CN1055009A - 人的碱性fgf突变蛋白质的制备 - Google Patents

人的碱性fgf突变蛋白质的制备 Download PDF

Info

Publication number
CN1055009A
CN1055009A CN90110115A CN90110115A CN1055009A CN 1055009 A CN1055009 A CN 1055009A CN 90110115 A CN90110115 A CN 90110115A CN 90110115 A CN90110115 A CN 90110115A CN 1055009 A CN1055009 A CN 1055009A
Authority
CN
China
Prior art keywords
mutein
amino acid
hbfgf
transformant
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN90110115A
Other languages
English (en)
Chinese (zh)
Inventor
北野一昭
栗山正人
西村纪
五十岚贡一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1055009A publication Critical patent/CN1055009A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • C07K14/503Fibroblast growth factor [FGF] basic FGF [bFGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN90110115A 1989-12-19 1990-12-19 人的碱性fgf突变蛋白质的制备 Pending CN1055009A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33022589 1989-12-19
JP330225/89 1989-12-19

Publications (1)

Publication Number Publication Date
CN1055009A true CN1055009A (zh) 1991-10-02

Family

ID=18230255

Family Applications (1)

Application Number Title Priority Date Filing Date
CN90110115A Pending CN1055009A (zh) 1989-12-19 1990-12-19 人的碱性fgf突变蛋白质的制备

Country Status (7)

Country Link
EP (1) EP0506963A1 (ko)
JP (1) JP3130313B2 (ko)
KR (1) KR920703789A (ko)
CN (1) CN1055009A (ko)
CA (1) CA2070989A1 (ko)
HU (1) HUT64593A (ko)
WO (1) WO1991009126A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100374310B1 (ko) * 1995-02-14 2003-05-22 주식회사 엘지생명과학 변형된인간염기성섬유아세포성장인자및이의생산방법
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
AU2002236477A1 (en) * 2000-11-21 2002-06-03 The Texas A & M University System Fgf-affinity chromatography
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP2083846B1 (en) 2006-09-28 2015-07-15 Hepacore Ltd. N-terminal fgf variants having increased receptor selectivity and uses thereof
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
DE102021211272A1 (de) 2021-10-06 2023-04-06 Ruhr-Universität Bochum, Körperschaft des öffentlichen Rechts Zusammensetzung enthaltend künstliche Sauerstoffträger zur Verhinderung von Organschäden in Transplantationsorganen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0178863A1 (en) * 1984-10-15 1986-04-23 Schering Corporation Novel expression systems utilizing bacteriophage T7 promoters and gene sequences
DE3723992A1 (de) * 1987-07-20 1989-02-02 Boehringer Mannheim Gmbh Verfahren zur herstellung von proteinen in loeslicher form
AU638402B2 (en) * 1987-11-24 1993-07-01 Amgen, Inc. Analogs of fibroblast growth factor
EP0326907A1 (en) * 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA and its use

Also Published As

Publication number Publication date
HUT64593A (en) 1994-01-28
CA2070989A1 (en) 1991-06-20
JPH05503006A (ja) 1993-05-27
HU9202039D0 (en) 1992-09-28
KR920703789A (ko) 1992-12-18
EP0506963A1 (en) 1992-10-07
WO1991009126A1 (en) 1991-06-27
JP3130313B2 (ja) 2001-01-31

Similar Documents

Publication Publication Date Title
CN1031893C (zh) 碱性成纤维细胞生长因子的突变蛋白,dna及其应用
CN1023900C (zh) 人初级成纤维细胞生长因子的制备方法
CN1055725C (zh) 编码巨核细胞增强因子的基因
JP5677918B2 (ja) アミド化生成物の調製に有用な酵素を発現させるための細胞株
TW494138B (en) Methods of producing hydrophobic polypeptides in E coli
Liang et al. Studies of structure-activity relationships of human interleukin-2.
CN1902311A (zh) 具有n-末端游离硫羟基的新的重组蛋白
CN86100868A (zh) 表达人类c蛋白的活性的载体和方法
FR2730495A1 (fr) Derive de proinsuline et procede pour la production d'insuline humaine
JPH08503612A (ja) 細菌におけるポリペプチド産生の調節方法
FR2594846A1 (fr) Procede de preparation de la serum albumine humaine mature
CN1134111A (zh) 使用胰岛素样生长因子结合蛋白质的方法
CN1055009A (zh) 人的碱性fgf突变蛋白质的制备
CN1075148A (zh) 新的巨核细胞扩增基因
JPH0463595A (ja) ヒトインターロイキン3誘導体
WO1993003061A1 (en) Hematopoietic stem cell multiplier
KR900004428B1 (ko) 용성 성숙 hIL-β 및 변경된 생물학적 활성을 갖는 유도체를 이.콜라이에서 고도로 발현시키는 플라즈미드 및 그 방법
Kumagai et al. Expression of goat α-lactalbumin in Escherichia coli and its refolding to biologically active protein
CN114657160B (zh) 一种糖基转移酶突变体及其应用
CN1346889A (zh) 在原核细胞内产生活性异二聚体amv-rt的方法
CN1021461C (zh) 人粒性白细胞集落刺激因子
CN113122525A (zh) 一种甲醛转化蛋白及其应用
Uchida et al. An active site of growth hormone for eliciting the differentiation of preadipose 3T3-F442A cells to adipose cells
CN114807205B (zh) 表达利拉鲁肽前体的重组工程菌及其构建方法和应用
JP2015508662A (ja) 1→3リーディングフレームシフトを減少させるための方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication