁花10-18重量份、何首乌10-20重量份、穞豆8-15重量份、八月札8-13重量份、虎尾轮根10-15重量份、苎麻根6-9重量份、羊红膻8-12重量份、黑种草4-8重量份、狮子七5-8重量份、一把伞10-15重量份、广枣8-13重量份、太白参15-20重量份、草苁蓉15-18重量份、地蚕7-13重量份、石斛4-10重量份、蜜环菌4-8重量份、桑椹10-15重量份、长梗排草8-13重量份、黄精6-12重量份、牛尾菜8-13重量份、一点血5-9重量份、黄背草果10-15重量份、防风8-12重量份和黄芪10-15重量份。
其中,包括以下质量份数的原料药材:枸杞子15重量份、山茶花8重量份、芜菁花16重量份、何首乌16重量份、穞豆12重量份、八月札10重量份、虎尾轮根12重量份、苎麻根7重量份、羊红膻10重量份、黑种草6重量份、狮子七7重量份、一把伞13重量份、广枣10重量份、太白参18重量份、草苁蓉17重量份、地蚕9重量份、石斛8重量份、蜜环菌6重量份、桑椹13重量份、长梗排草10重量份、黄精9重量份、牛尾菜10重量份、一点血7重量份、黄背草果12重量份、防风9重量份和黄芪13重量份。
本发明带来的有益效果是:本发明治疗慢性锰中毒植物神经紊乱,治疗效果好,通过对基体的调节,达到标本兼治的目的,且安全无毒,不具有反复性。
具体实施方式
为了达到上述目的,本发明提供了一种治疗慢性锰中毒植物神经紊乱的药物,其中,包括以下原来药材:枸杞子、山茶花、芜菁花、何首乌、穞豆、八月札、虎尾轮根、苎麻根、羊红膻、黑种草、狮子七、一把伞、广枣、太白参、草苁蓉、地蚕、石斛、蜜环菌、桑椹、长梗排草、黄精、牛尾菜、一点血、黄背草果、防风和黄芪。各味药材,通过科学的配比,达到治疗慢性锰中毒植物神经紊乱的效果。
以下为各种原来药材的药理:
枸杞子:【性味】甘,平。【归经】归肝、肾经。【功能主治】滋补肝肾,益精明目。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,内热消渴,血虚萎黄,目昏不明。
山茶花:【性味】甘苦辛,凉。①《本草经疏》:"味甘而微辛,气平而微寒。"②《本经逢原》:"苦,温,无毒。"③《百草镜》:"味涩。"【归经】①《本草再新》:"入肝、肺二经。"②《本草撮要》:"入足厥阴、手阳明经。"【功能主治】凉血,止血,散瘀,消肿。治吐血,衄血,血崩,肠风,血痢,血淋,跌扑损伤,烫伤。①朱震亨:"吐血、衄血、肠风下血,并用红者为末,入童溺、姜汁及酒调服,可代郁金。"②《纲目》:"汤火伤灼,研末麻油调涂。"③《医林纂要》:"补肝缓肝,破血去热。"
芜菁花:【来源】为十字花科植物芜菁的花或花蕾。【原形态】植物形态详"芜菁"条。【性味】《纲目》:"辛,平,无毒。"【功能主治】《千金方》:"补肝明目。三月采蔓菁花,阴干,治下筛,空心井华水服方寸匕。"
何首乌:【性味】苦甘涩,微温。①《何首乌录》:"味甘,温,无毒。"②《开宝本草》:"味苦涩,微温,无毒。"③《本草汇言》:"生用气寒,性敛,有毒;制熟气温,无毒。"【归经】入肝、肾经。①《纲目》:"足厥阴、少阴。"②《本草经解》:"入足少阳胆经、手少阳三焦经、手少阴心经、足少阴肾经。"③《本草再新》:"入脾、肺、肾三经。"【功能主治】补肝,益肾,养血,祛风。
穞豆:【来源】豆科穞豆,以种子入药。【生境分布】东北、河北、山东。【功能主治】健脾益肾,养阴除烦。主治阴虚烦热,自汗盗汗,风湿痹症。
八月札:【性味】昧微苦,性平。归肝、胃、膀胱经。【归经】肝;胃经【功能主治】疏肝和胃,活血止痛,软坚散结,利小便。主肝胃气滞,脘腹、胁助胀痛,饮食不消,下痢便泄,疝气疼痛,腰痛,经闭痛经,瘿瘤瘰疬,恶性肿瘤。
虎尾轮根:【性味】甘,温。①《广西中药志》:"味甘,性温,无毒。"②《泉州本草》:"味苦微辛,性涩而平。"【归经】入肺、胃、肾三经。①《广西中药志》:"入肺、胃二经。"②《泉州本草》:"入肝、肾、心、肺诸经。"【功能主治】理气,化痰,益肾。治心胃气痛,痰饮咳嗽,肾虚遗精。①《广西中药志》:"行气止痛,逐痰化饮。治心胃气痛,痰饮咳嗽。"②《泉州本草》:"益肾滋肝。治肾虚遗精。"
苎麻根:【来源】为荨麻科植物苎麻的根。冬春季采挖,洗净,晒干。【性味】性寒,味甘。【功能主治】清热利尿,安胎止血,解毒。用于感冒发热、麻疹高烧、尿路感染、肾炎水肿、孕妇腹痛、胎动不安、先兆流产、跌打损伤、骨折、疮疡肿痛、出血性疾病。
羊红膻:【来源】药材基源:为伞形科植物缺刻叶茴芹的根或全草。【性味】味甘;辛;性温。【功能主治】健脾益气;养心安神;止咳祛痰。主克山病;心改建;气短;咳喘。
黑种草:【来源】毛茛科黑种草,以种子入药。【生境分布】新疆。【性味】辛,热。【功能主治】补脑肾,通经,通乳,利尿。主治尿道结石,肾结石,耳鸣,乳汁缺少,闭经,白癫疯,疮疥。
狮子七:【来源】景天科红景天属植物狭叶红景天,以根状茎及根入药。草春或秋末采,除去须根及泥土,晒干。【性味】涩,温。【功能主治】止血化瘀,调经,固涩。用于跌打损伤,腰痛,吐血,崩漏,月经不调,白带,痢疾。
一把伞:【来源】药材基源:为真藓科植物暖地大叶藓的植物体。【性味】辛;苦;平。【功能主治】养心安神;清肝明目。主心悸怔忡;神经衰弱;目赤肿痛;冠心病;高血压等。
广枣:【来源】本品系蒙古族习用药材。为漆树科植物南酸枣的干燥成熟果实。秋季果实成熟时采收,除去杂质,干燥。【性味】甘、酸,平。【功能主治】行气活血,养心,安神。用于气滞血瘀,胸痹作痛,心悸气短,心神不安。
太白参:【性味】《北方常用中草药手册》:"甘微苦,温。"【功能主治】①《北方常用中草药手册》:"补虚,健脾胃,消炎止痛。"②《陕西中草药》:"滋阴补肾,补中益气,健脾和胃。治身体虚弱,肾虚骨蒸潮热,关节疼痛,不思饮食。"
草苁蓉:【性味】味甘;咸;性温。【功能主治】补肾壮阳;润肠通便;止血。主肾虚阳痿;遗精;腰膝冷痛;小梗遗沥;尿血;宫冷不孕;带下;崩漏;肠燥便移民。
地蚕:【来源】唇形科水苏属植物地蚕,以块茎入药。秋季采,洗净鲜用或蒸熟晒干。【性味】甘,平。【功能主治】益肾润肺,滋阴补血,清热除烦。用于肺结核咳嗽,肺虚气喘,吐血,盗汗,贫血,小儿疳积。
石斛:【性味】甘,微寒。【归经】归胃、肾经。【功能主治】益胃生津,滋阴清热。用于阴伤津亏,口干烦渴,食少干呕,病后虚热,目暗不明。
蜜环菌:【来源】药材基源:为白蘑科真菌假蜜环菌的子实体。【性味】甘;平。【归经】肝经。【功能主治】熄风平肝;祛风通络;强筋壮骨。主头晕;头痛;失眠;四肢麻木;腰腿疼痛;冠心病;高血压;血管性头痛;眩晕综合征;癫痫。
桑椹:【来源】本品为桑科植物桑的干燥果穗。4~6月果实变红时采收,晒干,或略蒸后晒干。【性味】甘、酸,寒。【归经】归心、肝、肾经。【功能主治】补血滋阴,生津润燥。用于眩晕耳鸣,心悸失眠,须发早白,津伤口渴,内热消渴,血虚便秘。
长梗排草:【来源】药材基源:为报春花科植物长梗过路黄的全草。【性味】甘;性平。【功能主治】熄风定惊;收敛止血。主小儿惊风;肺痨咯血;刀伤出血。。
黄精:【性味】甘,平。【归经】归脾、肺、肾经。【功能主治】补气养阴,健脾,润肺,益肾。用于脾胃虚弱,体倦乏力,口干食少,肺虚燥咳,精血不足,内热消渴。
牛尾菜:【来源】百合科菝葜属植物牛尾菜,以根及根状茎入药。夏季采,洗净切片,晒干。【性味】甘、苦,平。【功能主治】祛风活络,祛痰止咳。用于风湿性关节炎,筋骨疼痛,跌打损伤,腰肌劳损,支气管炎,肺结核咳嗽咯血。
一点血:【来源】为秋海棠科秋海棠属植物网脉秋海棠,以根茎入药。秋季采挖根状茎。【性味】甘、苦,平。【功能主治】补气健脾,养血、止血。病后虚弱,咳嗽咯血,功能性子宫出血,白带。
黄背草果:【来源】药材基源:为禾本科植物黄背草的果实。【性味】味甘;性平。【功能主治】固表敛汗。
防风:【性味】辛、甘,温。【归经】归膀胱、肝、脾经。【功能主治】解表祛风,胜湿,止痉。用于感冒头痛,风湿痹痛,风疹瘙痒,破伤风。
黄芪:【性味】甘,温。【归经】归肺、脾经。【功能主治】补气固表,利尿托毒,排脓,敛疮生肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难溃,久溃不敛,血虚痿黄,内热消渴;慢性肾炎蛋白尿,糖尿病。
本发明优选的仅包括以上原料药材。
以下采用实施例来详细说明本发明的实施方式,借此对本发明如何应用技术手段来解决技术问题,并达成技术效果的实现过程能充分理解并据以实施。
实施例1
配方:枸杞子10g、山茶花5g、芜菁花10g、何首乌10g、穞豆8g、八月札8g、虎尾轮根10g、苎麻根6g、羊红膻8g、黑种草4g、狮子七5g、一把伞10g、广枣8g、太白参15g、草苁蓉15g、地蚕7g、石斛4g、蜜环菌4g、桑椹10g、长梗排草8g、黄精6g、牛尾菜8g、一点血5g、黄背草果10g、防风8g和黄芪10g。
制备方法:
第一步,将所述各原料药材按比例混合,加入相对于混合物质量3倍的醇浓度为90%的乙醇,加热回流2小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量2倍的醇浓度为90%的乙醇,加热回流2小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1小时,粉碎,过筛,获得350目的超微细粉;
第三步,将第二步获得的超微细粉,加入相对于其质量0.2倍的微晶纤维素、0.1倍乳糖、0.2倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.01倍硬脂酸镁,整粒,压片,制成片剂。
实施例2
配方:枸杞子20g、山茶花9g、芜菁花18g、何首乌20g、穞豆15g、八月札13g、虎尾轮根15g、苎麻根9g、羊红膻12g、黑种草8g、狮子七8g、一把伞15g、广枣13g、太白参20g、草苁蓉18g、地蚕13g、石斛10g、蜜环菌8g、桑椹15g、长梗排草13g、黄精12g、牛尾菜13g、一点血9g、黄背草果15g、防风12g和黄芪15g。
制备方法:
第一步,将所述各原料药材按比例混合,加入相对于混合物质量3倍的醇浓度为90%的乙醇,加热回流2小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量2倍的醇浓度为90%的乙醇,加热回流2小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎2小时,粉碎,过筛,获得350目的超微细粉;
第三步,在第二步获得的超微细粉中依次加入滑石粉、硬脂酸镁,进行混匀处理,即得胶囊内容物;所述超微细粉、硬脂酸镁和滑石粉的重量比为100∶0.2:0.2,将所述胶囊内容物装入胶囊壳体中,即得胶囊剂。
实施例3
配方:枸杞子15g、山茶花8g、芜菁花16g、何首乌16g、穞豆12g、八月札10g、虎尾轮根12g、苎麻根7g、羊红膻10g、黑种草6g、狮子七7g、一把伞13g、广枣10g、太白参18g、草苁蓉17g、地蚕9g、石斛8g、蜜环菌6g、桑椹13g、长梗排草10g、黄精9g、牛尾菜10g、一点血7g、黄背草果12g、防风9g和黄芪13g。
制备方法:
第一步,将所述原料药材按比例混合,放入超微粉碎机中粉碎成1μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率为98%;
第二步,在第一步获得的混合粉料中加入相对于所述混合粉料的质量4倍的醇浓度为90%的乙醇,搅拌溶解获得乙醇溶液,将乙醇溶液在7℃的条件下静置24小时,采用渗漉法以每分钟2ml的速度缓缓渗漉,收集渗漉液,浓缩并干燥,并在此放入超微粉碎机中粉碎50分钟,获得1μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率为98%;
第三步,取第二步获得的混合粉料2g,加入氯化钠95g,加1000ml注射用水,搅拌使其溶解;加注射用水至10000ml;用0.23μm微孔滤膜过滤;分装灌封,每瓶250ml,灭菌即可得到注射液剂。
药物的毒性试验
①急性毒性试验:以本发明实施例1的片剂为对象,临床日用量的150倍给白鼠大肠内投药,观察7日。结果所有动物健存,其活动、饮食、毛发、排泄物未发现异常,未见毒性反应。对白鼠阴道和破损皮肤进行刺激性试验,未见有刺激性反应和其它不良反应。毒性试验证明,本药物没有毒性作用和不良反应,临床应用安全可靠。
②蓄积毒性试验:选用20只健康小白鼠,雌、雄各10只,以本发明实施例2的胶囊剂为对象,剂量设计每5天为一期,每期剂量分别为0.10LD50、0.15LD50、0.22LD50、0.34LD50、0.50LD50,此样品的雌性、雄性小鼠的LD50均为5000m份/k份BW(五个剂量为500、750、1100、1700、2500m份/k份BW)。每5天称体重一次,调整给药量,按0.1ml/10份BW经口灌胃。20天后,动物无死亡情况发生,试验结束,按递增剂量给受试物20天后,雌性、雄性动物均无死亡情况发生。说明本发明的药物,不具有蓄积毒性。
临床试验
病例选择:选择2014年5月-2015年3月期间,某医院诊治的慢性锰中毒植物神经紊乱的患者共200例。其中,男104例,女96例,工龄3-30年不等,随机分为四组,每组50人,实施例1组、实施例2组、实施例3组和对照组。四组患者在年龄、性别、病情轻重方面比较差异无统计学意义,具有可比性,并根据病情的轻重门诊治疗。
诊断标准:
情绪不宁、心悸、健忘、失眠、多梦、头晕、头痛、容易疲乏、五心烦热、盗汗、口咽干燥、肢体疼痛、下肢无力和沉重感,舌红少津,脉细数。
治疗方法:
实施例1组:本组50例使用本发明的实施例1的片剂进行治疗。每次1片,一日3次,5天为一个疗程,治疗进行2-4个疗程。
实施例2组:本组50例使用本发明的实施例2的胶囊剂进行治疗。每次1粒,一日3次,5天为一个疗程,治疗进行2-4个疗程。
实施例3组:本组50例使用本发明的实施例3的注射液剂进行治疗。每次肌肉注射250ml,一日1次,5天为一个疗程,治疗进行2-4个疗程。
对照组:本组50例采用依地酸二钠钙进行治疗。用EDTA0.5~1.0g加入5%葡萄糖液250ml中静脉滴注,每天一次,分别治疗2~11次,平均(5.8±2.8)次。EDTA总剂量为2.0~12.0g,5天为一个疗程,治疗进行1-4个疗程。
疗效评定
显著好转:症状明显减轻;好转:症状减轻;无效:症状未改善。
治疗结果
表1为各组的治疗情况对比
组别 | 显著好转 | 好转 | 无效 |
实施例1组 | 42(84%) | 8(16%) | 0(0%) |
实施例2组 | 44(88%) | 6(12%) | 0(0%) |
实施例3组 | 47(94%) | 3(6%) | 0(0%) |
对照组 | 14(28%) | 17(34%) | 19(38%) |
由表1可以看出,三个实施例组的治疗效果都很好,由此可知,本发明的药物,在治疗慢性锰中毒植物神经紊乱,治疗效果好,疗效确切。
表2为各组的复发以及副作用对比(毒副作用率=副作用人数/总人数,复发率=复发人数/明显好转人数)
组别 | 毒副作用发生率 | 复发率 |
实施例1组 | 0(0%) | 0(0%) |
实施例2组 | 0(0%) | 0(0%) |
实施例3组 | 0(0%) | 0(0%) |
对照组 | 5(10%) | 2(13%) |
由表2可以看出,本发明的药物治疗慢性锰中毒植物神经紊乱,没有毒副作用,不复发。
典型病例:山东省立医院接受诊治过的一患者,男,43岁,从事电弧焊工作已有8年之久,由此身体虚弱,出现以下症状:情绪不宁、心悸、健忘、失眠、多梦、头晕、头痛、容易疲乏、五心烦热、盗汗、口咽干燥、肢体疼痛、下肢无力和沉重感,舌红少津,脉细数。诊断为慢性锰中毒植物神经紊乱。使用本发明的实施例3的注射液剂进行治疗。每次肌肉注射250ml,一日1次,5天为一个疗程,治疗进行3个疗程明显好转。治疗过程中,未出现其他不良反应,后期跟进半年,未复发。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (3)
1.一种治疗慢性锰中毒植物神经紊乱的药物,其特征在于,包括以下原来药材:枸杞子、山茶花、芜菁花、何首乌、穞豆、八月札、虎尾轮根、苎麻根、羊红膻、黑种草、狮子七、一把伞、广枣、太白参、草苁蓉、地蚕、石斛、蜜环菌、桑椹、长梗排草、黄精、牛尾菜、一点血、黄背草果、防风和黄芪。
2.根据权利要求1所述的治疗慢性锰中毒植物神经紊乱的药物,其特征在于,包括以下质量份数的原料药材:枸杞子10-20重量份、山茶花5-9重量份、芜菁花10-18重量份、何首乌10-20重量份、穞豆8-15重量份、八月札8-13重量份、虎尾轮根10-15重量份、苎麻根6-9重量份、羊红膻8-12重量份、黑种草4-8重量份、狮子七5-8重量份、一把伞10-15重量份、广枣8-13重量份、太白参15-20重量份、草苁蓉15-18重量份、地蚕7-13重量份、石斛4-10重量份、蜜环菌4-8重量份、桑椹10-15重量份、长梗排草8-13重量份、黄精6-12重量份、牛尾菜8-13重量份、一点血5-9重量份、黄背草果10-15重量份、防风8-12重量份和黄芪10-15重量份。
3.根据权利要求1或2所述的治疗慢性锰中毒植物神经紊乱的药物,其特征在于,包括以下质量份数的原料药材:枸杞子15重量份、山茶花8重量份、芜菁花16重量份、何首乌16重量份、穞豆12重量份、八月札10重量份、虎尾轮根12重量份、苎麻根7重量份、羊红膻10重量份、黑种草6重量份、狮子七7重量份、一把伞13重量份、广枣10重量份、太白参18重量份、草苁蓉17重量份、地蚕9重量份、石斛8重量份、蜜环菌6重量份、桑椹13重量份、长梗排草10重量份、黄精9重量份、牛尾菜10重量份、一点血7重量份、黄背草果12重量份、防风9重量份和黄芪13重量份。
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吴维城: "《吴灼燊医论医案选析》", 31 August 2011, 中医古籍出版社 * |
方浿敏等: "《劳动保护工作指南》", 30 June 1999, 原子能出版社 * |
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