CN105431458A - 环糊精 - Google Patents

环糊精 Download PDF

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Publication number
CN105431458A
CN105431458A CN201480040709.2A CN201480040709A CN105431458A CN 105431458 A CN105431458 A CN 105431458A CN 201480040709 A CN201480040709 A CN 201480040709A CN 105431458 A CN105431458 A CN 105431458A
Authority
CN
China
Prior art keywords
cyclodextrin
substitution
beta
sbe
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480040709.2A
Other languages
English (en)
Chinese (zh)
Inventor
塔米·萨瓦
史蒂芬·威克斯
约翰·米切尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curadev Pharma Pvt Ltd
Original Assignee
Curadev Pharma Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49081370&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN105431458(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Curadev Pharma Pvt Ltd filed Critical Curadev Pharma Pvt Ltd
Publication of CN105431458A publication Critical patent/CN105431458A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16—Cyclodextrin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480040709.2A 2013-07-17 2014-07-16 环糊精 Pending CN105431458A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361847509P 2013-07-17 2013-07-17
US61/847,509 2013-07-17
GBGB1312737.8A GB201312737D0 (en) 2013-07-17 2013-07-17 Cyclodextrin
GB1312737.8 2013-07-17
PCT/GB2014/052173 WO2015008066A1 (en) 2013-07-17 2014-07-16 Cyclodextrin

Publications (1)

Publication Number Publication Date
CN105431458A true CN105431458A (zh) 2016-03-23

Family

ID=49081370

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480040709.2A Pending CN105431458A (zh) 2013-07-17 2014-07-16 环糊精

Country Status (14)

Country Link
US (2) US11117978B2 (enExample)
EP (1) EP3022231B1 (enExample)
JP (1) JP2016525600A (enExample)
KR (1) KR20160031019A (enExample)
CN (1) CN105431458A (enExample)
AP (1) AP2016008975A0 (enExample)
AU (1) AU2014291800A1 (enExample)
CA (1) CA2919501A1 (enExample)
CL (1) CL2016000082A1 (enExample)
GB (3) GB201312737D0 (enExample)
HU (1) HUE038911T2 (enExample)
MX (1) MX2016000553A (enExample)
PT (1) PT3022231T (enExample)
WO (1) WO2015008066A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112370451A (zh) * 2020-12-08 2021-02-19 河北科技大学 一种枸橼酸马罗匹坦包合物、注射液及制备方法
CN114369177A (zh) * 2021-12-31 2022-04-19 贵州省欣紫鸿药用辅料有限公司 一种采用管道反应器制备磺丁基醚-β-环糊精的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10532102B2 (en) 2016-08-19 2020-01-14 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical composition and methods of uses
CN110234696B (zh) 2017-01-30 2022-05-31 生物辐射实验室股份有限公司 乳液组合物及其使用方法
US11274164B2 (en) 2017-02-07 2022-03-15 Biophore India Pharmaceuticals Pvt. Ltd. Method for the preparation of sulfobutylether beta cyclodextrin sodium
CN112557541B (zh) * 2020-12-08 2022-07-12 河北科技大学 一种枸橼酸马罗匹坦及其有关物质的检测方法
WO2025229196A1 (en) 2024-05-03 2025-11-06 Aalborg Universitet Primary side modified sulfoalkyl ether- and hydroxypropyl-cyclodextrins, synthesis and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101686681A (zh) * 2007-04-27 2010-03-31 锡德克斯药物公司 包含氯吡格雷和磺基烷基醚环糊精的制剂和其使用方法
CN101959508A (zh) * 2008-04-28 2011-01-26 锡德克斯药物公司 磺烷基醚环糊精组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5874418A (en) 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
GB9713149D0 (en) 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
EP0889056B1 (en) * 1997-07-01 2006-04-12 Pfizer Products Inc. Process for making a cyclodextrin
US6337380B1 (en) * 1998-12-01 2002-01-08 Fuji Photo Film Co., Ltd. Polymer having sulfonic acid group and silver halide photographic photosensitive material using the polymer
US6869939B2 (en) 2002-05-04 2005-03-22 Cydex, Inc. Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
CN100503647C (zh) 2005-11-02 2009-06-24 南京师范大学 羟丙基-磺丁基-β-环糊精及其制备方法、分析方法以及在药学上的应用
ES2774901T3 (es) 2012-02-15 2020-07-23 Cydex Pharmaceuticals Inc Proceso para la fabricación de derivados de ciclodextrina
MX2012010891A (es) 2012-05-08 2014-03-05 Onyx Therapeutics Inc Procedimientos para la formacion de complejos de ciclodextrina para formular inhibidores del proteasoma peptidico.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101686681A (zh) * 2007-04-27 2010-03-31 锡德克斯药物公司 包含氯吡格雷和磺基烷基醚环糊精的制剂和其使用方法
CN101959508A (zh) * 2008-04-28 2011-01-26 锡德克斯药物公司 磺烷基醚环糊精组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D.TYLER MCQUADE ET AL.: ""Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis"", 《THE JOURNAL OF ORGANIC CHEMISTRY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112370451A (zh) * 2020-12-08 2021-02-19 河北科技大学 一种枸橼酸马罗匹坦包合物、注射液及制备方法
CN114369177A (zh) * 2021-12-31 2022-04-19 贵州省欣紫鸿药用辅料有限公司 一种采用管道反应器制备磺丁基醚-β-环糊精的方法

Also Published As

Publication number Publication date
GB201412644D0 (en) 2014-08-27
CL2016000082A1 (es) 2016-09-23
US20160024229A1 (en) 2016-01-28
US20150025023A1 (en) 2015-01-22
GB2519832B (en) 2021-03-03
GB201312737D0 (en) 2013-08-28
HUE038911T2 (hu) 2018-12-28
KR20160031019A (ko) 2016-03-21
GB2586104B (en) 2021-03-31
GB202015609D0 (en) 2020-11-18
AP2016008975A0 (en) 2016-01-31
GB2586104A (en) 2021-02-03
GB2519832A (en) 2015-05-06
EP3022231A1 (en) 2016-05-25
CA2919501A1 (en) 2015-01-22
EP3022231B1 (en) 2018-04-18
US11117978B2 (en) 2021-09-14
WO2015008066A1 (en) 2015-01-22
US10239961B2 (en) 2019-03-26
PT3022231T (pt) 2018-06-11
MX2016000553A (es) 2016-08-01
AU2014291800A1 (en) 2016-02-11
JP2016525600A (ja) 2016-08-25

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SE01 Entry into force of request for substantive examination
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Application publication date: 20160323