CN105434232A - Shampoo containing folium artemisiae argyi and having anti-itch effect - Google Patents
Shampoo containing folium artemisiae argyi and having anti-itch effect Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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Abstract
The invention discloses a shampoo containing folium artemisiae argyi and having an ant-itch effect. The shampoo comprises, by mass percentage, 10%-20% of traditional Chinese medicine extract liquor, 2%-5% of fatty alcohol polyoxyethylene ether sodium sulfate, 6%-8% of alkyl glycoside, 6%-8% of sodium cocoyl glutamate, 3%-5% of potassium myristoyl glutamate, 3%-5% of polydimethylsiloxane, 2%-5% of salicylic acid, 0.5%-1% of vitamin B5, 0.6%-1.2% of sodium citrate, 1%-3% of glycerinum, 0.5%-1.5% of essential oil and 37%-65% of deionized water. The traditional Chinese medicine extract liquor is extracted from the folium artemisiae argyi, bark of Chinese catalpa, oriental variegated coralbean bark, rhizoma curcumae longae, lemon grass and wild chrysanthemum. The shampoo belongs to the field of daily chemical products. The shampoo is suitable for the cleaning of human hair, good in anti-itch effect, free of irritation after skin irritation test and suitable for the use of all ages.
Description
Technical field
The invention belongs to daily chemical product field, especially relate to a kind of shampoo with antipruritic effect containing Folium Artemisiae Argyi.
Background technology
Hair, due to metabolism and causes for pathological, can produce dandruff and head pruritus phenomenon, has the human hair of 60% to be subject to the puzzlement of dandruff and head pruritus always, and dandruff and head pruritus have become the second largest scalp problems being only second to alopecia.The replacement period of normal header chrotoplast is 28 days, after scurf cell full maturity, peels off with the microcell that naked eyes cannot be seen, jejune cell arrives skin top layer, just peels off with macroscopic fragment.Have the shampoo of removing scurf and relieving itching function to be naturally subject to people to welcome, the functional shampoo made with chemicals such as Chinese medicine extract compound surfactants, can take good care of scalp, recovers the ecological environment balance of scalp, can prevent dandruff and head pruritus problem.
As Chinese patent application 201210467845.2 discloses a kind of containing Folium Isatidis, the antipruritic liquid shampoo of Fructus Forsythiae, this shampoo is by Chinese medicine Folium Isatidis, Fructus Forsythiae, raw Cacumen Platycladi (Cacumen Biotae), Fructus Lycii, Rhizoma Gastrodiae, the extracts such as Radix Sophorae Flavescentis and anion surfactant Cortex cocois radicis oleyl alcohol sodium sulfate and Cortex cocois radicis oleyl alcohol oxygen vinyl Ether sodium sulfate, non-ionic surface active agent Cortex cocois radicis oleyl alcohol alkylolamides and coconut oil alkyldimethyl base amine-oxides, pearling agent ethylene glycol macrogol ester, thickening agent hard fatty acids macrogol ester (6000), composite emulsifying amido silicon oil (BKN61), pH adjusting agent citric acid, skin-care agent glycerol, antiseptic hydantoin (DMDM-H), chelating agen EDTA-2Na, quintessence oil and pure water thereof formed.This shampoo has certain anti-dandruff and itching-relieving efficacies, but in skin of head protection DeGrain.
The antidandruff agent thing of current use mainly contains sulfur fine powder, salicylic acid, Zinc Undecylenate, coal tar sulfuration sulphur, Zinc Pyrithione (ZPT), octopirox (OCT) and climbazole etc.These chemical anti-dandruff and itching-relieving agents, while sterilization is anti-dandruff, also has stronger degreasing, therefore, after using the long period, the atrophy of sebum secretion gland in scalp layer hair follicle can be caused, the minimizing of sebum secretion amount, thus accelerate the aging of scalp cells, dandruff is increased, hair quality drying also can be caused withered and yellow, even cause alopecia and disconnected sending out to wait untoward reaction.In addition, in current shampoo, generally add antiseptic and prevent the putrid and deteriorated of shampoo, the health of these antiseptic to the mankind has certain danger, may have certain stimulation to skin simultaneously.In addition, if only using Chinese medicine as anti-dandruff pruritus, its removing scurf and relieving itching effect can be subject to a definite limitation, if middle dose adds too much, can affect foam and cardability and compliance.
Summary of the invention
In order to solve, the antipruritic effect existed in prior art is good not protects unconspicuous problem with skin of head; the object of this invention is to provide a kind of shampoo with antipruritic effect containing Folium Artemisiae Argyi; shampoo of the present invention can effective removing scurf and relieving itching; skin of head can also be protected and nonirritant; in addition; also provide the production technology of this shampoo of preparation, this production technology is simple, is conducive to large-scale production.
To achieve these goals, present invention employs following technical scheme:
A kind of shampoo with antipruritic effect containing Folium Artemisiae Argyi, comprise the component of following mass percent: Chinese medicine extract 10%-20%, polyoxyethylenated alcohol sodium sulfate 2%-5%, alkyl polyglucoside 6%-8%, sodium cocoyl glutamate 6%-8%, myristoyl glutamate potassium 3%-5%, polydimethylsiloxane 3%-5%, salicylic acid 2%-5%, vitamin B5 0.5%-1%, sodium citrate 0.6%-1.2%, glycerol 1%-3%, quintessence oil 0.5%-1.5% and deionized water 37%-65%, described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 3-6 part, Cortex catalpae ovatae radicis 2-5 part, Cortex erythrinae 2-5 part, Rhizoma Curcumae Longae 1-3 part, lemon grass (Cymbopogon citratus) 3-5 part and Flos Chrysanthemi Indici 1-3 part.
Further, described shampoo comprises the component of following mass percent: Chinese medicine extract 10%, polyoxyethylenated alcohol sodium sulfate 2%, alkyl polyglucoside 6%, sodium cocoyl glutamate 6%, myristoyl glutamate potassium 3%, polydimethylsiloxane 3%, salicylic acid 2%, vitamin B5 0.5%, sodium citrate 0.6%, glycerol 1%, quintessence oil 0.5% and deionized water 37%, and described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 3 parts, Cortex catalpae ovatae radicis 2 parts, Cortex erythrinae 2 parts, 1 part, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 3 parts and Flos Chrysanthemi Indici 1 part.
Further, described shampoo comprises the component of following mass percent: Chinese medicine extract 20%, polyoxyethylenated alcohol sodium sulfate 5%, alkyl polyglucoside 8%, sodium cocoyl glutamate 8%, myristoyl glutamate potassium 5%, polydimethylsiloxane 5%, salicylic acid 5%, vitamin B5 1%, sodium citrate 1.2%, glycerol 3%, quintessence oil 1.5% and deionized water 65%, and described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 6 parts, Cortex catalpae ovatae radicis 5 parts, Cortex erythrinae 5 parts, 3 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 5 parts and Flos Chrysanthemi Indici 3 parts.
Further, described shampoo comprises the component of following mass percent: Chinese medicine extract 15%, polyoxyethylenated alcohol sodium sulfate 3%, alkyl polyglucoside 7%, sodium cocoyl glutamate 7%, myristoyl glutamate potassium 4%, polydimethylsiloxane 4%, salicylic acid 3%, vitamin B5 0.8%, sodium citrate 0.9%, glycerol 2%, quintessence oil 1% and deionized water 51%, and described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 4 parts, Cortex catalpae ovatae radicis 4 parts, Cortex erythrinae 4 parts, 2 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 4 parts and Flos Chrysanthemi Indici 2 parts.
Further, described Chinese medicine extract is prepared by following methods: take Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici, mix homogeneously after pulverizing respectively, make Chinese medicine composition powder, powder is placed in supercritical fluid extraction instrument, at extraction kettle pressure 60-75Mpa, extraction kettle temperature 60-80 DEG C, separator pressure 50-60Mpa, under the condition of separator temperature 45-60 DEG C, with the mixture of carbon dioxide and dehydrated alcohol for medium carries out supercritical fluid extraction 5-8 hour, Chinese medicine extract is obtained from separator, be Chinese medicine extract of the present invention.
Further, the present invention can also comprise antiseptic and solubilizing agent.
Correspondingly, present invention also offers the preparation method with the shampoo of antipruritic effect containing Folium Artemisiae Argyi, comprise the following steps: in reaction cylinder, add deionized water, polyoxyethylenated alcohol sodium sulfate, alkyl polyglucoside, sodium cocoyl glutamate, myristoyl glutamate potassium, polydimethylsiloxane, salicylic acid, vitamin B5, sodium citrate and glycerol, add Chinese medicine extract and quintessence oil again, stir, to obtain final product.
Folium Artemisiae Argyi has blood of regulating the flow of vital energy, warming the meridian arteries and veins, and by cold-damp, only effect of cold type of pain, or a kind of medical herbs of natural antibacterial antiinflammatory, can be antipruritic, anti-dandruff, can also protect scalp; Cortex catalpae ovatae radicis has clearing away heat-damp and promoting diuresis, effect of killing parasites for relieving itching, has good antipruritic effect for skin pruritus; Cortex erythrinae has expelling wind and removing dampness, effect of killing parasites for relieving itching, and also Cortex catalpae ovatae radicis shares, better effects if in removing scurf and relieving itching; Rhizoma Curcumae Longae has powerful anti-dandruff effect, can prevent head pruritus, can also promote that skin of head blood circulation is normal, promote scalp metabolism, activation hair follicle tissue; Lemon grass (Cymbopogon citratus) fragrant, have the antitoxin effect of sterilization, also scalable fat secretion, is of value to oiliness skin quality and hair quality, can also blood circulation promoting; Flos Chrysanthemi Indici has heat-clearing and toxic substances removing, effect of wind-dispelling heat-dissipating, shares with other Chinese medicine, and in adjustment oils and fats, effect is better; Proportioning synergism is there is, more remarkable effect in removing scurf and relieving itching and protection scalp between the raw material components of Chinese medicine extract of the present invention.
Compared with prior art, shampoo of the present invention has following advantage:
(1) Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici other surfactant composite is adopted in shampoo prescription of the present invention, the removing scurf and relieving itching effect of further lifting shampoo, can also take good care of and protect scalp, recover the ecological environment balance of scalp, play the effect of prevention dandruff head pruritus;
(2) bacterial restrain experimental result shows that shampoo of the present invention has significant anti-dandruff effect, in addition, compares with commercially available antipruritic liquid shampoo, and antipruritic effect is better, and transdermal stimulation test belongs to nonirritant;
(3) shampoo of the present invention also has simple, the lower-cost advantage of production technology.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
Each component in the present invention is conventional commercial product, and such as, alkyl polyglucoside is purchased from Kening Co., Ltd APG1200.
embodiment 1: the preparation of shampoo of the present invention
Composition and the content of the embodiment of the present invention 1 shampoo are as follows: Chinese medicine extract 10%, polyoxyethylenated alcohol sodium sulfate 2%, alkyl polyglucoside 6%, sodium cocoyl glutamate 6%, myristoyl glutamate potassium 3%, polydimethylsiloxane 3%, salicylic acid 2%, vitamin B5 0.5%, sodium citrate 0.6%, glycerol 1%, quintessence oil 0.5% and deionized water 37%, and described Chinese medicine extract raw material comprises: Folium Artemisiae Argyi 3 parts, Cortex catalpae ovatae radicis 2 parts, Cortex erythrinae 2 parts, 1 part, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 3 parts and Flos Chrysanthemi Indici 1 part.
Preparation method: (1) prepares Chinese medicine extract: take Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici, mix homogeneously after pulverizing respectively, make Chinese medicine composition powder, powder is placed in supercritical fluid extraction instrument, under the condition of extraction kettle pressure 70Mpa, extraction kettle temperature 65 DEG C, separator pressure 55Mpa, separator temperature 50 DEG C, carry out supercritical fluid extraction 8 hours with the mixture of carbon dioxide and dehydrated alcohol for medium, from separator, obtain Chinese medicine extract;
(2) in reaction cylinder, deionized water, polyoxyethylenated alcohol sodium sulfate, alkyl polyglucoside, sodium cocoyl glutamate is added, myristoyl glutamate potassium, polydimethylsiloxane, salicylic acid, vitamin B5, sodium citrate and glycerol, add Chinese medicine extract and quintessence oil again, stir, to obtain final product.
embodiment 2: the preparation of shampoo of the present invention
Composition and the content of the embodiment of the present invention 2 shampoo are as follows: Chinese medicine extract 20%, polyoxyethylenated alcohol sodium sulfate 5%, alkyl polyglucoside 8%, sodium cocoyl glutamate 8%, myristoyl glutamate potassium 5%, polydimethylsiloxane 5%, salicylic acid 5%, vitamin B5 1%, sodium citrate 1.2%, glycerol 3%, quintessence oil 1.5% and deionized water 65%, and described Chinese medicine extract raw material comprises: Folium Artemisiae Argyi 6 parts, Cortex catalpae ovatae radicis 5 parts, Cortex erythrinae 5 parts, 3 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 5 parts and Flos Chrysanthemi Indici 3 parts.
Preparation method: (1) takes Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici, mix homogeneously after pulverizing respectively, make Chinese medicine composition powder, powder is placed in supercritical fluid extraction instrument, under the condition of extraction kettle pressure 70Mpa, extraction kettle temperature 60 C, separator pressure 50Mpa, separator temperature 45 DEG C, carry out supercritical fluid extraction 5 hours with the mixture of carbon dioxide and dehydrated alcohol for medium, from separator, obtain Chinese medicine extract;
(2) in reaction cylinder, deionized water, polyoxyethylenated alcohol sodium sulfate, alkyl polyglucoside, sodium cocoyl glutamate is added, myristoyl glutamate potassium, polydimethylsiloxane, salicylic acid, vitamin B5, sodium citrate and glycerol, add Chinese medicine extract and quintessence oil again, stir, to obtain final product.
embodiment 3: the preparation of shampoo of the present invention
Composition and the content of the embodiment of the present invention 3 shampoo are as follows: Chinese medicine extract 15%, polyoxyethylenated alcohol sodium sulfate 3%, alkyl polyglucoside 7%, sodium cocoyl glutamate 7%, myristoyl glutamate potassium 4%, polydimethylsiloxane 4%, salicylic acid 3%, vitamin B5 0.8%, sodium citrate 0.9%, glycerol 2%, quintessence oil 1% and deionized water 51%, and described Chinese medicine extract raw material comprises: Folium Artemisiae Argyi 4 parts, Cortex catalpae ovatae radicis 4 parts, Cortex erythrinae 4 parts, 2 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 4 parts and Flos Chrysanthemi Indici 2 parts.
Preparation method: (1) takes Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici, mix homogeneously after pulverizing respectively, make Chinese medicine composition powder, powder is placed in supercritical fluid extraction instrument, under the condition of extraction kettle pressure 75Mpa, extraction kettle temperature 80 DEG C, separator pressure 60Mpa, separator temperature 60 DEG C, carry out supercritical fluid extraction 8 hours with the mixture of carbon dioxide and dehydrated alcohol for medium, from separator, obtain Chinese medicine extract;
(2) in reaction cylinder, deionized water, polyoxyethylenated alcohol sodium sulfate, alkyl polyglucoside, sodium cocoyl glutamate is added, myristoyl glutamate potassium, polydimethylsiloxane, salicylic acid, vitamin B5, sodium citrate and glycerol, add Chinese medicine extract and quintessence oil again, stir, to obtain final product.
embodiment 4: the preparation of shampoo of the present invention
Composition and the content of the embodiment of the present invention 4 shampoo are as follows: Chinese medicine extract 13%, polyoxyethylenated alcohol sodium sulfate 4%, alkyl polyglucoside 6.5%, sodium cocoyl glutamate 7.5%, myristoyl glutamate potassium 4%, polydimethylsiloxane 3.5%, salicylic acid 4%, vitamin B5 0.8%, sodium citrate 0.9%, glycerol 1.5%, quintessence oil 0.9% and deionized water 55%, and described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 4.5 parts, Cortex catalpae ovatae radicis 3.5 parts, Cortex erythrinae 4 parts, 2 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 5 parts and Flos Chrysanthemi Indici 1.5 parts.
Preparation method: (1) takes Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici, mix homogeneously after pulverizing respectively, make Chinese medicine composition powder, powder is placed in supercritical fluid extraction instrument, under the condition of extraction kettle pressure 71Mpa, extraction kettle temperature 68 DEG C, separator pressure 52Mpa, separator temperature 55 DEG C, carry out supercritical fluid extraction 6.5 hours with the mixture of carbon dioxide and dehydrated alcohol for medium, from separator, obtain Chinese medicine extract;
(2) in reaction cylinder, deionized water, polyoxyethylenated alcohol sodium sulfate, alkyl polyglucoside, sodium cocoyl glutamate is added, myristoyl glutamate potassium, polydimethylsiloxane, salicylic acid, vitamin B5, sodium citrate and glycerol, add Chinese medicine extract and quintessence oil again, stir, to obtain final product.
embodiment 5: the preparation of shampoo of the present invention
Composition and the content of the embodiment of the present invention 5 shampoo are as follows: Chinese medicine extract 10%-20%, polyoxyethylenated alcohol sodium sulfate 2%-5%, alkyl polyglucoside 6%-8%, sodium cocoyl glutamate 6%-8%, myristoyl glutamate potassium 3%-5%, polydimethylsiloxane 3%-5%, salicylic acid 2%-5%, vitamin B5 0.5%-1%, sodium citrate 0.6%-1.2%, glycerol 1%-3%, quintessence oil 0.5%-1.5% and deionized water 37%-65%, described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 3-6 part, Cortex catalpae ovatae radicis 2-5 part, Cortex erythrinae 2-5 part, Rhizoma Curcumae Longae 1-3 part, lemon grass (Cymbopogon citratus) 3-5 part and Flos Chrysanthemi Indici 1-3 part
Preparation method: (1) takes Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici, mix homogeneously after pulverizing respectively, make Chinese medicine composition powder, powder is placed in supercritical fluid extraction instrument, under the condition of extraction kettle pressure 73Mpa, extraction kettle temperature 78 DEG C, separator pressure 53Mpa, separator temperature 58 DEG C, carry out supercritical fluid extraction 7.5 hours with the mixture of carbon dioxide and dehydrated alcohol for medium, from separator, obtain Chinese medicine extract;
(2) in reaction cylinder, deionized water, polyoxyethylenated alcohol sodium sulfate, alkyl polyglucoside, sodium cocoyl glutamate is added, myristoyl glutamate potassium, polydimethylsiloxane, salicylic acid, vitamin B5, sodium citrate and glycerol, add Chinese medicine extract and quintessence oil again, stir, to obtain final product.
comparative example 1:
Composition and the content of comparative example 1 shampoo of the present invention are as follows: Chinese medicine extract 15%, polyoxyethylenated alcohol sodium sulfate 3%, alkyl polyglucoside 7%, sodium cocoyl glutamate 7%, myristoyl glutamate potassium 4%, polydimethylsiloxane 4%, salicylic acid 3%, vitamin B5 0.8%, sodium citrate 0.9%, glycerol 2%, quintessence oil 1% and deionized water 51%, and described Chinese medicine extract raw material comprises: Cortex catalpae ovatae radicis 5 parts, Cortex erythrinae 5 parts, 3 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 5 parts and Flos Chrysanthemi Indici 3 parts.
The preparation method of this comparative example shampoo is with embodiment 1.
comparative example 2:
Composition and the content of comparative example 2 shampoo of the present invention are as follows: Chinese medicine extract 15%, polyoxyethylenated alcohol sodium sulfate 3%, alkyl polyglucoside 7%, sodium cocoyl glutamate 7%, myristoyl glutamate potassium 4%, polydimethylsiloxane 4%, salicylic acid 3%, vitamin B5 0.8%, sodium citrate 0.9%, glycerol 2%, quintessence oil 1% and deionized water 51%, and described Chinese medicine extract raw material comprises: Folium Artemisiae Argyi 6 parts, Cortex erythrinae 5 parts, 3 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 5 parts and Flos Chrysanthemi Indici 3 parts.
The preparation method of this comparative example shampoo is with embodiment 1.
comparative example 3:
Composition and the content of comparative example 3 shampoo of the present invention are as follows: Chinese medicine extract 15%, polyoxyethylenated alcohol sodium sulfate 3%, alkyl polyglucoside 7%, sodium cocoyl glutamate 7%, myristoyl glutamate potassium 4%, polydimethylsiloxane 4%, salicylic acid 3%, vitamin B5 0.8%, sodium citrate 0.9%, glycerol 2%, quintessence oil 1% and deionized water 51%, and described Chinese medicine extract raw material comprises: Folium Artemisiae Argyi 6 parts, Cortex catalpae ovatae radicis 5 parts, 3 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 5 parts and Flos Chrysanthemi Indici 3 parts.
The preparation method of this comparative example shampoo is with embodiment 1.
test example 1: the anti-dandruff effect experimental of liquid detergent of the present invention
(1) the anti-dandruff effect assessment standard of shampoo: the dandruff is the mild seborrheic dermatitis of scalp, its formed to divide with epidermis cell accelerate, epidermal area come off accelerate relevant; Pityrosporum furfur is the one of the main reasons causing epidermis cell division to be accelerated in scalp hyperplasia process, therefore selects measure and evaluate anti-dandruff effect to pityrosporum furfur with or without inhibitory action and action intensity outside comparing bulk.
(2) evaluation methodology: test sample made by the shampoo adopting embodiment of the present invention 1-3 and comparative example 1-3 to prepare, the consumption of shampoo is 200mg/ml, uses the Pityrosporum oval be separated in the from the beginning seborrheic dermatitis patient dandruff containing Oleum Brassicae campestris culture medium culturing as test strain; Bacterial restrain experiment is carried out to 6 groups of shampoo test samples, measures the inhibition zone diameter number of 6 groups of shampoos.
(3) experimental result, as shown in table 1:
The inhibition zone diameter number of table 1 shampoo
Experimental result shows that the inhibition zone diameter of embodiment of the present invention 1-3 shampoo is all up to more than 30mm, anti-dandruff successful, the effect of three is close, especially best with the antibacterial anti-dandruff effect of embodiment 3, in addition, the anti-dandruff effect of comparative example 1-3 is than the anti-dandruff weak effect of embodiment 1-3 shampoo, visible, and shampoo of the present invention has significant anti-dandruff effect.
the antipruritic effect experiment of test example 2 shampoo of the present invention
1, laboratory animal: 180 healthy kunming mices, SPF level, body weight 18-22g, male.
2, article: embodiment of the present invention 1-5 is tested, commercially available antipruritic liquid shampoo.
3, experimental technique: get 160 mices, be divided into 8 groups at random, often organizes 20, is respectively blank group, model group, positive controls, embodiment 1-5; Test first 2 days, mouse back shaves hair, experimental day, corresponding shampoo is evenly applied to each group of mice and shaves on the skin of hair-fields, blank group and model group are coated with the excipient of equivalent, often group is smeared once, after smearing 30min, except blank group injects isometric normal saline, all the other respectively organize mice, and to shave hair place subcutaneous injection concentration be the 4-aminopyridine of 1mg/kg, record the average response number of times that each treated animal licks body after injection 4-aminopyridine 10min, concrete outcome is as shown in table 2.
4, experimental result:
Table 24-aminopyridine causes the average response number of times that mice licks body
Compare with model group,
*p<0.01; With positive controls ratio,
##p<0.01.
5, experiment conclusion: as shown in Table 2, compares with model group, and positive controls, embodiment 1-5 average response number of times significantly reduce, and all has and changes (P<0.01) extremely significantly; Compare with positive controls, embodiment of the present invention 1-5 all has change (P<0.01) extremely significantly, and visible, shampoo antipruritic effect of the present invention is remarkable.
the zest test of test example 3 shampoo of the present invention
According to irritation test in cosmetics health specification (2007 editions), carry out dermoreaction scoring to the shampoo of embodiment 1-3, concrete operations are as follows:
1, laboratory animal: healthy white rabbit 9, female, 1.8 ~ 2.2kg, skin zero damage.
2, experimental procedure:
White rabbit is divided into 3 groups, often organizes 3,24h before test, cut off the hair of all experiment spinal column both sides, white rabbit back, not lesional epidermis is respectively 3cm × 3cm about unhairing scope.Get tested material (i.e. the shampoo of embodiment 1-3) 0.5g to be added on 4 layers of gauze of 2.5cm × 2.5cm, be affixed on side skin, after covering with one deck oilpaper, with immobilization with adhesive tape, opposite side is blank.Close after 4h and remove tested material, and wash away residual tested material with clear water, after removing tested material 1,24,48h observes the reaction of recipient site local skin, contrast rear scoring with matched group position.Put top average according to each observing time, evaluate the rank of this tested material to animal skin stimulus intensity.
Experimental result: in test, each observing time of embodiment 1-3 puts top average < 0.5, all belongs to nonirritant.Therefore, shampoo prescription of the present invention is gentle, nothing irritates, and effectively avoids the problem causing head pruritus because scalp irritates.
Below be only the preferred embodiment of the present invention, it should be pointed out that above-mentioned preferred implementation should not be considered as limitation of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For those skilled in the art, without departing from the spirit and scope of the present invention, can also make some improvement and modification, these improve and modify and also should be considered as protection scope of the present invention.
Claims (6)
1. the shampoo with antipruritic effect containing Folium Artemisiae Argyi, it is characterized in that, described shampoo comprises the component of following mass percent: Chinese medicine extract 10%-20%, polyoxyethylenated alcohol sodium sulfate 2%-5%, alkyl polyglucoside 6%-8%, sodium cocoyl glutamate 6%-8%, myristoyl glutamate potassium 3%-5%, polydimethylsiloxane 3%-5%, salicylic acid 2%-5%, vitamin B5 0.5%-1%, sodium citrate 0.6%-1.2%, glycerol 1%-3%, quintessence oil 0.5%-1.5% and deionized water 37%-65%, described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 3-6 part, Cortex catalpae ovatae radicis 2-5 part, Cortex erythrinae 2-5 part, Rhizoma Curcumae Longae 1-3 part, lemon grass (Cymbopogon citratus) 3-5 part and Flos Chrysanthemi Indici 1-3 part.
2. the shampoo with antipruritic effect containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described shampoo comprises the component of following mass percent: Chinese medicine extract 10%, polyoxyethylenated alcohol sodium sulfate 2%, alkyl polyglucoside 6%, sodium cocoyl glutamate 6%, myristoyl glutamate potassium 3%, polydimethylsiloxane 3%, salicylic acid 2%, vitamin B5 0.5%, sodium citrate 0.6%, glycerol 1%, quintessence oil 0.5% and deionized water 37%, described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 3 parts, Cortex catalpae ovatae radicis 2 parts, Cortex erythrinae 2 parts, 1 part, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 3 parts and Flos Chrysanthemi Indici 1 part.
3. the shampoo with antipruritic effect containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described shampoo comprises the component of following mass percent: Chinese medicine extract 20%, polyoxyethylenated alcohol sodium sulfate 5%, alkyl polyglucoside 8%, sodium cocoyl glutamate 8%, myristoyl glutamate potassium 5%, polydimethylsiloxane 5%, salicylic acid 5%, vitamin B5 1%, sodium citrate 1.2%, glycerol 3%, quintessence oil 1.5% and deionized water 65%, described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 6 parts, Cortex catalpae ovatae radicis 5 parts, Cortex erythrinae 5 parts, 3 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 5 parts and Flos Chrysanthemi Indici 3 parts.
4. the shampoo with antipruritic effect containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described shampoo comprises the component of following mass percent: Chinese medicine extract 15%, polyoxyethylenated alcohol sodium sulfate 3%, alkyl polyglucoside 7%, sodium cocoyl glutamate 7%, myristoyl glutamate potassium 4%, polydimethylsiloxane 4%, salicylic acid 3%, vitamin B5 0.8%, sodium citrate 0.9%, glycerol 2%, quintessence oil 1% and deionized water 51%, described Chinese medicine extract is obtained by the raw material abstraction of following weight portion: Folium Artemisiae Argyi 4 parts, Cortex catalpae ovatae radicis 4 parts, Cortex erythrinae 4 parts, 2 parts, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) 4 parts and Flos Chrysanthemi Indici 2 parts.
5. according to the arbitrary described shampoo with antipruritic effect containing Folium Artemisiae Argyi of claim 1-4, it is characterized in that, described Chinese medicine extract is prepared by following methods: take Folium Artemisiae Argyi, Cortex catalpae ovatae radicis, Cortex erythrinae, Rhizoma Curcumae Longae, lemon grass (Cymbopogon citratus) and Flos Chrysanthemi Indici, mix homogeneously after pulverizing respectively, make Chinese medicine composition powder, powder is placed in supercritical fluid extraction instrument, at extraction kettle pressure 60-75Mpa, extraction kettle temperature 60-80 DEG C, separator pressure 50-60Mpa, under the condition of separator temperature 45-60 DEG C, with the mixture of carbon dioxide and dehydrated alcohol for medium carries out supercritical fluid extraction 5-8 hour, Chinese medicine extract is obtained from separator, be Chinese medicine extract of the present invention.
6. according to the arbitrary described preparation method with the shampoo of antipruritic effect containing Folium Artemisiae Argyi of claim 1-4, it is characterized in that, comprise the following steps: in reaction cylinder, add deionized water, polyoxyethylenated alcohol sodium sulfate, alkyl polyglucoside, sodium cocoyl glutamate, myristoyl glutamate potassium, polydimethylsiloxane, salicylic acid, vitamin B5, sodium citrate and glycerol, add Chinese medicine extract and quintessence oil again, stir, to obtain final product.
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| CN201510899900.9A CN105434232A (en) | 2015-12-08 | 2015-12-08 | Shampoo containing folium artemisiae argyi and having anti-itch effect |
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| CN105902450A (en) * | 2016-06-20 | 2016-08-31 | 合肥丰瑞隆生物科技有限公司 | Itching relieving shampoo and preparation method thereof |
| CN107375130A (en) * | 2017-07-12 | 2017-11-24 | 湖南七纬科技有限公司 | A kind of antiallergy nutrition hair-washing water and preparation method thereof |
| CN108113931A (en) * | 2018-03-01 | 2018-06-05 | 上海前引科技有限公司 | A kind of medical stone skin moistening and itch stopping shower cream |
| CN110200877A (en) * | 2019-07-18 | 2019-09-06 | 李卓达 | A kind of Chinese medicine shampoo and preparation method thereof |
| WO2020033649A1 (en) * | 2018-08-10 | 2020-02-13 | The Procter & Gamble Company | Rinse-off cleansing compositions |
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| CN108113931A (en) * | 2018-03-01 | 2018-06-05 | 上海前引科技有限公司 | A kind of medical stone skin moistening and itch stopping shower cream |
| WO2020033649A1 (en) * | 2018-08-10 | 2020-02-13 | The Procter & Gamble Company | Rinse-off cleansing compositions |
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Effective date of registration: 20161108 Address after: 516000 East Lake West Road in Guangdong province Huizhou city Huicheng District No. 8 Donghua Hong Nga Court two B501 Applicant after: Guangdong sunny Biomedical Technology Co., Ltd. Address before: South 5 building 510632 Guangdong city of Guangzhou province Tianhe District Whampoa Road West, No. 601 Jinan University College of life science and technology Applicant before: Guangzhou Jinan Biomedicine Research & Development Base Co., Ltd., |
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