CN105477343A

CN105477343A - Pediatric acute suppurative tonsillitis treating traditional Chinese medicine and preparation method thereof

Info

Publication number: CN105477343A
Application number: CN201510966683.0A
Authority: CN
Inventors: 梁爽; 鞠茂秀; 李阿妮; 闫云霞; 薛婉青; 李坤; 吕咸进
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-20
Filing date: 2015-12-20
Publication date: 2016-04-13

Abstract

The invention provides a pediatric acute suppurative tonsillitis treating traditional Chinese medicine and a preparation method thereof. The traditional Chinese medicine is prepared from Broomjutre sida herb, spider cocoon, Creeping dichondra herb, disinfectant, Manystem stonecrop herb, semen plantaginis, Indian rorippa herb, Siam psychotria herb, Botrychiam ternatum, Decaisnea fargesii, Chinese arundina herb, rhizoma bistortae, Inbolute spikemoss herb, Bentham dichrocephala herb, Cudrania cochin chinensis, Lobedfruit schizocapsa rhizome, Ixora chinensis, Radermachera sinica, Carduus crispus, root of Shorthairy antenoron herb, Meadowrue root and rhizome, Bulbophyllum odoratissimum, Polygonum capitatum and Canton fairybells root and rhizome. The pediatric acute suppurative tonsillitis treating traditional Chinese medicine has good efficacy without toxic and side effect or adverse reaction and the preparation method thereof is simple.

Description

A kind of Chinese medicine and preparation method for the treatment of children's acute suppurative tonsillitis

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine and preparation method for the treatment of children's acute suppurative tonsillitis.

Background technology

Acute suppurative tonsillitis is a kind of common disease of pharynx, has recurrent exerbation, easily causes the features such as local and systemic complications.Children's acute suppurative tonsillitis means the acute non-specific inflammation of palatine tonsil, is often secondary to upper respiratory tract infection, and with pharyngeal mucosa in various degree and adenoid acute inflammation.Multiplely be born in 3-10 year child, easily fall ill when seasonal law, temperature Change.Beta hemolytic streptococcus is Main Pathogenic Bacteria, and anhemolytic streptococcus, staphylococcus, Diplococcus pneumoniae, hemophilus influenza and adenovirus or rhinovirus, herpes simplex etc. also can cause this sick.Infection genesis in tonsillar crypts, or by droplet infection with the approach such as directly to contact and infected by the external world.Inflammation is many from crypts, is spreading to whole tonsil.Lymph germinal center forms multiple microabscess.When microabscess does not communicate with crypts, prompting is infected by blood circulation and is caused.Children's acute suppurative tonsillitis, in department of pediatrics upper respiratory tract infection case, accounts for 10%-15%.When children's suffers from tonsillitis, clearly, child shows as the infection symptoms of whole body: hyperpyrexia can reach 39-40 DEG C, simultaneously with shiver with cold, and malaise, headache and pantalgia, inappetence, nausea and vomiting.Can find when checking pharyngeal that tonsil has pus.If take effective treatment not in time, a series of complication acute otitis media, acute rhinitis, sinusitis, acute lymphadenitis can be caused, even cause myocarditis, acute nephritis etc., serious harm infant healthy.Along with increasing of many pathogen fastbacteria pearls, adding upper part infant irritated to antibiotic, is that antibiotic treatment is subject to a definite limitation.And surgical removal tonsil is a Therapeutic Method having wound, need avoid as far as possible.

The suppurative tonsil adenitis of children's acute is common clinical, and the traditional Chinese medical science is called " tonsillitis ".Children's is pure-yang constituent, and circulation of qi promoting is not filled, easy being invaded by exogenous pathogen, and wind-heat evil toxin can be entered by mouth and nose, attacking the lung first, throat is the door of lung stomach, hurts first, and exopathogen is fought mutually with pharyngeal QI and blood and tied, send out as pharyngeal tonsils congestion and swelling pain, very then burning hot rising, pyretic toxicity blood trouble corruption becomes pus.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of therapeutic effect good and the Chinese medicine of the treatment children's acute suppurative tonsillitis had no side effect and preparation method.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of children's acute suppurative tonsillitis, described Chinese medicine comprises following raw medicinal material: Folium sidae alnifoliae, Uroctea compatilis Koch., Herba Dichondrae Repentis, disinfectant, Herba Sedi Multicaulis, Semen Plantaginis, Herba Rorippae, Herba Psychotriae Siamicae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix decaisneae fargesii, Herba Arundinae Chinensis, Rhizoma Bistortae, Herba Selaginellae Involventis, Herba Houttuyniae, Radix Cudraniae, Rhizoma Schizocapsae Plantagineae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Radix radermacherae sinicae, Herba Cardui Crispi, Radix Antenoronis Filiformis, Radix et Rhizoma Thalictri, Herba Bulbophylli Odoratissim, Herba Polygoni Capitati and Radix et Rhizoma Dispori Cantoniensis.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Folium sidae alnifoliae 10 ~ 25 parts, Uroctea compatilis Koch. 15 ~ 25 parts, Herba Dichondrae Repentis 10 ~ 25 parts, disinfectant 15 ~ 30 parts, Herba Sedi Multicaulis 20 ~ 30 parts, Semen Plantaginis 10 ~ 25 parts, Herba Rorippae 15 ~ 25 parts, Herba Psychotriae Siamicae 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 15 ~ 25 parts, Radix decaisneae fargesii 20 ~ 30 parts, Herba Arundinae Chinensis 15 ~ 25 parts, Rhizoma Bistortae 10 ~ 20 parts, Herba Selaginellae Involventis 15 ~ 30 parts, Herba Houttuyniae 10 ~ 30 parts, Radix Cudraniae 10 ~ 20 parts, Rhizoma Schizocapsae Plantagineae 15 ~ 25 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 20 ~ 30 parts, Radix radermacherae sinicae 5 ~ 15 parts, Herba Cardui Crispi 10 ~ 25 parts, Radix Antenoronis Filiformis 15 ~ 25 parts, Radix et Rhizoma Thalictri 10 ~ 25 parts, Herba Bulbophylli Odoratissim 20 ~ 35 parts, Herba Polygoni Capitati 10 ~ 20 parts and Radix et Rhizoma Dispori Cantoniensis 15 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Folium sidae alnifoliae 20 ~ 25 parts, Uroctea compatilis Koch. 15 ~ 20 parts, Herba Dichondrae Repentis 20 ~ 25 parts, disinfectant 20 ~ 30 parts, Herba Sedi Multicaulis 25 ~ 30 parts, Semen Plantaginis 15 ~ 20 parts, Herba Rorippae 20 ~ 25 parts, Herba Psychotriae Siamicae 15 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 20 ~ 25 parts, Radix decaisneae fargesii 20 ~ 25 parts, Herba Arundinae Chinensis 20 ~ 25 parts, Rhizoma Bistortae 10 ~ 15 parts, Herba Selaginellae Involventis 20 ~ 30 parts, Herba Houttuyniae 15 ~ 20 parts, Radix Cudraniae 10 ~ 15 parts, Rhizoma Schizocapsae Plantagineae 15 ~ 20 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25 ~ 30 parts, Radix radermacherae sinicae 10 ~ 15 parts, Herba Cardui Crispi 15 ~ 25 parts, Radix Antenoronis Filiformis 15 ~ 20 parts, Radix et Rhizoma Thalictri 15 ~ 25 parts, Herba Bulbophylli Odoratissim 20 ~ 25 parts, Herba Polygoni Capitati 15 ~ 20 parts and Radix et Rhizoma Dispori Cantoniensis 20 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Folium sidae alnifoliae 22 parts, Uroctea compatilis Koch. 18 parts, Herba Dichondrae Repentis 21 parts, disinfectant 27 parts, Herba Sedi Multicaulis 26 parts, Semen Plantaginis 18 parts, Herba Rorippae 22 parts, Herba Psychotriae Siamicae 19 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 21 parts, Radix decaisneae fargesii 24 parts, Herba Arundinae Chinensis 23 parts, Rhizoma Bistortae 11 parts, Herba Selaginellae Involventis 23 parts, Herba Houttuyniae 19 parts, Radix Cudraniae 12 parts, Rhizoma Schizocapsae Plantagineae 19 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 26 parts, Radix radermacherae sinicae 14 parts, Herba Cardui Crispi 17 parts, Radix Antenoronis Filiformis 16 parts, Radix et Rhizoma Thalictri 23 parts, Herba Bulbophylli Odoratissim 21 parts, Herba Polygoni Capitati 19 parts and Radix et Rhizoma Dispori Cantoniensis 22 parts.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, by Uroctea compatilis Koch., Herba Dichondrae Repentis, disinfectant, Herba Sedi Multicaulis, Semen Plantaginis, Herba Rorippae and Herba Psychotriae Siamicae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Herba Arundinae Chinensis, Rhizoma Bistortae, Herba Selaginellae Involventis, Herba Houttuyniae and Radix Cudraniae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;

3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

Beneficial effect of the present invention: the Chinese medicine that children's acute suppurative tonsillitis of the present invention uses, therapeutic effect is good, and have no side effect and untoward reaction, preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of children's acute suppurative tonsillitis, Chinese medicine comprises following raw medicinal material: Folium sidae alnifoliae, Uroctea compatilis Koch., Herba Dichondrae Repentis, disinfectant, Herba Sedi Multicaulis, Semen Plantaginis, Herba Rorippae, Herba Psychotriae Siamicae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix decaisneae fargesii, Herba Arundinae Chinensis, Rhizoma Bistortae, Herba Selaginellae Involventis, Herba Houttuyniae, Radix Cudraniae, Rhizoma Schizocapsae Plantagineae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Radix radermacherae sinicae, Herba Cardui Crispi, Radix Antenoronis Filiformis, Radix et Rhizoma Thalictri, Herba Bulbophylli Odoratissim, Herba Polygoni Capitati and Radix et Rhizoma Dispori Cantoniensis.

The pharmacology of various raw medicinal material is as follows:

Folium sidae alnifoliae: [another name] draw out the pus cream, pus see disappear, Radix sidae acutae, little Radix Bupleuri, Herba Sidae Rhombifoliae, Herba Malvastri Coromandeliani, hitching post, Herba Gnaphalii Adnati, tendon Bovis seu Bubali fiber crops, Herba Sidae alnifoliae, Oryza glutinosa medicine, the peaceful root of sand, other grass, Di Pang Betel.[source] medical material Ji Yuan: be leaf or the root of Malvaceae plant alder leaf Radix sidae acutae.[nature and flavor] are bitter; Pungent; Cold nature.[return through] heart channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery; Jaundice; Laryngopharynx swelling and pain; Carbuncle sore tumefacting virus; Bee venom sting.[extracts] " China's book on Chinese herbal medicine "

Uroctea compatilis Koch.: [another name] wall cocoon, Uroctea compatilis Koch. nest curtain, white, Bi Spider nest, spider nest, Bi Spider Wo, Spider spider nest, happiness youngster nest, Uroctea compatilis Koch. cocoon, gossamer urocteae.[source] medical material Ji Yuan: be nest and the egg capsule of Uroctea compatilis Koch. section animal Uroctea compactilis (L. Koch) and Uroctea lessert.[nature and flavor] salty in the mouth; Bitter; Property is put down.[return through] lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Hemostasis; Sore.Main sore throat; Tonsillitis; Toothache; Epistaxis; Traumatic hemorrhage; The open sore part is not held back; Vomiting; Cough.[each discussion] " Suzhou this product medical material ": control sore throat, tonsillitis, congenital deformity of the tongue.[extracts] " China's book on Chinese herbal medicine "

Herba Dichondrae Repentis: [another name] pocket grass, JINSUOSHI, Herba Dichodrae, the big grass of spiral shell, little Hydrocotyle vulgaris L., wineglass nest, Herba Carpesii Divaricati, Herba Kummerowiae Striatae, little Herba Centellae, little grass windward, little bowl bowl grass, little Herba Lobeliae Chinensis.[source] medical material Ji Yuan: be the herb of dicotyledon scammonia section plant Herba Dichodrae.[nature and flavor] toil; Cool.[return through] lung; Liver Channel.[function cures mainly] heat clearing away; Dampness removing; Removing toxic substances.Main jaundice; Dysentery; Sand Stranguria; Nebulousurine; Edema; Furuncle swelling toxin; Traumatic injury; Venom.[extracts] " China's book on Chinese herbal medicine "

Disinfectant: [another name] Viola arcuata, arrow grass, tank mouth dish, little Herba Violae japonicae, Viola grypoceras A. Gray, water-white Viola grypoceras A. Gray, spend Carnis Arca inflata shell grass in vain, band blood Herba Violae japonicae, triumph grass, Bai Laowan, triangle gold brick, Cipangopaludina chinensis teacher, the rotten bean of water.[source] medical material Ji Yuan: be the herb of Violaceae plant common violet.[nature and flavor] mildly bitter flavor; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Cough-relieving; Hemostasis.Main cough due to lung-heat; Tonsillitis; Eye conjunctivitis; Furuncle swelling toxin; Agkistrodon halys bites; Knife injury is hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Herba Sedi Multicaulis: [another name] Herba Orostachyos, watt flower, Dian Wahua, Parmelia saxatilis Ach., Shi Gen, Herba Peristrophes, rock are complied with one's wishes.[source] medical material Ji Yuan: be stem and leaf or the root of crassulaceae plants gold stem Herba hylotelephii erythrosticti.[nature and flavor] sweet in the mouth; Micro-pungent; Cold nature.[return through] lung; Kidney; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis; Wind-damp dispelling.Main laryngopharynx swelling and pain; Burst soup in oral cavity; Eczema sore; Epistaxis; Hemoptysis; Spitting of blood; Rheumatic arthralgia; Headache due to pathogenic wind-heat.[each discussion] be " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: control laryngopharynx swelling and pain, disappear tonsillitis, network anemofrigid-damp arthralgia of passing through, and bones and muscles pain washes the damp and hot poison of skin ulcer.2. " Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, hemostasis, blood pressure lowering, wind-damp dispelling.[extracts] " China's book on Chinese herbal medicine "

Semen Plantaginis: [source] this product is the dry mature seed of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.[nature and flavor] are sweet, are slightly cold.[return through] returns liver, kidney, lung, small intestine meridian.[function cures mainly] clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.[extracts] " Chinese Pharmacopoeia "

Herba Rorippae: [another name] peppery rice dish, sarson, pool Pueraria lobota dish, Herba Rorippae, Radix Loxostigmatis griffithii, Carnis Gallus domesticus dish, Tian Gecai, Herba Rorippae, wild potherb mustard, wild mustard grass, wild herbs, barbarea, Du Gencai, chervil, spun gold pod.[source] medical material Ji Yuan: be that thing Herba Rorippae and the herb without lobe Han are planted by ten Zi Hua sections.[nature and flavor] acrid in the mouth; Bitter; Slightly warm in nature.[return through] lung; Liver Channel.[function cures mainly] expelling phlegm for arresting cough; Induce sweat cold expelling; Promoting blood circulation and detoxication; Dampness removing jaundice eliminating.Main cough phlegm dyspnea; Cold, fever; Measles is sent out not smooth thoroughly; Rheumatic arthralgia; Laryngopharynx swelling and pain; Furuncle carbuncle; Dermatitis rhus; Amenorrhea; Traumatic injury; Jaundice; Edema.[each discussion] 1. " Kweiyang medicinal herbs among the people ": heat-clearing and toxic substances removing, relieving cough and resolving phlegm.Dermatitis rhus is controlled in external, furuncle, carbuncle.2. Guangzhou army " conventional Chinese herbal medicine handbook ": clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure cold heating, laryngopharynx swelling and pain, aphonia; Cough due to lung-heat, hemoptysis; Acute rheumatic arthritis; Edema.3. " Fujian Chinese herbal medicine ": dispelling wind expelling pathogenic factors from the exterior, regulating qi-flowing for harmonizing stomach.[extracts] " China's book on Chinese herbal medicine "

Herba Psychotriae Siamicae: [another name] Herba Equiseti Hiemalis, Herba Clinopodii Polycephali, Radix Sophorae Tonkinensis grass, synthetism Herba pteridii latiusculi, horse Radix Ginseng, a tower grass, nib grass, tower careless, hair cylinder grass, rich knotweed.[source] medical material Ji Yuan: for Herba Equiseti Hiemalis produces the herb of plant Radix Scorzonerae Albicaulis.[nature and flavor] are bitter; Cool; Sweet.[return through] lung; Liver; Spleen; Large intestine channel.[function cures mainly] improving eyesight; Heat clearing away; Dampness removing; Hemostasis.The red distending pain of argument; Pterygium; Gonorrhea; Icterohepatitis; Hematuria; Metrorrhagia.[each discussion] 1. " register planted by Guangxi medicine ": root: hemostasis, cough-relieving, controls traumatic injury.Leaf: detumescence, wind dispelling.2. " choosing of Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, pain relieving.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: [another name] YIDUOYUN, Jue Qi.[source] medical material Ji Yuan: be root or the herb of Botrychiaceae plant Herba pteridii latiusculi beanstalk.[nature and flavor] are bitter; Puckery; Cool; Sweet; Be slightly cold.[return through] lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Suppressing the hyperactive liver eliminating stagnation; Expelling wind for relieving convulsion.Main lung abscess; Venom; Conjunctival congestion; Scrofula; Cough; Serpentis poison; Acute infantile convulsion wind; Rheumatic arthralgia; Traumatic injury.[each discussion] 1. " Shaanxi Chinese herbal medicine ": heat-clearing and toxic substances removing, suppressing the hyperactive liver eliminating stagnation.Control lung abscess, conjunctivitis, impairment caused by overstrain, venom, scrofula.2. Nanchuan " conventional Chinese herbal medicine handbook ": tonify deficiency lung moistening, relieving cough and resolving phlegm.Control cough, weak and celostomia after being ill.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix decaisneae fargesii: [another name] cat melon, Intestinum Gallus domesticus, cat dung melon, cat dung maple, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp..[source] medical material Ji Yuan: be root or the stem of plants of Lardizabalaceae Radix decaisneae fargesii.[nature and flavor] Gan Xin; Pungent; Property is put down.[return through] returns lung; Liver Channel.[function cures mainly] expelling wind and removing dampness; Clearing away lung-heat to relieve cough.Main air pain of dampness syndrome; Anus wets rotten; Pudendal pruritus; Pulmonary tuberculosis cough.[each discussion] 1. " Guizhou medical herbs ": clearing away lung-heat to relieve cough, evil-wind expelling and dampness removing.2. " Shaanxi Chinese herbal medicine ": root and fruit heat-clearing and toxic substances removing.[extracts] " China's book on Chinese herbal medicine "

Herba Arundinae Chinensis: [another name] great Ye Radix Cynanchi Paniculati, careless Rhizoma Zingiberis Recens, mountain Corm Eleocharitis.[source] medical material Ji Yuan: be herb and the root stock of orchid Herba Murdanniae Divergentis.[nature and flavor] are bitter; Be slightly cold.[return through] liver; Kidney; Urinary bladder channel.[function cures mainly] heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main pyretic stranguria; Jaundice; Edema; Beriberi edema; Hernia is suffered from abdominal pain; Rheumatic arthralgia; Venom; Sore and toxic; Traumatic injury.[each discussion] be " choosing of Simao, Yunnan Chinese herbal medicine " 1.: heat-clearing and toxic substances removing, wind-damp dispelling, antiinflammatory, diuresis.Treating rheumatic lumbago and skelalgia, stomachache, urinary tract infection, beriberi edema, alimentary toxicosis.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Bistortae: [another name] Herba Salviae Chinensis, Rhizoma Paridis, cutter cut medicine, copper sieve, shrimp ginseng, shrimp, mountain shrimp.[source] this product is the dry rhizome of polygonaceae plant Rhizoma Bistortae.[nature and flavor] are bitter, puckery, are slightly cold.[return through] returns lung, liver, large intestine channel.[function cures mainly] heat-clearing and toxic substances removing, detumescence, hemostasis.For bloody dysentery, diarrhea of heat type, cough due to lung-heat, carbuncle, scrofula, aphtha of the mouth and tongue, spits blood, epistaxis, bleeding hemorrhoids, venom.[extracts] " Chinese Pharmacopoeia "

Herba Selaginellae Involventis: [another name] Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Selaginellae Involventis, golden almond, Shi Yangcao, Rana nigromaculata pawl, flower lung gold.[source] medical material Ji Yuan: be the herb of Spikemoss plant Herba Selaginellae Involventis.[nature and flavor] light, micro-hardship, cool.[return through] lung; Liver; The heart; Spleen channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Cough-relieving; Hemostasis; Removing toxic substances.Main jaundice due to damp-heat; Dysentery; Edema; Ascites; Stranguria; Productive cough due to phlegm-damp; Spitting of blood; Spit blood; Have blood in stool; Metrorrhagia; Traumatic hemorrhage; Acute mastitis; Scrofula; Hemorrhoid; Scald.[each discussion] 1. " Fujian traditional herbal medicine ": can flexibilizing tendon and strengthening bone, and QI invigorating improving eyesight, removing heat from the liver, treats jaundice.2. " Luchuan book on Chinese herbal medicine ": cooling blood for hemostasis, inducing diuresis to remove edema.Control proctoptosis hematochezia, edema.3. " Traditional Chinese Medicine in Sichuan will ": heat-clearing and toxic substances removing.Control haematemesis, bleeding hemorrhoids, gonorrhea, burn and injury by sword or axe hemorrhage.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Herba Houttuyniae: [another name] three rosetangle, constellation grass, Fructus Piperis, drum fourth grass, the sub-grass of nebula, Herba Asari, little trowel head grass, bright head careless.[source] medical material Ji Yuan: be the herb of the little Herba Houttuyniae of feverfew and chrysanthemum leaf Herba Houttuyniae.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Dispelling pathogenic wind for improving eyesight.Main pneumonia; Hepatitis; Dysentery; Dyspepsia; Malaria; Nyctalopia; Leukorrhagia; Skin infection.[each discussion] " choosing of Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, pain relieving, antidiarrheal.Cure cold high heat, diarrhoea, hepatitis.[extracts] " China's book on Chinese herbal medicine "

Radix Cudraniae: [another name] three-bristle cudrania root, river break stone, cotton root, draw cattle to enter stone, three-bristle cudrania rattan root, yellow Serpentis, the yellow dustpan in mountain, ferrum hedge root, HUANGLONG decortication, thorn paper mulberry, kuling supplejack root, the wild Radix Astragali, Semen Sterculiae Nobilis, thousand layers of skin.[source] medical material Ji Yuan: be the root of moraceae plants cudrania cochinchinensis or Zhe Shu.[nature and flavor] are lightly seasoned; Micro-hardship; Cool in nature.[function cures mainly] dispelling wind and removing obstruction in the collateral; Removing damp-heat; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Traumatic injury; Yellow cellulitis; Parotitis; Pulmonary tuberculosis; Gastric duodenal ulcer; Stranguria with turbid discharge; Distention of the abdomen caused by various parasites; Amenorrhea; Impairment caused by overstrain hemoptysis; Treatment carbuncle sore swells.[each discussion] be Guangzhou army " conventional Chinese herbal medicine handbook " 1.: cool the blood dissipate blood stasis.Control amenorrhea.2. " the practical Chinese herbal medicine in Guangxi newly selects ": heat clearing and blood circulation promoting, eliminating phlegm and stopping cough.Control impairment caused by overstrain hemoptysis.3. " choosing of Yunnan Chinese herbal medicine ": anti-inflammatory analgetic.Control mumps, furuncle and phyma.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Schizocapsae Plantagineae: [source] medical material base source: is the tuber of Rhizoma amorphophalli potato section plant dehiscent fruit potato.[function cures mainly] heat-clearing and toxic substances removing; Eliminating phlegm and stopping cough; Regulate the flow of vital energy and stop production capacity; Dissipating blood stasis stops blooding.Main cold, fever; Phlegm-heat cough; Pertussis; Abdominal distention; Dysentery is suffered from abdominal pain; Dyspepsia; Infantile malnutrition; Hepatitis; Laryngopharynx swelling and pain; Toothache; Mumps; Scrofula; Skin ulcer swells; Scald, burn; Herpes zoster; Traumatic injury; Traumatic hemorrhage.[each discussion] 1. " Nanning City's medicine is forgotten ": antiinflammatory, removing toxic substances, pain relieving.Control peratodynia, acid regurgitation, cough, Hakuri, pharyngalgia, carbuncle skin ulcer is controlled in external application.2. " choosing of Simao, Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, anti-inflammatory analgetic.Control gastric and duodenal ulcers, hypertension, hepatitis, stomachache, scald, burn, skin infection.3. " the practical Chinese herbal medicine in Guangxi newly selects ": cooling blood and relieving pain, dissipating blood stasis for subsidence of swelling.Control Peptic Ulcers, infantile malnutrition, stomachache, traumatic injury, carbuncle, innominate toxic swelling, gastric heat pain, acute gastroenteritis, toothache.[extracts] " China's book on Chinese herbal medicine "

Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati): [another name] Ixora stricta, red silk ball, Bulbus lilii concoloris, May Flower, buy son wood, Rhododendron simsii Planch., Niu Lan, pearl paulownia, kind Caulis et folium euphorbiae milii, Flos Ixorae Chinensis, Brassaiopsis glomerulata (Bl.) Regel wood, red oriental cherry, Folium Lantanae Camarae, Lagerstroemia indica L., the elixir of life are colored.[source] medical material Ji Yuan: be the flower of dicotyledon medicine Maguireothamnus speciosus Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati).[nature and flavor] are sweet light; Cool.[return through] Liver Channel.[function cures mainly] clearing away heat and cooling blood; Eliminating stasis to stop pain.Main hypertension; Menoxenia; Amenorrhea; Traumatic injury; Skin infection furuncle and phyma.[each discussion] be " the SHENGCAO property of medicine is standby to be wanted " 1.: disappear skin ulcer, and pus of tut-tuting, dispels the wind, pain relieving, reason phlegm-fire.2. " Guangxi Chinese medicinal herbal ": dissipating blood stasis, continuous muscle, synthetism, pain relieving.Control injured.3. Guangzhou army " conventional Chinese herbal medicine handbook ": removing heat from the liver to lower the high blood pressure, promoting blood circulation to remove blood stasis.[extracts] " China's book on Chinese herbal medicine "

Radix radermacherae sinicae: [source] medical material Ji Yuan: be the root of Bignoniaceae plant Radix radermacherae sinicae, leaf or fruit.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] summer heat clearing toxin resolving; Dissipating blood stasis for subsidence of swelling.Main Sunstroke heating; Carbuncle; Injury and bone fracture; Venom.[each discussion] 1. " Guangxi Chinese herbal medicine ": dissipating blood stasis for subsidence of swelling, heat-clearing and toxic substances removing.2. Guangzhou air force " conventional Chinese herbal medicine handbook ": cool the blood dissipate blood stasis, reducing swelling and alleviating pain.Zhi Gaore has a headache, stomachache, bruise, fracture, carbuncle furuncle, venom.[extracts] " China's book on Chinese herbal medicine "

Herba Cardui Crispi: [source] medical material Ji Yuan: be feverfew silk hair Herba Cardui Crispi and the herb or the root that save hair Herba Cardui Crispi.[nature and flavor] mildly bitter flavor; Cool in nature.[function cures mainly] dispels the wind; Heat clearing away; Dampness removing; Cooling blood for hemostasis; Promoting blood circulation and detumescence.Main cold cough; Have a headache dizzy; Urinary system infection; Chyluria; Leucorrhea; Jaundice; Rheumatic arthralgia; Spit blood; Epistaxis; Hematuria; Menorrhagia; Dysfunctional uterine hemorrhage; Traumatic injury; Furuncle furuncle and phyma; Swelling and pain of hemorrhoid; Burn.[each discussion] 1. " Chinese herbal medicine is commonly used in Tibet ": removing heat from blood, hemostasis, dissipating blood stasis for subsidence of swelling.Control various hemorrhage, traumatic injury congestive edema, malignant boil, burn, scald.2. Soviet Union doctor " Chinese herbal medicine handbook ": dispel the wind, dampness removing, heat clearing away, detumescence.Control chyluria, hematuria, urinary tract infection, influenza, leukorrhagia, menorrhagia; External curing pyogenic infections from tumour or sore, swelling and pain of hemorrhoid.[extracts] " China's book on Chinese herbal medicine "

Radix Antenoronis Filiformis: [another name] extra large root, ferrum corner angle Radix Notoginseng, Cortex cynoglossi zeylanici radicis, Herba Lycianthis Biflorae, waterline flower root, knotweed seven, Herba Senecionis Chrysanthemoidis, shorthairy antenoron root.[source] medical material Ji Yuan: be the rhizome of few section plant Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) and undercoat Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis).[nature and flavor] are bitter; Pungent; Cold nature.[function cures mainly] cooling blood for hemostasis; Eliminating stasis to stop pain; Heat-clearing and toxic substances removing.Main cough spitting of blood; Spit blood; Metrorrhagia; Menoxenia; Dysmenorrhea; Epigastric pain; Have loose bowels; Dysentery; Traumatic injury; Rheumatic arthralgia; Scrofula; Swollen ulcer drug; Burn and scald; Biting of poison.[each discussion] 1. supplement to the Herbal: main cholera attacked by pestiferous factors, cardiac and abdominal pain, sore throat, diseases due to noxious agents produced by various parasites, carbuncle is disliked swollen, and red white trip gizzard, Serpentis stings dog poison.Wine and water mill clothes, that applies is also good.2. " Chinese herbal medicine is commonly used in Sichuan ": dissipating blood stasis circulation of qi promoting, reducing swelling and alleviating pain.Control traumatic injury, consumptive disease wound is spitted blood.3. Jiangxi " medical herbs handbook ": dissipating blood stasis stops blooding, removing toxic substances promoting the circulation of QI.[extracts] " China's book on Chinese herbal medicine "

Radix et Rhizoma Thalictri: [another name] Radix et Rhizoma Thalictri.[source] medical material Ji Yuan: be the root and rhizome of ranunculaceae plant spun gold Radix et Rhizoma Thalictri, Zhaotong Thalictrum aquilegifolium L. var. sibiricum Regel, plateau Thalictrum aquilegifolium L. var. sibiricum Regel, leafy Thalictrum aquilegifolium L. var. sibiricum Regel, baikal meadowrue root, long column baikal meadowrue root, yellow Thalictrum aquilegifolium L. var. sibiricum Regel, sticky Thalictrum aquilegifolium L. var. sibiricum Regel etc.[nature and flavor] bitter in the mouth; Cold in nature.[return through] GUIXIN; Liver; Large intestine channel.[function cures mainly] heat clearing and damp drying; Eliminating fire and detoxication.Cure mainly damp-heat dysentery; Jaundice; Sore swollen toxin; Conjunctival congestion and swelling pain; Cold, fever; Cancerous protuberance.[each discussion] " Chinese herbal medicine is commonly used in Tibet ": heat-clearing and toxic substances removing, dispel the wind removing heat from blood, anti-inflammtory anti-dysentery.Control conjunctivitis, infectious hepatitis, carbuncle furuncle, dysentery.Leaf, flower curing arthritis.[extracts] " China's book on Chinese herbal medicine "

Herba Bulbophylli Odoratissim: [another name] little Herba Bulbophylli Odoratissim, Bulbophyllum calodictyon schlecht., extremely fragrant Bulbophyllum, elaeagnus conferta fruits.[source] medical material Ji Yuan: be the herb of orchid Bulbophyllum odoratissimum Lindl..[nature and flavor] are sweet; Light; Cool.[return through] lung; Liver; Kidney channel.[function cures mainly] moistening the lung and resolving phlegm; Removing obstruction in the collateral to relieve pain.Main hemoptysis of pulmonary tuberculosis; Chronic tracheitis; Chronic pharyngitis; Hernia pain; Menoxenia; Rheumatic arthralgia; Traumatic injury.[each discussion] be " Kunming conventional medical herbs among the people " 1.: wind-damp dispelling, active, circulation of qi promoting, pain relieving.2. " choosing of Yunnan Chinese herbal medicine ": synthetism antiinflammatory, moistening the lung and resolving phlegm.Control fracture, pulmonary tuberculosis, spitting of blood, chronic tracheitis, pneumonia convalescent period, chronic pharyngitis, menoxenia.3. " catalogue planted by Guizhou medicine ": clearing heat and moistening dryness, promoting the production of body fluid to quench thirst.[extracts] " China's book on Chinese herbal medicine "

Herba Polygoni Capitati: [source] medical material Ji Yuan: be the herb of polygonaceae plant Herba Polygoni Capitati.[nature and flavor] are bitter; Pungent; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation and stopping pain.Main dysentery; Pyelonephritis; Cystitis; Lithangiuria; Rheumatalgia; Traumatic injury; Mumps; Skin infection; Eczema.[each discussion] 1. " Guangxi Chinese medicinal herbal ": wind-damp dispelling, eliminating stasis to stop pain.Dispelling the wind and dampness pathogens, traumatic injury.2. " Guangxi Chinese herbal medicine ": detoxicating, relieving inflammation.Control dysentery, skin ulcer, innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Radix et Rhizoma Dispori Cantoniensis: [source] medical material Ji Yuan: be the root and rhizome of liliaceous plant cantonese fairy bells.[nature and flavor] bitter in the mouth; Pungent; Cool in nature.[function cures mainly] wind-damp dispelling; Relaxing muscles and tendons to promote blood circulation; Heat clearing away expelling phlegm for arresting cough.Main air arthralgia chiefly caused by damp pathogen is demonstrate,proved; Joint lumbago and skelalgia; Traumatic injury; Fracture; Asthenia; Osteopyrexia and fever; Pulmonary tuberculosis is spat blood; Cough due to lung-heat; Burn and scald.[each discussion] 1. " Shaanxi Chinese herbal medicine ": YIN nourishing tonify deficiency, wind-damp dispelling, activating collaterals to relieve pain.Control asthenia, osteopyrexia and fever, pulmonary tuberculosis, palpitation and short breath, lumbago, skelalgia of rheumatism, sciatica.2. " Yunnan Chinese herbal medicine ": synthetism is stopped blooding, anti-inflammatory analgetic, expelling wind and removing dampness.3. " Jiangxi medical herbs ": wind and heat eliminating, relaxing muscles and tendons to promote blood circulation.[extracts] " China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can more preferably: Folium sidae alnifoliae 10 ~ 25 parts, Uroctea compatilis Koch. 15 ~ 25 parts, Herba Dichondrae Repentis 10 ~ 25 parts, disinfectant 15 ~ 30 parts, Herba Sedi Multicaulis 20 ~ 30 parts, Semen Plantaginis 10 ~ 25 parts, Herba Rorippae 15 ~ 25 parts, Herba Psychotriae Siamicae 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 15 ~ 25 parts, Radix decaisneae fargesii 20 ~ 30 parts, Herba Arundinae Chinensis 15 ~ 25 parts, Rhizoma Bistortae 10 ~ 20 parts, Herba Selaginellae Involventis 15 ~ 30 parts, Herba Houttuyniae 10 ~ 30 parts, Radix Cudraniae 10 ~ 20 parts, Rhizoma Schizocapsae Plantagineae 15 ~ 25 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 20 ~ 30 parts, Radix radermacherae sinicae 5 ~ 15 parts, Herba Cardui Crispi 10 ~ 25 parts, Radix Antenoronis Filiformis 15 ~ 25 parts, Radix et Rhizoma Thalictri 10 ~ 25 parts, Herba Bulbophylli Odoratissim 20 ~ 35 parts, Herba Polygoni Capitati 10 ~ 20 parts and Radix et Rhizoma Dispori Cantoniensis 15 ~ 25 parts.

The present invention further provides again a kind of preparation method of Chinese medicine of above-mentioned treatment children's acute suppurative tonsillitis, and the dosage form of described Chinese medicine is granule, and it comprises the following steps:

The present invention further provides again a kind of preparation method of Chinese medicine of above-mentioned treatment children's acute suppurative tonsillitis, and the dosage form of described Chinese medicine is syrup, and it comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule prepared by the present invention

Get Folium sidae alnifoliae 220g, Uroctea compatilis Koch. 180g, Herba Dichondrae Repentis 210g, disinfectant 270g, Herba Sedi Multicaulis 260g, Semen Plantaginis 180g, Herba Rorippae 220g, Herba Psychotriae Siamicae 190g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 210g, Radix decaisneae fargesii 240g, Herba Arundinae Chinensis 230g, Rhizoma Bistortae 110g, Herba Selaginellae Involventis 230g, Herba Houttuyniae 190g, Radix Cudraniae 120g, Rhizoma Schizocapsae Plantagineae 190g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 260g, Radix radermacherae sinicae 140g, Herba Cardui Crispi 170g, Radix Antenoronis Filiformis 160g, Radix et Rhizoma Thalictri 230g, Herba Bulbophylli Odoratissim 210g, Herba Polygoni Capitati 190g and Radix et Rhizoma Dispori Cantoniensis 220g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 85%, be heated to boiling reflux 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.06, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 55 DEG C of dryings, obtains granule.

Embodiment 2: syrup prepared by the present invention

Get Folium sidae alnifoliae 240g, Uroctea compatilis Koch. 160g, Herba Dichondrae Repentis 230g, disinfectant 220g, Herba Sedi Multicaulis 290g, Semen Plantaginis 160g, Herba Rorippae 240g, Herba Psychotriae Siamicae 170g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 250g, Radix decaisneae fargesii 220g, Herba Arundinae Chinensis 210g, Rhizoma Bistortae 140g, Herba Selaginellae Involventis 280g, Herba Houttuyniae 160g, Radix Cudraniae 150g, Rhizoma Schizocapsae Plantagineae 160g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 280g, Radix radermacherae sinicae 110g, Herba Cardui Crispi 220g, Radix Antenoronis Filiformis 190g, Radix et Rhizoma Thalictri 170g, Herba Bulbophylli Odoratissim 240g, Herba Polygoni Capitati 160g and Radix et Rhizoma Dispori Cantoniensis 250g.

Its preparation method comprises the following steps:

The first step, Uroctea compatilis Koch., Herba Dichondrae Repentis, disinfectant, Herba Sedi Multicaulis, Semen Plantaginis, Herba Rorippae and Herba Psychotriae Siamicae are mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 85%, heating and refluxing extraction 3 times, each reflux, extract, 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the medicinal liquid of 1.06, by dry with spray dryer for the concentrated solution after concentrated, be ground into 150 orders subsequently, obtain dry powder;

Second step, Herba Arundinae Chinensis, Rhizoma Bistortae, Herba Selaginellae Involventis, Herba Houttuyniae and Radix Cudraniae being mixed in described ratio, be ground into powder, is that the ethanol of 85% is as solvent with determining alcohol, flood 60 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.26, dry with spray dryer, be ground into 150 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;

3rd step, mixes surplus stock medical material in described ratio, add relative to mixture 5 times amount determining alcohol be 75% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20, in 65 DEG C of reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 50%, potassium sorbate 0.24%.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 24-36g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.62g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.1 crude drugs/kg), and matched group gives normal saline, administration in one day 3 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>43.1 crude drug/kg of the present invention, every day, maximum dosage-feeding was 129.3 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 9.26g crude drug/day/people, adult body weight in 60KG, average dosage is 0.1543g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 30g) oral administration gavage Chinese medicine of the present invention is 838 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 13.27,25.38 and 42.46g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all 90 routine cases are this Out-patient Department and inpatient, age 2-12 year, male 47 example, women 43 example, course of disease 1-6 days; Tonsil II ° of enlargement 52 example, tonsil III ° of enlargement 38 example.Be divided into treatment group and matched group at random, wherein, treatment group 45 example, age 2-12 year, male 24 example, women 21 example, course of disease 1-6 days; Tonsil II ° of enlargement 26 example, tonsil III ° of enlargement 19 example.Matched group 45 example, age 2-11 year, male 23 example, women 22 example, course of disease 1-5 days; Tonsil II ° of enlargement 26 example, tonsil III ° of enlargement 19 example.Treatment group and matched group no significant difference in age, sex and the state of an illness, two groups of data comparing difference not statistically significants (P > 0.05), have comparability.

Diagnostic criteria: (1) medical history: suffer from cold, tired and upper respiratory tract has the inducements such as chronic lesion existence.(2) symptom: onset urgency, fear of cold heating, headache, pharyngalgia, dysphagia, inappetence, general malaise, weak, constipation etc.(3) sign: pharynx and tonsil hyperemia, tonsil II ° ~ III ° enlargement, can show yellow-white pus point on its surface, or pus point is fused into lamellar pseudomembrane, but do not exceed tonsil scope, be easy to wipe away, do not reserve blood wound surface, angle of mandible lymphadenectasis, or companion's tenderness.(4) lab testing: numeration of leukocyte and neutrophilic granulocyte increase.In conjunction with above medical history, symptom, sign and lab testing, acute suppurative tonsillitis can be diagnosed as.

Antiadoncus calibration standard: clinically amygdaline profile size is divided into I ~ III degree.I degree of antiadoncus exceeds palatoglossal arch, but is no more than pharyngopalatine arch; II degree of antiadoncus exceedes pharyngopalatine arch, but does not reach pharynx rear wall center line; III degree of antiadoncus reaches pharynx rear wall center line or exceedes pharynx rear wall center line.

Therapeutic Method:

Treatment group: oral Chinese medicine embodiment 1 granule of the present invention, each 15g, every day 3 times.It within 5 days, is a course for the treatment of.

Matched group: give penicillin 100,000 U/ (kg time), adds normal saline 100-250ml medium-sized vein drop, every day 2 times.If penicillin anaphylaxis person uses Azithromycin injection 10mg/ (kgd) instead, add 5% glucose injection, by 1mg/ml concentration preparation intravenous drip, every day 1 time.It within 5 days, is a course for the treatment of.

Criterion of therapeutical effect: draft with reference to " new Chinese medicine guideline of clinical investigations ": (1) fully recovers: in 5 days, temperature recovery is normal, pharyngalgia, the transference cure such as weak, pharynx is without congested, and bilateral amygdala is without enlargement, and leukocyte recovers normal.(2) take a turn for the better: medication after 5 days temperature recovery normal, pharyngalgia, the symptom such as weak are clearly better, and pharynx and tonsil mild hyperaemia, the enlargement of bilateral amygdala I degree, it adheres to without purulent secretion, and leukocyte is less than 12.0*10 ⁹/ L.(3) invalid: symptom is without being clearly better or increasing the weight of, and sign is without improvement.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1.

Table 1 liang group treats Clinical efficacy comparison (unit: example) after 1 course for the treatment of respectively

Group	Number of cases	Recovery from illness	Take a turn for the better	Invalid	Total effective rate
						Treatment group	45	35	8	2	43(95.6％)
Matched group	45	27	9	9	36(80％)

As can be seen from Table 1, adopt Children Treated with Chinese Traditional Drugs acute suppurative tonsillitis of the present invention, relative to matched group on therapeutic effect, there is significant improvement.

Untoward reaction: two groups all do not occur untoward reaction.

Concrete case: infant Zhao, female, 4 years old, occurs that because suffering from cold heating is to 39 DEG C suddenly, accompany fear of cold, pharyngalgia, dysphagia, inappetence etc. simultaneously, pharynx and tonsil hyperemia, tonsil III ° of enlargement, there is yellow-white pus point on tonsil surface, angle of mandible lymphadenectasis, companion's tenderness, numeration of leukocyte and neutrophilic granulocyte increase, and are diagnosed as children's acute suppurative tonsillitis.The granule of oral administration inventive embodiments 1, each 15g, every day 3 times, take clinical symptoms and sign after 4 days and disappear, body temperature, numeration of leukocyte, tonsil recover normal, and clinical diagnosis is fully recovered.Follow up a case by regular visits to 3 months without recurrence.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat the Chinese medicine of children's acute suppurative tonsillitis for one kind, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Folium sidae alnifoliae, Uroctea compatilis Koch., Herba Dichondrae Repentis, disinfectant, Herba Sedi Multicaulis, Semen Plantaginis, Herba Rorippae, Herba Psychotriae Siamicae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix decaisneae fargesii, Herba Arundinae Chinensis, Rhizoma Bistortae, Herba Selaginellae Involventis, Herba Houttuyniae, Radix Cudraniae, Rhizoma Schizocapsae Plantagineae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Radix radermacherae sinicae, Herba Cardui Crispi, Radix Antenoronis Filiformis, Radix et Rhizoma Thalictri, Herba Bulbophylli Odoratissim, Herba Polygoni Capitati and Radix et Rhizoma Dispori Cantoniensis.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Folium sidae alnifoliae 10 ~ 25 parts, Uroctea compatilis Koch. 15 ~ 25 parts, Herba Dichondrae Repentis 10 ~ 25 parts, disinfectant 15 ~ 30 parts, Herba Sedi Multicaulis 20 ~ 30 parts, Semen Plantaginis 10 ~ 25 parts, Herba Rorippae 15 ~ 25 parts, Herba Psychotriae Siamicae 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 15 ~ 25 parts, Radix decaisneae fargesii 20 ~ 30 parts, Herba Arundinae Chinensis 15 ~ 25 parts, Rhizoma Bistortae 10 ~ 20 parts, Herba Selaginellae Involventis 15 ~ 30 parts, Herba Houttuyniae 10 ~ 30 parts, Radix Cudraniae 10 ~ 20 parts, Rhizoma Schizocapsae Plantagineae 15 ~ 25 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 20 ~ 30 parts, Radix radermacherae sinicae 5 ~ 15 parts, Herba Cardui Crispi 10 ~ 25 parts, Radix Antenoronis Filiformis 15 ~ 25 parts, Radix et Rhizoma Thalictri 10 ~ 25 parts, Herba Bulbophylli Odoratissim 20 ~ 35 parts, Herba Polygoni Capitati 10 ~ 20 parts and Radix et Rhizoma Dispori Cantoniensis 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Folium sidae alnifoliae 20 ~ 25 parts, Uroctea compatilis Koch. 15 ~ 20 parts, Herba Dichondrae Repentis 20 ~ 25 parts, disinfectant 20 ~ 30 parts, Herba Sedi Multicaulis 25 ~ 30 parts, Semen Plantaginis 15 ~ 20 parts, Herba Rorippae 20 ~ 25 parts, Herba Psychotriae Siamicae 15 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 20 ~ 25 parts, Radix decaisneae fargesii 20 ~ 25 parts, Herba Arundinae Chinensis 20 ~ 25 parts, Rhizoma Bistortae 10 ~ 15 parts, Herba Selaginellae Involventis 20 ~ 30 parts, Herba Houttuyniae 15 ~ 20 parts, Radix Cudraniae 10 ~ 15 parts, Rhizoma Schizocapsae Plantagineae 15 ~ 20 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25 ~ 30 parts, Radix radermacherae sinicae 10 ~ 15 parts, Herba Cardui Crispi 15 ~ 25 parts, Radix Antenoronis Filiformis 15 ~ 20 parts, Radix et Rhizoma Thalictri 15 ~ 25 parts, Herba Bulbophylli Odoratissim 20 ~ 25 parts, Herba Polygoni Capitati 15 ~ 20 parts and Radix et Rhizoma Dispori Cantoniensis 20 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Folium sidae alnifoliae 22 parts, Uroctea compatilis Koch. 18 parts, Herba Dichondrae Repentis 21 parts, disinfectant 27 parts, Herba Sedi Multicaulis 26 parts, Semen Plantaginis 18 parts, Herba Rorippae 22 parts, Herba Psychotriae Siamicae 19 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 21 parts, Radix decaisneae fargesii 24 parts, Herba Arundinae Chinensis 23 parts, Rhizoma Bistortae 11 parts, Herba Selaginellae Involventis 23 parts, Herba Houttuyniae 19 parts, Radix Cudraniae 12 parts, Rhizoma Schizocapsae Plantagineae 19 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 26 parts, Radix radermacherae sinicae 14 parts, Herba Cardui Crispi 17 parts, Radix Antenoronis Filiformis 16 parts, Radix et Rhizoma Thalictri 23 parts, Herba Bulbophylli Odoratissim 21 parts, Herba Polygoni Capitati 19 parts and Radix et Rhizoma Dispori Cantoniensis 22 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

7. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and it comprises the following steps:

8. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps: