CN105461684B - 抗菌的环戊二烯并[c]吡咯取代的3,4-二氢-1h-[1,8]萘啶酮 - Google Patents

抗菌的环戊二烯并[c]吡咯取代的3,4-二氢-1h-[1,8]萘啶酮 Download PDF

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Publication number
CN105461684B
CN105461684B CN201511000870.XA CN201511000870A CN105461684B CN 105461684 B CN105461684 B CN 105461684B CN 201511000870 A CN201511000870 A CN 201511000870A CN 105461684 B CN105461684 B CN 105461684B
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CN105461684A (zh
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J.E.G.圭尔勒蒙特
D.F.A.兰科伊斯
M.M.S.莫特
A.考尔
W.M.A.巴勒曼斯
E.P.A.阿诺特
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Janssen Sciences Ireland ULC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201511000870.XA 2011-08-10 2012-08-10 抗菌的环戊二烯并[c]吡咯取代的3,4-二氢-1h-[1,8]萘啶酮 Expired - Fee Related CN105461684B (zh)

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EP11177119.2 2011-08-10
EP11177119 2011-08-10
CN201280038643.4A CN103874698B (zh) 2011-08-10 2012-08-10 抗菌的环戊二烯并[c]吡咯取代的3,4-二氢-1h-[1,8]萘啶酮

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CN105461684B true CN105461684B (zh) 2018-09-25

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CN201280038643.4A Expired - Fee Related CN103874698B (zh) 2011-08-10 2012-08-10 抗菌的环戊二烯并[c]吡咯取代的3,4-二氢-1h-[1,8]萘啶酮

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US (7) US8906923B2 (cg-RX-API-DMAC7.html)
EP (1) EP2742045B1 (cg-RX-API-DMAC7.html)
JP (2) JP5921687B2 (cg-RX-API-DMAC7.html)
KR (1) KR101996862B1 (cg-RX-API-DMAC7.html)
CN (2) CN105461684B (cg-RX-API-DMAC7.html)
AR (1) AR087508A1 (cg-RX-API-DMAC7.html)
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CA (1) CA2842518C (cg-RX-API-DMAC7.html)
CL (1) CL2014000289A1 (cg-RX-API-DMAC7.html)
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WO2013021052A1 (en) 2011-08-10 2013-02-14 Janssen R&D Ireland Antibacterial piperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
WO2014023814A1 (en) * 2012-08-10 2014-02-13 Janssen R&D Ireland New antibacterial compounds
US9540324B2 (en) 2013-09-26 2017-01-10 Luc Therapeutics, Inc. Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
AR111295A1 (es) 2017-03-20 2019-06-26 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
US11691967B2 (en) 2018-03-12 2023-07-04 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
LT3880675T (lt) 2018-11-12 2024-12-27 Debiopharm International Sa Antibiotikų junginiai, jų gamybos būdas, farmacinės kompozicijos, kurių sudėtyje jie yra, ir jų panaudojimas
MX2022003025A (es) 2019-09-19 2022-04-07 Forma Therapeutics Inc Activacion de la piruvato cinasa r.
MX2023010941A (es) * 2021-03-17 2023-11-28 Janssen Sciences Ireland Unlimited Co Compuestos antibacterianos.
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

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JP4831907B2 (ja) 1999-10-08 2011-12-07 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
ES2231275T3 (es) 1999-10-08 2005-05-16 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
JP4387804B2 (ja) 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
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WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
CA2776849A1 (en) * 2009-11-18 2011-05-26 Fab Pharma S.A.S. Novel heterocyclic acrylamides and their use as pharmaceuticals
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CA2843643A1 (en) 2011-07-29 2013-02-07 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hiv
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
CN104039782A (zh) 2011-08-10 2014-09-10 爱尔兰詹森研发公司 抗菌的高哌啶基取代的3,4二氢1h[1,8]萘啶酮类
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MX348128B (es) 2017-05-26
HK1199243A1 (zh) 2015-06-26
UA111210C2 (uk) 2016-04-11
TWI568731B (zh) 2017-02-01
CA2842518A1 (en) 2013-02-14
US8906923B2 (en) 2014-12-09
US9884864B2 (en) 2018-02-06
US20150080413A1 (en) 2015-03-19
ES2721658T3 (es) 2019-08-02
CA2842518C (en) 2019-07-23
US20160194324A1 (en) 2016-07-07
JP2016190843A (ja) 2016-11-10
AR087508A1 (es) 2014-03-26
PH12014500317A1 (en) 2014-04-14
IL230549A0 (en) 2014-03-31
US9290493B2 (en) 2016-03-22
KR101996862B1 (ko) 2019-07-05
IL230549A (en) 2017-07-31
EP2742045B1 (en) 2019-01-23
US10155759B2 (en) 2018-12-18
CL2014000289A1 (es) 2014-07-11
CN103874698B (zh) 2016-03-23
UY34253A (es) 2013-02-28
JO3611B1 (ar) 2020-08-27
NZ620212A (en) 2015-10-30
KR20140072034A (ko) 2014-06-12
WO2013021054A1 (en) 2013-02-14
US20190084982A1 (en) 2019-03-21
TW201313714A (zh) 2013-04-01
BR112014003063B1 (pt) 2020-11-17
AU2012293621B2 (en) 2016-07-21
HUE042978T2 (hu) 2019-07-29
US10501463B2 (en) 2019-12-10
US9617262B2 (en) 2017-04-11
TR201905537T4 (tr) 2019-05-21
JP2014531404A (ja) 2014-11-27
MX2014001600A (es) 2014-04-25
HK1223352A1 (zh) 2017-07-28
US20140171451A1 (en) 2014-06-19
EA201490438A1 (ru) 2014-06-30
US10526331B2 (en) 2020-01-07
US20170174683A1 (en) 2017-06-22
BR112014003063A2 (pt) 2017-02-21
JP5921687B2 (ja) 2016-05-24
CN105461684A (zh) 2016-04-06
US20190194194A1 (en) 2019-06-27
US20180105525A1 (en) 2018-04-19
DK2742045T3 (en) 2019-04-23
EP2742045A1 (en) 2014-06-18
CN103874698A (zh) 2014-06-18
PE20141410A1 (es) 2014-10-13
AU2012293621A1 (en) 2014-02-13

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