CN105535589A - 一种降血压胶囊及其制备方法 - Google Patents

一种降血压胶囊及其制备方法 Download PDF

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CN105535589A
CN105535589A CN201510992012.1A CN201510992012A CN105535589A CN 105535589 A CN105535589 A CN 105535589A CN 201510992012 A CN201510992012 A CN 201510992012A CN 105535589 A CN105535589 A CN 105535589A
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周琪
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Abstract

本发明涉及一种降血压胶囊及其制备方法，该降血压胶囊囊心由玉米须、葛根、决明子、苦丁茶、绞股蓝、山楂、菊花、三七叶、枸杞按特定的比例配制而成。先将各原料浸泡、煎煮、加热浓缩至膏状；加入淀粉、乙醇，过筛制成软材颗粒，溶于明胶水溶液，制备出微胶囊。该降血压胶囊由中草药配制而成，无毒、无副作用，缓释性能好，而且容易防止芯材药物受潮。

Description

一种降血压胶囊及其制备方法
技术领域
本发明属于医疗药品微胶囊制备领域，特别涉及一种降血压微胶囊及其制备方法。
背景技术
目前，心血管疾病是危害人类健康的头号杀手，全世界每年约有1300万人死于心血管疾病。2006年，卫生部发布了我国第一部心血管疾病的报告，揭示出我国心血管疾病的危险因素呈明显增长的态势。高血糖、高血脂、高血压逐渐成为威胁人类健康的三大杀手，并呈现年轻化的趋势，已经严重影响了人们的生活质量。
高血压是心血管疾病之一，严重威胁着人们的生命和健康。血液从心脏流经血管到达全身各处时对血管壁产生的压力，叫做血压。某些人血液不能很容易地通过全身，病变使血管变狭窄了，血流的压力就会升高以保证血流通过。这样一来，动脉血压超过正常值就形成了高血压。日常我们可以通过合理饮食、锻炼，服用降压药等有利于降压的小偏方等达到预防、治疗高血压的目的。
目前市场上长期使用的降血压药物，会使人产生依赖性，必须长期服用，且给身体带来副作用。
发明内容
本发明的目的是克服现有技术的不足，提供一种用于降血压的保健胶囊及其制备方法，制备了一种由中草药配制而成，无毒、无副作用，能够辅助降血压的微胶囊，本发明采用的技术方案是：提供了一种降血压微胶囊，囊壁为明胶，囊芯的组成按重量份数计为：玉米须30～50份，葛根10～20份，决明子3～10份，苦丁茶8～15份，绞股蓝3～10份，山楂8～20份，菊花5～7份，三七叶3～5份，枸杞6～8份。
作为优选：其中，玉米须40份，葛根15份，决明子8份，苦丁茶9份，绞股蓝5份，山楂15份，菊花6份，三七叶4份，枸杞8份。
本发明还提供了一种降血压胶囊的制备方法，具体操作为(下述的“倍量”均是指质量倍数)：
(1)原料配制：按重量比称取原料玉米须、葛根、决明子、苦丁茶、绞股蓝、山楂、菊花、三七叶、枸杞，放入提取器内搅拌混合均匀，加入5～15倍量的水浸泡30分钟；
(2)高温浸提及过滤：加热煎煮步骤(1)中配制好的原料2～3小时，滤取煎液，其渣再加入5～10倍量的水，加热煎煮1.5～2小时，滤取煎液，再往其渣加入3～5倍量的水，加热煎煮1～1.5小时，过滤后合并这三次所得滤液；
(3)加热浓缩：将步骤(2)最后所得的滤液，加热浓缩至膏状，使水分含量降至28～31％；
(4)制成软材：将步骤(3)所得的膏，加入2.5～3.5倍体积的淀粉，搅拌均匀，然后再加入体积比占70～90％的乙醇，搅拌成均匀的软材；
(5)成粒干燥：将步骤(4)得到的软材，经20目筛制成颗粒，再将所得颗粒于60～90℃通风均匀干燥；
(6)微胶囊的制备：采用乳液法，将步骤(5)中的药物颗粒包覆在明胶微胶囊中，具体为，在35～65℃条件下，将0.2～0.75份步骤(5)中的药物颗粒，溶于16.5～28份的明胶水溶液中，再加入1～4.5份的吐温-80，搅拌均匀形成混合液；再将上述混合液加入到70～85份的温度为40～70℃的豆油中，形成油包水型乳液，在此温度下搅拌2～5小时，冷却至5～30℃，滴加入戊二醛溶液，引起相分离凝聚，搅拌30～60分钟，升温或降温至室温，搅拌3～6小时，收集得到降血压胶囊。
胶水溶液中，明胶质量含量为10～30％；戊二醛溶液中，戊二醛质量含量为5～25％。
本发明的有益效果在于：在降血压中药外面包覆了明胶微胶囊，不但改善了中药的口感，而且延长了降血压的药效，也可以药物吸潮，利于储存。
具体实施方式
实施例1：
本实施例中，囊芯部分的降血压药物的组成，按重量份数计为：玉米须30份，葛根10份，决明子5份，苦丁茶15份，绞股蓝3份，山楂8份，菊花5份，三七叶3份，枸杞6份。
降血压胶囊的制备方法如说明书部分所示。
实施例2：
本实施例中，囊芯部分的降血压药物的组成，按重量份数计为：玉米须40份，葛根15份，决明子8份，苦丁茶9份，绞股蓝5份，山楂15份，菊花6份，三七叶4份，枸杞8份。
降血压胶囊的制备方法如说明书部分所示。
实施例3
本实施例中，囊芯部分的降血压药物的组成，按重量份数计为：玉米须50份，葛根20份，决明子10份，苦丁茶8份，绞股蓝10份，山楂20份，菊花7份，三七叶5份，枸杞7份。
降血压胶囊的制备方法如说明书部分所示。

Claims (5)

1.一种降血压胶囊，其特征在于：所述的降血压胶囊中，囊壁为明胶，囊芯的组成，按重量份数计为，玉米须30～50份，葛根10～20份，决明子3～10份，苦丁茶8～15份，绞股蓝3～10份，山楂8～20份，菊花5～7份，三七叶3～5份，枸杞6～8份。
2.如权利要求1所述的降血压胶囊，其特征在于：所述的降血压胶囊中，囊壁为明胶，囊芯的组成，按重量份数计为，玉米须40份，葛根15份，决明子8份，苦丁茶9份，绞股蓝5份，山楂15份，菊花6份，三七叶4份，枸杞8份。
3.如权利要求1或2所述的降血压胶囊的制备方法，其特征在于：所述的降血压胶囊的制备方法为：
(1)原料配制：按重量比称取原料，玉米须、葛根、决明子、苦丁茶、绞股蓝、山楂、菊花、三七叶、枸杞，放入提取器内搅拌混合均匀，加入5～15倍量的水浸泡30分钟；
(2)高温浸提及过滤：加热煎煮步骤(1)中配制好的原料2～3小时，滤取煎液，其渣再加入5～10倍量的水，加热煎煮1.5～2小时，滤取煎液，再往其渣加入3～5倍量的水，加热煎煮1～1.5小时，过滤后合并这三次所得滤液；
(3)加热浓缩：将步骤(2)最后所得的滤液，加热浓缩至膏状，使水分含量降至28～31％；
(4)制成软材：将步骤(3)所得的膏，加入2.5～3.5倍体积的淀粉，搅拌均匀，然后再加入体积比占70～90％的乙醇，搅拌成均匀的软材；
(5)成粒干燥：将步骤(4)得到的软材，经20目筛制成颗粒，再将所得颗粒于60～90℃通风均匀干燥；
(6)微胶囊的制备：采用乳液法，将步骤(5)中的药物颗粒包覆在明胶微胶囊中，具体为，在35～65℃条件下，将0.2～0.75份步骤(5)中的药物颗粒，溶于16.5～28份的明胶水溶液中，再加入1～4.5份的吐温-80，搅拌均匀形成混合液；再将上述混合液加入到70～85份的温度为40～70℃的豆油中，形成油包水型乳液，在此温度下搅拌2～5小时，冷却至5～30℃，滴加入戊二醛溶液，引起相分离凝聚，搅拌30～60分钟，升温或降温至室温，搅拌3～6小时，收集得到降血压胶囊。
4.如权利要求3所述的降血压胶囊的制备方法，其特征在于：步骤(6)中所述的明胶水溶液中，明胶质量含量为10～30％。
5.如权利要求3所述的降血压胶囊的制备方法，其特征在于：步骤(6)中所述的戊二醛溶液中，戊二醛质量含量为5～25％。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106362142A (zh) * 2016-10-28 2017-02-01 武汉庄守和生物科技有限公司 一种可以降低血压的配方组合
CN108686144A (zh) * 2017-08-15 2018-10-23 苏建林 能够降三高的燕麦混合粉的制备方法
CN109699790A (zh) * 2019-02-28 2019-05-03 周栖 一种具有降高血压、高血糖和高血脂效果的保健茶

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106362142A (zh) * 2016-10-28 2017-02-01 武汉庄守和生物科技有限公司 一种可以降低血压的配方组合
CN108686144A (zh) * 2017-08-15 2018-10-23 苏建林 能够降三高的燕麦混合粉的制备方法
CN109699790A (zh) * 2019-02-28 2019-05-03 周栖 一种具有降高血压、高血糖和高血脂效果的保健茶

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