CN105535135A - A traditional Chinese medicine composition having an anti-influenza virus function, a preparing method thereof and uses of the composition - Google Patents
A traditional Chinese medicine composition having an anti-influenza virus function, a preparing method thereof and uses of the composition Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition having an anti-influenza virus function, a preparing method thereof and uses of the composition. Channel tropisms, properties and flavors of traditional Chinese medicines are fully considered, and a ratio of the traditional Chinese medicines is selected to allow the traditional Chinese medicines to be matched and cooperated according to a "monarch, minister, assistant and guide" compatibility relation, thus fully exerting the anti-influenza virus function.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of to there is Chinese medicine composition of resisiting influenza virus effect and preparation method thereof and purposes.
Background technology
Influenza is the Acute respiratory infectious disease that influenza virus causes.In history, worldwide flu outbreak once occurred repeatedly, wherein serious with the influenza pandemic of 1918, its death toll reaches more than 2,000 ten thousand, and died majority is the person between twenty and fifty of 15 ~ 45 years old.At present, the threat of influenza still exists.According to statistics, the whole world has 50 ~ 1,000,000 people to die from influenza every year on average.WHO just started influenza plan as far back as 1948, and in the whole world, 83 countries establish 111 national research centers and 4 cooperation centers, and infected by influenza carries out sample collection, detection and research.However, scientists still wishes that dropping into 4,500 ten thousand dollars with 5 years sets up a global laboratory and study influenza.As can be seen here, influenza as a kind of viral infectious not only serious threat public health, and give country and society bring heavy financial burden.
Influenza virus belongs to orthomyxoviridae family.According to virus nucleoprotein (NP) and the antigenic difference of stromatin, first (A) type, second (B) type, 3 kinds, third (C) type can be divided into; Different hypotypes (HxNy) is divided into again according to the antigenicity of hemagglutinin (HA) and neuraminidase (NA).From the historical summary analysis of influenza pandemic, B-mode more stable with influenza virus C antigenicity; Surface antigen HA and NA of influenza A virus then more easily morphs.At present, popular in crowd influenza virus sub-strain is H1N1 and H3N2.Because the antigenic variation ability of influenza virus is strong; in addition the difference of individual immunity power, the protective rate of vaccine is not high, moreover; vaccine only has preventive effect to known influenza virus sub-strain, and invalid for the novel influenza produced by antigenic drift or antigenicity conversion.
Chinese patent literature CN1943656A discloses the medicine of a kind for the treatment of and preventing cold and influenza and parotitis disease, be made up of the raw material of following weight proportioning: Radix Puerariae 250-400 weight portion, Radix Angelicae Dahuricae 250-400 weight portion, Flos Lonicerae 400-550 weight portion, Flos Chrysanthemi 400-550 weight portion, Fructus Forsythiae 250-400 weight portion, Radix Scutellariae 400-550 weight portion, Fructus Gardeniae 250-400 weight portion, Herba Artemisiae Scopariae 400-550 weight portion, Radix Isatidis 400-550 weight portion, Rhizoma Osmundae 400-550 weight portion, Folium Isatidis 400-550 weight portion.But above-mentioned Chinese medicine composition exists the shortcomings such as composition is complicated, cost is higher, thus limit its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, to form simple, the lower-cost medicine with resisiting influenza virus effect significant.
Summary of the invention
Therefore, the invention provides that a kind of therapeutic effect is good, toxic and side effects is little, form simple, the lower-cost Chinese medicine composition with resisiting influenza virus effect, and then its preparation method and purposes are provided.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
The invention provides a kind of Chinese medicine composition with resisiting influenza virus effect, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20-40 weight portion, Periostracum Cicadae 5-20 weight portion, Gypsum Fibrosum 30-60 weight portion, Talcum 30-60 weight portion, Radix Scutellariae 20-40 weight portion, Radix Et Rhizoma Rhei 5-20 weight portion, Radix Paeoniae Rubra 20-40 weight portion, Radix Isatidis 20-40 weight portion, Herba Pogostemonis 20-40 weight portion, Cornu Saigae Tataricae 2-4 weight portion.
Preferably, the above-mentioned Chinese medicine composition with resisiting influenza virus effect of the present invention, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5-10 weight portion, Gypsum Fibrosum 35-40 weight portion, Talcum 35-40 weight portion, Radix Scutellariae 20-30 weight portion, Radix Et Rhizoma Rhei 5-10 weight portion, Radix Paeoniae Rubra 20-30 weight portion, Radix Isatidis 30-40 weight portion, Herba Pogostemonis 30-40 weight portion, Cornu Saigae Tataricae 2-3 weight portion.Further preferably, the above-mentioned Chinese medicine composition with resisiting influenza virus effect of the present invention, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5 weight portion, Gypsum Fibrosum 35 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 30 weight portion, Herba Pogostemonis 30 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 35 weight portion, Herba Pogostemonis 35 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 40 weight portion, Radix Scutellariae 30 weight portion, Radix Et Rhizoma Rhei 10 weight portion, Radix Paeoniae Rubra 30 weight portion, Radix Isatidis 40 weight portion, Herba Pogostemonis 40 weight portion, Cornu Saigae Tataricae 3 weight portion.
The present invention also provides a kind of above-mentioned preparation method with the Chinese medicine composition of resisiting influenza virus effect, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 1-10 hour of 6-14 weight times amount for the 1st time, add the water extraction 1-8 hour of 6-12 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 0.5-5 hour of 6-14 weight times amount for 1st time, add the water extraction 0.5-3 hour of 6-12 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.05-1.30, and adding ethanol to the percent by volume of contained ethanol is 30%-70%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 220-280 parts by volume, obtain final product.
Preferably, the above-mentioned preparation method with the Chinese medicine composition of resisiting influenza virus effect of the present invention, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 4-8 hour of 6-12 weight times amount for the 1st time, add the water extraction 2-6 hour of 6-10 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1-3 hour of 6-12 weight times amount for 1st time, add the water extraction 0.5-1.5 hour of 6-10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.25, and adding ethanol to the percent by volume of contained ethanol is 40%-60%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 230-270 parts by volume, obtain final product.
Further preferably, the above-mentioned preparation method with the Chinese medicine composition of bacteriostasis of the present invention, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250 parts by volume, obtain final product.
The present invention also provides to comprise above-mentionedly to be had the preparation of the Chinese medicine composition of resisiting influenza virus effect or comprises the preparation of the Chinese medicine composition that above-mentioned preparation method prepares,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose are received; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The application had in the medicine of resisiting influenza virus effect prepared by the Chinese medicine composition that the present invention also provides above-mentioned Chinese medicine composition, above-mentioned preparation method prepares or the preparation of above-mentioned Chinese medicine composition.
Technical scheme tool of the present invention has the following advantages:
[Cornu Saigae Tataricae] is cold in nature, salty in the mouth, returns Liver Channel, heart channel, has effect of suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, loose blood removing toxic substances.
[Flos Lonicerae] is cold in nature, sweet in the mouth, returns lung meridian, heart channel, stomach warp, has effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens.
[Periostracum Cicadae] is cold in nature, sweet in the mouth, returns lung meridian, Liver Channel, has effect of dispelling wind and heat pathogens.
[Gypsum Fibrosum] is cold in nature, sweet in the mouth, pungent, returns lung meridian, stomach warp, has clearing away heat-fire, effect that relieving restlessness is quenched the thirst.
[Talcum] is cold in nature, sweet in the mouth, light, return urinary bladder channel, lung meridian, stomach through, there is effect of inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.
[Radix Et Rhizoma Rhei] is cold in nature, bitter in the mouth, returns spleen channel, stomach warp, large intestine channel, Liver Channel, pericardium channel, has effect of heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.
[Radix Paeoniae Rubra] cold nature, bitter in the mouth, returns Liver Channel, has effect of clearing away heat and cooling blood, eliminating stasis to stop pain.
[Radix Isatidis] is cold in nature, bitter in the mouth, and GUIXIN warp, stomach warp, have effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.
[Herba Pogostemonis] slightly warm in nature, acrid in the mouth, returns spleen channel, stomach through, lung meridian, has eliminating turbid pathogen with aromatics and middle preventing or arresting vomiting, delivers effect of expelling summer-heat.
[Radix Scutellariae] is cold in nature, bitter in the mouth, returns lung meridian, gallbladder meridian, spleen channel, large intestine channel, small intestine meridian, has effect of heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.
The present invention has the Chinese medicine composition of resisiting influenza virus effect, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make that each Chinese medicine cooperatively interacts according to the compatibility relationship of " monarch, minister, help, make ", combined effect, thus play resisiting influenza virus effect.
Detailed description of the invention
To be clearly and completely described technical scheme of the present invention below, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
embodiment 1
The crude drug that the present embodiment has the Chinese medicine composition of resisiting influenza virus effect consists of:
Flos Lonicerae 20g, Periostracum Cicadae 5g, Gypsum Fibrosum 35g, Talcum 35g, Radix Scutellariae 20g, Radix Et Rhizoma Rhei 5g, Radix Paeoniae Rubra 20g, Radix Isatidis 30g, Herba Pogostemonis 30g, Cornu Saigae Tataricae 2g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250mL, to obtain final product.
The Chinese medicine composition that the present embodiment has resisiting influenza virus effect adds customary adjuvant, conveniently technique, makes oral liquid.
embodiment 2
The crude drug that the present embodiment has the Chinese medicine composition of resisiting influenza virus effect consists of:
Flos Lonicerae 20g, Periostracum Cicadae 10g, Gypsum Fibrosum 40g, Talcum 35g, Radix Scutellariae 20g, Radix Et Rhizoma Rhei 5g, Radix Paeoniae Rubra 20g, Radix Isatidis 35g, Herba Pogostemonis 35g, Cornu Saigae Tataricae 2g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 4 hours of 8 weight times amount for the 1st time, add the water extraction 6 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1 hour of 8 weight times amount for 1st time, add the water extraction 1.5 hours of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.20, and adding ethanol to the percent by volume of contained ethanol is 40%, fully stirs, leaves standstill, get supernatant, be concentrated into 230mL, to obtain final product.
The Chinese medicine composition that the present embodiment has resisiting influenza virus effect adds customary adjuvant, conveniently technique, makes capsule.
embodiment 3
The crude drug that the present embodiment has the Chinese medicine composition of resisiting influenza virus effect consists of:
Flos Lonicerae 20g, Periostracum Cicadae 10g, Gypsum Fibrosum 40g, Talcum 40g, Radix Scutellariae 30g, Radix Et Rhizoma Rhei 10g, Radix Paeoniae Rubra 30g, Radix Isatidis 40g, Herba Pogostemonis 40g, Cornu Saigae Tataricae 3g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 8 hours of 10 weight times amount for the 1st time, add the water extraction 2 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 3 hours of 12 weight times amount for 1st time, add the water extraction 0.5 hour of 10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20-1.25, and adding ethanol to the percent by volume of contained ethanol is 60%, fully stirs, leaves standstill, get supernatant, be concentrated into 270mL, to obtain final product.The Chinese medicine composition that the present embodiment has resisiting influenza virus effect adds customary adjuvant, conveniently technique, makes tablet.
experimental examplethe research of Chinese medicine composition resisiting influenza virus of the present invention effect
1, experiment purpose
In order to the curative effect of the oral liquid resisiting influenza virus of the Chinese medicine composition of research performation example 1 preparation, carry out experiment in vivo with influenza virus A-prime Mus lung adapted strain FMI, further its dose-effect relationship of research.
2, experimental design
Mice is divided into six groups at random by body weight, is respectively dosage group in experimental group low dose group, experimental group, experimental group high dose group, positive controls, infection matched group and Normal group.
In experimental group high dose group, experimental group, dosage group, the experimental group low dose group oral liquid with the Chinese medicine composition of bacteriostasis that respectively prepared by gavage embodiment 1 is equivalent to 30 times, 15 times, 7.5 times of clinical dosage; Positive controls, infection matched group and Normal group are all to the distilled water of same volume; Positive controls and infect matched group with under ether light anesthesia, with 15 LD
50(mice median lethal dose(LD 50)) Flu virus FMI virus liquid collunarium infects, every Mus 0.05mL.
Dosage group, experimental group high dose group, positive controls, infection matched group and Normal group all administration or feedwater from infecting the previous day in experimental group low dose group, experimental group, every day 2 times, each 0.4mL, continuous 5 days, dissects after within every 6 days, taking Mouse Weight.
3, experimental result
Result shows, compared with matched group, the Lung Exponent value of the animal of experimental group high dose group significantly reduces; In experimental group high dose group and experimental group dosage group mouse lung in proliferation of influenza virus amount all have significant reduction; In certain dose-effect relationship in tested dosage range.
In sum, Chinese medicine composition of the present invention has the effect of resisiting influenza virus A-prime Mus lung adapted strain FMI, can as the medicine of potential resisiting influenza virus.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (8)
1. have a Chinese medicine composition for resisiting influenza virus effect, it is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20-40 weight portion, Periostracum Cicadae 5-20 weight portion, Gypsum Fibrosum 30-60 weight portion, Talcum 30-60 weight portion, Radix Scutellariae 20-40 weight portion, Radix Et Rhizoma Rhei 5-20 weight portion, Radix Paeoniae Rubra 20-40 weight portion, Radix Isatidis 20-40 weight portion, Herba Pogostemonis 20-40 weight portion, Cornu Saigae Tataricae 2-4 weight portion.
2. the Chinese medicine composition with resisiting influenza virus effect according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5-10 weight portion, Gypsum Fibrosum 35-40 weight portion, Talcum 35-40 weight portion, Radix Scutellariae 20-30 weight portion, Radix Et Rhizoma Rhei 5-10 weight portion, Radix Paeoniae Rubra 20-30 weight portion,
Radix Isatidis 30-40 weight portion, Herba Pogostemonis 30-40 weight portion, Cornu Saigae Tataricae 2-3 weight portion.
3. the Chinese medicine composition with resisiting influenza virus effect according to claim 2, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5 weight portion, Gypsum Fibrosum 35 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 30 weight portion, Herba Pogostemonis 30 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 35 weight portion, Herba Pogostemonis 35 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 40 weight portion, Radix Scutellariae 30 weight portion, Radix Et Rhizoma Rhei 10 weight portion, Radix Paeoniae Rubra 30 weight portion, Radix Isatidis 40 weight portion, Herba Pogostemonis 40 weight portion, Cornu Saigae Tataricae 3 weight portion.
4. the preparation method with the Chinese medicine composition of resisiting influenza virus effect described in any one of claim 1-3, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 1-10 hour of 6-14 weight times amount for the 1st time, add the water extraction 1-8 hour of 6-12 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 0.5-5 hour of 6-14 weight times amount for 1st time, add the water extraction 0.5-3 hour of 6-12 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.05-1.30, and adding ethanol to the percent by volume of contained ethanol is 30%-70%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 220-280 parts by volume, obtain final product.
5. the preparation method with the Chinese medicine composition of resisiting influenza virus effect according to claim 4, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 4-8 hour of 6-12 weight times amount for the 1st time, add the water extraction 2-6 hour of 6-10 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1-3 hour of 6-12 weight times amount for 1st time, add the water extraction 0.5-1.5 hour of 6-10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.25, and adding ethanol to the percent by volume of contained ethanol is 40%-60%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 230-270 parts by volume, obtain final product.
6. the preparation method with the Chinese medicine composition of resisiting influenza virus effect according to claim 5, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250 parts by volume, obtain final product.
7. comprise the preparation with the Chinese medicine composition of resisiting influenza virus effect described in any one of claim 1-3 or comprise the preparation of the Chinese medicine composition that the preparation method described in any one of claim 4-6 prepares, it is characterized in that,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
8. the application had in the medicine of resisiting influenza virus effect prepared by the preparation of the Chinese medicine composition that the Chinese medicine composition described in any one of claim 1-3, preparation method described in any one of claim 4-6 prepare or Chinese medicine composition according to claim 7.
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| CN105456385A (en) * | 2015-12-21 | 2016-04-06 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with antipyretic effect and preparation method and application thereof |
| CN105535136A (en) * | 2015-12-21 | 2016-05-04 | 北京同仁堂科技发展股份有限公司 | A traditional Chinese medicine composition having a bacteriostasis function, a preparing method thereof and uses of the composition |
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