CN105412980B - 一种门诊小手术切口用医疗胶以及制备方法 - Google Patents

一种门诊小手术切口用医疗胶以及制备方法 Download PDF

Info

Publication number
CN105412980B
CN105412980B CN201510988752.8A CN201510988752A CN105412980B CN 105412980 B CN105412980 B CN 105412980B CN 201510988752 A CN201510988752 A CN 201510988752A CN 105412980 B CN105412980 B CN 105412980B
Authority
CN
China
Prior art keywords
outpatient service
minor operation
operation notch
service minor
uniform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201510988752.8A
Other languages
English (en)
Other versions
CN105412980A (zh
Inventor
任新界
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guizhou Tongji Zhiyi Technology Co ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201510988752.8A priority Critical patent/CN105412980B/zh
Publication of CN105412980A publication Critical patent/CN105412980A/zh
Application granted granted Critical
Publication of CN105412980B publication Critical patent/CN105412980B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0038—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明公开了一种门诊小手术切口用医疗胶以及制备方法，其包括由下列重量份的原料：芦荟蛋白3‑5、山药蛋白3‑5、可溶性银杏多糖7‑9、聚氧化乙烯水溶液12‑15、a‑氰基丙稀酸酯3‑5、壳聚糖2‑3、聚乙烯醇12‑14、多醛基海藻酸钠4‑6、果胶1‑3、明胶1‑3、氢化茶花油12‑13等。本发明采用功能性添加液，具有黏胶性质好，能够消毒抑制伤口感染的功效；采用处理的壳聚糖、醛基海藻酸钠、果胶、明胶作为主料具有凝固速度小，促进门诊小手术切口消炎愈合不留疤的功效，同时采用氢化茶花油，能够给患者良好的体验效果；本发明能够满足门诊小手术切口的需要；原材料来源广泛，医疗效果好。

Description

一种门诊小手术切口用医疗胶以及制备方法
技术领域
本发明涉及医疗胶领域，具体地说是涉及一种门诊小手术切口用医疗胶制备方法。
背景技术
在外科手术中，门诊小手术是很重要的一部分，而手术带来的疼痛程度、伤口愈合后外观的好坏、疤痕额大小往往对患者的心理和生理都造成一定的影响，采用医用胶代替缝针来减少门诊小手术的缝针的不良后果，具有很大的医疗价值。
目前医用胶的主要成分是a-氰基丙稀酸酯，其在生物体组织的聚合速度最快，在创面血液和组织液中阴离子的作用下，能快速聚合固化成膜并与创面镶嵌紧密，可牢固地保持伤口的对合状态，且胶膜可阻止血球、血小板通过，在凝血酶和纤维蛋白原的共同作用下，封闭创面断裂的小血管可以有效止血，同时胶膜将组织和细菌隔离，还具有抗感染和保护创面的作用。但是目前医用胶因原材料限制以及使用过程中凝固慢等原因受到限制。
发明内容
为解决上述技术问题，本发明提供一种门诊小手术切口用医疗胶以及制备方法。
为达到上述目的，本发明所采取的技术方案为：
一种门诊小手术切口用医疗胶，包括由下列重量份的原料：芦荟蛋白3-5、山药蛋白3-5、可溶性银杏多糖7-9、干酪素1-3、聚氧化乙烯水溶液12-15、a-氰基丙稀酸酯3-5、壳聚糖2-3、聚乙烯醇12-14、乙烯/醋酸乙烯共聚物10-13、多醛基海藻酸钠4-6、果胶1-3、明胶1-3、氢化茶花油12-13。
一种门诊小手术切口用医疗胶的制备方法，包括以下步骤：
（1）将聚氧化乙烯水溶液加热至52-55℃，之后芦荟蛋白、山药蛋白、可溶性银杏多糖、干酪素、聚氧化乙烯水溶液混合搅拌反应20-30min均匀，得混合液备用；将氢化茶花油加热至180-190℃，之后冷却至100-120℃加入混合液中，搅拌15-20min至均匀，得功能性混合液一备用；
（2）将聚乙烯醇、乙烯/醋酸乙烯共聚物混合，在68-72℃加热搅拌12-15min，之后加入壳聚糖、醛基海藻酸钠、果胶、明胶混合搅拌均匀，得复合液二备用；
（3）在68-72℃将功能性混合液一缓慢加入复合液二，搅拌25-35min至均匀，之后在加入a-氰基丙稀酸酯高速1000r/min搅拌3-5min，至均匀，冷却至室温，即得。
本发明的有益效果：
本发明采用可溶性银杏多糖改性芦荟蛋白、山药蛋白作为功能性添加液，具有黏胶性质好，能够消毒抑制伤口感染的功效；采用乙烯醇、乙烯/醋酸乙烯共聚物处理的壳聚糖、醛基海藻酸钠、果胶、明胶作为主料具有凝固速度小，促进门诊小手术切口消炎愈合不留疤的功效，同时采用氢化茶花油，使得该医用胶具有医疗功效的同时，还具有淡淡的香味，能够给患者良好的体验效果；本发明能够满足门诊小手术切口的需要；原材料来源广泛，医疗效果好。
具体实施方式
下面结合具体实施例对本发明所述技术方案作进一步的说明。
实施例1：
一种门诊小手术切口用医疗胶，包括由下列重量（kg）的原料：芦荟蛋白3、山药蛋白3、可溶性银杏多糖7、干酪素1、聚氧化乙烯水溶液12、氢化茶花油12、a-氰基丙稀酸酯4、聚乙烯醇14、乙烯/醋酸乙烯共聚物13、壳聚糖3、多醛基海藻酸钠6、果胶3、明胶3。
一种门诊小手术切口用医疗胶的制备方法，包括以下步骤：
（1）将聚氧化乙烯水溶液加热至53.5℃，之后芦荟蛋白、山药蛋白、可溶性银杏多糖、干酪素、聚氧化乙烯水溶液混合搅拌反应20-30min均匀，得混合液备用；将氢化茶花油加热至185℃，之后冷却至105℃加入混合液中，搅拌17.5min至均匀，得功能性混合液一备用；
（2）将聚乙烯醇、乙烯/醋酸乙烯共聚物混合，在70℃加热搅拌13.5min，之后加入壳聚糖、醛基海藻酸钠、果胶、明胶混合搅拌均匀，得复合液二备用；
（3）在70℃将功能性混合液一中缓慢加入复合液二，搅拌30min至均匀，之后在加入a-氰基丙稀酸酯高速1000r/min搅拌4min，至均匀，冷却至室温，即得。
实施例2：
一种门诊小手术切口用医疗胶，包括由下列重量（kg）的原料：芦荟蛋白4、山药蛋白4、可溶性银杏多糖4、干酪素4、聚氧化乙烯水溶液13.5、氢化茶花油12.5、a-氰基丙稀酸酯4、聚乙烯醇13、乙烯/醋酸乙烯共聚物11.5、壳聚糖2.5、多醛基海藻酸钠5、果胶1.5、明胶1.5。
一种门诊小手术切口用医疗胶的制备方法，包括以下步骤：
（1）将聚氧化乙烯水溶液加热至53.5℃，之后芦荟蛋白、山药蛋白、可溶性银杏多糖、干酪素、聚氧化乙烯水溶液混合搅拌反应20-30min均匀，得混合液备用；将氢化茶花油加热至185℃，之后冷却至105℃加入混合液中，搅拌17.5min至均匀，得功能性混合液一备用；
（2）将聚乙烯醇、乙烯/醋酸乙烯共聚物混合，在70℃加热搅拌13.5min，之后加入壳聚糖、醛基海藻酸钠、果胶、明胶混合搅拌均匀，得复合液二备用；
（3）在70℃将功能性混合液一中缓慢加入复合液二，搅拌30min至均匀，之后在加入a-氰基丙稀酸酯高速1000r/min搅拌4min，至均匀，冷却至室温，即得。
实施例3：
一种门诊小手术切口用医疗胶，包括由下列重量（kg）的原料：芦荟蛋白5、山药蛋白5、可溶性银杏多糖9、干酪素3、聚氧化乙烯水溶液15、氢化茶花油13、a-氰基丙稀酸酯4、聚乙烯醇12、乙烯/醋酸乙烯共聚物10、壳聚糖2、多醛基海藻酸钠4、果胶1、明胶1。
一种门诊小手术切口用医疗胶的制备方法，包括以下步骤：
（1）将聚氧化乙烯水溶液加热至53.5℃，之后芦荟蛋白、山药蛋白、可溶性银杏多糖、干酪素、聚氧化乙烯水溶液混合搅拌反应20-30min均匀，得混合液备用；将氢化茶花油加热至185℃，之后冷却至105℃加入混合液中，搅拌17.5min至均匀，得功能性混合液一备用；
（2）将聚乙烯醇、乙烯/醋酸乙烯共聚物混合，在70℃加热搅拌13.5min，之后加入壳聚糖、醛基海藻酸钠、果胶、明胶混合搅拌均匀，得复合液二备用；
（3）在70℃将功能性混合液一中缓慢加入复合液二，搅拌30min至均匀，之后在加入a-氰基丙稀酸酯高速1000r/min搅拌4min，至均匀，冷却至室温，即得。
以小白鼠外科手术为例，分别采用本发明实施例1-3的医疗胶，发现实施例2的医疗胶的凝固时间要比实施例1的医疗胶的凝固时间短2-3min，比比实施例1的医疗胶的凝固时间短5-6min，当医疗医疗胶作用6-8d逐渐降解完，观察小白鼠切口的愈合情况，发现使用实施例2医疗胶的和3医疗胶的小白鼠切口愈合情况更好，使用实施例2医疗胶的和3医疗胶的小白鼠切口愈合处还能看到轻微的伤口情况。

Claims (1)

1.一种门诊小手术切口用医疗胶，其特征在于，包括下列重量份的原料：芦荟蛋白3-5、山药蛋白3-5、可溶性银杏多糖7-9、干酪素1-3、聚氧化乙烯水溶液12-15、a-氰基丙稀酸酯3-5、壳聚糖2-3、聚乙烯醇12-14、乙烯/醋酸乙烯共聚物10-13、多醛基海藻酸钠4-6、果胶1-3、明胶1-3、氢化茶花油12-13；
所述的门诊小手术切口用医疗胶的制备方法，包括以下步骤：
（1）将聚氧化乙烯水溶液加热至52-55℃，之后芦荟蛋白、山药蛋白、可溶性银杏多糖、干酪素、聚氧化乙烯水溶液混合搅拌反应20-30min均匀，得混合液备用；将氢化茶花油加热至180-190℃，之后冷却至100-120℃加入混合液中，搅拌15-20min至均匀，得功能性混合液一备用；
（2）将聚乙烯醇、乙烯/醋酸乙烯共聚物混合，在68-72℃加热搅拌12-15min，之后加入壳聚糖、多醛基海藻酸钠、果胶、明胶混合搅拌均匀，得复合液二备用；
（3）在68-72℃将功能性混合液一缓慢加入复合液二，搅拌25-35min至均匀，之后再加入a-氰基丙稀酸酯高速1000r/min搅拌3-5min，至均匀，冷却至室温，即得。
CN201510988752.8A 2015-12-28 2015-12-28 一种门诊小手术切口用医疗胶以及制备方法 Active CN105412980B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510988752.8A CN105412980B (zh) 2015-12-28 2015-12-28 一种门诊小手术切口用医疗胶以及制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510988752.8A CN105412980B (zh) 2015-12-28 2015-12-28 一种门诊小手术切口用医疗胶以及制备方法

Publications (2)

Publication Number Publication Date
CN105412980A CN105412980A (zh) 2016-03-23
CN105412980B true CN105412980B (zh) 2018-09-28

Family

ID=55491808

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510988752.8A Active CN105412980B (zh) 2015-12-28 2015-12-28 一种门诊小手术切口用医疗胶以及制备方法

Country Status (1)

Country Link
CN (1) CN105412980B (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105617455A (zh) * 2016-03-30 2016-06-01 吴美燕 一种中药创可贴药膏的制备方法
CN110869062A (zh) * 2017-07-19 2020-03-06 贝拉英特拉大学 用于在皮肤损伤的处理中局部应用的薄膜及其获得和应用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352704B1 (en) * 1999-06-30 2002-03-05 Closure Medical Corporation Flavored cyanoacrylate compositions
CN100546660C (zh) * 2006-05-23 2009-10-07 广州中医药大学第一附属医院 一种伤口免缝组织胶
RU2468824C1 (ru) * 2011-08-11 2012-12-10 Леплянина Елена Геннадьевна Клей медицинский и способ его приготовления
CN103083718B (zh) * 2011-11-02 2015-06-10 中国人民解放军军事医学科学院毒物药物研究所 一种可生物降解的医用粘合剂及其制备方法和用途

Also Published As

Publication number Publication date
CN105412980A (zh) 2016-03-23

Similar Documents

Publication Publication Date Title
CN107335091A (zh) 一种长效抗菌水凝胶及其制备方法
CN103333349A (zh) 一种注射用透明质酸-胶原蛋白复合水凝胶及其制备方法
CN105770980A (zh) 一种医用胶水及其制备方法
CN101491688A (zh) 可溶性止血纱布及其制备方法
CN105412980B (zh) 一种门诊小手术切口用医疗胶以及制备方法
CN104623720B (zh) 一种淀粉基止血海绵及其制备方法
CN102302796A (zh) 吸收性止血生物材料及制备方法
CN108421081B (zh) 一种抗感染、安全高效的止血气凝胶及其制备方法
CN103203014B (zh) 一种共混功能性手术冲洗液的制备方法
CN105327382B (zh) 双交联法制备医用透明聚乙烯醇水凝胶的方法
CN104922722A (zh) 可吸收降解淀粉止血材料的制备方法
CN107903411A (zh) 羧甲基棉纤维水凝胶的制备方法
CN104606723A (zh) 可吸收性淀粉止血粉及其制备方法、应用
CN105536036A (zh) 一种医用新材料
CN105617452A (zh) 一种医用生物新材料
CN105561380A (zh) 一种医用凝胶及其制备方法
CN102432895B (zh) 一种温敏型纤维素季铵盐/β-甘油磷酸钠水凝胶的制备方法
CN107970486A (zh) 一种壳聚糖基复合止血膜的制备方法
CN104307031A (zh) 一种皮肤外用修复材料的制备方法及用途
CN103893821A (zh) 一种仿生复合补片及其制备方法和用途
CN1552465A (zh) 纤维蛋白止血贴
CN106215221A (zh) 壳寡糖‑明胶‑镁黄长石纳米纤维生物敷料及其制备方法
CN110559473A (zh) 一种羧甲基壳聚糖止血海绵的制备工艺
CN105056282A (zh) 一种淀粉多孔微粒止血材料及其制作方法
CN103265719B (zh) 一种止血海绵及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP02 Change in the address of a patent holder

Address after: No.23, Beijiao Road, Qianyuan Town, Deqing County, Huzhou City, Zhejiang Province

Patentee after: Ren Xinjie

Address before: 325000 Zhejiang city of Wenzhou province Ruian City Ma Yu Zhen Cao Cun Cao Xi Cun New Road No. 112

Patentee before: Ren Xinjie

CP02 Change in the address of a patent holder
TR01 Transfer of patent right

Effective date of registration: 20210726

Address after: 556000 No.18, Jinyuan West Avenue, Kaili Economic Development Zone, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province

Patentee after: Guizhou Weike Medical Technology Co.,Ltd.

Address before: 313200 No. 23, Beijiao Road, Qianyuan Town, Deqing County, Huzhou City, Zhejiang Province

Patentee before: Ren Xinjie

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20221017

Address after: No. 11, 12th Floor, Unit 1, Building 14, Guiyang International Financial Center Phase I Business District Project, Lincheng Road, Changling Sub-district Office, Guanshanhu District, Guiyang City, Guizhou Province, 550000

Patentee after: Guizhou Tongji Zhiyi Technology Co.,Ltd.

Address before: 556000 No.18, Jinyuan West Avenue, Kaili Economic Development Zone, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province

Patentee before: Guizhou Weike Medical Technology Co.,Ltd.

TR01 Transfer of patent right