CN105535460A - Traditional Chinese medicine dropping pills for treating mild type 2 diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine dropping pills for treating mild type 2 diabetes and preparation method thereof Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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Abstract
The invention provides traditional Chinese medicine dropping pills for treating mild type 2 diabetes and a preparation method thereof. The traditional Chinese medicine dropping pills for treating mild type 2 diabetes are prepared from extract of such traditional Chinese medicine as rhizoma polygonati odorati, raw radix rehmanniae, radix scrophulariae, Chinese wolfberry fruits, radix astragali, kudzu vine roots, folium mori and bitter gourd, and base material. The traditional Chinese medicine dropping pills can effectively inhibit blood glucose, lower resistance of insulin and meanwhile can enhance the function of an insulin receptor. A certain curative effect is achieved on the aspects of inhibiting generation of sugar toxin, restoring damaged islet cells, driving the islet cells to release insulin normally, rapidly lowering blood glucose and the like. The traditional Chinese medicine dropping pills can prevent hyperglycemia from destroying nerves and blood vessels, restore damaged nerves and blood vessels and prevent and treat various diabetic complications.
Description
Technical field
The present invention relates to medicine and preparation field thereof, specifically relate to and a kind ofly treat Chinese medicine dripping pills of slight type 2 diabetes mellitus and preparation method thereof.
Background technology
Type 2 diabetes mellitus (T2DM), also referred to as non-insulin-dependent diabetes mellitus, accounts for 90% of diabetic sum, and age of onset is most after 35 years old.Onset is slow, concealment, and some patients finds in physical examination or when checking other diseases.Insulin receptor INSR on insulin target cell or postreceptor defects account for critical role in morbidity.In type 2 diabetes mellitus patient, about 60% is overweight or obesity.Most patient Absorbable organic halogens after diet control and oral antidiabetic drug treatment controls blood glucose; But still have some patients, especially very fat client need exogenous insulin controls blood glucose.Type 2 diabetes mellitus patient is due to factors such as heredity and environment, and defect appears in β cell function, makes insulin resistant and hypoinsulinism, causes the disease of type 2 diabetes mellitus to be sent out.Along with change (Energy intaking increase and hypokinesia etc.) and the aged tendency of population of socioeconomic development, people life style, type 2 diabetes mellitus sickness rate is in the world in increasing trend year by year, especially gather way faster (expect 2025 and may increase by 170%) in developing country, present Epidemiological state.Diabetes have now become after cardiovascular diseases and tumor, the noninfectious of the 3rd threat health of people and life.
Present stage, diabetes cannot be cured completely, and needs of patients life-long therapy, comprises medication treatment and insulinize etc.Patient after suitable treatment, and be careful in one's diet in daily life take good care of, discontinue the habit of smoking and drinking, prevent various infection and suitably after sports health invigorating, blood glucose can be controlled in normal range.Diabetes complicated cardiovascular and cerebrovascular disease and diabetic nephropathy, renal failure are the main causes of death, and severe infection, retinopathy, neuropathy are also key factors that is lethal, that disable.For can by keeping on a diet and strengthening taking exercise the slight patients with NIDDM controlling blood glucose, generally hypoglycemic medicine need not be taken, but the continuation development of the state of an illness and the generation of complications can not be avoided, for this problem, the invention provides and be a kind ofly used for the treatment of Chinese medicine dripping pills of slight type 2 diabetes mellitus and preparation method thereof, this Chinese medicine dripping pills can effectively be prevented and the generation of delaying complications of diabetes and development.
Summary of the invention
In order to the slight PD of type 2 diabetes mellitus patient and the generation of complication better can be controlled, the invention provides and a kind ofly treat Chinese medicine dripping pills of slight type 2 diabetes mellitus and preparation method thereof.
Treat a Chinese medicine dripping pills for slight type 2 diabetes mellitus, by effective ingredient and substrate with 1: 5 ~ 50 weight ratio combine.
Described effective ingredient is: Folium Mori extract deoxynojirimycin 0.1 ~ 1 part, Rhizoma Polygonati Odorati composite extract 10 ~ 20 parts, Radix Rehmanniae composite extract 5 ~ 10 parts, Radix Scrophulariae composite extract 5 ~ 10 parts, Fructus Lycii composite extract 10 ~ 20 parts, Radix Astragali composite extract 5 ~ 10 parts, Radix Puerariae composite extract 15 ~ 20 parts, Fructus Momordicae charantiae composite extract 15 ~ 20 parts.
Described substrate comprises: polyethylene glycol 1500, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000, PEG 20000, s6, betacyclodextrin, poloxamer, carboxymethyl starch sodium, stearic acid, sodium stearate, glycerin gelatine, glyceryl monostearate, Lac, polyoxyethylene monostearate, polyethers, mixed mutually by wherein one or more.
Described drop pill can be made into common drop pill, also can be made into slow-release pill preparation, controlled release dropping pill formulation, enteric coated drop pill preparation, coated drop pill preparation.
A kind of preparation method for the treatment of the Chinese medicine dripping pills of slight type 2 diabetes mellitus of the present invention, realizes as follows:
(1) take effective ingredient and substrate respectively according to the above ratio, and fully mix;
(2) mixed material is heated to molten condition, stirs;
(3) above molten mixture is inserted in pill dripping machine funnel, insulation;
(4) sizeable drip nozzle is selected, with suitable speed, in molten mixture instillation condensing agent;
(5) treat that molten mixture shrinks molding at condensing agent, take out, the agent of removing surface condensation, namely drying can be made into a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention.
The described mode of heating of step (2) adopts water-bath, oil bath, electrical heating or other mode of heating.
Step (3) described holding temperature is 80-120 DEG C.
The temperature of the described instillation condensing agent of step (4) is-5 DEG C to-40 DEG C.
Step (4) described condensing agent can be that one or more in liquid paraffin, methyl-silicone oil, vegetable oil mix mutually.
Beneficial effect
1. a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention, effectively can suppress blood glucose, reduces insulin resistant, strengthens again the function of Insulin receptor INSR simultaneously.
2. a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention, can effectively suppress sugared toxin to produce, and repairs damaged islet cells, impels the normal uelralante of islet cells, reduce blood glucose rapidly.
3. a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention, can stop hyperglycemia to the destruction of nervus vasculairs, repairs damaged blood vessels nerve, the various diabetic complication of prevention and therapy; The generation of effective prevention and therapy complication and development.
Detailed description of the invention
Embodiment 1:
A kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of part of the present invention, can effectively prevent and the generation of delaying complications of diabetes and development.
Take effective ingredient and substrate according to the following formulation, can be made into the Chinese medicine dripping pills 10000 for the treatment of slight type 2 diabetes mellitus:
Effective ingredient: Folium Mori extract deoxynojirimycin 0.1g, Rhizoma Polygonati Odorati composite extract 10g, Radix Rehmanniae composite extract 5g, Radix Scrophulariae composite extract 5g, Fructus Lycii composite extract 10g, Radix Astragali composite extract 5g, Radix Puerariae composite extract 15g, Fructus Momordicae charantiae composite extract 15g.
Substrate: 80g polyethylene glycol 6000,80g PEG 8000,80g PEG20000,100g Lac.
After having taken by formula, make Chinese medicine dripping pills as follows:
(1) take effective ingredient and substrate respectively according to the above ratio, adopt ultrasonic mixing method by each component mix homogeneously;
(2) adopt oil bath heating, mixed material is heated to molten condition, stirs;
(3) inserted in pill dripping machine funnel by above molten mixture, be incubated, temperature is 80 DEG C;
(4) select sizeable drip nozzle, with suitable speed, in molten mixture instillation condensing agent, condensing agent is vegetable oil, and condensation temperature is-25 DEG C;
(5) treat that molten mixture shrinks molding at condensing agent, take out, the agent of removing surface condensation, namely drying can be made into a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention.
Embodiment 2:
A kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of part of the present invention, can effectively prevent and the generation of delaying complications of diabetes and development.
Take effective ingredient and substrate according to the following formulation, can be made into the Chinese medicine dripping pills 10000 for the treatment of slight type 2 diabetes mellitus:
Effective ingredient: Folium Mori extract deoxynojirimycin 0.5g, Rhizoma Polygonati Odorati composite extract 15g, Radix Rehmanniae composite extract 5g, Radix Scrophulariae composite extract 5g, Fructus Lycii composite extract 15g, Radix Astragali composite extract 10g, Radix Puerariae composite extract 15g, Fructus Momordicae charantiae composite extract 15g.
Substrate: 80g polyethylene glycol 6000,80g PEG 8000,80g PEG20000,100g Lac.
After having taken by formula, make Chinese medicine dripping pills as follows:
(1) take effective ingredient and substrate respectively according to the above ratio, adopt ultrasonic mixing method by each component mix homogeneously;
(2) adopt oil bath heating, mixed material is heated to molten condition, stirs;
(3) inserted in pill dripping machine funnel by above molten mixture, be incubated, temperature is 80 DEG C;
(4) select sizeable drip nozzle, with suitable speed, in molten mixture instillation condensing agent, condensing agent is vegetable oil, and condensation temperature is-25 DEG C;
(5) treat that molten mixture shrinks molding at condensing agent, take out, the agent of removing surface condensation, namely drying can be made into a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention.
Embodiment 3:
A kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of part of the present invention, can effectively prevent and the generation of delaying complications of diabetes and development.
Take effective ingredient and substrate according to the following formulation, can be made into the Chinese medicine dripping pills 10000 for the treatment of slight type 2 diabetes mellitus:
Effective ingredient: Folium Mori extract deoxynojirimycin 1g, Rhizoma Polygonati Odorati composite extract 20g, Radix Rehmanniae composite extract 10g, Radix Scrophulariae composite extract 10g, Fructus Lycii composite extract 20g, Radix Astragali composite extract 10g, Radix Puerariae composite extract 20g, Fructus Momordicae charantiae composite extract 20g.
Substrate: 80g polyethylene glycol 6000,80g PEG 8000,80g PEG20000,100g Lac.
After having taken by formula, make Chinese medicine dripping pills as follows:
(1) take effective ingredient and substrate respectively according to the above ratio, adopt ultrasonic mixing method by each component mix homogeneously;
(2) adopt oil bath heating, mixed material is heated to molten condition, stirs;
(3) inserted in pill dripping machine funnel by above molten mixture, be incubated, temperature is 80 DEG C;
(4) select sizeable drip nozzle, with suitable speed, in molten mixture instillation condensing agent, condensing agent is vegetable oil, and condensation temperature is-25 DEG C;
(5) treat that molten mixture shrinks molding at condensing agent, take out, the agent of removing surface condensation, namely drying can be made into a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention.
Claims (7)
1. treat a Chinese medicine dripping pills for slight type 2 diabetes mellitus, it is characterized in that, the composition of this Chinese medicine dripping pills be by effective ingredient and substrate with 1: 5 ~ 50 weight ratio combine,
Described effective ingredient is: Folium Mori extract deoxynojirimycin 0.1 ~ 1 part, Rhizoma Polygonati Odorati composite extract 10 ~ 20 parts, Radix Rehmanniae composite extract 5 ~ 10 parts, Radix Scrophulariae composite extract 5 ~ 10 parts, Fructus Lycii composite extract 10 ~ 20 parts, Radix Astragali composite extract 5 ~ 10 parts, Radix Puerariae composite extract 15 ~ 20 parts, Fructus Momordicae charantiae composite extract 15 ~ 20 parts;
Described substrate comprises: polyethylene glycol 1500, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000, PEG 20000, s6, betacyclodextrin, poloxamer, carboxymethyl starch sodium, stearic acid, sodium stearate, glycerin gelatine, glyceryl monostearate, Lac, polyoxyethylene monostearate, polyethers, mixed mutually by wherein one or more.
2. a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus as claimed in claim 1, it is characterized in that, described Chinese medicine dripping pills can be made into common drop pill, also can be made into slow-release pill preparation, controlled release dropping pill formulation, enteric coated drop pill preparation, coated drop pill preparation.
3. a kind of Chinese medicine dripping pills preparation method for the treatment of slight type 2 diabetes mellitus as claimed in claim 1, is characterized in that, realize as follows:
(1) take effective ingredient and substrate respectively according to the above ratio, and fully mix;
(2) mixed material is heated to molten condition, stirs;
(3) above molten mixture is inserted in pill dripping machine funnel, insulation;
(4) sizeable drip nozzle is selected, with suitable speed, in molten mixture instillation condensing agent;
(5) treat that molten mixture shrinks molding at condensing agent, take out, the agent of removing surface condensation, namely drying can be made into a kind of Chinese medicine dripping pills for the treatment of slight type 2 diabetes mellitus of the present invention.
4. a kind of preparation method for the treatment of the Chinese medicine dripping pills of slight type 2 diabetes mellitus as claimed in claim 3, is characterized in that, the mode of heating of described step (2) adopts water-bath, oil bath, electrical heating or other mode of heating.
5. a kind of preparation method for the treatment of the Chinese medicine dripping pills of slight type 2 diabetes mellitus as claimed in claim 3, it is characterized in that, the holding temperature of described step (3) is 80-120 DEG C.
6. a kind of preparation method for the treatment of the Chinese medicine dripping pills of slight type 2 diabetes mellitus as claimed in claim 3, it is characterized in that, the temperature of the instillation condensing agent of described step (4) is-5 DEG C to-40 DEG C.
7. a kind of preparation method for the treatment of the Chinese medicine dripping pills of slight type 2 diabetes mellitus as claimed in claim 3, is characterized in that, the condensing agent of described step (4) can be that one or more in liquid paraffin, methyl-silicone oil, vegetable oil mix mutually.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610012501.0A CN105535460A (en) | 2016-01-07 | 2016-01-07 | Traditional Chinese medicine dropping pills for treating mild type 2 diabetes and preparation method thereof |
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| CN201610012501.0A CN105535460A (en) | 2016-01-07 | 2016-01-07 | Traditional Chinese medicine dropping pills for treating mild type 2 diabetes and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344808A (en) * | 2016-08-31 | 2017-01-25 | 浙江天方科技股份有限公司 | Compound dendrobium officinale health care product capable of assisting in reducing blood sugar |
| CN106860412A (en) * | 2017-02-24 | 2017-06-20 | 贵州神奇药业有限公司 | A kind of Sustained Release Preparations of Chinese Medicinal for treating diabetes and its complication and preparation method thereof |
-
2016
- 2016-01-07 CN CN201610012501.0A patent/CN105535460A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344808A (en) * | 2016-08-31 | 2017-01-25 | 浙江天方科技股份有限公司 | Compound dendrobium officinale health care product capable of assisting in reducing blood sugar |
| CN106860412A (en) * | 2017-02-24 | 2017-06-20 | 贵州神奇药业有限公司 | A kind of Sustained Release Preparations of Chinese Medicinal for treating diabetes and its complication and preparation method thereof |
| CN106860412B (en) * | 2017-02-24 | 2019-11-26 | 贵州神奇药业有限公司 | A kind of Sustained Release Preparations of Chinese Medicinal and preparation method thereof for treating diabetes and its complication |
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Application publication date: 20160504 |
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