CN105456385A - Traditional Chinese medicine composition with antipyretic effect and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with antipyretic effect and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition with an antipyretic effect and a preparation method and the application of the traditional Chinese medicine composition. According to the traditional Chinese medicine composition with the antipyretic effect, disclosed by the invention, the channel tropism, the property and the flavor of all traditional Chinese medicines are fully considered, and all the traditional Chinese medicines are in mutual cooperation and co-action according to a monarch, minister, assistant and guide matching relationship by selecting a proportion between every two traditional Chinese medicines, so that the antipyretic effect can be expressed.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition with refrigeration function and preparation method thereof and purposes.
Background technology
Heating is human defense's disease and a kind of compensatory response adapting to internal and external environment temperature anomaly, be common in the diseases such as upper respiratory tract infection, influenza, acute bronchitis, pneumonia, cardinal symptom has hyperpyrexia, micro evil wind, nasal obstruction, watery nasal discharge, head general pain, cough, thirsty, laryngopharynx swelling and pain, tongue tip side of red, floating and rapid pulse etc.According to statistics, the whole world causes dead number to have more than 2,000,000 at least due to heating every year, especially the high heat that causes of upper respiratory tract infection and influenza, and the healthy of people in serious threat, and the expense be used for the treatment of every year is up to tens yuan.
Cause the reason of high heat to have a lot, as viral infection, mycoplasma infection, parasitic infection etc., wherein commonly the height that causes of virus or bacterial infection is warm.Heating was a kind of defense reaction of body originally, and can accelerate metabolic processes, antiviral growth and breeding, impels leukocytosis, strengthened the function of reticuloendothelial system, was conducive to the recovery of disease.On the other hand, heating can make physical demands, causes headache, has a sleepless night and even faint from fear.Excessive heat or persistent fever also can cause permanent brain damage and lethally to die.
Chinese patent literature CN102349971A discloses a kind of heat stroke granules, comprises Gypsum Fibrosum 672-675g; Flos Lonicerae 133-139g; Radix Scrophulariae 102-110g; Radix Rehmanniae 82-85g; Fructus Forsythiae 63-70g; Fructus Gardeniae 65-70g; Herba Gueldenstaedtiae 66-70g; Radix Scutellariae 65-71g; Radix Gentianae 65-67g; Radix Isatidis 64-70g; Rhizoma Anemarrhenae 50-56g; Radix Ophiopogonis 50-58g, its be mainly used in heat-clearing and toxic substances removing, treatment flu, upper respiratory tract infection.But above-mentioned Chinese medicine composition exists the shortcomings such as composition is complicated, cost is higher, thus limit its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, to form simple, the lower-cost medicine with refrigeration function significant.
Summary of the invention
Therefore, the invention provides that a kind of therapeutic effect is good, toxic and side effects is little, form simple, the lower-cost Chinese medicine composition with refrigeration function, and then its preparation method and purposes are provided.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
The invention provides a kind of Chinese medicine composition with refrigeration function, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20-40 weight portion, Periostracum Cicadae 5-20 weight portion, Gypsum Fibrosum 30-60 weight portion, Talcum 30-60 weight portion, Radix Scutellariae 20-40 weight portion, Radix Et Rhizoma Rhei 5-20 weight portion, Radix Paeoniae Rubra 20-40 weight portion, Radix Isatidis 20-40 weight portion, Herba Pogostemonis 20-40 weight portion, Cornu Saigae Tataricae 2-4 weight portion.
Preferably, the above-mentioned Chinese medicine composition with refrigeration function of the present invention, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5-10 weight portion, Gypsum Fibrosum 35-40 weight portion, Talcum 35-40 weight portion, Radix Scutellariae 20-30 weight portion, Radix Et Rhizoma Rhei 5-10 weight portion, Radix Paeoniae Rubra 20-30 weight portion, Radix Isatidis 30-40 weight portion, Herba Pogostemonis 30-40 weight portion, Cornu Saigae Tataricae 2-3 weight portion.
Further preferably, the above-mentioned Chinese medicine composition with refrigeration function of the present invention, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5 weight portion, Gypsum Fibrosum 35 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 30 weight portion, Herba Pogostemonis 30 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 35 weight portion, Herba Pogostemonis 35 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 40 weight portion, Radix Scutellariae 30 weight portion, Radix Et Rhizoma Rhei 10 weight portion, Radix Paeoniae Rubra 30 weight portion, Radix Isatidis 40 weight portion, Herba Pogostemonis 40 weight portion, Cornu Saigae Tataricae 3 weight portion.
The present invention also provides a kind of above-mentioned preparation method with the Chinese medicine composition of refrigeration function, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 1-10 hour of 6-14 weight times amount for the 1st time, add the water extraction 1-8 hour of 6-12 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 0.5-5 hour of 6-14 weight times amount for 1st time, add the water extraction 0.5-3 hour of 6-12 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.05-1.30, and adding ethanol to the percent by volume of contained ethanol is 30%-70%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 220-280 parts by volume, obtain final product.
Preferably, the above-mentioned preparation method with the Chinese medicine composition of refrigeration function of the present invention, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 4-8 hour of 6-12 weight times amount for the 1st time, add the water extraction 2-6 hour of 6-10 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1-3 hour of 6-12 weight times amount for 1st time, add the water extraction 0.5-1.5 hour of 6-10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.25, and adding ethanol to the percent by volume of contained ethanol is 40%-60%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 230-270 parts by volume, obtain final product.
Further preferably, the above-mentioned preparation method with the Chinese medicine composition of bacteriostasis of the present invention, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250 parts by volume, obtain final product.
The present invention also provides to comprise above-mentionedly to be had the preparation of the Chinese medicine composition of refrigeration function or comprises the preparation of the Chinese medicine composition that above-mentioned preparation method prepares,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose are received; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The application had in the medicine of refrigeration function prepared by the Chinese medicine composition that the present invention also provides above-mentioned Chinese medicine composition, above-mentioned preparation method prepares or the preparation of above-mentioned Chinese medicine composition.
Technical scheme tool of the present invention has the following advantages:
[Cornu Saigae Tataricae] is cold in nature, salty in the mouth, returns Liver Channel, heart channel, has effect of suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, loose blood removing toxic substances.
[Flos Lonicerae] is cold in nature, sweet in the mouth, returns lung meridian, heart channel, stomach warp, has effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens.
[Periostracum Cicadae] is cold in nature, sweet in the mouth, returns lung meridian, Liver Channel, has effect of dispelling wind and heat pathogens.
[Gypsum Fibrosum] is cold in nature, sweet in the mouth, pungent, returns lung meridian, stomach warp, has clearing away heat-fire, effect that relieving restlessness is quenched the thirst.
[Talcum] is cold in nature, sweet in the mouth, light, return urinary bladder channel, lung meridian, stomach through, there is effect of inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.
[Radix Et Rhizoma Rhei] is cold in nature, bitter in the mouth, returns spleen channel, stomach warp, large intestine channel, Liver Channel, pericardium channel, has effect of heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.
[Radix Paeoniae Rubra] cold nature, bitter in the mouth, returns Liver Channel, has effect of clearing away heat and cooling blood, eliminating stasis to stop pain.
[Radix Isatidis] is cold in nature, bitter in the mouth, and GUIXIN warp, stomach warp, have effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.
[Herba Pogostemonis] slightly warm in nature, acrid in the mouth, returns spleen channel, stomach through, lung meridian, has eliminating turbid pathogen with aromatics and middle preventing or arresting vomiting, delivers effect of expelling summer-heat.
[Radix Scutellariae] is cold in nature, bitter in the mouth, returns lung meridian, gallbladder meridian, spleen channel, large intestine channel, small intestine meridian, has effect of heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.
The present invention has the Chinese medicine composition of refrigeration function, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make that each Chinese medicine cooperatively interacts according to the compatibility relationship of " monarch, minister, help, make ", combined effect, thus play refrigeration function.
Detailed description of the invention
To be clearly and completely described technical scheme of the present invention below, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
embodiment 1
The crude drug that the present embodiment has the Chinese medicine composition of refrigeration function consists of:
Flos Lonicerae 20g, Periostracum Cicadae 5g, Gypsum Fibrosum 35g, Talcum 35g, Radix Scutellariae 20g, Radix Et Rhizoma Rhei 5g, Radix Paeoniae Rubra 20g, Radix Isatidis 30g, Herba Pogostemonis 30g, Cornu Saigae Tataricae 2g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250mL, to obtain final product.
The Chinese medicine composition that the present embodiment has refrigeration function adds customary adjuvant, conveniently technique, makes oral liquid.
embodiment 2
The crude drug that the present embodiment has the Chinese medicine composition of refrigeration function consists of:
Flos Lonicerae 20g, Periostracum Cicadae 10g, Gypsum Fibrosum 40g, Talcum 35g, Radix Scutellariae 20g, Radix Et Rhizoma Rhei 5g, Radix Paeoniae Rubra 20g, Radix Isatidis 35g, Herba Pogostemonis 35g, Cornu Saigae Tataricae 2g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 4 hours of 10 weight times amount for the 1st time, add the water extraction 6 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1 hour of 12 weight times amount for 1st time, add the water extraction 1.5 hours of 10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.20, and adding ethanol to the percent by volume of contained ethanol is 40%, fully stirs, leaves standstill, get supernatant, be concentrated into 230mL, to obtain final product.
The Chinese medicine composition that the present embodiment has refrigeration function adds customary adjuvant, conveniently technique, makes capsule.
embodiment 3
The crude drug that the present embodiment has the Chinese medicine composition of refrigeration function consists of:
Flos Lonicerae 20g, Periostracum Cicadae 10g, Gypsum Fibrosum 40g, Talcum 40g, Radix Scutellariae 30g, Radix Et Rhizoma Rhei 10g, Radix Paeoniae Rubra 30g, Radix Isatidis 40g, Herba Pogostemonis 40g, Cornu Saigae Tataricae 3g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) get the Cornu Saigae Tataricae of selected weight, the reflux, extract, that adds water 2 times, add the water extraction 8 hours of 12 weight times amount for the 1st time, add the water extraction 2 hours of 10 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 3 hours of 10 weight times amount for 1st time, add the water extraction 0.5 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20-1.25, and adding ethanol to the percent by volume of contained ethanol is 60%, fully stirs, leaves standstill, get supernatant, be concentrated into 270mL, to obtain final product.
The Chinese medicine composition that the present embodiment has refrigeration function adds customary adjuvant, conveniently technique, makes tablet.
experimental examplethe research of Chinese medicine composition refrigeration function of the present invention
experimental example 1
1, experiment purpose
The refrigeration function of the oral liquid of Chinese medicine composition prepared by research performation example 1, and study dose-effect relationship further.
2, experimental design
Rabbit is divided into 4 groups at random, often organizes 6, male and female dual-purpose.
Before experiment, every rabbit all uses GJ-RJY thermal source auto testing instrument Fundamentals of Measurement body temperature repeatedly, is less than 0.2 DEG C of person for experiment with the temperature difference.Pyrogenicity mode is 10% fresh yeast every rabbit sc (subcutaneous) 20mL/kg, pyrogenicity 4 hours, when body temperature raises more than 1.5 DEG C, start administration, and start thermometric in administration (oral liquid of Chinese medicine composition prepared by embodiment 1) after 1 hour.Later measurement per hour once, continuous 4 times.
3, experimental result
Result shows, the rabbit body temperature of oral liquid to yeast pyrogenicity of Chinese medicine composition prepared by embodiment 1 has certain refrigeration function; Compared with matched group, administration 2 hours (P < 0.05), administration 3 hours refrigeration functions peak (P < 0.01).
experimental example 2
1, experimental design
Experimenter is provided by Dongzhimen Hospital, Beijing Univ of Traditional Chinese Medicine etc. four, from year November October to 2002 calendar year 2001, accepts for medical treatment and observes case 418 example (inpatient 56 example), reject 4 examples, wherein, man 217, female 197, age 1-6 year.
By experimenter with reference to factors such as age, sex, the courses of disease, be divided into 2 groups, treatment group outpatient service 264 example, 45 examples of being in hospital; Matched group outpatient service 94 example, 11 examples of being in hospital.
2, experimental result
Treatment group 309 example, clinical cure 98 example, effective 150 examples, account for 80.26% more than effective; Matched group 105 example, clinical cure 20 example, effective 50 examples, account for 66.67% more than effective.Treatment group compares with matched group, and U=3.04, PP < 0.01, difference has significance.Obvious adverse reaction is not found in clinical experiment.
Therefore, the oral liquid of Chinese medicine composition prepared by embodiment 1 can treat cold anemopyretic syndrome, and within 6 years old, children's's curative effect and age have nothing to do, with sex without obvious relation.
experimental example 3
1, experimental design
Experimenter is provided by BJ Children's Hospital's department of Chinese medicine, from June, 1985 to August, accepts for medical treatment and observes case 50 example; Wherein, man 30, female 20, age reckling 4 months, the maximum 12 years old.Heating is person 39 example in 3 days, the degree of heat 38-40 DEG C of 46 examples.
2, experimental result
After accepting treatment, 47 examples of bringing down a fever in 3 days, account for 94%; Clinical cure 44 example, effective 5 examples, treatment total effective rate is 98%.
Therefore, the oral liquid of the Chinese medicine composition of embodiment 1 preparation is better to fever of children disease curative effect.
In sum, Chinese medicine composition of the present invention has refrigeration function, can as potential antipyretic medicine.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (8)
1. have a Chinese medicine composition for refrigeration function, it is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20-40 weight portion, Periostracum Cicadae 5-20 weight portion, Gypsum Fibrosum 30-60 weight portion, Talcum 30-60 weight portion, Radix Scutellariae 20-40 weight portion, Radix Et Rhizoma Rhei 5-20 weight portion, Radix Paeoniae Rubra 20-40 weight portion, Radix Isatidis 20-40 weight portion, Herba Pogostemonis 20-40 weight portion, Cornu Saigae Tataricae 2-4 weight portion.
2. the Chinese medicine composition with refrigeration function according to claim 1, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5-10 weight portion, Gypsum Fibrosum 35-40 weight portion, Talcum 35-40 weight portion, Radix Scutellariae 20-30 weight portion, Radix Et Rhizoma Rhei 5-10 weight portion, Radix Paeoniae Rubra 20-30 weight portion, Radix Isatidis 30-40 weight portion, Herba Pogostemonis 30-40 weight portion, Cornu Saigae Tataricae 2-3 weight portion.
3. the Chinese medicine composition with refrigeration function according to claim 2, is characterized in that, the crude drug of described Chinese medicine composition consists of:
Flos Lonicerae 20 weight portion, Periostracum Cicadae 5 weight portion, Gypsum Fibrosum 35 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 30 weight portion, Herba Pogostemonis 30 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 35 weight portion, Radix Scutellariae 20 weight portion, Radix Et Rhizoma Rhei 5 weight portion, Radix Paeoniae Rubra 20 weight portion, Radix Isatidis 35 weight portion, Herba Pogostemonis 35 weight portion, Cornu Saigae Tataricae 2 weight portion; Or
Flos Lonicerae 20 weight portion, Periostracum Cicadae 10 weight portion, Gypsum Fibrosum 40 weight portion, Talcum 40 weight portion, Radix Scutellariae 30 weight portion, Radix Et Rhizoma Rhei 10 weight portion, Radix Paeoniae Rubra 30 weight portion, Radix Isatidis 40 weight portion, Herba Pogostemonis 40 weight portion, Cornu Saigae Tataricae 3 weight portion.
4. the preparation method with the Chinese medicine composition of refrigeration function described in any one of claim 1-3, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 1-10 hour of 6-14 weight times amount for the 1st time, add the water extraction 1-8 hour of 6-12 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 0.5-5 hour of 6-14 weight times amount for 1st time, add the water extraction 0.5-3 hour of 6-12 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.05-1.30, and adding ethanol to the percent by volume of contained ethanol is 30%-70%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 220-280 parts by volume, obtain final product.
5. the preparation method with the Chinese medicine composition of refrigeration function according to claim 4, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 4-8 hour of 6-12 weight times amount for the 1st time, add the water extraction 2-6 hour of 6-10 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 1-3 hour of 6-12 weight times amount for 1st time, add the water extraction 0.5-1.5 hour of 6-10 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.15-1.25, and adding ethanol to the percent by volume of contained ethanol is 40%-60%, abundant stirring, leaves standstill, gets supernatant, be concentrated into 230-270 parts by volume, obtain final product.
6. the preparation method with the Chinese medicine composition of refrigeration function according to claim 5, is characterized in that, comprise the following steps:
(1) get the Cornu Saigae Tataricae of selected weight portion, the reflux, extract, that adds water 2 times, add the water extraction 6 hours of 10 weight times amount for the 1st time, add the water extraction 4 hours of 8 weight times amount for the 2nd time, filter, merging filtrate, obtains extracting solution A, for subsequent use;
(2) Flos Lonicerae of selected weight portion, Periostracum Cicadae, Gypsum Fibrosum, Talcum, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Isatidis and Herba Pogostemonis is got respectively, the reflux, extract, that adds water 2 times, add the water extraction 2 hours of 10 weight times amount for 1st time, add the water extraction 1 hour of 8 weight times amount for 2nd time, filter, merging filtrate, obtains extracting solution B, for subsequent use;
(3) described extracting solution A and described extracting solution B are merged, mix homogeneously, being concentrated into 50 DEG C of relative densities is 1.20, and adding ethanol to the percent by volume of contained ethanol is 50%, fully stirs, leaves standstill, get supernatant, be concentrated into 250 parts by volume, obtain final product.
7. comprise the preparation with the Chinese medicine composition of refrigeration function described in any one of claim 1-3 or comprise the preparation of the Chinese medicine composition that the preparation method described in any one of claim 4-6 prepares, it is characterized in that,
Described Chinese medicine composition adds customary adjuvant, conveniently technique, makes acceptable oral liquid, granule, tablet, capsule, powder, pill, syrup or unguentum clinically.
8. the application had in the medicine of refrigeration function prepared by the preparation of the Chinese medicine composition that the Chinese medicine composition described in any one of claim 1-3, preparation method described in any one of claim 4-6 prepare or Chinese medicine composition according to claim 7.
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| CN105535136A (en) * | 2015-12-21 | 2016-05-04 | 北京同仁堂科技发展股份有限公司 | A traditional Chinese medicine composition having a bacteriostasis function, a preparing method thereof and uses of the composition |
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