CN105535136A - A traditional Chinese medicine composition having a bacteriostasis function, a preparing method thereof and uses of the composition - Google Patents
A traditional Chinese medicine composition having a bacteriostasis function, a preparing method thereof and uses of the composition Download PDFInfo
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- CN105535136A CN105535136A CN201510964136.9A CN201510964136A CN105535136A CN 105535136 A CN105535136 A CN 105535136A CN 201510964136 A CN201510964136 A CN 201510964136A CN 105535136 A CN105535136 A CN 105535136A
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- chinese medicine
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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Abstract
The invention belongs to the field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine composition having a bacteriostasis function, a preparing method thereof and uses of the composition. Channel tropisms, properties and flavors of traditional Chinese medicines are fully considered, and a ratio of the traditional Chinese medicines is selected to allow the traditional Chinese medicines to be matched and cooperated according to a "monarch, minister, assistant and guide" compatibility relation, thus fully exerting the bacteriostasis function.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition with bacteriostasis and preparation method thereof and purposes.
Background technology
Along with all kinds of antibiotic taking penicillin as representative constantly occur, bacterial infection disease is effectively controlled, thus antibiotic is become powerful mean that the mankind resist pathogenic bacterial infection.But in recent years, people use antibiotic to cause the drug resistance of antibacterial constantly to strengthen for a long time widely, and Resistant frequency increases gradually, so that conventional antibiotic cannot meet clinical needs.The bamboo telegraph of the methicillin resistant staphylococcus aureus (MRSA) found in recent years, the enterococcus (VER) of vancomycin resistance, extensively Resistance Mycobacterium Tuberculosis (XDR-TB) etc., allows people have a headache endlessly.Along with global disease spectrum and the important change of medical model, progressively integrating with of China and World Economics, culture and drug level, compatriots are enhanced to antibiotic understanding, recognize the impact of many untoward reaction that antibiotic brings and corresponding drug resistance thereof, people are filled with expectation to Chinese medicine maintaining healthy and disease preventing and treating.Medical circle is also expected to tackle by rational use of drug and exploitation new Chinese medicine the fastbacteria constantly produced.The present inventor uses modern Chinese medicine extractive technique to develop anti-inflammation definite effect, Chinese medicine with strong points based on this, meet the needs of clinical treatment with this.
Chinese patent literature CN103816255A discloses a kind of pharmaceutical composition with antibacterial, antiinflammatory, itching-relieving action, is made up: Radix Sophorae Flavescentis 45-60 part, Flos Lonicerae 20-35 part, Radix Astragali 30-40 part, Radix Sanguisorbae 40-60 part of following raw material.But aforementioned pharmaceutical compositions makes external preparation more greatly due to toxic and side effects, thus limit its application.
Therefore, the medicine with bacteriostasis that novel therapeutic effect is good, toxic and side effects is little is studied significant.
Summary of the invention
Therefore, the invention provides the Chinese medicine composition with bacteriostasis that a kind of therapeutic effect is good, toxic and side effects is little, and then its preparation method and purposes are provided.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
The invention provides a kind of Chinese medicine composition with bacteriostasis, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20-40 weight portion, Periostracum Cicadae 5-20 weight portion, Gypsum Fibrosum 30-60 weight portion, Talcum 30-60 weight portion, Radix Scutellariae 20-40 weight portion, Radix Et Rhizoma Rhei 5-20 weight portion, Radix Paeoniae Rubra 20-40 weight portion, Radix Isatidis 20-40 weight portion, Herba Pogostemonis 20-40 weight portion, Cornu Saigae Tataricae 2-4 weight portion.
Preferably, the above-mentioned Chinese medicine composition with bacteriostasis of the present invention, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5-10 weight portion, Gypsum Fibrosum 35-40 weight portion, Talcum 35-40 weight portion, Radix Scutellariae 20-30 weight portion, Radix Et Rhizoma Rhei 5-10 weight portion, Radix Paeoniae Rubra 20-30 weight portion, Radix Isatidis 30-40 weight portion, Herba Pogostemonis 30-40 weight portion, Cornu Saigae Tataricae 2-3 weight portion.
Further preferably, the above-mentioned Chinese medicine composition with bacteriostasis of the present invention, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5 weight portion, Gypsum Fibrosum 35 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 30 weight portion, Herba Pogostemonis 30 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 35 weight portion, Herba Pogostemonis 35 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 40 weight portion, Radix Scutellariae 30 weight portion, Radix Et Rhizoma Rhei 10 weight portion, Radix Paeoniae Rubra 30 weight portion, Radix Isatidis 40 weight portion, Herba Pogostemonis 40 weight portion, Cornu Saigae Tataricae 3 weight portion.
The present invention also provides the above-mentioned preparation method with the Chinese medicine composition of bacteriostasis, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 1-10 hour of 6-14 weight times amount for the 1st time, add the water extraction 1-8 hour of 6-12 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 0.5-5 hour of 6-14 weight times amount for 1st time, add the water extraction 0.5-3 hour of 6-12 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.05-1.30, and adding ethanol to the percent by volume of contained ethanol is 30%-70%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 220-280 parts by volume, obtain final product.
Preferably, the above-mentioned preparation method with the Chinese medicine composition of bacteriostasis of the present invention, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 4-8 hour of 6-12 weight times amount for the 1st time, add the water extraction 2-6 hour of 6-10 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1-3 hour of 6-12 weight times amount for 1st time, add the water extraction 0.5-1.5 hour of 6-10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.25, and adding ethanol to the percent by volume of contained ethanol is 40%-60%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 230-270 parts by volume, obtain final product.
Further preferably, the above-mentioned preparation method with the Chinese medicine composition of bacteriostasis of the present invention, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250 parts by volume, obtain final product.
The present invention also provides to comprise above-mentionedly to be had the preparation of the Chinese medicine composition of bacteriostasis or comprises the preparation of the Chinese medicine composition that above-mentioned preparation method prepares,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose are received; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The application had in the medicine of bacteriostasis prepared by the Chinese medicine composition that the present invention also provides above-mentioned Chinese medicine composition, above-mentioned preparation method prepares or the preparation of above-mentioned Chinese medicine composition.
Technical scheme tool of the present invention has the following advantages:
[Cornu Saigae Tataricae] is cold in nature, salty in the mouth, returns Liver Channel, heart channel, has effect of suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, loose blood removing toxic substances.
[Flos Lonicerae] is cold in nature, sweet in the mouth, returns lung meridian, heart channel, stomach warp, has effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens.
[Periostracum Cicadae] is cold in nature, sweet in the mouth, returns lung meridian, Liver Channel, has effect of dispelling wind and heat pathogens.
[Gypsum Fibrosum] is cold in nature, sweet in the mouth, pungent, returns lung meridian, stomach warp, has clearing away heat-fire, effect that relieving restlessness is quenched the thirst.
[Talcum] is cold in nature, sweet in the mouth, light, return urinary bladder channel, lung meridian, stomach through, there is effect of inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.
[Radix Et Rhizoma Rhei] is cold in nature, bitter in the mouth, returns spleen channel, stomach warp, large intestine channel, Liver Channel, pericardium channel, has effect of heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.
[Radix Paeoniae Rubra] cold nature, bitter in the mouth, returns Liver Channel, has effect of clearing away heat and cooling blood, eliminating stasis to stop pain.
[Radix Isatidis] is cold in nature, bitter in the mouth, and GUIXIN warp, stomach warp, have effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.
[Herba Pogostemonis] slightly warm in nature, acrid in the mouth, returns spleen channel, stomach through, lung meridian, has eliminating turbid pathogen with aromatics and middle preventing or arresting vomiting, delivers effect of expelling summer-heat.
[Radix Scutellariae] is cold in nature, bitter in the mouth, returns lung meridian, gallbladder meridian, spleen channel, large intestine channel, small intestine meridian, has effect of heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.
The present invention has the Chinese medicine composition of bacteriostasis, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make that each Chinese medicine cooperatively interacts according to the compatibility relationship of " monarch, minister, help, make ", combined effect, thus play bacteriostasis.
Detailed description of the invention
To be clearly and completely described technical scheme of the present invention below, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
embodiment 1
The crude drug that the present embodiment has the Chinese medicine composition of bacteriostasis consists of:
Flos Lonicerae 20g, Periostracum Cicadae 5g, Gypsum Fibrosum 35g, Talcum 35g, Radix Scutellariae 20g, Radix Et Rhizoma Rhei 5g, Radix Paeoniae Rubra 20g, Radix Isatidis 30g, Herba Pogostemonis 30g, Cornu Saigae Tataricae 2g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250mL, to obtain final product.
The Chinese medicine composition that the present embodiment has bacteriostasis adds customary adjuvant, conveniently technique, makes oral liquid.
embodiment 2
The crude drug that the present embodiment has the Chinese medicine composition of bacteriostasis consists of:
Flos Lonicerae 20g, Periostracum Cicadae 10g, Gypsum Fibrosum 40g, Talcum 35g, Radix Scutellariae 20g, Radix Et Rhizoma Rhei 5g, Radix Paeoniae Rubra 20g, Radix Isatidis 35g, Herba Pogostemonis 35g, Cornu Saigae Tataricae 2g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 4 hours of 8 weight times amount for the 1st time, add the water extraction 6 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1 hour of 8 weight times amount for 1st time, add the water extraction 1.5 hours of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.20, and adding ethanol to the percent by volume of contained ethanol is 40%, fully stirs, leaves standstill, get supernatant, be concentrated into 230mL, to obtain final product.
The Chinese medicine composition that the present embodiment has bacteriostasis adds customary adjuvant, conveniently technique, makes capsule.
embodiment 3
The crude drug that the present embodiment has the Chinese medicine composition of bacteriostasis consists of:
Flos Lonicerae 20g, Periostracum Cicadae 10g, Gypsum Fibrosum 40g, Talcum 40g, Radix Scutellariae 30g, Radix Et Rhizoma Rhei 10g, Radix Paeoniae Rubra 30g, Radix Isatidis 40g, Herba Pogostemonis 40g, Cornu Saigae Tataricae 3g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 8 hours of 10 weight times amount for the 1st time, add the water extraction 2 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 3 hours of 12 weight times amount for 1st time, add the water extraction 0.5 hour of 10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20-1.25, and adding ethanol to the percent by volume of contained ethanol is 60%, fully stirs, leaves standstill, get supernatant, be concentrated into 270mL, to obtain final product.
The Chinese medicine composition that the present embodiment has bacteriostasis adds customary adjuvant, conveniently technique, makes tablet.
experimental examplethe research of present composition bacteriostasis
1, experiment purpose
The oral liquid of Chinese medicine composition prepared by research performation example 1 to the protective effect of infection of staphylococcus aureus mice, and studies dose-effect relationship further.
2, experimental design
Get NIH kind mice 100, body weight 12.8 ± 0.968g, male and female half and half, be divided into 5 groups at random, comprise normal group, infect matched group, positive controls, experimental group low dose group, experimental group high dose group, each group weight ratio comparatively there was no significant difference (P > 0.05).
Before infection, experimental group low dose group, experimental group high dose group difference gastric infusion 1 day, 2 times on the one, each 0.4mL/ is only; Second day, normal group lumbar injection equal-volume normal saline, other only respectively organized lumbar injection S. aureus L-forms 0.4mL/, and infection dosage is 6 × 10
8/ only.
After infection, normal group, infection matched group gavage distilled water 0.4mL, positive controls is disposable gavages amoxicillin dry syrup 0.5g/kg, experimental group low dose group, experimental group high dose group are respectively according to 48.9 crude drugs/kg/d and 97.8g crude drug/kg/d gastric infusion, one day 2 times, successive administration 2 days, Continuous Observation 15 days.
3, experimental result
Result shows, the survival rate of experimental group low dose group is significantly higher than the survival rate (P < 0.05) infecting matched group, and has certain dose-effect relationship.
In sum, Chinese medicine composition of the present invention has bacteriostasis, can as potential antibacterial medicine.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (8)
1. have a Chinese medicine composition for bacteriostasis, it is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20-40 weight portion, Periostracum Cicadae 5-20 weight portion, Gypsum Fibrosum 30-60 weight portion, Talcum 30-60 weight portion, Radix Scutellariae 20-40 weight portion, Radix Et Rhizoma Rhei 5-20 weight portion, Radix Paeoniae Rubra 20-40 weight portion, Radix Isatidis 20-40 weight portion, Herba Pogostemonis 20-40 weight portion, Cornu Saigae Tataricae 2-4 weight portion.
2. the Chinese medicine composition with bacteriostasis according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5-10 weight portion, Gypsum Fibrosum 35-40 weight portion, Talcum 35-40 weight portion, Radix Scutellariae 20-30 weight portion, Radix Et Rhizoma Rhei 5-10 weight portion, Radix Paeoniae Rubra 20-30 weight portion, Radix Isatidis 30-40 weight portion, Herba Pogostemonis 30-40 weight portion, Cornu Saigae Tataricae 2-3 weight portion.
3. the Chinese medicine composition with bacteriostasis according to claim 2, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5 weight portion, Gypsum Fibrosum 35 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 30 weight portion, Herba Pogostemonis 30 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 35 weight portion, Herba Pogostemonis 35 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 40 weight portion, Radix Scutellariae 30 weight portion, Radix Et Rhizoma Rhei 10 weight portion, Radix Paeoniae Rubra 30 weight portion, Radix Isatidis 40 weight portion, Herba Pogostemonis 40 weight portion, Cornu Saigae Tataricae 3 weight portion.
4. the preparation method with the Chinese medicine composition of bacteriostasis described in any one of claim 1-3, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 1-10 hour of 6-14 weight times amount for the 1st time, add the water extraction 1-8 hour of 6-12 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 0.5-5 hour of 6-14 weight times amount for 1st time, add the water extraction 0.5-3 hour of 6-12 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.05-1.30, and adding ethanol to the percent by volume of contained ethanol is 30%-70%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 220-280 parts by volume, obtain final product.
5. the preparation method with the Chinese medicine composition of bacteriostasis according to claim 4, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 4-8 hour of 6-12 weight times amount for the 1st time, add the water extraction 2-6 hour of 6-10 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1-3 hour of 6-12 weight times amount for 1st time, add the water extraction 0.5-1.5 hour of 6-10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.25, and adding ethanol to the percent by volume of contained ethanol is 40%-60%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 230-270 parts by volume, obtain final product.
6. the preparation method with the Chinese medicine composition of bacteriostasis according to claim 5, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250 parts by volume, obtain final product.
7. comprise the preparation with the Chinese medicine composition of bacteriostasis described in any one of claim 1-3 or comprise the preparation of the Chinese medicine composition that the preparation method described in any one of claim 4-6 prepares, it is characterized in that,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
8. the application had in the medicine of bacteriostasis prepared by the preparation of the Chinese medicine composition that the Chinese medicine composition described in any one of claim 1-3, preparation method described in any one of claim 4-6 prepare or Chinese medicine composition according to claim 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510964136.9A CN105535136A (en) | 2015-12-21 | 2015-12-21 | A traditional Chinese medicine composition having a bacteriostasis function, a preparing method thereof and uses of the composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456385A (en) * | 2015-12-21 | 2016-04-06 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with antipyretic effect and preparation method and application thereof |
| CN105535135A (en) * | 2015-12-21 | 2016-05-04 | 北京同仁堂科技发展股份有限公司 | A traditional Chinese medicine composition having an anti-influenza virus function, a preparing method thereof and uses of the composition |
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| CN1762455A (en) * | 2005-09-22 | 2006-04-26 | 太阳石（唐山）药业有限公司 | Chinese medicinal formulation for treating infant lung and stomach exuberance heat |
| CN105535135A (en) * | 2015-12-21 | 2016-05-04 | 北京同仁堂科技发展股份有限公司 | A traditional Chinese medicine composition having an anti-influenza virus function, a preparing method thereof and uses of the composition |
| CN105456385B (en) * | 2015-12-21 | 2018-02-23 | 北京同仁堂科技发展股份有限公司 | A kind of Chinese medicine composition with refrigeration function and preparation method thereof and purposes |
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| CN1491711A (en) * | 2003-09-03 | 2004-04-28 | 扬子江制药股份有限公司 | Medicine for treating cold in summer and autumn |
| CN1762455A (en) * | 2005-09-22 | 2006-04-26 | 太阳石（唐山）药业有限公司 | Chinese medicinal formulation for treating infant lung and stomach exuberance heat |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456385A (en) * | 2015-12-21 | 2016-04-06 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with antipyretic effect and preparation method and application thereof |
| CN105535135A (en) * | 2015-12-21 | 2016-05-04 | 北京同仁堂科技发展股份有限公司 | A traditional Chinese medicine composition having an anti-influenza virus function, a preparing method thereof and uses of the composition |
| CN105535135B (en) * | 2015-12-21 | 2019-05-31 | 北京同仁堂科技发展股份有限公司 | A kind of Chinese medicine composition with resisiting influenza virus effect and preparation method thereof and purposes |
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