CN105477225B - Traditional Chinese veterinary medicine for enhancing anti-stress capability of chicks, preparation method and feeding method - Google Patents

Traditional Chinese veterinary medicine for enhancing anti-stress capability of chicks, preparation method and feeding method Download PDF

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Publication number
CN105477225B
CN105477225B CN201511027082.XA CN201511027082A CN105477225B CN 105477225 B CN105477225 B CN 105477225B CN 201511027082 A CN201511027082 A CN 201511027082A CN 105477225 B CN105477225 B CN 105477225B
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chicks
enhancing
stress capability
traditional chinese
chinese veterinary
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CN105477225A (en
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姜国均
周帮会
权普明
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Shanxi Langxin Biotechnology Co.,Ltd.
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Hebei Agricultural University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube

Abstract

The invention discloses a traditional Chinese veterinary medicine for enhancing the anti-stress capability of chicks, which consists of the following components: 20-30% of rhizoma acori graminei, 20-30% of keel, 20-30% of spina date seed, 8-16% of eucommia ulmoides and 8-16% of semen cuscutae, and the invention also discloses a preparation method and a feeding method of the traditional Chinese veterinary medicine for enhancing the anti-stress capability of chicks. The invention can enhance the anti-stress capability of the chicks, further improve the production performance of the later-formed chickens and avoid the drug residue caused by using chemical drugs. In addition, the formula, the preparation method and the feeding method of the veterinary drug for enhancing the anti-stress capability of the chicks are simple, and the veterinary drug has the advantages of environmental protection.

Description

Traditional Chinese veterinary medicine for enhancing anti-stress capability of chicks, preparation method and feeding method
Technical Field
The invention belongs to the field of agricultural product cultivation, and particularly relates to a traditional Chinese veterinary medicine for enhancing the anti-stress capability of chicks.
Background
The development of chicken is a very complex metabolic process, and the production performance of the chicken is influenced by genetic factors and environmental factors. In recent years, with the rapid development of livestock and poultry breeding, high-density intensive breeding methods are widely used, however, the high-density intensive breeding methods are liable to cause poor growth and development conditions, reduced growth performance and reduced stress resistance of chicks. In addition, as the breeding density of chicks increases, the breeding environment gradually deteriorates, so that the morbidity and mortality of chicks during breeding are high.
In the practical production process, in the past, chlorpromazine and other chemical medicaments are commonly added into feed to prevent and treat the influence of stress reaction on livestock and poultry, but because the chlorpromazine and other chemical medicaments have long residual time and obvious side effects, the chlorpromazine and other chemical medicaments are forbidden to be added into the feed by the country, and new veterinary medicaments which can enhance the anti-stress reaction of chicks and have no toxic or side effect are researched and developed, so that the chlorpromazine and other chemical medicaments are an important problem which needs to be solved urgently in the current chicken raising production.
The traditional Chinese medicine is gradually valued for the advantages of environmental protection, no medicine residue, small toxic and side effects, safety, reliability and lasting medicine effect, and a traditional Chinese medicine with high safety needs to be developed to enhance the anti-stress capability of the chicks.
Disclosure of Invention
The traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks, the preparation method and the feeding method thereof can avoid antibiotic residues in the chicks caused by using antibiotics and can enhance the anti-stress capability of the chicks at the same time.
The invention aims to provide a traditional Chinese veterinary medicine for enhancing the anti-stress capability of chicks, which consists of the following components: 20-30% of rhizoma acori graminei, 20-30% of keel, 20-30% of spina date seed, 8-16% of eucommia bark and 8-16% of semen cuscutae, wherein the percentages are mass percentages.
Preferably, the traditional Chinese veterinary medicine for enhancing the anti-stress of the chicks consists of 20% of rhizoma acori graminei, 20% of keel, 28% of spina date seed, 16% of eucommia ulmoides and 16% of semen cuscutae.
Preferably, the traditional Chinese veterinary medicine for enhancing the anti-stress of the chicks consists of 26% of rhizoma acori graminei, 26% of keel, 26% of spina date seed, 11% of eucommia ulmoides and 11% of semen cuscutae.
Preferably, the traditional Chinese veterinary medicine for enhancing the anti-stress of the chicks consists of 30% of rhizoma acori graminei, 30% of keel, 23% of spina date seed, 8% of eucommia ulmoides and 9% of semen cuscutae.
The second purpose of the invention is to provide a preparation method of a traditional Chinese veterinary medicine for enhancing the anti-stress capability of chicks, which is implemented according to the following steps:
step 1, weighing 20-30% of rhizoma acori graminei, 20-30% of keel, 20-30% of spina date seed, 8-16% of eucommia bark and 8-16% of semen cuscutae in percentage by weight, wherein the sum of the mass percentages of the components is 100%;
step 2, respectively crushing the components weighed in the step 1, and sieving the crushed components with a 600-mesh sieve to obtain powder;
and 3, fully mixing the powder obtained in the step 2 to obtain the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks.
The third purpose of the invention is to provide a feeding method of traditional Chinese veterinary medicines for enhancing the anti-stress capability of chicks, wherein the traditional Chinese veterinary medicines are mixed in the basic feed according to the proportion that the mass of the traditional Chinese veterinary medicines accounts for 2 per mill of the mass of the basic feed for feeding, the feeding days are 7-14 days, and then the basic feed is still used for feeding;
preferably, the mixed feed is fed twice a day, and the feeding time is respectively 9:30-11:00 in the morning and 13:00-14:30 in the afternoon;
preferably, the brand of the basic feed is a mixed feed for Nongdali 511 chicks.
The invention has the beneficial effects that the traditional Chinese veterinary medicine which is high in safety and can enhance the anti-stress capability of the chicks is developed, the traditional Chinese veterinary medicine can improve the growth development condition and the growth performance of the chicks, further improve the production performance of the later-formed chicks and avoid medicine residues caused by using chemical medicines. In addition, the formula, the preparation method and the feeding method of the traditional Chinese veterinary medicine are simple, and the traditional Chinese veterinary medicine has the advantages of environmental protection.
Detailed Description
The present invention will be described in detail with reference to specific examples.
The traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks consists of the following components: 20-30% of rhizoma acori graminei, 20-30% of keel, 20-30% of spina date seed, 8-16% of eucommia bark and 8-16% of semen cuscutae, wherein the percentages are mass percentages.
The functions of the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks by the components are as follows:
grassleaf sweelflag rhizome: pungent and bitter taste, slightly warm in nature; it enters heart, liver and spleen meridians. The functional indications are as follows: regulating qi-flowing, promoting blood circulation, dispelling pathogenic wind, eliminating dampness, promoting appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence, and rhizoma Acori Graminei has certain effect of inhibiting dermatophytes.
Keel: astringent, sweet and neutral; it enters heart, liver, kidney and large intestine meridians. Has the effects of calming the heart and tranquilizing the mind, calming the liver and suppressing yang hyperactivity, and astringing and arresting depletion to stop bleeding.
Wild jujube seed: sweet in nature, sour and neutral. Enter liver, gallbladder and heart meridians. The functional indications are as follows: the wild jujube seed alcohol extract has the functions of tonifying liver, calming heart, arresting sweating and promoting the production of body fluid, and in addition, the wild jujube seed alcohol extract also has the function of enhancing the anti-stress capability.
Eucommia ulmoides: sweet in flavor and warm in nature. Has effects in tonifying liver and kidney, strengthening muscle and bone, regulating Chong and ren meridians, and preventing miscarriage. Modern researches show that eucommia bark has the effects of clearing away in-vivo garbage, strengthening the metabolism of human cell substances, preventing the aging of muscles and bones, balancing the blood pressure of a human body, decomposing cholesterol in the body, reducing fat in the body, recovering the elasticity of blood vessels, inducing diuresis, clearing heat, resisting bacteria in a broad spectrum, exciting central nerves and improving white blood cells.
Dodder seed: warm in nature and sweet in taste. Has effects in nourishing liver and kidney, nourishing essence, and improving eyesight.
Based on the same inventive concept, the invention provides a preparation method of a traditional Chinese veterinary medicine for enhancing the anti-stress capability of chicks, but the invention is not understood to be limited by the invention.
The preparation method of the traditional Chinese veterinary medicine is specifically implemented according to the following steps:
step 1, weighing 20-30% of rhizoma acori graminei, 20-30% of keel, 20-30% of spina date seed, 8-16% of eucommia bark and 8-16% of semen cuscutae in percentage by weight, wherein the sum of the mass percentages of the components is 100%;
step 2, respectively crushing the components weighed in the step 1, and sieving the crushed components with a 600-mesh sieve to obtain powder;
and 3, fully mixing the powder obtained in the step 2 to obtain the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks.
Preferably, the preparation method of the veterinary drug for enhancing the anti-stress capability of the chicks further comprises the following embodiments:
example 1
The veterinary drug for enhancing the anti-stress capability of the chicks in the embodiment 1 consists of 20% of rhizoma acori graminei, 20% of keel, 28% of spina date seed, 16% of eucommia ulmoides and 16% of semen cuscutae, and is specifically implemented according to the following steps:
step 1, weighing 20% of rhizoma acori graminei, 20% of keel, 28% of spina date seed, 16% of eucommia bark and 16% of semen cuscutae in percentage by mass;
step 2, respectively crushing the components weighed in the step 1, and sieving the crushed components with a 600-mesh sieve to obtain powder;
and 3, fully mixing the powder obtained in the step 2 to obtain the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks.
Example 2
The veterinary drug for enhancing the anti-stress capability of the chicks in the embodiment 2 is composed of 26% of acorus gramineus, 26% of dragon bone, 26% of spina date seed, 11% of eucommia ulmoides and 11% of semen cuscutae, and is specifically implemented according to the following steps:
step 1, weighing 26% of rhizoma acori graminei, 26% of keel, 26% of spina date seed, 11% of eucommia ulmoides and 11% of semen cuscutae in percentage by mass;
step 2, respectively crushing the components weighed in the step 1, and sieving the crushed components with a 600-mesh sieve to obtain powder;
and 3, fully mixing the powder obtained in the step 2 to obtain the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks.
Example 3
The veterinary drug for enhancing the anti-stress capability of the chicks in the embodiment 3 consists of 30% of acorus gramineus, 30% of fossilizid, 23% of spina date seeds, 8% of eucommia ulmoides and 9% of semen cuscutae, and is specifically implemented according to the following steps:
step 1, weighing 30% of rhizoma acori graminei, 30% of keel, 23% of spina date seed, 8% of eucommia ulmoides and 9% of semen cuscutae in percentage by mass;
step 2, respectively crushing the components weighed in the step 1, and sieving the crushed components with a 600-mesh sieve to obtain powder;
and 3, fully mixing the powder obtained in the step 2 to obtain the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks.
Based on the same invention concept, the invention also provides a feeding method of the veterinary drug for enhancing the anti-stress capability of the chicks, which is implemented according to the following steps:
the veterinary drug is mixed in the basic feed according to the proportion that the weight of the veterinary drug accounts for 2 thousandth of the weight of the basic feed, the feeding days are 7-14 days, then the basic feed is still used for feeding, the feeding times are twice a day, the feeding time is 9:30-11:00 in the morning and 13:00-14:30 in the afternoon, the interval time of feeding the traditional Chinese veterinary drug cannot exceed 1 day when the traditional Chinese veterinary drug is fed, and preferably, the brand of the basic feed is the mixed feed for the Nongdali 511 chicks.
The veterinary drug for enhancing the anti-stress capability of the chicks in the embodiments 1 to 3 of the invention is used for performing zoology experiments on the chicks:
1. test method
1.1 Experimental grouping and treatment: 100 chicks of 14 days old with good growth condition are selected from the densely bred chicks, 1mL of LPS (lipopolysaccharide) with the mass percentage of 1600 mug/kg is respectively injected to induce the chicks to generate stress reaction, the chicks generate obvious stress reaction after one week, and the specific characteristics are that the body temperature is increased, the mental condition is depressed, the chicks are like to gather together, the chicks are easy to be frightened, and the food intake and the weight of the chicks are obviously reduced. Stress-producing 21-day-old chicks were divided into a control group, an example 1 group, an example 2 group and an example 3 group, each of which was 25, and labeled. The control group is fed with basal feed, and the feeding method of each group of the embodiment comprises the following steps: weighing each component according to the formula of the veterinary drug for enhancing the anti-stress capability of the chicks in the examples 1 to 3, crushing, sieving with a 600-mesh sieve, mixing the powder, blending the total weight of the veterinary drug for enhancing the anti-stress capability of the chicks in the basal feed according to the proportion of 2 per mill of the weight of the basal feed, feeding for 7 days, and then feeding with the basal feed. The control group and each example group were fed twice a day at the time of 9:30-11:0 in the morning and 13:00-14:30 in the afternoon, respectively, and were immunized and anthelmintic according to the normal immunization program. The brand of the basic feed is the mixed feed for the Nongdali 511 chicks.
1.2 index determination: during the experiment, the growth status of each group of chicks was observed daily, and the feed intake and body weight were measured, and the mental state was observed, and further, the spleen index, thymus index, bursa index, number of red/white blood cells in blood, total protein in serum, albumin, interleukin-1 (IL-1), interleukin-6 (IL-6), immunoglobulin a (iga), immunoglobulin m (igm), immunoglobulin g (igg), and corticosterone content were measured in each group of chicks at 35 days of age.
2 results of the experiment
2.1 the traditional Chinese veterinary medicine can improve the growth performance of chicks and improve the growth condition:
as shown in Table 1, the average daily gain of the chicks of examples 1 to 3 was increased to different degrees compared with the control group, and the difference was significant (P < 0.05) compared with the control group, the feed weight ratios of the chicks of examples 1 to 3 were decreased to different degrees, and the chicks of examples 1 to 3 were observed to have good mental status, and were not easy to be frightened, and the mental status of the chicks of the control group was still depressed.
2.2 the traditional Chinese veterinary medicine of the invention enhances the anti-stress capability of chicks:
as shown in Table 2, the chicken spleen index, thymus index and bursal index of the groups of examples 1-3 were increased to different degrees compared with the control group, and the difference was significant (P < 0.05) compared with the control group, which indicates that the corresponding immune organs, i.e. spleen, thymus and bursal, were well developed compared with the control group; as shown in Table 3, the number of leukocytes in the blood of the chicks in the groups of examples 1 to 3 was increased to different degrees compared with the control group, and the total protein, albumin, IL-6, IgM, IgG and corticosterone in the serum were increased to different degrees compared with the control group (P < 0.05), which indicates that the veterinary drug for enhancing the anti-stress capability of the chicks of the present invention has an accelerating effect on the increase of the anti-stress capability and the immune function of the chicks.
TABLE 1 Effect on growth Performance
Figure BSA0000125499860000071
TABLE 2 Effect on immune organ index
Figure BSA0000125499860000081
TABLE 3 influence on stress and immune function related indices of chicks
Figure BSA0000125499860000082
The traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks is a high-safety traditional Chinese veterinary medicine, can enhance the anti-stress capability of the chicks and improve the growth condition and the growth performance of the chicks, thereby improving the production performance of the later-formed chicks and avoiding medicine residues caused by using chemical medicines. In addition, the formula, the preparation method and the feeding method of the traditional Chinese veterinary medicine are simple, and the traditional Chinese veterinary medicine has the advantages of environmental protection.
Various modifications and variations of the present invention may be made by those skilled in the art without departing from the spirit and scope of the present invention, and it is intended that the present invention cover the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.

Claims (6)

1. A traditional Chinese veterinary medicine for enhancing the anti-stress capability of chicks is characterized by comprising the following components: 20-30% of rhizoma acori graminei, 20-30% of keel, 20-30% of spina date seed, 8-16% of eucommia bark and 8-16% of semen cuscutae, wherein the percentages are mass percentages.
2. The veterinary drug for enhancing the anti-stress capability of chicks as claimed in claim 1, wherein the veterinary drug for enhancing the anti-stress capability of chicks is composed of 20% of grassleaf sweelflag rhizome, 20% of dragon bone, 28% of spina date seed, 16% of eucommia bark and 16% of south dodder seed.
3. The veterinary drug for enhancing the anti-stress capability of chicks as claimed in claim 1, wherein the veterinary drug for enhancing the anti-stress capability of chicks is composed of 26% of grassleaf sweelflag rhizome, 26% of dragon bone, 26% of spina date seed, 11% of eucommia bark and 11% of south dodder seed.
4. The veterinary drug for enhancing the anti-stress capability of chicks as claimed in claim 1, wherein the veterinary drug for enhancing the anti-stress capability of chicks is composed of 30% of grassleaf sweelflag rhizome, 30% of dragon bone, 23% of spina date seed, 8% of eucommia bark and 9% of south dodder seed.
5. The preparation method of the veterinary drug for enhancing the anti-stress capability of the chicks as claimed in any one of claims 1 to 4 is characterized by comprising the following steps:
step 1, weighing according to the weight percentage, wherein the sum of the mass percentages of all the components is 100%;
step 2, respectively crushing the components weighed in the step 1, and sieving the crushed components with a 600-mesh sieve to obtain powder;
and 3, fully mixing the powder obtained in the step 2 to obtain the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks.
6. The use method of the traditional Chinese veterinary medicine for enhancing the anti-stress capability of the chicks as claimed in any one of claims 1 to 4 is characterized by comprising the following steps:
mixing the traditional Chinese veterinary medicines in the basic feed according to the proportion that the mass of the traditional Chinese veterinary medicines accounts for 2 per mill of the mass of the basic feed for feeding, wherein the feeding days are 7-14 days, and then, feeding by adopting the basic feed; the brand of the basic feed is the mixed feed for the Nongdali 511 chicks.
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CN106177559A (en) * 2016-08-22 2016-12-07 牛金鹏 A kind of herbal medicine preventing and treating chicken heat shock reaction
CN106139103A (en) * 2016-08-24 2016-11-23 牛金鹏 A kind of herbal medicine preventing and treating the reaction of chicken cold stress
CN106334007A (en) * 2016-11-11 2017-01-18 孙希丹 Traditional Chinese veterinary medicine for preventing chicken transportation stress responses

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Publication number Priority date Publication date Assignee Title
CN103168965A (en) * 2013-03-29 2013-06-26 重庆市畜牧科学院 Anti-stress synbiotics traditional Chinese medicine composition applicable to chicken and preparation method of anti-stress synbiotics traditional Chinese medicine composition
CN103190544A (en) * 2013-04-12 2013-07-10 重庆市畜牧科学院 Duckling anti-stress synbiotics and traditional Chinese medicine composition and preparation method of composition
CN104082532A (en) * 2014-07-10 2014-10-08 南宁荣港生物科技有限公司 Preparation method of anti-stress traditional Chinese medicine synbiotics composition for chickens

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Publication number Priority date Publication date Assignee Title
CN103168965A (en) * 2013-03-29 2013-06-26 重庆市畜牧科学院 Anti-stress synbiotics traditional Chinese medicine composition applicable to chicken and preparation method of anti-stress synbiotics traditional Chinese medicine composition
CN103190544A (en) * 2013-04-12 2013-07-10 重庆市畜牧科学院 Duckling anti-stress synbiotics and traditional Chinese medicine composition and preparation method of composition
CN104082532A (en) * 2014-07-10 2014-10-08 南宁荣港生物科技有限公司 Preparation method of anti-stress traditional Chinese medicine synbiotics composition for chickens

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