CN105412491A - Pharmaceutic preparation for treating hypomenorrhea and endometritis - Google Patents
Pharmaceutic preparation for treating hypomenorrhea and endometritis Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention belongs to the field of traditional Chinese medicine and discloses a pharmaceutic preparation for treating hypomenorrhea and endometritis and a preparing method thereof. The pharmaceutic preparation is prepare from roots of lagerflower triplostegia, serissa serissoide, Chinese yam, flatstem milkvetch seeds, fructus lycii, stems of manyflower fissistigma, cantonese speranskia, winged laggera herb, herba aristolochiae, Japanese coniogramme rhizome herb and sargentgloryvine stems elaborately based on a certain weight proportion. All the medicinal materials are compatible to realize the purposes of nourishing blood and promoting the circulation of qi, promoting blood circulation to remove blood stasis, warming and nourishing thoroughfare and conception vessels, clearing heat and promoting dieresis and relieving swelling and internal heat or fever together, and the pharmaceutic preparation can also nourish liver and kidney, strength spleen and stomach and treat both symptoms and root causes and has a unique effect on hypomenorrhea and endometritis. The pharmaceutic preparation has a multi-target, multi-link and multi-level comprehensive regulating effect and a small side effect, patient compliance is high, the pharmaceutic preparation is convenient to take, burdens and pains of patients can be effectively relieved, both symptoms and root causes can be treated, and the pharmaceutic preparation is worth wide clinical application and popularization.
Description
Technical field
The invention belongs to the field of Chinese medicines, disclose one and treat hypomenorrhea and accompany endometrial pharmaceutical preparation and preparation method thereof.
Background technology
It is normal that hypomenorrhea refers to menstrual cycle, and be obviously less than in the past through measuring, and less than two days, or drop was namely clean, is referred to as " hypomenorrhea ".Ancient books is also known as " a small amount of menses and menstruating unsmoothly " " very few through measuring " etc.Generally think that menstruation is less than 20mL through blood volume and is hypomenorrhea.Hypomenorrhea is one of performance of menoxenia, and existing sickness rate is raising year by year.
" Plain Questions innocence in ancient times opinion " one is write: " woman's kidney qi is contained, the menarche, and conception vessel leads to, and taichong channel is contained, regular menstrual cycle." illustrate that menstruation is female normal physiological activity.Menstruation is monthly gone under normal circumstances, its menstrual period and blood volume and color, should be all normal through matter.The exception of menstruation, does not just show as merely gynaecopathia so simple, is often a reaction of whole body pathologic condition change yet.Hypomenorrhea is exactly one of performance of irregular menstruation.This symptom of hypomenorrhea is found in premature ovarian failure, polycystic ovarian syndrome, uterine hypoplasia, endometritis, artificial abortion operation etc. in western medicine.
Can be found by the clinical people coming to go to a doctor, hypomenorrhea has become a problem of the numerous women of puzzlement, and the patient of many hypomenorrhea is when gynecologial examination, light or heavy can find with endometrial inflammation, Abwehrkraft des Koepers weakens, and pathogen can be availed oneself of the opportunity to get in, retrograde infection endometrium, cause cellular level metabolism and dysfunction, cause cytopathy, increase the weight of endometrial damage, make endometrial stroma fibrosis, even calcification, ossified, Adhesion formation in uterine cavity.Inner membrance and body of gland part or major part substitute by simple epithelium, it stimulates insensitive to gonadal hormone, and body of gland becomes sparse, and the thinning or became uneven of endometrium, partial function layer disappears, and endometrium blood finally reduces through amount for reducing.
At present, the medicine for the treatment of hypomenorrhea has Western medicine and the large class of Chinese medicine two, but this two classes medicine all can not prevent or treat endometritis, and western medicine hypomenorrhea administration time is long, and side effect is large, curative effect is not thorough, not only easily cause gastrointestinal reaction, easily increase the weight of endocrine disturbance again, although and existing Chinese patent medicine preparation can treat female irregular menstruation, but offer limited effectiveness, and the endometritis occurred together to hypomenorrhea is often invalid.And differentiation of tcm, often evident in efficacy.
Summary of the invention
In order to solve the problem, the present invention aims to provide a kind of hypomenorrhea for the treatment of and accompanies pharmaceutical preparation of endometritis and preparation method thereof.
An object of the present invention is to provide a kind of pharmaceutical preparation for the treatment of hypomenorrhea companion endometritis.
A kind of pharmaceutical preparation for the treatment of hypomenorrhea companion endometritis provided by the invention, is made up of Radix Triplostegiae Grandiflorae, Serissa foetida, Rhizoma Dioscoreae, Semen Astragali Complanati, Fructus Lycii, Caulis Fissistigmatis, Herba speranskiae cantonensis, Herba Laggerae Alatae, Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae medicinal raw material.In side, the weight of each medicinal raw material is as follows: Radix Triplostegiae Grandiflorae 10-30 part, Serissa foetida 10-20 part, Rhizoma Dioscoreae 12-36 part, Semen Astragali Complanati 10-20 part, Fructus Lycii 15-35 part, Caulis Fissistigmatis 8-18 part, Herba speranskiae cantonensis 10-20 part, Herba Laggerae Alatae 13-26 part, Herba Aristolochiae 15-38 part, Coniogramme japonica (Thunb.) Diels 5-15 part, Caulis Sargentodoxae 13-26 part.
Further preferably, treat a pharmaceutical preparation for hypomenorrhea companion endometritis, it is characterized in that being made up of the medicinal raw material of following weight: Radix Triplostegiae Grandiflorae 18-24 part, Serissa foetida 10-15 part, Rhizoma Dioscoreae 20-26 part, Semen Astragali Complanati 11-16 part, Fructus Lycii 18-24 part, Caulis Fissistigmatis 8-13 part, Herba speranskiae cantonensis 11-16 part, Herba Laggerae Alatae 18-24 part, Herba Aristolochiae 22-28 part, Coniogramme japonica (Thunb.) Diels 8-13 part, Caulis Sargentodoxae 17-23 part.
Further preferably, treat a pharmaceutical preparation for hypomenorrhea companion endometritis, it is characterized in that being made up of the medicinal raw material of following weight: Radix Triplostegiae Grandiflorae 20 parts, Serissa foetida 12 parts, Rhizoma Dioscoreae 24 parts, Semen Astragali Complanati 12 parts, Fructus Lycii 24 parts, Caulis Fissistigmatis 10 parts, Herba speranskiae cantonensis 15 parts, Herba Laggerae Alatae 20 parts, Herba Aristolochiae 25 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Caulis Sargentodoxae 20 parts.
Side of the present invention separates: monarch drug: Herba Laggerae Alatae is worked hard tepor, and expelling wind and removing dampness, changes stagnant dissipating blood stasis, subduing swelling and detoxicating; The bitter temperature of Herba Aristolochiae, promoting flow of QI and blood, inducing diuresis to remove edema, removing toxic substances.
Ministerial drug: Semen Astragali Complanati sweet temperature temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs; Fructus Lycii is sweet flat, nourishing the liver and kidney, benefit essence; Two medicine nourishing the liver and kidney, consolidate and adjust punching to appoint.The micro-pungent micro-hardship of Coniogramme japonica (Thunb.) Diels is cool, expelling wind and removing dampness, heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis; Caulis Sargentodoxae hardship is flat, and removing toxicity for eliminating carbuncles, expelling wind and removing dampness, two medicine heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, Caulis Sargentodoxae is enriched blood in addition and stimulates the menstrual flow, the effect of bone and muscle strengthening.
Adjuvant drug: the sweet micro-hardship of Radix Triplostegiae Grandiflorae is put down, tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation; Serissa foetida is light micro-pungent cool, invigorating spleen to remove dampness, and soothing liver-QI is invigorated blood circulation; Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission; Casting skin falls the meridian dredging, bone and muscle strengthening, spleen invigorating warming middle-JIAO; Herba speranskiae cantonensis wind-damp dispelling, the meridian dredging, removing blood stasis with potent drugs blood and relieving pain.
All medicines closes 5, and with circulation of qi promoting of nourishing blood, blood circulation promoting and blood stasis dispelling, replenishing vital QI with drugs of warm nature punching is appointed, and has effect of clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating concurrently simultaneously, treating both the principal and the secondary aspects of a disease at the same time and repair impaired endometrium, so curative effect is good.
The pharmaceutical research present situation of the present invention's each medical material used is as described below.
Radix Triplostegiae Grandiflorae: [nature and flavor] sweet, micro-hardship is flat.[function cures mainly] tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, removing toxic substances.For lumbago due to renal deficiency, anemia, cough, seminal emission, sexual impotence, rheumatic arthritis, menoxenia, vicarious menstruation, metrorrhagia, leukorrhagia, infertility.External is stopped blooding." Yunnan Chinese herbal medicine ": regulating menstruation and activating blood, kidney tonifying.Control amenorrhea, menoxenia, lumbago due to renal deficiency, seminal emission, sexual impotence, infertility.
Serissa foetida: [nature and flavor] are lightly seasoned, micro-pungent, cool in nature.[function cures mainly] invigorating spleen to remove dampness, soothing liver-QI is invigorated blood circulation.For infantile malnutrition, acute, chronic hepatitis, amenorrhea, leucorrhea, lumbago due to pathogenic wind-dampness." Chinese herbal medicine handbook is commonly used in Shanghai " carries: " invigorate blood circulation, detumescence, dispel the wind, removing dampness, has again strong effect.Control woman's amenorrhea, leukorrhagia, dizzy unable.”
Rhizoma Dioscoreae: [nature and flavor] are sweet, flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Semen Astragali Complanati: [nature and flavor] are sweet, temperature.[return through] returns liver, kidney channel.[function cures mainly] temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.[usage and dosage] 9 ~ 15g.
Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Bencao Jingshu ": " Fructus Lycii, profit and nourishing doublely can be brought down a fever, and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, be the key medicine of Liver and kidney kidney-YIN being deficient, tired interior-heat tonification.”
Caulis Fissistigmatis: [nature and flavor] temperature; Sweet.[return through] liver; Kidney channel.[function cures mainly] the meridian dredging; Bone and muscle strengthening; Spleen invigorating warming middle-JIAO.Main traumatic injury; Rheumatic arthritis; Rheumatoid arthritis; Flu; Menoxenia.
Herba speranskiae cantonensis: [nature and flavor] are bitter; Flat.[return through] lung; Liver; Large intestine channel.[function cures mainly] wind-damp dispelling; The meridian dredging; Removing blood stasis with potent drugs pain relieving.Main air pain of dampness syndrome; Lump in the abdomen; Scrofula; Furuncle swelling toxin; Traumatic injury." Chinese herbal medicine is commonly used in Sichuan ": wind-damp dispelling, the meridian dredging, disappear hard block, invigorates blood circulation, pain relieving.Control enclosed mass in abdomen, tuberculous lymphadenitis, rheumatic ostalgia, chronic consumptive disease is coughed, sore tumor.
Herba Laggerae Alatae: [nature and flavor] acrid in the mouth; Bitter; Slightly warm in nature.[function cures mainly] dispels the wind, and dehumidifying, changes stagnant, dissipating blood stasis, detumescence, removing toxic substances.Main cold, fever; Cough due to lung-heat; Rheumatic arthritis; Diarrhoea; Oedema due to nephritis; Amenorrhea; Traumatic injury; Furuncle carbuncle; Scrofula; Venom; Eczema pruritus.
Herba Aristolochiae: [nature and flavor] are bitter; Temperature.[return through] liver; Spleen; Kidney channel.[function cures mainly] promoting flow of QI and blood; Inducing diuresis to remove edema; Removing toxic substances.Main stomachache; Colicky; Edema during pregnancy; Puerperal, vim and vigour were suffered from abdominal pain; Snake bite and insect sting." book on Chinese herbal medicine converges and says ": Herba Aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable then peaceful, the inverse then vexed work of pain.
Coniogramme japonica (Thunb.) Diels: [nature and flavor] micro-pungent micro-hardship; Cool.[return through] Liver Channel.[function cures mainly] expelling wind and removing dampness; Loose blood and relieving pain; Heat-clearing and toxic substances removing.Main rheumatic arthritis; Abdominal pain due to blood stasis; Amenorrhea; Traumatic injury; Conjunctival congestion and swelling pain; Acute mastitis; Various toxic swelling from the beginning of.
Caulis Sargentodoxae: [nature and flavor] are bitter; Flat; Nontoxic.[return through] liver; Large intestine channel.[function cures mainly] removing toxicity for eliminating carbuncles; Promoting blood circulation and stopping pain; Expelling wind and removing dampness; Parasite killing.Main intestinal carbuncle; Dysentery; Mastalgia; Dysmenorrhea; Amenorrhea; Traumatic injury; Rheumatic arthralgia; Abdominal pain due to worm stagnation.
Present invention also offers the preparation method of described pharmaceutical preparation, the method mainly comprises the steps: to get Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae pulverizing, add Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae weight 4-10 70% alcoholic solution doubly and extract secondary, each 1.5 hours, extracting solution reclaims after ethanol and is concentrated into extractum, dry, be ground into fine powder, get Radix Triplostegiae Grandiflorae, Serissa foetida, Rhizoma Dioscoreae, Semen Astragali Complanati, Fructus Lycii, Caulis Fissistigmatis, Herba speranskiae cantonensis, Herba Laggerae Alatae and Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, filtering residue after Caulis Sargentodoxae alcoholic solution extracts, add 4-8 times of weight parts water to soak, decoct extraction 2 times, each 1.5-2.0 hour (timing from during boiling), merge decoction liquor, relative density 1.05-1.10 when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 40%, leave standstill after 24 hours, discard lower sediment thing, obtain supernatant, extractum is concentrated into after reclaiming ethanol, extract dry, be ground into fine powder, by gained fine powder mix homogeneously, directly be used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and make clinical acceptable dosage form.As the peroral dosage form of the solid dosage form such as conventional tablet, dispersible tablet, effervescent tablet, chewable tablet, capsule, granule, pill, powder can be made, the peroral dosage form of the liquid forms such as syrup, oral liquid, decoction also can be made.
The peroral dosage form of pharmaceutical preparation further preferably of the present invention is tablet, capsule or granule, most preferably is capsule.
The present invention relatively and prior art, has following clear superiority:
Hypomenorrhea can be significantly improved with the clinical cure rate of patient with endometritis and obvious effective rate compared with matched group by the known pharmaceutical preparation observation group of the present invention of clinical observation experiment embodiment 11; Have better late result, and the clinical symptoms of patient not easily recurs, untoward reaction is few.
Selected by pharmaceutical preparation of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and legislation comprehensively, medication is thoughtful, play special effect, play circulation of qi promoting of nourishing blood altogether, blood circulation promoting and blood stasis dispelling, replenishing vital QI with drugs of warm nature punching is appointed, have the effect of clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating concurrently, take a tonic or nourishing food to build up one's health Liver and kidney, solid protection taste simultaneously, treating both the principal and secondary aspects of a disease, has unique effect to hypomenorrhea companion patient with endometritis; Traditional Chinese medicine preparation of the present invention has Mutiple Targets, too many levels, multi-level comprehensive regulation effect, and side effect is less, and patient compliance is better, taking convenience, can effectively alleviate patient's burden and misery, the object for the treatment of both the principal and secondary aspects of a disease can be reached, wide popularization and application on clinic.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
Prescription: Radix Triplostegiae Grandiflorae 20 parts, Serissa foetida 12 parts, Rhizoma Dioscoreae 24 parts, Semen Astragali Complanati 12 parts, Fructus Lycii 24 parts, Caulis Fissistigmatis 10 parts, Herba speranskiae cantonensis 15 parts, Herba Laggerae Alatae 20 parts, Herba Aristolochiae 25 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Caulis Sargentodoxae 20 parts.
Preparation method: get Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae pulverize, add Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae weight 4-10 70% alcoholic solution doubly and extract secondary, each 1.5 hours, extracting solution is concentrated into extractum after reclaiming ethanol, dry, be ground into fine powder, get Radix Triplostegiae Grandiflorae, Serissa foetida, Rhizoma Dioscoreae, Semen Astragali Complanati, Fructus Lycii, Caulis Fissistigmatis, Herba speranskiae cantonensis, Herba Laggerae Alatae and Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, filtering residue after Caulis Sargentodoxae alcoholic solution extracts, add 4-8 times of weight parts water to soak, decoct extraction 2 times, each 1.5-2.0 hour (timing from during boiling), merge decoction liquor, relative density 1.05-1.10 when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 40%, leave standstill after 24 hours, discard lower sediment thing, obtain supernatant, extractum is concentrated into after reclaiming ethanol, extract dry, be ground into fine powder, by gained fine powder mix homogeneously, normal process steps makes capsule.
The present embodiment capsule, every containing crude drug 1.3g.
Embodiment 2 capsule
Prescription: Radix Triplostegiae Grandiflorae 18 parts, Serissa foetida 10 parts, Rhizoma Dioscoreae 25 parts, Semen Astragali Complanati 15 parts, Fructus Lycii 20 parts, Caulis Fissistigmatis 8 parts, Herba speranskiae cantonensis 12 parts, Herba Laggerae Alatae 15 parts, Herba Aristolochiae 20 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Caulis Sargentodoxae 15 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 3 capsule
Prescription: Radix Triplostegiae Grandiflorae 22 parts, Serissa foetida 15 parts, Rhizoma Dioscoreae 25 parts, Semen Astragali Complanati 15 parts, Fructus Lycii 25 parts, Caulis Fissistigmatis 15 parts, Herba speranskiae cantonensis 10 parts, Herba Laggerae Alatae 18 parts, Herba Aristolochiae 22 parts, Coniogramme japonica (Thunb.) Diels 12 parts, Caulis Sargentodoxae 18 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 4 capsule
Prescription: Radix Triplostegiae Grandiflorae 24 parts, Serissa foetida 12 parts, Rhizoma Dioscoreae 30 parts, Semen Astragali Complanati 10 parts, Fructus Lycii 20 parts, Caulis Fissistigmatis 15 parts, Herba speranskiae cantonensis 16 parts, Herba Laggerae Alatae 26 parts, Herba Aristolochiae 20 parts, Coniogramme japonica (Thunb.) Diels 12 parts, Caulis Sargentodoxae 22 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 5 capsule
Prescription: Radix Triplostegiae Grandiflorae 25 parts, Serissa foetida 15 parts, Rhizoma Dioscoreae 20 parts, Semen Astragali Complanati 16 parts, Fructus Lycii 32 parts, Caulis Fissistigmatis 12 parts, Herba speranskiae cantonensis 16 parts, Herba Laggerae Alatae 18 parts, Herba Aristolochiae 26 parts, Coniogramme japonica (Thunb.) Diels 12 parts, Caulis Sargentodoxae 20 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 6 capsule
Prescription: Radix Triplostegiae Grandiflorae 15 parts, Serissa foetida 10 parts, Rhizoma Dioscoreae 25 parts, Semen Astragali Complanati 12 parts, Fructus Lycii 18 parts, Caulis Fissistigmatis 12 parts, Herba speranskiae cantonensis 15 parts, Herba Laggerae Alatae 13 parts, Herba Aristolochiae 16 parts, Coniogramme japonica (Thunb.) Diels 8 parts, Caulis Sargentodoxae 16 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 7 capsule
Prescription: Radix Triplostegiae Grandiflorae 20 parts, Serissa foetida 15 parts, Rhizoma Dioscoreae 36 parts, Semen Astragali Complanati 20 parts, Fructus Lycii 25 parts, Caulis Fissistigmatis 10 parts, Herba speranskiae cantonensis 10 parts, Herba Laggerae Alatae 15 parts, Herba Aristolochiae 35 parts, Coniogramme japonica (Thunb.) Diels 15 parts, Caulis Sargentodoxae 25 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 8 capsule
Prescription: Radix Triplostegiae Grandiflorae 22 parts, Serissa foetida 10 parts, Rhizoma Dioscoreae 25 parts, Semen Astragali Complanati 16 parts, Fructus Lycii 24 parts, Caulis Fissistigmatis 8 parts, Herba speranskiae cantonensis 16 parts, Herba Laggerae Alatae 18 parts, Herba Aristolochiae 26 parts, Coniogramme japonica (Thunb.) Diels 12 parts, Caulis Sargentodoxae 22 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 9 tablet
Prescription: Radix Triplostegiae Grandiflorae 20 parts, Serissa foetida 12 parts, Rhizoma Dioscoreae 24 parts, Semen Astragali Complanati 12 parts, Fructus Lycii 24 parts, Caulis Fissistigmatis 10 parts, Herba speranskiae cantonensis 15 parts, Herba Laggerae Alatae 20 parts, Herba Aristolochiae 25 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Caulis Sargentodoxae 20 parts.
Preparation method: get Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae pulverize, add Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae weight 4-10 70% alcoholic solution doubly and extract secondary, each 1.5 hours, extracting solution is concentrated into extractum after reclaiming ethanol, dry, be ground into fine powder, get Radix Triplostegiae Grandiflorae, Serissa foetida, Rhizoma Dioscoreae, Semen Astragali Complanati, Fructus Lycii, Caulis Fissistigmatis, Herba speranskiae cantonensis, Herba Laggerae Alatae and Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, filtering residue after Caulis Sargentodoxae alcoholic solution extracts, add 4-8 times of weight parts water to soak, decoct extraction 2 times, each 1.5-2.0 hour (timing from during boiling), merge decoction liquor, relative density 1.05-1.10 when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 40%, leave standstill after 24 hours, discard lower sediment thing, obtain supernatant, extractum is concentrated into after reclaiming ethanol, extract dry, be ground into fine powder, by gained fine powder mix homogeneously, normal process steps makes tablet.
Embodiment 10 granule
Prescription: Radix Triplostegiae Grandiflorae 20 parts, Serissa foetida 12 parts, Rhizoma Dioscoreae 24 parts, Semen Astragali Complanati 12 parts, Fructus Lycii 24 parts, Caulis Fissistigmatis 10 parts, Herba speranskiae cantonensis 15 parts, Herba Laggerae Alatae 20 parts, Herba Aristolochiae 25 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Caulis Sargentodoxae 20 parts.
Preparation method: get Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae pulverize, add Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae weight 4-10 70% alcoholic solution doubly and extract secondary, each 1.5 hours, extracting solution is concentrated into extractum after reclaiming ethanol, dry, be ground into fine powder, get Radix Triplostegiae Grandiflorae, Serissa foetida, Rhizoma Dioscoreae, Semen Astragali Complanati, Fructus Lycii, Caulis Fissistigmatis, Herba speranskiae cantonensis, Herba Laggerae Alatae and Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, filtering residue after Caulis Sargentodoxae alcoholic solution extracts, add 4-8 times of weight parts water to soak, decoct extraction 2 times, each 1.5-2.0 hour (timing from during boiling), merge decoction liquor, relative density 1.05-1.10 when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 40%, leave standstill after 24 hours, discard lower sediment thing, obtain supernatant, extractum is concentrated into after reclaiming ethanol, extract dry, be ground into fine powder, by gained fine powder mix homogeneously, normal process steps makes granule.
Embodiment 11 clinical observation is tested
1 data and method
1.1 physical data: observe in January, 2014 to a 2014 year December and go to a doctor in my institute's Out-patient Clinic of Department of Gynecology, are diagnosed as patient 102 example that hypomenorrhea card suffers from endometritis simultaneously, are divided into observation group and matched group to observe at random, often organize 51 routine.Observation group's age 18-to 34-year-old, 25.5 ± 3.8 years old mean age, matched group age 18-33 year, average 25.9 ± 4.1 years old; Observation group's course of disease is the longest 4.5 years, the shortest 6 months, and average 1.75 ± 0.78 years, the matched group course of disease was the longest 4.5 years, the shortest 5 months, average 1.86 ± 0.91 years; Observation group has 47 routine patients to have abortion history, and matched group has 46 routine patients to have abortion history.Two groups of physical data compare no difference of science of statistics (P > 0.05), have comparability.
1.2 diagnostic criterias: the diagnostic criteria of writing the hypomenorrhea of " guideline of clinical investigations of new Chinese medicine treatment menoxenia " of " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China promulgation in 2002 according to Zhang Yuzhen etc.
Hypomenorrhea: hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through line time less than 2 days, through the menopathy that amount is also few.
1.3 exclusion standards: have cryptorrhea, luteal phase defect; There are the Chronic consumptions persons such as hyperthyroidism, tuberculosis, severe anemia; There is oral hormone in 3 months, use contraceptive person; Untoward reaction person is there is in drug administration process; Not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or statistical disposition person.
1.4 Therapeutic Method:
Observation group: the capsule that menstruation brings into use the embodiment of the present invention 1 to prepare on the 5th day, each 2-4 grain, every day 2 times, was a course for the treatment of with 3 months, takes 3 months continuously.
Matched group: use Western medicine capable artificial cycle estrogen and progestogen sequential therapy, take FUKE QIANJIN PIAN, every day three times, each 2-4 grain simultaneously.
1.5 observation index: adverse effect during observing the therapeutic effect of two groups of patients and medication; Treatment is followed up a case by regular visits to after terminating rear third time menstrual onset, and record related symptoms is observed.
1.6 statistical methods: adopt SPSS15.0 statistical software to calculate.Each numerical value with
represent, measurement data adopts t inspection, and enumeration data adopts χ
2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 criterions of therapeutical effect: according to " guideline of clinical investigations of new Chinese medicine treatment menoxenia ", draft following criterion of therapeutical effect: recovery from illness: treat rear menstrual cycle, recover normal through amount, other transference cures, drug withdrawal 3 non-recidivists of menstrual cycle.Effective: menstrual blood volume increases by 1/3, and other transference cures alleviate, and drug withdrawal 3 menstrual cycle are without recidivist.Effective: treat rear menstrual cycle, through amount, comparatively treat front improvement menstrual period, other symptoms alleviate before comparatively treating.Invalid: treatment after menstrual cycle, through amount and menstrual period without improvement.
2.2 observation of curative effect
2.2.1 two groups of patient's comparitive study: observation group's recovery from illness 20 example, effective 18 examples, effective 13 examples, invalid 0 example, obvious effective rate 74.5%, total effective rate 100%; Matched group recovery from illness 10 example, effective 14 examples, effective 17 examples, invalid 10 examples, obvious effective rate 47.1%, total effective rate 80.4%, observation group compares with matched group obvious effective rate, total effective rate, difference has statistical significance (P < 0.05), illustrates that clinical cure rate and the obvious effective rate of hypomenorrhea significantly can improve compared with matched group in observation group.In table 1.
Table 1 liang group patient comparitive study (n%, example)
Note: compare with matched group, * P < 0.05.
2.2.2 after two groups of treatments, Follow-up results compares
Time after treatment is finished to effective follow-up of patients, in the routine patient of observation group 38, there is 1 routine patient when following up a case by regular visits to, hypomenorrhea, and in the routine patient of matched group 24, have 8 routine patient menstrual very few, 1 routine patient's amenorrhea, illustrates that the patient of matched group clinical symptoms after drug withdrawal has bounce-back.Can illustrate that observation group compares with matched group and has better late result accordingly, and the clinical symptoms of patient not easily recurs, also demonstrate the disease that pharmaceutical preparation of the present invention can treat hypomenorrhea companion endometritis, make body obtain good recovery.
2.2.3 the observation of adverse effect during medication: have 1 routine patient to occur slight gastrointestinal reaction during observation group's patient medication.15 routine patients are had to occur slight gastrointestinal reaction during matched group patient medication, as Nausea and vomiting, upper abdomen dull pain; Have 3 routine patients to occur irregular colporrhagia, observation group compares with matched group, and difference has statistical significance, and observation group's less adverse effect, patient compliance is better.
Therapeutic outcome shows: observation group can significantly improve clinical cure rate and the obvious effective rate of hypomenorrhea companion patient with endometritis compared with matched group; Have better late result, and the clinical symptoms of patient not easily recurs, untoward reaction is few, is one pharmaceutical preparation safely and effectively, for Chinese medicine hypomenorrhea provides new method, is worth studying and applying further.
Claims (10)
1. treat a pharmaceutical preparation for hypomenorrhea companion endometritis, it is characterized in that being made up of Radix Triplostegiae Grandiflorae, Serissa foetida, Rhizoma Dioscoreae, Semen Astragali Complanati, Fructus Lycii, Caulis Fissistigmatis, Herba speranskiae cantonensis, Herba Laggerae Alatae, Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae medicinal raw material.
2. the pharmaceutical preparation for the treatment of hypomenorrhea companion endometritis as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Radix Triplostegiae Grandiflorae 10-30 part, Serissa foetida 10-20 part, Rhizoma Dioscoreae 12-36 part, Semen Astragali Complanati 10-20 part, Fructus Lycii 15-35 part, Caulis Fissistigmatis 8-18 part, Herba speranskiae cantonensis 10-20 part, Herba Laggerae Alatae 13-26 part, Herba Aristolochiae 15-38 part, Coniogramme japonica (Thunb.) Diels 5-15 part, Caulis Sargentodoxae 13-26 part.
3. the pharmaceutical preparation for the treatment of hypomenorrhea companion endometritis as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Radix Triplostegiae Grandiflorae 18-24 part, Serissa foetida 10-15 part, Rhizoma Dioscoreae 20-26 part, Semen Astragali Complanati 11-16 part, Fructus Lycii 18-24 part, Caulis Fissistigmatis 8-13 part, Herba speranskiae cantonensis 11-16 part, Herba Laggerae Alatae 18-24 part, Herba Aristolochiae 22-28 part, Coniogramme japonica (Thunb.) Diels 8-13 part, Caulis Sargentodoxae 17-23 part.
4. the pharmaceutical preparation for the treatment of hypomenorrhea companion endometritis as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Radix Triplostegiae Grandiflorae 20 parts, Serissa foetida 12 parts, Rhizoma Dioscoreae 24 parts, Semen Astragali Complanati 12 parts, Fructus Lycii 24 parts, Caulis Fissistigmatis 10 parts, Herba speranskiae cantonensis 15 parts, Herba Laggerae Alatae 20 parts, Herba Aristolochiae 25 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Caulis Sargentodoxae 20 parts.
5. the pharmaceutical preparation of the treatment hypomenorrhea companion endometritis as described in as arbitrary in claim 1-4, it is characterized in that preparation method comprises the steps: to get Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae pulverizing, add Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, Caulis Sargentodoxae weight 4-10 70% alcoholic solution doubly and extract secondary, each 1.5 hours, extracting solution reclaims after ethanol and is concentrated into extractum, dry, be ground into fine powder, get Radix Triplostegiae Grandiflorae, Serissa foetida, Rhizoma Dioscoreae, Semen Astragali Complanati, Fructus Lycii, Caulis Fissistigmatis, Herba speranskiae cantonensis, Herba Laggerae Alatae and Herba Aristolochiae, Coniogramme japonica (Thunb.) Diels, filtering residue after Caulis Sargentodoxae alcoholic solution extracts, add 4-8 times of weight parts water to soak, decoct extraction 2 times, each 1.5-2.0 hour (timing from during boiling), merge decoction liquor, relative density 1.05-1.10 when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 40%, leave standstill after 24 hours, discard lower sediment thing, obtain supernatant, extractum is concentrated into after reclaiming ethanol, extract dry, be ground into fine powder, by gained fine powder mix homogeneously, directly be used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and make clinical acceptable dosage form.
6. the pharmaceutical preparation of the treatment hypomenorrhea companion endometritis as described in as arbitrary in claim 1-5, is characterized in that the dosage form of described pharmaceutical preparation is peroral dosage form.
7. the pharmaceutical preparation for the treatment of hypomenorrhea companion endometritis as claimed in claim 6, it is characterized in that described peroral dosage form is the peroral dosage form of the solid dosage form such as tablet, dispersible tablet, effervescent tablet, chewable tablet, capsule, granule, pill, powder, also the peroral dosage form of the liquid forms such as syrup, oral liquid, decoction be can make, tablet, capsule or granule are preferably.
8. the pharmaceutical preparation for the treatment of hypomenorrhea companion endometritis as claimed in claim 7, is characterized in that described peroral dosage form is capsule.
9. the purposes of the arbitrary described pharmaceutical preparation of claim 1-4 in the medicine of preparation treatment hypomenorrhea companion endometritis.
10. the purposes of the arbitrary described pharmaceutical preparation of claim 1-4 in preparation treatment hypomenorrhea medicine.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041100A (en) * | 2012-12-14 | 2013-04-17 | 青岛中科英泰商用系统有限公司 | Traditional Chinese medicine preparation for treatment of hypomenorrhea and preparation method thereof |
| CN104306583A (en) * | 2014-11-12 | 2015-01-28 | 李德敏 | Traditional Chinese medicine composition for treating scanty menstruation and preparation method of traditional Chinese medicine composition |
-
2016
- 2016-01-15 CN CN201610024917.4A patent/CN105412491A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041100A (en) * | 2012-12-14 | 2013-04-17 | 青岛中科英泰商用系统有限公司 | Traditional Chinese medicine preparation for treatment of hypomenorrhea and preparation method thereof |
| CN104306583A (en) * | 2014-11-12 | 2015-01-28 | 李德敏 | Traditional Chinese medicine composition for treating scanty menstruation and preparation method of traditional Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 范红霞等主编: "《妇产科中西医结合诊疗技巧》", 30 April 2005, 广东科技出版社 * |
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