CN1054754C - Medicinal composite for rheumatism - Google Patents
Medicinal composite for rheumatism Download PDFInfo
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- CN1054754C CN1054754C CN94113387A CN94113387A CN1054754C CN 1054754 C CN1054754 C CN 1054754C CN 94113387 A CN94113387 A CN 94113387A CN 94113387 A CN94113387 A CN 94113387A CN 1054754 C CN1054754 C CN 1054754C
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Abstract
The present invention relates to a medicine compound for treating rheumatism and a method for preparing medicines (such as tablets, pills, oral solutions or capsules) by the compound. The medicine compound contains malaytea scurfpea fruit, common floweringqince fruit, musk, scorpio, ant, danshen root, herba epimedii, prepared common monkshood mother root, eucommia bark, white peony alba, milkvetch root, prepared curare, clematis root, long-noded pit viper, Sushu and paris polyphylla. The total effective rate of the medicine compound for treating rheumatism is 90% and has no poison side effect.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of rheumatic four diseases, and this pharmaceutical composition is made the method for medicament.
Rheumatic four diseases is a kind of chronic systemic autoimmune disease, and this sick course of disease is long, and the disability rate height is commonly encountered diseases, the frequently-occurring disease that has a strong impact on human health.But, still do not have specific short so far both at home and abroad.General traditional traditional Chinese medical science is treated rheumatic four diseases with the ruling by law of expelling wind and removing dampness, but curative effect is not remarkable.
The present inventor is according to the traditional theory of the traditional Chinese medical science, in conjunction with clinical position practice and the gains in depth of comprehension of self, on the basis of the combination of Chinese and Western medicine, outstanding tcm characteristic, superintend and direct so that the kidney invigorating is strong, assistant with eliminating evil, invigorate blood circulation, the rule of treatment of spleen invigorating, the liver benefiting and pain relieving, design a kind of compositions of treatment rheumatic four diseases evident in efficacy.
The present inventor has carried out system's analysis to the cause of disease, pathogenesis, pathology and disease the levying of rheumatic four diseases, rheumatic four diseases belongs to the arthromyodynia category of the traditional Chinese medical science, and the traditional Chinese medical science thinks that " wind, cold, wet " three gas are assorted to being combined into " numbness ", and this is the total pathogenesis of arthromyodynia, in addition, rheumatic four diseases still has the existence of " suffering from a deficiency of the kidney ".Ming Dynasty's physician's Wang Kentang is pointed out: arthromyodynia pathogenesis multiterminal, be " mark disease ", " have only and suffer from a deficiency of the kidney Fang Weiqi originally also ", the arthromyodynia pathological changes is at bone, and bone is led by kidney, again because of rheumatic four diseases is an obstinate disease, so argumentations such as " the many stasis of bloods of prolonged illness ", " prolonged illness is how empty ", " must reach kidney for a long time " are arranged, based on above-mentioned theory, what the present inventor proposed is that the main treatment rheumatic four diseases meets theory of Chinese medical science with strong the superintending and directing of the kidney invigorating.This also is therapy of the present invention and the general traditional traditional Chinese medical science key with the difference of the therapy of expelling wind and removing dampness.Prove by clinical practice, because the patient of rheumatic four diseases has the existence of " wind, cold, wet, heresy " more, the stop of blood stasis, deficiency of spleen-QI and the liver failing to be nourished and disorder of QI movement etc., thus the kidney invigorating is strong must be eliminating evil when superintending and directing, invigorate blood circulation, multi-level comprehensive medications such as spleen invigorating, nourishing the liver and pain relieving.
The purpose of this invention is to provide a kind of pharmaceutical composition of treatment rheumatic four diseases evident in efficacy, the method for making medicaments such as tablet, electuary with said composition also is provided.
The pharmaceutical composition of treatment rheumatic four diseases of the present invention contains following component (ratio of weight and number):
Fructus Psoraleae 3-4 Fructus Chaenomelis 3-3.5
Moschus 0.1-0.3 Scorpio 1-1.5
Formica fusca 2-3 Radix Salviae Miltiorrhizae 3-4
Herba Epimedii 3-4 Radix Aconiti Preparata 1-1.5
Cortex Eucommiae 3-4 Radix Paeoniae Alba 3-5
Radix Astragali 3-4 Agkistrodon 1-1.5
Radix Clematidis 2-3 Lignum Sappan 2.5-3
Rhizoma Paridis 1-1.5 Semen Strychni (processed) 1.5-2.5
Treatment rheumatic four diseases pharmaceutical composition of the present invention can be made into capsule, or makes conventional dose dosage forms such as tablet, electuary, pill with commonly used carrier or additive (as excipient etc.), promptly as the active pharmaceutical compositions of these medicaments.
The kidney invigorating medicine in the pharmaceutical composition of treatment rheumatic four diseases of the present invention can act on hypothalamus-hypophysis-epinephrine axle system by different modes, carry out integrally-regulated to neuroendocrine function, why the kidney invigorating medicine participates in immunoregulation effect trace element zinc contained with it, copper etc. are relevant, zinc, trace element such as copper are to nucleic acid and proteinic synthetic, immunologic process, the breathing of cell, division, breeding and metabolism etc. all have direct relation, therefore the pharmaceutical composition of treatment rheumatic four diseases of the present invention can strengthen urogenital function and the brain relevant with " kidney " function, spinal cord, thyroid, endocrine functions such as adrenal gland, improve immune function, thereby reach the curative effect of treatment rheumatic four diseases.
The pharmaceutical composition warp of treatment rheumatic four diseases of the present invention is from 412 routine rheumatism patients' of 11 provinces and cities such as Yunnan, Sichuan, Shaanxi, Hunan, Shandong, Liaoning, Tianjin, Beijing treatment checking, prove that this therapy effect is remarkable, its clinical cure rate is 21%, obvious effective rate is 38%, effective percentage is 31%, and total effective rate is 90%.
The pharmaceutical composition of treatment rheumatic four diseases of the present invention carries out toxicological experiment by the mice lavage method, proves that in order to people's consumption 30 times are done experiment not find toxic reaction, proves that the pharmaceutical composition of treatment rheumatic four diseases of the present invention has no side effect.
Further specify the composition of the pharmaceutical composition of treatment rheumatic four diseases of the present invention below by embodiment, and said composition is made the manufacture method of pharmaceutical formulations such as tablet, electuary, pill, capsule.Embodiment 1
The present invention treats pharmaceutical composition specifically composed as follows of rheumatic four diseases;
Fructus Psoraleae 300 gram Fructus Chaenomeliss 300 grams
Moschus 15 gram Scorpios 120 grams
Formica fusca 250 gram Radix Salviae Miltiorrhizaes 340 grams
Herba Epimedii 360 is restrained Radix Aconiti 120 grams
The Cortex Eucommiae 320 gram Radix Paeoniae Albas 410 grams
The Radix Astragali 340 gram Agkistrodons 150 grams
Radix Clematidis 250 gram Lignum Sappans 250 grams
Rhizoma Paridis 150 is restrained Semen Strychni 200 grams
Above-mentioned composition is made medicinal tablet.
Required adjuvant:
Starch: an amount of, ethanol (95%): an amount of, dextrin: 3-5% (with composition weight meter), deionized water: 1.5% (with composition weight meter), magnesium stearate: 1% (with composition weight meter).
Manufacture method:
Above-mentioned Fructus Psoraleae, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Clematidis, Lignum Sappan, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Rhizoma Paridis, Herba Epimedii are put into pot, the decocting that adds quintuple is endured three times, for the first time, decoct 90 minutes for the second time, decoct 60 minutes for the third time, merge three times and decoct liquid, be evaporated to thick paste, standby.
120 mesh sieves are pulverized, crossed to above-mentioned Formica fusca, Scorpio, Radix Aconiti Preparata, Semen Strychni (processed), Agkistrodon in 60 ℃ of oven dry.Get this sieve powder and above-mentioned Moschus uniform mixing, obtain temperature and close uniform fine powder.
With above-mentioned thick paste and fine powder uniform mixing, add an amount of starch and ethanol, mix homogeneously is made soft powder, granulates drying with 10 mesh sieves, smash with universal mill the back, add dextrin and water and magnesium stearate, cross 16-18 mesh sieve corning, mix homogeneously, be pressed into the sheet of 0.5 gram, promptly get the tablet of pharmaceutical composition of the present invention.
Embodiment 2
The used pharmaceutical composition of the present invention of present embodiment specifically composed as follows:
Fructus Psoraleae 350 gram Fructus Chaenomeliss 350 grams
Moschus 20 gram Scorpios 150 grams
Formica fusca 250 gram Radix Salviae Miltiorrhizaes 350 grams
Herba Epimedii 350 is restrained Radix Aconiti 120 grams
The Cortex Eucommiae 350 gram Radix Paeoniae Albas 400 grams
The Radix Astragali 300 gram Agkistrodons 120 grams
Radix Clematidis 250 gram Lignum Sappans 300 grams
Rhizoma Paridis 250 is restrained Semen Strychni 200 grams
Aforementioned pharmaceutical compositions is made pill, and manufacture method is as follows:
Ten five kinds of Chinese medicine except that Moschus in the aforementioned pharmaceutical compositions are worn into fine powder respectively, cross 120 mesh sieves, the fine powder with gained mixes then, mix homogeneously.After again refined honey (in right amount) being done temperature, add the Moschus mix homogeneously, add fine powder again and stir, make pill at last, each pill weight is 9 grams, promptly makes the pill of pharmaceutical composition of the present invention.
Embodiment 3
The used pharmaceutical composition of the present invention of present embodiment specifically composed as follows:
Fructus Psoraleae 400 gram Fructus Chaenomeliss 350 grams
Moschus 20 gram Scorpios 100 grams
Formica fusca 300 gram Radix Salviae Miltiorrhizaes 380 grams
Herba Epimedii 400 is restrained Radix Aconiti 150 grams
The Cortex Eucommiae 400 gram Radix Paeoniae Albas 400 grams
The Radix Astragali 350 gram Agkistrodons 150 grams
Radix Clematidis 300 gram Lignum Sappans 300 grams
Seven leaves, one plate spends 140 to restrain Semen Strychni 200 grams
Aforementioned pharmaceutical compositions is made capsule, and method for making is as follows:
Fructus Psoraleae in the aforementioned pharmaceutical compositions, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Clematidis, Lignum Sappan, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Rhizoma Paridis, Herba Epimedii are put into pot, the decocting that adds quintuple is endured three times, first and second time decocts 90 minutes respectively, decoct 60 minutes for the third time, merge three times and decoct liquid, be evaporated to thick paste, standby.
Formica fusca in the above-mentioned composition, Scorpio, Radix Aconiti Preparata, Semen Strychni (processed), Agkistrodon in 60 ℃ of oven dry, are pulverized, cross 120 mesh sieves, obtain fine powder.
With above-mentioned gained thick paste and fine powder mix homogeneously, fully oven dry grinds, and crosses 80 mesh sieves, adds Moschus, and fully mix homogeneously incapsulates, and promptly makes the capsule preparations of pharmaceutical composition of the present invention.
Embodiment 4
The used pharmaceutical composition of the present invention of present embodiment specifically composed as follows:
Fructus Psoraleae 380 gram Fructus Chaenomeliss 300 grams
Moschus 30 gram Scorpios 150 grams
Formica fusca 200 gram Radix Salviae Miltiorrhizaes 400 grams
Herba Epimedii 300 is restrained Radix Aconiti 150 grams
The Cortex Eucommiae 350 gram Radix Paeoniae Albas 450 grams
The Radix Astragali 300 gram Agkistrodons 150 grams
Radix Clematidis 250 gram Lignum Sappans 300 grams
Seven leaves, one plate spends 150 to restrain Semen Strychni 200 grams
The invention described above pharmaceutical composition is made electuary, and manufacture method is as follows:
The decocting that 15 kinds of Chinese medicines except that Moschus in the aforementioned pharmaceutical compositions add quintuple is endured three times, first and second time decocts 90 minutes, decoct 60 minutes for the third time, merge three times and decoct liquid, be evaporated to equivalent extract, add above-mentioned Moschus and an amount of sugar again, make soft powder, granulate again,, promptly obtain the electuary of pharmaceutical composition of the present invention through intensive drying, granulate.
As can be seen from the above embodiments, the pharmaceutical composition of treatment rheumatic four diseases of the present invention can be made required pharmaceutical dosage form, as tablet, pill, electuary and capsule etc. easily with conventional method.
Claims (1)
1. a medicine for the treatment of rheumatic four diseases is characterized in that it is the tablet of being made by the raw material of following ratio of weight and number, pill, electuary or capsule: Fructus Psoraleae 3-4 Fructus Chaenomelis 3-3.5 Moschus 0.1-0.3 Scorpio 1-1.5 Formica fusca 2-3 Radix Salviae Miltiorrhizae 3-4 Herba Epimedii 3-4 Radix Aconiti Preparata 1-1.5 Cortex Eucommiae 3-4 Radix Paeoniae Alba 3-5 Radix Astragali 3-4 Agkistrodon 1-1.5 Radix Clematidis 2-3 Lignum Sappan 2.5-3 Rhizoma Paridis 1-1.5 Semen Strychni (processed) 1.5-2.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94113387A CN1054754C (en) | 1994-12-27 | 1994-12-27 | Medicinal composite for rheumatism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94113387A CN1054754C (en) | 1994-12-27 | 1994-12-27 | Medicinal composite for rheumatism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1116940A CN1116940A (en) | 1996-02-21 |
| CN1054754C true CN1054754C (en) | 2000-07-26 |
Family
ID=5036716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94113387A Expired - Fee Related CN1054754C (en) | 1994-12-27 | 1994-12-27 | Medicinal composite for rheumatism |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1054754C (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053263A (en) * | 1990-01-06 | 1991-07-24 | 吴廷玉 | Producing method of medical wine for eliminating disease and body-nourishing |
| CN1061158A (en) * | 1991-01-31 | 1992-05-20 | 伊卫国 | The manufacture method of specially medicinal liquor for rheumatism |
-
1994
- 1994-12-27 CN CN94113387A patent/CN1054754C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053263A (en) * | 1990-01-06 | 1991-07-24 | 吴廷玉 | Producing method of medical wine for eliminating disease and body-nourishing |
| CN1061158A (en) * | 1991-01-31 | 1992-05-20 | 伊卫国 | The manufacture method of specially medicinal liquor for rheumatism |
Non-Patent Citations (3)
| Title |
|---|
| 中草药通讯1974(4) 1974.4.30 关于灵芝研究的进展 * |
| 药学通报198116(8) 1981.8.30 复方蛇片的制备与临床初步观察 * |
| 药学通报198116(8) 1981.8.30 复方蛇片的制备与临床初步观察;中草药通讯1974(4) 1974.4.30 关于灵芝研究的进展 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1116940A (en) | 1996-02-21 |
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