CN105491997B - 舌下及颊面膜组合物 - Google Patents

舌下及颊面膜组合物 Download PDF

Info

Publication number
CN105491997B
CN105491997B CN201480027179.8A CN201480027179A CN105491997B CN 105491997 B CN105491997 B CN 105491997B CN 201480027179 A CN201480027179 A CN 201480027179A CN 105491997 B CN105491997 B CN 105491997B
Authority
CN
China
Prior art keywords
film dosage
film
dosage composition
agonist
naloxone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201480027179.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN105491997A (zh
Inventor
G·L·迈尔斯
E·戴迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aquitif Therapy Co
Original Assignee
Aquitif Therapy Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquitif Therapy Co filed Critical Aquitif Therapy Co
Publication of CN105491997A publication Critical patent/CN105491997A/zh
Application granted granted Critical
Publication of CN105491997B publication Critical patent/CN105491997B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480027179.8A 2013-03-15 2014-03-14 舌下及颊面膜组合物 Active CN105491997B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/842,543 US20140271788A1 (en) 2013-03-15 2013-03-15 Sublingual and buccal film compositions
US13/842,543 2013-03-15
US14/196,082 2014-03-04
US14/196,082 US9511033B2 (en) 2013-03-15 2014-03-04 Sublingual and buccal film compositions
PCT/US2014/028568 WO2014144241A1 (en) 2013-03-15 2014-03-14 Sublingual and buccal film compositions

Publications (2)

Publication Number Publication Date
CN105491997A CN105491997A (zh) 2016-04-13
CN105491997B true CN105491997B (zh) 2019-12-17

Family

ID=51528033

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480027179.8A Active CN105491997B (zh) 2013-03-15 2014-03-14 舌下及颊面膜组合物

Country Status (15)

Country Link
US (5) US20140271788A1 (cg-RX-API-DMAC7.html)
EP (1) EP2968121B1 (cg-RX-API-DMAC7.html)
JP (2) JP6448096B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160029730A (cg-RX-API-DMAC7.html)
CN (1) CN105491997B (cg-RX-API-DMAC7.html)
AU (1) AU2014227693B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015023725A2 (cg-RX-API-DMAC7.html)
CA (1) CA2906773C (cg-RX-API-DMAC7.html)
DK (1) DK2968121T3 (cg-RX-API-DMAC7.html)
IL (1) IL241441B (cg-RX-API-DMAC7.html)
MX (1) MX2015013184A (cg-RX-API-DMAC7.html)
MY (1) MY181159A (cg-RX-API-DMAC7.html)
RU (1) RU2015143647A (cg-RX-API-DMAC7.html)
WO (1) WO2014144241A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201507685B (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140271788A1 (en) * 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
WO2016071767A1 (en) 2014-11-07 2016-05-12 Indivior Uk Limited Buprenorphine dosing regimens
US20160175296A1 (en) * 2014-12-23 2016-06-23 Arx, Llc Method of producing uniform buprenorphine-containing formulations
JPWO2016163403A1 (ja) * 2015-04-07 2018-02-01 ニプロ株式会社 経口フィルム製剤
DK3411031T3 (da) 2016-02-04 2024-10-21 Cindome Pharma Inc Deutererede domperidonpræparater og fremgangsmåder til terapi af lidelser
US11738036B2 (en) 2016-05-28 2023-08-29 Rajiv Gandhi Centre For Biotechnology, An Autonomous Institute Under The Department Of Biotechnology, Government Of India Uttroside B and derivatives thereof as therapeutics for hepatocellular carcinoma
IL266537B2 (en) 2016-11-15 2023-12-01 Klaria Pharma Holding Ab Pharmaceutical formulation
MX2019007923A (es) 2016-12-31 2019-09-10 Bioxcel Therapeutics Inc Uso de dexmedetomidina sublingual para el tratamiento de la agitacion.
GB201709141D0 (en) 2017-06-08 2017-07-26 Klaria Pharma Holding Ab Pharmaceutical formulation
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
US12478612B2 (en) 2017-06-30 2025-11-25 Cindome Pharma, Inc. Deuterated domperidone compositions, methods, and preparation
KR20240125702A (ko) 2017-06-30 2024-08-19 신돔 파마, 인크. 중수소화 돔페리돈 조성물, 방법, 및 제조
EP3473246A1 (en) 2017-10-19 2019-04-24 Capsugel Belgium NV Immediate release abuse deterrent formulations
GB201808462D0 (en) * 2018-05-23 2018-07-11 Klaria Pharma Holding Ab Pharmaceutical formulation
JPWO2019240212A1 (ja) 2018-06-14 2021-06-24 株式会社カネカ 薬学的活性成分を含む製剤
PT3813802T (pt) 2018-06-27 2025-01-15 Arx Llc Formulações de películas contendo dexmedetomidina e métodos de produção das mesmas
WO2020006073A1 (en) * 2018-06-28 2020-01-02 Arx, Llc Dispensing method for producing dissolvable unit dose film constructs
GB201819978D0 (en) * 2018-12-11 2019-01-23 Univ Strathclyde Oral thin films
JP7287032B2 (ja) 2019-03-20 2023-06-06 株式会社リコー シート、シート積層体、医薬品、シートの製造方法、及びシート積層体の製造方法
KR20220049526A (ko) 2019-07-19 2022-04-21 바이오엑셀 테라퓨틱스 인코포레이티드 비-진정성 덱스메데토미딘 치료 양생법
US11806320B2 (en) * 2020-02-19 2023-11-07 Endo Ventures Limited Isoproterenol compositions and methods
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
WO2025147530A1 (en) * 2024-01-05 2025-07-10 Taho Pharmaceuticals Ltd. Naloxone buccal film product and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117838A1 (en) * 2004-06-02 2005-12-15 Galephar M/F Stable oral pharmaceutical compositions of buprenorphine and derivatives
CN102481250A (zh) * 2009-08-07 2012-05-30 莫诺索尔克斯有限公司 舌下和口腔膜组合物
CN102548535A (zh) * 2009-08-07 2012-07-04 雷克特本克斯尔保健(英国)有限公司 舌下和口腔用薄膜组合物

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493657A (en) 1961-03-14 1970-02-03 Mozes Juda Lewenstein Therapeutic compositions of n-allyl-14-hydroxy - dihydronormorphinane and morphine
US4457933A (en) 1980-01-24 1984-07-03 Bristol-Myers Company Prevention of analgesic abuse
US4366159A (en) 1981-09-08 1982-12-28 Michael Richard Magruder Nalbuphine-narcotic analgesic composition and method of producing analgesia
GB8332556D0 (en) 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions
US5225417A (en) 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5223507A (en) 1992-01-21 1993-06-29 G. D. Searle & Co. Method of using opioid compounds as delta opioid selective agonist analgesics
GB9202464D0 (en) 1992-02-05 1992-03-18 Danbiosyst Uk Composition for nasal administration
EP0782445B1 (en) 1994-09-19 2002-03-13 Dupont Pharmaceuticals Company Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence
US5866154A (en) * 1994-10-07 1999-02-02 The Dupont Merck Pharmaceutical Company Stabilized naloxone formulations
AT403162B (de) 1995-10-11 1997-11-25 Nycomed Austria Gmbh Neue kristallform von morphin-6-glucuronid
DE19602959A1 (de) 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DK0914097T3 (da) 1996-03-12 2002-04-29 Alza Corp Sammensætning og doseringsform omfattende opioid antagonist
WO1998035679A1 (de) 1997-02-14 1998-08-20 Gödecke Aktiengesellschaft Stabilisierung von naloxonhydrochlorid
ES2217563T3 (es) 1997-07-11 2004-11-01 Toray Industries, Inc. Compuestos medicinales estables que contienen derivados de 4,5-epoximorfinado.
ATE210983T1 (de) 1997-11-03 2002-01-15 Stada Arzneimittel Ag Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum
IT1302682B1 (it) 1998-10-16 2000-09-29 Formenti Farmaceutici Spa Composizioni farmaceutiche orali contenenti buprenorfina
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20140271788A1 (en) * 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
CA2530843A1 (en) * 2003-07-01 2005-01-20 Todd Maibach Film comprising therapeutic agents
US20060046962A1 (en) * 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
US7666442B2 (en) * 2004-08-31 2010-02-23 Tracie Martyn International, Llc Topical compositions comprising benfotiamine and pyridoxamine
JP2007304673A (ja) 2006-05-09 2007-11-22 Kyocera Mita Corp 監視装置及び監視システム並びに監視プログラム

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117838A1 (en) * 2004-06-02 2005-12-15 Galephar M/F Stable oral pharmaceutical compositions of buprenorphine and derivatives
CN102481250A (zh) * 2009-08-07 2012-05-30 莫诺索尔克斯有限公司 舌下和口腔膜组合物
CN102548535A (zh) * 2009-08-07 2012-07-04 雷克特本克斯尔保健(英国)有限公司 舌下和口腔用薄膜组合物

Also Published As

Publication number Publication date
US20140271789A1 (en) 2014-09-18
MX2015013184A (es) 2016-04-07
IL241441A0 (en) 2015-11-30
AU2014227693B2 (en) 2018-06-21
US20170296482A1 (en) 2017-10-19
KR20160029730A (ko) 2016-03-15
WO2014144241A1 (en) 2014-09-18
ZA201507685B (en) 2017-06-28
US9511033B2 (en) 2016-12-06
US20200315984A1 (en) 2020-10-08
CA2906773A1 (en) 2014-09-18
JP2019048882A (ja) 2019-03-28
DK2968121T3 (en) 2019-02-04
JP6448096B2 (ja) 2019-01-09
AU2014227693A1 (en) 2015-10-29
IL241441B (en) 2019-07-31
CA2906773C (en) 2023-12-12
RU2015143647A (ru) 2017-04-21
MY181159A (en) 2020-12-19
EP2968121A1 (en) 2016-01-20
EP2968121B1 (en) 2018-12-19
JP2016513736A (ja) 2016-05-16
US20190038570A1 (en) 2019-02-07
BR112015023725A2 (pt) 2017-07-18
CN105491997A (zh) 2016-04-13
US20140271788A1 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
CN105491997B (zh) 舌下及颊面膜组合物
AU2020200651B2 (en) Sublingual and buccal film compositions
CN102548535B (zh) 舌下和口腔用薄膜组合物
US10285910B2 (en) Sublingual and buccal film compositions
HK1171960B (en) Sublingual and buccal film compositions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: new jersey

Applicant after: Aquitif Therapy Company

Address before: new jersey

Applicant before: MONOSOL RX LLC

GR01 Patent grant
GR01 Patent grant