CN105477437A

CN105477437A - Traditional Chinese medicine for treating ischemic cardiomyopathy and preparation method

Info

Publication number: CN105477437A
Application number: CN201610049839.3A
Authority: CN
Inventors: 娄明晓
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-26
Filing date: 2016-01-26
Publication date: 2016-04-13

Abstract

The invention provides a traditional Chinese medicine for treating ischemic cardiomyopathy and a preparation method. Raw medicine materials of the traditional Chinese medicine include silene conoidea, pholidota chinensis lindl, erianthus arundinaceus, clematis finetiana, pigeonpea, cudweed herb, herb of Wight Parnassia, ginkgo roots, Ficus stenophylla Hemsl., clinopodium herb, laciniate begonia herb, gray vernonia, goat-ear elecampane, lance asiabell roots, sargent craneberrybuch branchlet and leaves, herba pimpinellae and vitis coignetiae. The traditional Chinese medicine has the advantages that traditional Chinese medicine and western medicine are used in cooperation for treatment and have a precise treatment effect on ischemic cardiomyopathy, the obvious effect rate and the total effective rate can be effectively increased, and toxic and side effects and adverse effects do not exist.

Description

A kind of Chinese medicine and preparation method for the treatment of ischemic cardiomyopathy

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of ischemic cardiomyopathy.

Background technology

Ischemic cardiomyopathy (ischemiccardiomyopathy, ICM) a kind of specific type or the late stage of coronary heart disease is belonged to, refer to and cause long-term myocardial ischemia by coronary atherosclerosis, cause myocardium diffuse fibrosis, produce the clinical syndrome similar with Original Dilated Cardiomyopathy.Along with the continuous increase of Incidence of CHD, the harm that ICM causes human health is also day by day serious.Nineteen ninety-five, WHO/ISFC was defined as ischemic cardiomyopathy: show as dilated cardiomyopathy, the infringement of companion's contractile function, but can not explain by Severity of Coronary Lesion and ischemic damage degree.

According to the different clinical manifestations of patient, ischemic cardiomyopathy can be divided into two large class, i.e. Congestive Ischemic Cardiomyopathy: A Reports and restricted type ischemic cardiomyopathys.Their clinical manifestation is very similar to dilated cardiomyopathy in primary cardiac myopathy and restrictive cardiomyopathy.But ischemic cardiomyopathy and primary cardiac myopathy have difference again in itself.Ischemic cardiomyopathy patients have nothing in common with each other, and the performance of congestive cardiomyopathy or restrictive cardiomyopathy can appear in most of patient, and small part patient can not have obvious clinical symptoms.According to the dissimilar of ischemic cardiomyopathy, its corresponding clinical manifestation is described respectively below.1. Congestive Ischemic Cardiomyopathy: A Reports: the patient of this congestive cardiomyopathy performance accounts for the myocardiac overwhelming majority.In being common in, old people, in the majority with male patient, have obvious history of coronary heart disease, male: women is about 5 ~ 7: 1, symptom generally occurs gradually.Patient's main manifestations is the following aspects.(1) angina pectoris: angina pectoris is one of patient's cardinal symptom, but with the appearance of heart failure, angina pectoris can reduce gradually and even disappear.Ischemic cardiomyopathy has clear and definite history of coronary heart disease more, and the overwhelming majority has the medical history of more than 1 time myocardial infarction.Angina pectoris is one of common clinical symptoms of Ischemic Cardiomyopathy.But angina pectoris is not the symptom of Patients with Myocardial Ischemia indispensability, and some patients also only can show as silent myocardial ischemia, all the time without the performance of angina pectoris or myocardial infarction.There is angina pectoris attacks in the ischemic cardiomyopathy case of nearly 72% ~ 92%.Also someone reports that the myocardial infarction case of 1/3 ~ 1/2 was once failed to pinpoint a disease in diagnosis.Thisly repeatedly to occur and ever-present silent myocardial ischemia or myocardial infarction progressively can cause Congestive Ischemic Cardiomyopathy: A Reports.These patients do not occur that angina pectoris may be because its threshold of pain is higher, and this has the warning system of Protection significance to lack angina pectoris.In this kind of patient, to the infringement also sustainable existence of cardiac muscle, until there is congestion type heart failure in silent myocardial ischemia sustainable existence.Someone thinks that the clinical meaning of this silent myocardial ischemia and hazardness have the myocardial ischemia of angina pectoris symptom identical together.Occur that anginal angina pectoris symptom may along with the progress of the state of an illness, running down of congestive heart failure, angina pectoris attacks alleviates gradually and even disappears, and only shows as the symptoms such as uncomfortable in chest, weak, dizzy or dyspnea.(2), once there is heart failure progress rapidly in heart failure: heart failure often ischemic cardiomyopathy develops into the performance that certain phase must occur, makes slow progress in early days.Most patient is in episode or myocardial infarction i.e. heart failure performance in early days, and this is because acute myocardial ischemia causes caused by myocardial relaxation and contractile dysfunction.Current research shows, transient myocardial, the early stage diastolic function of main damage, performance of namely releiving; Prolonged and repeated generation myocardial ischemia, causes abnormality of diastolic function in obvious late period, and namely left room compliance reduces, stiffness index raises.Large Area Myocardial Infarction makes cardiac interstitium network be destroyed, and causes acute ventricular dilatation, and the compliance of the chambers of the heart is raised; And collections myocardial infarction or fibrosis, chambers of the heart stiffness index can be caused to increase, and compliance reduces.I.e. ventricular dilatation after myocardial infarction, compliance raises, if there is myocardial ischemia again, still can occur that left room diastole early filling obstacle and chambers of the heart hardness increase.Patient often shows as exertional dyspnea, can develop into the performance of the left ventricular insufficiency such as orthopnea and nocturnal paroxysmal dyspnea, with tired, weakness symptom time serious.Cardiac auscultation decreased loudness of first sound, audible and diastole middle and advanced stage gallop rhythm.Two base of lung audibles and be dispersed in moist rales.If be associated with right ventricular function exhaustion late period, there is the symptoms such as anorexia, peripheral edema and the vexed swollen sense of upper right abdomen in patient.The visible jugular vein of health check-up fills or anger is opened, the expansion of heart circle, liver enlargement, tenderness, and hepatojugular reflux is positive.This peripheral edema slower development and hiding, for referring to sunken property edema, often from sagging position, upwards develops gradually.(3) arrhythmia: long-term, chronic myocardial ischemia causes myocardial necrosis, myocardial stunning, myocardial hibernation and focal or diffuse fibrosis until cicatrization, cause myocardial electrical activity obstacle, comprise the formation of impulsion, granting and conduction and all can produce exception.Various types of arrhythmia can be there is in the course of disease of Congestive Ischemic Cardiomyopathy: A Reports, especially common with premature ventricular beat, atrial fibrillation and bundle branch block.At same ischemic cardiomyopathy patient, arrhythmia performance is complicated and changeable.Main cause is: 1. arrhythmia Crack cause is complicated, if myocardial necrosis, fibrosis, ischemia or other reasons are to the damage of cardiac muscle; 2. the mechanism that formed of arrhythmia is complicated, comprises foldback mechanism, self-disciplining increases or trigger mechanism; 3. ARR type is complicated, and same patient not only supraventricular and ventricular arrhythmia can occur, and conduction block can also occur; 4. pathological changes types of arrhythmia in late period is instantaneous changeable, and about the ischemic cardiomyopathy of half dies from various serious arrhythmia.(4) thrombosis and thromboembolism: the case forming thrombosis and thromboembolism in heart chamber is more common in: 1. heart chamber is obviously enlarger; 2. atrial fibrillation and non-anticoagulant therapy person; 3. heart output obviously reduction person., after coming off, there is pulmonary infarction in long-term bed and do not carry out the easy venous thrombosis in lower extremities of the patient of limb activity and formed.Bibliographical information Ischemic Cardiomyopathy incidence of thrombus is had to be 14% ~ 24%.Although it should be pointed out that the common clinical manifestation of Congestive Ischemic Cardiomyopathy: A Reports is congestive heart failure, also have the serious symptoms of some patients and the extent of damage of left ventricular function and myocardial abnormality change between Chang Bucheng ratio.This may be relevant with the number at the size of myocardial infarct size and position.The myocardial infarction of some patient occurs in multiple position, and be distributed within the scope of the coronary artery domination of more than two, with regard to single infarct location, downright bad scope may be also not very big, though the impact of myocardial necrosis for ventricular function be confined to a position person of cardiac muscle infringement more than those have onesize myocardial necrosis occurs at multiple position want large many.In addition, though the average chamber wall thickness of Ischemic Cardiomyopathy heart is than having repeatedly myocardial infarction but ventricle wall without Congestive Ischemic Cardiomyopathy: A Reports person, congestion type DCM (dilated cardiomyopathy) person or cardiac valve patient is thin, this may be because coronary artery pathological changes widely, seriously limit blood confession, make not downright bad cardiac muscle can not the loose or myocardium temporary hypertrophy of appropriateness afterwards eventually because of ischemia atrophy again again.2. restricted type ischemic cardiomyopathy: although most of ischemic cardiomyopathy patient performance is similar to DCM (dilated cardiomyopathy); the clinical manifestation of small number of patients is main abnormal based on left ventricular diastolic function; and myocardium shrinkage function normally or only mile abnormality; be similar to the sings and symptoms of restrictive cardiomyopathy, therefore be called as restricted type ischemic cardiomyopathy or hard-core syndrome (stiffheartsyndrome).Patient often has exertional dyspnea and (or) angina pectoris, therefore limitation of activity.These patients often go to a doctor because repeatedly there is pulmonary edema.Patient can without myocardial infarction medical history, and heart does not often expand.The voltage rise of Left Ventricular end-diastolic is high, end-diastolic volume increases and ejection fraction only slightly reduces, even if when there is acute myocardial infarction, although some patient there occurs pulmonary venous pleonaemia even pulmonary edema, can have close to normal left ventricular ejection fraction.Absolutely prove that the core function abnormality of these patients is not normal based on diastolic function.This type Ischemic Cardiomyopathy often has abnormal pressure volume curve; patient is under quiescent condition; left ventricular end diastolic presssure is also higher than normally; when acute ischemic events; the compliance of ventricle decline further (i.e. the further increase of heart stiffness index) make left ventricular end diastolic presssure be increased to generation pulmonary edema, and contractile function can normally or only slightly impaired.

Ischemic cardiomyopathy is under the jurisdiction of Chinese medicine edema, thoracic obstruction category.The generation of edema mainly blame in lung, spleen, the dirty functional disorder of kidney three, water is wet to spread unchecked.The thoracic obstruction many with inward invasion of pathogenic cold, improper diet, disorder of emotion, body deficiency due to old age's factors are relevant, pathogenesis is deficiency in origin and excess in superficiality.False heart spleen deficiency of the liver and kindey, heart arteries and veins loses supports; Be cold coagulation, the stagnation of QI, blood stasis, stagnation of phlegm in fact, stagnated chest-YANG, stagnating heart meridian.Primary disease is that the thoracic obstruction further develops, and deficiency of heart-YANG and kidney-YANG pathogenic water spreads unchecked, and insult the heart and penetrate lung, sick position is at the heart, lung, spleen, kidney.Right gas is sun, and blood is cloudy, " qi as the commander of blood ", and " also, carrier gas person's blood also for fortune blood person gas ", then blood fortune is unable for insufficiency of heart-QI, warm weary power, stagnation of heart-blood, blood stasis causing water retention.Heart failure pathogenesis is with the deficiency of vital energy, yang deficiency for this, and blood stasis, edema are mark.Yang-energy is weak, and blood fortune is unable, and thrombosis causes the stasis of blood; Transporting or gasify unable, water is wet to stop poly-ly forming swollen, and recent studies shows that deficiency of vital energy person has heart contraction, diastolic function in various degree to lower.The deficiency of vital energy be yang deficiency gradually, yang deficiency be the deficiency of vital energy very, therefore blood stasis due to qi deficiency is the main pathomechanism of primary disease.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of ischemic cardiomyopathy, Chinese medicine of the present invention and Western medicine partner treatment, have definite curative effect to ischemic cardiomyopathy, toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of ischemic cardiomyopathy, the each raw medicinal material of described Chinese medicine comprises: Herba Silenes conoideae, Pseudobulbus Pholidotae Chinensis, Radix sacchari arundinacei, Caulis Clematidis Finetianae, Semen Cajani, Herba Gnaphalii Affinis, Herba Parnassiae Wightianae, Radix Ginkgo, Herba Fici Stenophyliae, Herba clinopodii confinis (Herba Clinopodii Gracilis), Herba Begoniae Laciniatae, Herba Vernoniae Cinereae, Herba Inulae cappae, Radix Codonopsis lanceolatae, Folium et Cacumen Viburni Sargentii, Radix Pimpinellae Candolleanae and purple Pueraria lobota.

The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Silenes conoideae 10 ~ 20 parts, Pseudobulbus Pholidotae Chinensis 15 ~ 25 parts, Radix sacchari arundinacei 10 ~ 20 parts, Caulis Clematidis Finetianae 20 ~ 30 parts, Semen Cajani 10 ~ 20 parts, Herba Gnaphalii Affinis 5 ~ 15 parts, Herba Parnassiae Wightianae 15 ~ 25 parts, Radix Ginkgo 20 ~ 30 parts, Herba Fici Stenophyliae 10 ~ 20 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 20 ~ 30 parts, Herba Begoniae Laciniatae 22 ~ 32 parts, Herba Vernoniae Cinereae 10 ~ 20 parts, Herba Inulae cappae 10 ~ 20 parts, Radix Codonopsis lanceolatae 20 ~ 30 parts, Folium et Cacumen Viburni Sargentii 13 ~ 23 parts, Radix Pimpinellae Candolleanae 20 ~ 30 parts and purple Pueraria lobota 12 ~ 22 parts.

The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Silenes conoideae 15 ~ 20 parts, Pseudobulbus Pholidotae Chinensis 17 ~ 22 parts, Radix sacchari arundinacei 13 ~ 18 parts, Caulis Clematidis Finetianae 22 ~ 27 parts, Semen Cajani 10 ~ 15 parts, Herba Gnaphalii Affinis 8 ~ 13 parts, Herba Parnassiae Wightianae 18 ~ 23 parts, Radix Ginkgo 25 ~ 30 parts, Herba Fici Stenophyliae 13 ~ 18 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 25 ~ 30 parts, Herba Begoniae Laciniatae 24 ~ 29 parts, Herba Vernoniae Cinereae 14 ~ 19 parts, Herba Inulae cappae 10 ~ 15 parts, Radix Codonopsis lanceolatae 25 ~ 30 parts, Folium et Cacumen Viburni Sargentii 16 ~ 21 parts, Radix Pimpinellae Candolleanae 24 ~ 29 parts and purple Pueraria lobota 14 ~ 19 parts.

The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Silenes conoideae 20 parts, Pseudobulbus Pholidotae Chinensis 18 parts, Radix sacchari arundinacei 16 parts, Caulis Clematidis Finetianae 23 parts, Semen Cajani 14 parts, Herba Gnaphalii Affinis 9 parts, Herba Parnassiae Wightianae 22 parts, Radix Ginkgo 26 parts, Herba Fici Stenophyliae 16 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 26 parts, Herba Begoniae Laciniatae 28 parts, Herba Vernoniae Cinereae 15 parts, Herba Inulae cappae 15 parts, Radix Codonopsis lanceolatae 25 parts, Folium et Cacumen Viburni Sargentii 20 parts, Radix Pimpinellae Candolleanae 25 parts and purple Pueraria lobota 18 parts.

The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Silenes conoideae 16 parts, Pseudobulbus Pholidotae Chinensis 20 parts, Radix sacchari arundinacei 14 parts, Caulis Clematidis Finetianae 26 parts, Semen Cajani 12 parts, Herba Gnaphalii Affinis 11 parts, Herba Parnassiae Wightianae 20 parts, Radix Ginkgo 30 parts, Herba Fici Stenophyliae 15 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 28 parts, Herba Begoniae Laciniatae 25 parts, Herba Vernoniae Cinereae 18 parts, Herba Inulae cappae 10 parts, Radix Codonopsis lanceolatae 28 parts, Folium et Cacumen Viburni Sargentii 17 parts, Radix Pimpinellae Candolleanae 27 parts and purple Pueraria lobota 15 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

Beneficial effect of the present invention: Chinese medicine of the present invention and Western medicine partner treatment, have definite curative effect to ischemic cardiomyopathy, can effectively improve obvious effective rate and total effective rate, have no side effect and untoward reaction.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of ischemic cardiomyopathy, its raw medicinal material comprises: Herba Silenes conoideae, Pseudobulbus Pholidotae Chinensis, Radix sacchari arundinacei, Caulis Clematidis Finetianae, Semen Cajani, Herba Gnaphalii Affinis, Herba Parnassiae Wightianae, Radix Ginkgo, Herba Fici Stenophyliae, Herba clinopodii confinis (Herba Clinopodii Gracilis), Herba Begoniae Laciniatae, Herba Vernoniae Cinereae, Herba Inulae cappae, Radix Codonopsis lanceolatae, Folium et Cacumen Viburni Sargentii, Radix Pimpinellae Candolleanae and purple Pueraria lobota.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Silenes conoideae: [another name] Coelogyne barbata Eriff., incense burner grass, rice crock, Flos Mume bottle, noodles dish, Pericarpium Citri Reticulatae dish, wooden dipper are chewed, Radix Betae, wheat Punica granatum L., oil bottle dish, Radix Rumicis Japonici, red not English dish, Hu Ping Cai, wheat dishes made from scrambled eggs, Fructus Seu Herba Pubescentis; Physalis minima L.; Bottle & Can flower.[source] medical material Ji Yuan: be the herb of pinkwort Herba Silenes conoideae.[nature and flavor] are sweet; Micro-hardship; Cool in nature.[return through] heart; Liver Channel.[function cures mainly] yin nourishing; Heat clearing away; Blood-arresting catamenia-regulating.Main haematemesis; Epistaxis; Chronic consumptive disease is coughed; Spitting of blood; Hematuria; Menoxenia.[extracts] " China's book on Chinese herbal medicine "

Pseudobulbus Pholidotae Chinensis: [another name] tor lotus, stone Fructus Canarii albi, Herba Bulbophylli Odoratissim, blue, the large bracketplant of short, Herba Bulbophylli inconspicui, little clasp in thousand, Pumex dry measure used in former times, upper Pseudobulbus Pholidotae Chinensis, Pseudobulbus Pholidotae Chinensis grass, Ma Liugen, upper Bulbus Lycoridis Radiatae, Herba Bulbophylli inconspicui orchid, stone Fructus Corni, didactic literary composition orchid, the Oviductus Ranae that climbs the tree, Ishikawa dish.[source] medical material Ji Yuan: be pseudobulb or the herb of orchid Pseudobulbus Pholidotae Chinensis.[nature and flavor] are sweet; Micro-hardship; Cool in nature.[return through] lung; Kidney channel.[function cures mainly] nourishing YIN and moistening the lung; Heat-clearing and toxic substances removing; Dampness removing; Repercussive.Main cough due to lung-heat; Hemoptysis; Spit blood; Dizzy; Headache; Nocturnal emission; Laryngopharynx swelling and pain; Rheumatalgia; Damp and hot edema; Dysentery; Leucorrhea; Infantile malnutrition; Scrofula; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix sacchari arundinacei: [another name] is close greatly, fragrant plant thatch.[source] medical material Ji Yuan: be the root of grass Radix sacchari arundinacei.Gather and store: summer, autumn gather, cleaning, dry.[nature and flavor] are sweet; Talk; Flat.[function cures mainly] promoting blood circulation to restore menstrual flow; Sensible diuretic.Main traumatic injury; Muscles and bones wind pain; Amenorrhea; Menoxenia; Edema distention of the abdomen caused by various parasites.[each discussion] 1. Cui Yu stannum " cuisine canon ": main continuous wound absolutely, the hard muscles and bones of invigorating middle warmer, physical strength profiting, good order becomes to.2. " good right book on Chinese herbal medicine ": main improving eyesight, its meat of polyphagia, QI invigorating, helps negative and positive.3. amplification on Canon of Materia Medica: the deficient people of prolonged illness eats it, QI invigorating.4. " detailed outline ": eat it, make us not choking.[extracts] " China's book on Chinese herbal medicine "

Caulis Clematidis Finetianae: [another name] Radix scopoliae sinensis.[source] medical material Ji Yuan: be root, stem, the leaf of ranunculaceae plant Caulis Clematidis Finetianae.Gather and store: the four seasons can adopt, using fresh herb or dry.[nature and flavor] are pungent; Bitter; Warm in nature.[return through] returns liver, urinary bladder channel.[function cures mainly] expelling wind and activating blood circulation; Inducing diuresis for treating stranguria syndrome.Main joint swells and ache; Traumatic injury; Dysuria; Galactostasis.[each discussion] 1. " Zhiwu Mingshi Tukao ": stem: sensible, diuretic.2. " will planted by Tianmu Mountains of Zhejiang Province medicine ": leaf: control arthralgia, mash and apply ointment or plaster, make foaming agent; Root: control punctate keratitis, mashes, in Bu Baosai nose.3. " Jiangxi medical herbs ": promoting blood circulation and stopping pain, dispelling wind and removing obstruction in the collateral.Treating rheumatic arthralgia, gastroenteritis, malaria, acute gangrenous stomatitis, corneal ulcer, acute mastitis, blood stasis swells and ache, discharging fresh blood stool.[extracts] " Chinese Pharmacopoeia "

Semen Cajani: [another name] kwan-yin bean, large Semen Cajani, tree bean, Russian red clover, flower spiral shell are set bean, turned round bean, wild Semen Glycines.[source] medical material Ji Yuan: be the seed of leguminous plant Semen Cajani.Gather and store: gathering when spring, fruit maturation in autumn, strip seed, dry.[nature and flavor] are pungent, puckery; Flat; Nontoxic.[return through] liver; Spleen channel.[function cures mainly] dampness removing, detumescence, dissipating blood stasis, hemostasis.Main air pain of dampness syndrome, traumatic injury, epistaxis, has blood in stool, furuncle toxic swelling, prolonged lochia, edema, icterohepatitis.[each discussion] " Quanzhou book on Chinese herbal medicine ": heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI, diuretic helps digestion, row's carbuncle, hemostasis and dysentery-stopping.Control and have a guilty conscience, edema, stranguria with blood, hemorrhoidal bleeding, the secondary poison of carbuncle, dysentery, beriberi.[extracts] " China's book on Chinese herbal medicine "

Herba Gnaphalii Affinis: [another name] Mus ear, swamp cudweed, common mouse ear, Herba Cymbopogonis Citrari, ant wine grass, Hemerocallis citrina Baroni ends in vain, Herba Gnaphalii Affinis, fine and soft female, HUANGSONG, rice-koji, hair ear, water chrysanthemum, continuous wadding head grass, Herba Inulae, ground lotus, Hemerocallis citrina Baroni grass, water ant grass, clear and bright fragrant, Flos Echinopsis latifolii, affine cudweed, Cotton Gossypii dish, spinach spinach grass, cotton cocoon head, wide tight grass, clear and bright Artemisia, one bluish complexion, the close Chinese mugwort of Mus, water Artemisia, target dish, hoary hair's grass, water is bent, yorkshire fog grass, silk flosssilk wadding grass, sheep ear grass, Radix seu Herba Gymnopteris vestitae, Herba rungiae pectinatae, cat foot medicinal herbs, Hua Focao, mao mao's head grass, Hemerocallis citrina Baroni fruit, glutinous rice is blue or green, cotton dish, Hemerocallis citrina Baroni Anacamptis pyromaidalis, Bai Mangcao, Tian Ai, felt grass.[source] medical material Ji Yuan: be the herb of feverfew Mus song.[nature and flavor] sweet in the mouth; Micro-acid; Property is put down.[return through] returns lung meridian.[function cures mainly] preventing phlegm from forming and stopping coughing; Expelling wind and removing dampness; Removing toxic substances.Main cough with asthma abundant expectoration; Rheumatic arthralgia; Have loose bowels; Edema; Favism; Leucorrhea with red and white discharge; Carbuncle furuncle; Scrotum pruritus due to damp pathogen; Urticaria; Hypertension.[extracts] " China's book on Chinese herbal medicine "

Herba Parnassiae Wightianae: [another name] Herba Parnassiae foliosae, water are picked up the ears, Herba Kummerowiae Striatae, Flos Jasmini Nudiflori flowers and plants, Webster Herba Xanthii seven, Bulbophylulm ambrosirm (Hance) Schlir. (Bulbophyllum wat-sonianum Heichb. F.), Hydrocotyle vulgaris L., Herba Parnassiae foliosae grass, buckwheat all grass, Indian Skullcap Herb.[source] medical material Ji Yuan: be the herb of saxifragaceae plant clavus Herba parnassiae.Gather and store: herb of gathering the 8-9 month.[nature and flavor] are lightly seasoned, cool in nature.[return through] lung; Spleen channel.[function cures mainly] tonifying the lung and stopping cough; Hemostasis; Dampness removing.Cure mainly cough due to lung-heat, spitting of blood, spit blood, renal calculus, cholelithiasis, leucorrhea, damp and hot sore.[extracts] " China's book on Chinese herbal medicine "

Radix Ginkgo: [another name] Radix Ginkgo.[source] medical material Ji Yuan: be root or the root bark of Ginkgoaceae plant Ginkgo biloba.[nature and flavor] are sweet; Warm in nature.[function cures mainly] QI invigorating tonify deficiency.Main seminal emission; The enuresis; Night is frequently many, leucorrhea, stranguria caused by urinary stone.[extracts] " China's book on Chinese herbal medicine "

Herba Fici Stenophyliae: [another name] slimleaf fig, waterside willow, hundred grass, Archontophoenix alexandrae Wendl et Orude, spire water banyan tree, small size milk are young, small size car pusher enters stone, milk bubble, Folium Bambusae Fructus Elaeagni Umbellatae, Folium Bambusae Fici hispidae.[source] medical material Ji Yuan: be the Herb of moraceae plants Ficus stenophylla Hemsl.Gather and store: gathering between spring, autumn, cleaning, section, dries.Leaf is using fresh herb also.[nature and flavor] are bitter; Warm in nature.[function cures mainly] expelling phlegm for arresting cough; Expelling wind and removing dampness; Promoting blood circulation and detumescence; Antiabortive; Lactogenesis.Main cough chest pain; Rheumatic ostalgia; Frequent fetal movement; Nephritis; Acute mastitis; Furuncle toxic swelling; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba clinopodii confinis (Herba Clinopodii Gracilis): [another name] jade comply with one's wishes, Herba Dracocephali, native Herba Menthae, wild mint, wild Mesona chinensis Benth, lobule Mesona chinensis Benth, Herba Alternantherae sessilis, vanillon.[source] medical material Ji Yuan: the herb of finishing the meeting for labiate C. gracile and contiguous wind wheel.Gather and store: the 6-8 month gathers, cleaning, dry or using fresh herb.[nature and flavor] bitter in the mouth; Pungent; Cool in nature.[function cures mainly] expelling wind and clearing away heat; Promoting flow of QI and blood; Removing toxic substances and promoting subsidence of swelling.Main cold, fever; Abdominal pain due to retention of food; Vomiting; Have loose bowels; Dysentery; Diphtheria; Laryngopharynx swelling and pain; Carbuncle erysipelas; Urticaria; Insect-bite; Traumatic injury wound is hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Herba Begoniae Laciniatae: [another name] Rhizoma Begoniae Fimbristipulatae, tiger spot Caulis et folium euphorbiae milii, Semen Nelumbinis, Herba Lobeliae Chinensis, nine tooth lotuses, Shi Honglian, rock are red, Blood Scolopendra, Rhizoma cypripedii macranthi, Radix et Rhizoma Dysosmatis, red bar fly upward.[source] medical material Ji Yuan: be the herb of Begoniaceae plant Begonia pedatifida.Gather and store: summer, autumn take herb, cleaning, dry.[nature and flavor] sweet in the mouth; Acid; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main cough due to lung-heat; Furuncle carbuncle; Dysmenorrhea; Amenorrhea; Beriberoid pyretic arthralgia; Treating swelling and pain by traumatic injury; Serpentis flood dragon hinders.[extracts] " China's book on Chinese herbal medicine "

Herba Vernoniae Cinereae: [another name] ipomoea bonanox, star are wiped grass, are posted color grass, perfume (or spice) of returning from the grave, XIAOSHANHU, false salty shrimp, branch Rhizoma et radix valerianae, Flos Carthami Herba Veronicae, four eyed grass, the red grass in sky, cane ginseng.[source] medical material Ji Yuan: be herb or the root of feverfew Herba Vernoniae Cinereae.[nature and flavor] bitter in the mouth; Pungent; Cool in nature.[function cures mainly] wind and heat dispersing; Dehumidifying; Removing toxic substances.Main sense heating; Cough; Acute icterohepatitis; Damp-heat diarrhea; Stagnant in vain; Parent's pyogenic infections from tumour or sore; Mastitis; Rhinitis; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Inulae cappae: [another name] hair tiger, pig rumor, energetically Huang, Radix seu Caulis Embeliae Parviflorae, Bai Yeju, machete medicine, in vain leeward, Aries wind, Aries ear, Hua Ermu, golden-rimmed grass, upper Radix Et Rhizoma Rhei, Clausena excavata Burm.f., large spicy hot, hair Radix Bupleuri, flour wind, native Flos Buddlejae, sheep Herba Inulae cappae, raw tea, the Radix Pulsatillae, fly upward medicine, kwan-yin tea, the young ear of sheep, flour cat bone, strong cattle wave, octahedral wind, wax hair perfume, sheep rumor.[source] medical material Ji Yuan: be the herb of feverfew Herba Inulae cappae.Gather and store: the whole year all can adopt, using fresh herb or dry.[nature and flavor] acrid in the mouth; Sweet; Micro-hardship; Warm in nature.[function cures mainly] expelling wind and cold; Circulation of qi promoting dampness removing; Removing toxic substances and promoting subsidence of swelling.Main anemofrigid cold; Cough; Rheumatic arthralgia; Let out dysentery; Hepatitis; Mastitis; Hemorrhoid; Eczema; Scabies.[each discussion] 1. " Guangxi wild resource plant ": control dysentery, watery diarrhea.2. " Quanzhou book on Chinese herbal medicine ": promoting the circulation of QI to relieve pain, open breast profit diaphragm, eliminating pathogen in the liver improving eyesight, dampness removing helps digestion.3. " practical Chinese herbal medicine ": dispelling wind to relieve the exterior syndrome, damp eliminating diuretic.Flu, pain due to blood stasis after managing property, anuresis during pregnancy, hepatitis, stomachache, dyspepsia, stomachache, gum erosion, lymphonodi cervicales swells.[extracts] " China's book on Chinese herbal medicine "

Radix Codonopsis lanceolatae: [another name] Radix Rehmanniae, Omoto Nipponlily Rhizome, cattle Radix Aconiti Lateralis Preparata, newborn madam, Codonopsis ussuriensis Hemsl., Radix Codonopsis Lanceolatae, white boa meat, lance asiabell root, Radix Campanumoeae, milk ginseng, newborn potato, lactogenesis grass, grandmother produce head, old nipple, wild herbs produce sand, milk calabash, milk mattress, old, milk party, Radix Codonopsis Lanceolatae, MAIMAROU, Lance Asiabell Root, JIAOSHEN, Radix Panacis Quinquefolii, Ha La party, dog head party, Canis familiaris L. are joined, dog head is joined.[source] medical material Ji Yuan: be the root of Campanulaceae Lac caprae seu ovis.Gather and store: the 7-8 month excavates, clean, using fresh herb or section are dried.[nature and flavor] sweet in the mouth; Pungent; Property is put down.[return through] returns spleen; Lung meridian.[function cures mainly] supplementing QI and nourishing YIN; Removing toxic substances and promoting subsidence of swelling; Evacuation of pus; Lactogenesis.Main spiritlessness and weakness; Dizziness headache; Lung abscess; Acute mastitis; Intestinal future; Furuncle toxic swelling; Throat moth; Scrofula; Puerperal, breast was few; Leucorrhea; Venom.[extracts] " China's book on Chinese herbal medicine "

Folium et Cacumen Viburni Sargentii: [another name] Folium et Cacumen Viburni Sargentii, Cortex Garciniae.[source] medical material Ji Yuan: be branch, the leaf of caprifoliaceae plant Folium et Cacumen Viburni Sargentii or Radix Vibumi opuli.[nature and flavor] sweet in the mouth; Bitter; Property is put down.[function cures mainly] dredge the meridian passage; Detoxifying and relieving itching.Main lumbago and skelalgia; Lumbar sprain and QI divergeny; Furuncle; Scabies; Skin pruritus.[extracts] " China's book on Chinese herbal medicine "

Radix Pimpinellae Candolleanae: that [another name] Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clear Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi.[source] medical material Ji Yuan: be root or the herb of samphire Folium Pruni Pimpinella anisum Linn..Gather and store: summer, autumn gather, cleaning, dry or using fresh herb.[nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature.[return through] returns lung; Spleen; Stomach; Liver Channel.[function cures mainly] warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.[extracts] " China's book on Chinese herbal medicine "

Purple Pueraria lobota: disappear in [another name] JIANZHONGXIAO, dream, see that poison disappears, redly to disappear outward, the civilian seedling of the climing son of mountain calabash, corbie eye, pleat.[source] medical material Ji Yuan: be the root bark of vitaceae A.humulifoliavar. Heterophylla.Gather and store: autumn takes root, cleaning earth, strip root bark, dry.[nature and flavor] are sweet; Micro-hardship; Cold; Nontoxic.[function cures mainly] heat clearing away tonify deficiency; Dissipating blood stasis dredging collateral; Removing toxic substances.Restlessness and thirst after main product; Apoplexy and hemiplegia; Traumatic injury; Carbuncle malignant boil.[extracts] " China's book on Chinese herbal medicine "

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: granule

Get Herba Silenes conoideae 160g, Pseudobulbus Pholidotae Chinensis 200g, Radix sacchari arundinacei 140g, Caulis Clematidis Finetianae 260g, Semen Cajani 120g, Herba Gnaphalii Affinis 110g, Herba Parnassiae Wightianae 200g, Radix Ginkgo 300g, Herba Fici Stenophyliae 150g, Herba clinopodii confinis (Herba Clinopodii Gracilis) 280g, Herba Begoniae Laciniatae 250g, Herba Vernoniae Cinereae 180g, Herba Inulae cappae 100g, Radix Codonopsis lanceolatae 280g, Folium et Cacumen Viburni Sargentii 170g, Radix Pimpinellae Candolleanae 270g and purple Pueraria lobota 150g;

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 95%, be heated to boiling reflux 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.06, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, makes granule, in 40 DEG C of dryings, obtains granule.

Embodiment 2: powder

Get Herba Silenes conoideae 200g, Pseudobulbus Pholidotae Chinensis 180g, Radix sacchari arundinacei 160g, Caulis Clematidis Finetianae 230g, Semen Cajani 140g, Herba Gnaphalii Affinis 90g, Herba Parnassiae Wightianae 220g, Radix Ginkgo 260g, Herba Fici Stenophyliae 160g, Herba clinopodii confinis (Herba Clinopodii Gracilis) 260g, Herba Begoniae Laciniatae 280g, Herba Vernoniae Cinereae 150g, Herba Inulae cappae 150g, Radix Codonopsis lanceolatae 250g, Folium et Cacumen Viburni Sargentii 200g, Radix Pimpinellae Candolleanae 250g and purple Pueraria lobota 180g;

Its preparation method comprises the following steps:

Second step, the first step is obtained powder and add in cold water and soak 8 hours, with slow fire boiling, decocting time is 3 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 3 hours, filters acquisition second filtrate, and the quality of the water added is 2 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 100 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 20%, and by the material pouch subpackage after mixing, every 10 grams is one bag of subpackage.

Toxicity test:

Acute toxicity testing: application mice 70, male and female half and half, body weight 22 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.46g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage medicine granule of the present invention LD50>42.3 crude drug/kg, every day, maximum dosage-feeding was 84.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 7.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.13g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine of the present invention is 651 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 15.26,22.47 and 38.36g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 80 routine cases are my Out-patient Department or inpatient, are divided into treatment group and matched group at random, wherein treatment group 40 people, male 34 example, women 6 example, 43 ~ 70 years old age; The course of disease 1 ~ 9 year; Cardiac functional grading (NYHA): II grade of 8 example, III grade of 21 example, IV grade of 11 example.Matched group 40 people, male 33 example, women 7 example, 45 ~ 72 years old age; The course of disease 1 ~ 8 year; Cardiac functional grading (NYHA): II grade of 8 example, III grade of 20 example, IV grade of 12 example.Two groups of ages, sex, cardiac function and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).

Diagnostic criteria: the diagnostic criteria according to the ischemic cardiomyopathy in " clinical disease diagnosis and curative effect judging standard " that hospital associate of Hunan Province writes is formulated.One, in being more common in, elderly men, have angina pectoris or myocardial infarction medical history, often with hypertension.Two, cardiac dilatation, based on left ventricular enlargement, late period is both sides cardiac dilatation then.Three, the left heart failure occurred gradually, concurrent right heart failure in late period.Four, all kinds arrhythmia, sick sinus syndrome dynamic with ventricular premature contraction, atrial fibrillation, atrioventricular block and bundle branch block are common.Five, radionuclide myocardial imaging shows and expands whole-heartedly, and myocardial segment fills sparse or disappearance.Six, ultrasoundcardiogram: expand whole-heartedly, based on left ventricular enlargement, Abnormal Wall Motion, ejection fraction reduces.Seven, coronary angiography: branched, multiple arteria coronaria serious change as seen.

Therapeutic Method:

Matched group: the clinical manifestation different according to patient gives the western medicine routine treatment such as aspirin, nitrate, angiotensin converting enzyme inhibitor (ACEI) or Angiotensin Ⅱ receptor antagonist (ARB), diuretic, beta-blocker, Folium Digitalis Purpureae.30 days courses for the treatment of, treat 2 courses for the treatment of.

Treatment group: on matched group western medical treatment basis, gives and the embodiment of the present invention 1 granule, each 20g, every day 3 times.30 days courses for the treatment of, treat 2 courses for the treatment of.

Curative effect judging standard: effective: clinical symptom disappearance, cardiac function improves more than 2 grades, and cardiac size recovers normally or obviously to reduce.Effective: clinical symptoms is obviously improved, cardiac function improves more than 1 grade, and cardiac size reduces to some extent.Invalid: clinical symptoms is not improved or worsens, cardiac function is unchanged or worsen.

Therapeutic outcome: before and after two groups of treatments, total effects compares, in table 1.

A table 1 liang group total effects compares (example):

Treatment group and matched group comparitive study: P<0.05.Treatment group curative effect is better than matched group.

Untoward reaction: in two groups of therapeutic processes, does not all find gastrointestinal upset, hepatic and renal function injure, anaphylaxis or other untoward reaction.

Concrete case: patient Zhang, man, 65 years old, patient's 6 years causes are uncomfortable in chest, tachypnea is uncomfortable was diagnosed as coronary heart disease (ischemic cardiomyopathy) after local hospital inspection, always in locality treatment, the state of an illness still recurrent exerbation in increasing the weight of trend year by year.Afterwards because again feeling discomfort uncomfortable in chest, seek medical advice to the court, check Color Sonography finds to expand whole-heartedly, left atrium 50mm, left ventricle 89mm, regional wall motion abnormality, slight pulmonary hypertension; Cardiac functional grading is III grade; Electrocardiogram: myocardial ischemia, Left ventricular hypervoltage.Have a medical check-up: body temperature 36.6 DEG C, 108 beats/min, pulse, breathes 24 beats/min, blood pressure 90/60mmHg.Two pulmonary respiration sound is slightly thick, does not hear and dry moist rales.Apex beat is positioned at the outer 1cm of left side the 6th intercostal midclavicular line, and heart rate 108 beats/min, rule is neat, and pareordia is without obvious noise.Edema that two lower limb are slight.On the western medicine routine treatment basis of above-mentioned matched group, give and the embodiment of the present invention 1 granule, each 20g, every day 3 times, treat 60 days, clinical symptom disappearance, cardiac function improves more than 2 grades simultaneously, and cardiac size recovers normal, effective, follows up a case by regular visits to and does not recur for 3 months.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat the Chinese medicine of ischemic cardiomyopathy for one kind, it is characterized in that, the each raw medicinal material of described Chinese medicine comprises: Herba Silenes conoideae, Pseudobulbus Pholidotae Chinensis, Radix sacchari arundinacei, Caulis Clematidis Finetianae, Semen Cajani, Herba Gnaphalii Affinis, Herba Parnassiae Wightianae, Radix Ginkgo, Herba Fici Stenophyliae, Herba clinopodii confinis (Herba Clinopodii Gracilis), Herba Begoniae Laciniatae, Herba Vernoniae Cinereae, Herba Inulae cappae, Radix Codonopsis lanceolatae, Folium et Cacumen Viburni Sargentii, Radix Pimpinellae Candolleanae and purple Pueraria lobota.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Silenes conoideae 10 ~ 20 parts, Pseudobulbus Pholidotae Chinensis 15 ~ 25 parts, Radix sacchari arundinacei 10 ~ 20 parts, Caulis Clematidis Finetianae 20 ~ 30 parts, Semen Cajani 10 ~ 20 parts, Herba Gnaphalii Affinis 5 ~ 15 parts, Herba Parnassiae Wightianae 15 ~ 25 parts, Radix Ginkgo 20 ~ 30 parts, Herba Fici Stenophyliae 10 ~ 20 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 20 ~ 30 parts, Herba Begoniae Laciniatae 22 ~ 32 parts, Herba Vernoniae Cinereae 10 ~ 20 parts, Herba Inulae cappae 10 ~ 20 parts, Radix Codonopsis lanceolatae 20 ~ 30 parts, Folium et Cacumen Viburni Sargentii 13 ~ 23 parts, Radix Pimpinellae Candolleanae 20 ~ 30 parts and purple Pueraria lobota 12 ~ 22 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Silenes conoideae 15 ~ 20 parts, Pseudobulbus Pholidotae Chinensis 17 ~ 22 parts, Radix sacchari arundinacei 13 ~ 18 parts, Caulis Clematidis Finetianae 22 ~ 27 parts, Semen Cajani 10 ~ 15 parts, Herba Gnaphalii Affinis 8 ~ 13 parts, Herba Parnassiae Wightianae 18 ~ 23 parts, Radix Ginkgo 25 ~ 30 parts, Herba Fici Stenophyliae 13 ~ 18 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 25 ~ 30 parts, Herba Begoniae Laciniatae 24 ~ 29 parts, Herba Vernoniae Cinereae 14 ~ 19 parts, Herba Inulae cappae 10 ~ 15 parts, Radix Codonopsis lanceolatae 25 ~ 30 parts, Folium et Cacumen Viburni Sargentii 16 ~ 21 parts, Radix Pimpinellae Candolleanae 24 ~ 29 parts and purple Pueraria lobota 14 ~ 19 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Silenes conoideae 20 parts, Pseudobulbus Pholidotae Chinensis 18 parts, Radix sacchari arundinacei 16 parts, Caulis Clematidis Finetianae 23 parts, Semen Cajani 14 parts, Herba Gnaphalii Affinis 9 parts, Herba Parnassiae Wightianae 22 parts, Radix Ginkgo 26 parts, Herba Fici Stenophyliae 16 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 26 parts, Herba Begoniae Laciniatae 28 parts, Herba Vernoniae Cinereae 15 parts, Herba Inulae cappae 15 parts, Radix Codonopsis lanceolatae 25 parts, Folium et Cacumen Viburni Sargentii 20 parts, Radix Pimpinellae Candolleanae 25 parts and purple Pueraria lobota 18 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Silenes conoideae 16 parts, Pseudobulbus Pholidotae Chinensis 20 parts, Radix sacchari arundinacei 14 parts, Caulis Clematidis Finetianae 26 parts, Semen Cajani 12 parts, Herba Gnaphalii Affinis 11 parts, Herba Parnassiae Wightianae 20 parts, Radix Ginkgo 30 parts, Herba Fici Stenophyliae 15 parts, Herba clinopodii confinis (Herba Clinopodii Gracilis) 28 parts, Herba Begoniae Laciniatae 25 parts, Herba Vernoniae Cinereae 18 parts, Herba Inulae cappae 10 parts, Radix Codonopsis lanceolatae 28 parts, Folium et Cacumen Viburni Sargentii 17 parts, Radix Pimpinellae Candolleanae 27 parts and purple Pueraria lobota 15 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps: