CN105411871A - Compound medicinal toothpaste - Google Patents
Compound medicinal toothpaste Download PDFInfo
- Publication number
- CN105411871A CN105411871A CN201510916722.6A CN201510916722A CN105411871A CN 105411871 A CN105411871 A CN 105411871A CN 201510916722 A CN201510916722 A CN 201510916722A CN 105411871 A CN105411871 A CN 105411871A
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- CN
- China
- Prior art keywords
- content
- combination
- acid
- medicinal toothpaste
- zinc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 32
- 239000000606 toothpaste Substances 0.000 title claims abstract description 32
- 150000001875 compounds Chemical class 0.000 title abstract 2
- CUCUKLJLRRAKFN-UHFFFAOYSA-N 7-Hydroxy-(S)-usnate Chemical compound CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O CUCUKLJLRRAKFN-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940004858 usnic acid Drugs 0.000 claims abstract description 20
- ICTZCAHDGHPRQR-UHFFFAOYSA-N usnic acid Natural products OC1=C(C)C(O)=C(C(C)=O)C2=C1C1(C)C(O)=C(C(=O)C)C(=O)C=C1O2 ICTZCAHDGHPRQR-UHFFFAOYSA-N 0.000 claims abstract description 20
- WEYVVCKOOFYHRW-UHFFFAOYSA-N usninic acid Natural products CC12C(=O)C(C(=O)C)=C(O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O WEYVVCKOOFYHRW-UHFFFAOYSA-N 0.000 claims abstract description 20
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims abstract description 18
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims abstract description 14
- 229960000401 tranexamic acid Drugs 0.000 claims abstract description 14
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000007524 organic acids Chemical class 0.000 claims abstract description 13
- 239000011701 zinc Substances 0.000 claims abstract description 13
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000002131 composite material Substances 0.000 claims description 20
- 241000006302 Usnea Species 0.000 claims description 18
- 235000013599 spices Nutrition 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 230000002421 anti-septic effect Effects 0.000 claims description 9
- 239000011230 binding agent Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 239000000080 wetting agent Substances 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- BHWMZEPWQUFLLQ-HSHFZTNMSA-N (2R)-2-hydroxypropanoic acid zinc Chemical compound [Zn].C[C@@H](O)C(O)=O BHWMZEPWQUFLLQ-HSHFZTNMSA-N 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 3
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 3
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 3
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 3
- 244000269722 Thea sinensis Species 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 3
- YGZOLUSJFYDOMD-UHFFFAOYSA-N [Na].CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O Chemical group [Na].CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O YGZOLUSJFYDOMD-UHFFFAOYSA-N 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 3
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000010233 benzoic acid Nutrition 0.000 claims description 3
- 229960004365 benzoic acid Drugs 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 235000009569 green tea Nutrition 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 229960003415 propylparaben Drugs 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- 229960004029 silicic acid Drugs 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 229960003885 sodium benzoate Drugs 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 235000019408 sucralose Nutrition 0.000 claims description 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 3
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 239000011746 zinc citrate Substances 0.000 claims description 3
- 235000006076 zinc citrate Nutrition 0.000 claims description 3
- 229940068475 zinc citrate Drugs 0.000 claims description 3
- 239000011670 zinc gluconate Substances 0.000 claims description 3
- 235000011478 zinc gluconate Nutrition 0.000 claims description 3
- 229960000306 zinc gluconate Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 206010018276 Gingival bleeding Diseases 0.000 abstract description 5
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 2
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 2
- 210000004195 gingiva Anatomy 0.000 abstract description 2
- 230000023597 hemostasis Effects 0.000 abstract description 2
- 230000008961 swelling Effects 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- SIZDUQQDBXJXLQ-UHFFFAOYSA-N 2-(3-acetyl-2,2-dimethylcyclobutyl)acetic acid Chemical compound CC(=O)C1CC(CC(O)=O)C1(C)C SIZDUQQDBXJXLQ-UHFFFAOYSA-N 0.000 abstract 1
- 206010015150 Erythema Diseases 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000002439 hemostatic effect Effects 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 10
- 208000024283 Gingival haemorrhages Diseases 0.000 description 4
- 230000002364 anti-haemorrhagic effect Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 241000186044 Actinomyces viscosus Species 0.000 description 1
- 208000000412 Avitaminosis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 241000605861 Prevotella Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to compound medicinal toothpaste, which takes an abrasive, a humectant and deionized water as main components, and is at least added with the combination of tranexamic acid, organic acid zinc, usnic acid and/or usnate. The toothpaste has strong functions of hemostasis, antibiosis and anti-inflammation by adopting a mode of combining tranexamic acid, pinonic acid and/or pinonate and zinc ions, can quickly prevent gingival bleeding, and effectively relieves symptoms such as redness and swelling of gingiva, oral ulcer, dental plaque and the like; meanwhile, the introduced magnolol can generate a synergistic effect with the formula, so that the antibacterial and hemostatic effects of the toothpaste are further improved.
Description
Technical field
The present invention relates to a kind of toothpaste, be specifically related to a kind of composite medicinal toothpaste.
Background technology
Gingivitis is common periodontal tissue disease, owing to not noting oral hygiene, tooth is subject to the long-time stimulus caused by tartar of soft tartar that the things such as around teeth food debris, antibacterial form and hard, and incorrect tooth-brushing habit, and the reasons such as vitamin deficiency caused.35 years old ~ 44 years old age bracket crowd periodontal health rate in the whole nation is 14.5%, and city is higher than rural area, and women is higher than male, and west area is the highest; Gingival hemorrhage recall rate is 77.3%, has the tooth number of gingival hemorrhage to be 8.77 per capita, women higher than male, town and country zero difference, middle part is the highest; Periodontal pocket recall rate is 40.9%, and city is lower than rural area, and male is higher than women, and middle part is the highest; Attachment loss equals or the recall rate of 4 millimeters is 38.9%, and male is higher than women, and town and country zero difference, eastern region is the highest.
Also there is the uneven medicated toothpaste of some quality in the market, but the fungistatic effect of some toothpaste is poor, really cannot realizes effect of anti-inflammation.
Summary of the invention
For the deficiencies in the prior art part, the object of the present invention is to provide a kind of composite medicinal toothpaste, it can play and prevent gingival hemorrhage fast, effectively suppresses the object of oral cavity bacterium.
Technical scheme of the present invention is summarized as follows:
A kind of composite medicinal toothpaste, it for main component, and is at least added with the combination of tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate with abrasivus, wetting agent and deionized water.
Preferably, described composite medicinal toothpaste, wherein, the content of described tranexamic acid is 0.01 ~ 1wt%.
Preferably, described composite medicinal toothpaste, wherein, the content of described organic acid zinc is 0.01 ~ 5wt%, and described organic acid zinc is selected from zinc citrate, zinc gluconate, D-lactic acid zinc or its combination.
Preferably, described composite medicinal toothpaste, wherein, the total content of described usnic acid and Usnea hydrochlorate is 0.01 ~ 10wt%, and described Usnea hydrochlorate is selected from usnic acid sodium, usnic acid potassium or its combination.
Preferably, described composite medicinal toothpaste, wherein, described abrasivus is selected from calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydrated silica, aluminium hydroxide or its combination; The content of described abrasivus is 10 ~ 30wt%;
Described wetting agent is selected from glycerol, sorbitol, propylene glycol, Polyethylene Glycol or its combination; The content of described wetting agent is 30 ~ 50wt%.
Preferably, described composite medicinal toothpaste, wherein, also comprises binding agent, surfactant, sweeting agent, essence, freshener and antiseptic.
Preferably, described composite medicinal toothpaste, wherein, described binding agent is selected from guar gum, carrageenan, xanthan gum, sodium carboxymethyl cellulose, aluminium-magnesium silicate, sodium alginate, cellulose gum or its combination; The content of described binding agent is 0.2 ~ 1.5wt%;
Described surfactant is selected from sodium lauryl sulfate or sodium lauryl sulphate; The content of described surfactant is 1 ~ 5wt%;
Described sweeting agent is selected from glucide, saccharin sodium, aspartame, stevioside, sucralose, xylitol or its combination; The content of described sweeting agent is 0.1 ~ 0.5wt%;
Described spice is selected from mint flavouring, Herba Menthae Rotundifoliae material, green tea spice, milk flavour, fruits spice or its combination; The content of described spice is 0.1 ~ 0.5wt%;
Described freshener is selected from Borneolum Syntheticum, Mentholum or its combination; The content of described freshener is 0.1 ~ 0.8wt%;
Described antiseptic is selected from benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methyl hydroxybenzoate, propylparaben, butoben or its combination; The content of described antiseptic is 0.05 ~ 0.5wt%.
Preferably, described composite medicinal toothpaste, wherein, also comprises the magnolol of 0.05 ~ 0.2wt%.
The invention has the beneficial effects as follows: this case adopt tranexamic acid, loose sieve acid and/or loose sieve hydrochlorate, zinc ion conbined usage mode, toothpaste is made to have very strong hemostasis, antibacterial, anti-inflammatory properties, gingival hemorrhage can be prevented fast, effectively alleviate the symptoms such as red swelling of gingiva, oral ulcer, dental plaque; Meanwhile, the magnolol of introducing can produce synergistic effect with above-mentioned formula, improves the antibacterial anti hemorrhagic effect of toothpaste further.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
This case proposes the composite medicinal toothpaste of an embodiment, and it for main component, and is at least added with the combination of tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate with abrasivus, wetting agent and deionized water.Any combination being meant to single usnic acid or single Usnea hydrochlorate or usnic acid+Usnea hydrochlorate of usnic acid and/or Usnea hydrochlorate.Tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate are inseparable organic wholes, can to mutually promote between these compositions generation synergistic effect, the antibacterial anti hemorrhagic ability of common raising toothpaste, such as, tranexamic acid can work in coordination with the anti-microbial property after improving zinc ion and usnic acid or usnic acid salt binding; Zinc ion and usnic acid or Usnea hydrochlorate also can work in coordination with the blood coagulation anthemorrhagic performance improving tranexamic acid.Further, the content of this several composition should be defined, specific as follows:
In the above-described embodiments, the content of tranexamic acid is preferably 0.01 ~ 1wt%.
In the above-described embodiments, the content of organic acid zinc is preferably 0.01 ~ 5wt%, and organic acid zinc is preferably selected from zinc citrate, zinc gluconate, D-lactic acid zinc or its combination.
In the above-described embodiments, the total content of usnic acid and Usnea hydrochlorate is preferably 0.01 ~ 10wt%, can be all usnic acid in total content or be all Usnea hydrochlorate, or any combination of usnic acid+Usnea hydrochlorate, Usnea hydrochlorate is preferably selected from usnic acid sodium, usnic acid potassium or its combination.
If the content of the some compositions in above-mentioned several composition exceeds the scope of restriction, or some compositions of leaving out wherein or have more another new ingredient, the fungistatic effect of toothpaste and haemostatic effect all will be caused to decline.
In the above-described embodiments, abrasivus is preferably selected from calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydrated silica, aluminium hydroxide or its combination; The content of abrasivus is preferably 10 ~ 30wt%;
Wetting agent is preferably selected from glycerol, sorbitol, propylene glycol, Polyethylene Glycol or its combination; The content of wetting agent is preferably 30 ~ 50wt%.
As another embodiment of this case, wherein, binding agent, surfactant, sweeting agent, essence, freshener and antiseptic is also comprised.
Wherein, binding agent is selected from guar gum, carrageenan, xanthan gum, sodium carboxymethyl cellulose, aluminium-magnesium silicate, sodium alginate, cellulose gum or its combination; The content of binding agent is 0.2 ~ 1.5wt%;
Surfactant is selected from sodium lauryl sulfate or sodium lauryl sulphate; The content of surfactant is 1 ~ 5wt%;
Sweeting agent is selected from glucide, saccharin sodium, aspartame, stevioside, sucralose, xylitol or its combination; The content of sweeting agent is 0.1 ~ 0.5wt%;
Spice is selected from mint flavouring, Herba Menthae Rotundifoliae material, green tea spice, milk flavour, fruits spice or its combination; The content of spice is 0.1 ~ 0.5wt%;
Freshener is selected from Borneolum Syntheticum, Mentholum or its combination; The content of freshener is 0.1 ~ 0.8wt%;
Antiseptic is selected from benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methyl hydroxybenzoate, propylparaben, butoben or its combination; The content of antiseptic is 0.05 ~ 0.5wt%.
As the another embodiment of this case, wherein, the magnolol of 0.05 ~ 0.2wt% is also comprised.Magnolol can work in coordination with the antibacterial ability improving tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate, but the synergistic effect of magnolol also needs by the integrity of synergistic height, lack any one in tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate or any one content in these compositions exceeds preferred scope, its synergistic effect all will be caused to reduce, even disappear.If only containing a kind of composition of magnolol in toothpaste, the antibacterial anti hemorrhagic function that it shows is very faint; The content of magnolol also should be restricted, and exceeds preferred scope, and its synergistic effect can be made to be affected.
Table one lists concrete composition and the content thereof of different embodiment and comparative example, and the surplus wherein outside each composition is deionized water, and the summation of each composition and deionized water is 100%, omits deionized water in table one.
Table one
Porphyromonas gingivalis, Prevotella, actinomyces viscosus, escherichia coli, these five kinds of bacterium of staphylococcus aureus carry out antibacterial experiment with reference to GB15979-2002 appendix C 3 are chosen in this case.
Table two lists the antibacterial experiment result of embodiment 1,2 and comparative example 1,2.
Table two
Table three lists the antibacterial experiment result of embodiment 3,4 and comparative example 3,4.
Table three
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and shown here embodiment.
Claims (8)
1. a composite medicinal toothpaste, is characterized in that, it for main component, and is at least added with the combination of tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate with abrasivus, wetting agent and deionized water.
2. composite medicinal toothpaste according to claim 1, is characterized in that, the content of described tranexamic acid is 0.01 ~ 1wt%.
3. composite medicinal toothpaste according to claim 1, is characterized in that, the content of described organic acid zinc is 0.01 ~ 5wt%, and described organic acid zinc is selected from zinc citrate, zinc gluconate, D-lactic acid zinc or its combination.
4. composite medicinal toothpaste according to claim 1, is characterized in that, the total content of described usnic acid and Usnea hydrochlorate is 0.01 ~ 10wt%, and described Usnea hydrochlorate is selected from usnic acid sodium, usnic acid potassium or its combination.
5. composite medicinal toothpaste according to claim 1, is characterized in that, described abrasivus is selected from calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydrated silica, aluminium hydroxide or its combination; The content of described abrasivus is 10 ~ 30wt%;
Described wetting agent is selected from glycerol, sorbitol, propylene glycol, Polyethylene Glycol or its combination; The content of described wetting agent is 30 ~ 50wt%.
6. composite medicinal toothpaste according to claim 1, is characterized in that, also comprises binding agent, surfactant, sweeting agent, essence, freshener and antiseptic.
7. composite medicinal toothpaste according to claim 6, is characterized in that, described binding agent is selected from guar gum, carrageenan, xanthan gum, sodium carboxymethyl cellulose, aluminium-magnesium silicate, sodium alginate, cellulose gum or its combination; The content of described binding agent is 0.2 ~ 1.5wt%;
Described surfactant is selected from sodium lauryl sulfate or sodium lauryl sulphate; The content of described surfactant is 1 ~ 5wt%;
Described sweeting agent is selected from glucide, saccharin sodium, aspartame, stevioside, sucralose, xylitol or its combination; The content of described sweeting agent is 0.1 ~ 0.5wt%;
Described spice is selected from mint flavouring, Herba Menthae Rotundifoliae material, green tea spice, milk flavour, fruits spice or its combination; The content of described spice is 0.1 ~ 0.5wt%;
Described freshener is selected from Borneolum Syntheticum, Mentholum or its combination; The content of described freshener is 0.1 ~ 0.8wt%;
Described antiseptic is selected from benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methyl hydroxybenzoate, propylparaben, butoben or its combination; The content of described antiseptic is 0.05 ~ 0.5wt%.
8. composite medicinal toothpaste according to claim 1, is characterized in that, also comprises the magnolol of 0.05 ~ 0.2wt%.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
WO2019018588A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Zinc:usnic acid complexes, oral care compositions and methods of use |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1803123A (en) * | 2001-01-18 | 2006-07-19 | 株式会社资生堂 | Process for producing dry water |
CN101578045A (en) * | 2006-12-26 | 2009-11-11 | 斯特里莱克斯科技有限责任公司 | Antimicrobial compositions |
CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
CN101973973A (en) * | 2010-07-26 | 2011-02-16 | 南京泽朗农业发展有限公司 | Method for extracting usnic acid from sun-lo |
-
2015
- 2015-12-10 CN CN201510916722.6A patent/CN105411871A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1803123A (en) * | 2001-01-18 | 2006-07-19 | 株式会社资生堂 | Process for producing dry water |
CN101578045A (en) * | 2006-12-26 | 2009-11-11 | 斯特里莱克斯科技有限责任公司 | Antimicrobial compositions |
CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
CN101973973A (en) * | 2010-07-26 | 2011-02-16 | 南京泽朗农业发展有限公司 | Method for extracting usnic acid from sun-lo |
Non-Patent Citations (1)
Title |
---|
刘青云主编: "《全国高等医药院校中医药系列教材 中药药理学 供中医药类专业本、专科及成人教育用 第2版》", 31 December 1997, 人民卫生出版社 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
WO2019018588A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Zinc:usnic acid complexes, oral care compositions and methods of use |
CN110868991A (en) * | 2017-07-19 | 2020-03-06 | 高露洁-棕榄公司 | Contains zinc: lichenin complex personal care compositions and methods of use |
CN110868992A (en) * | 2017-07-19 | 2020-03-06 | 高露洁-棕榄公司 | Zinc: lichenin complex, oral care compositions and methods of use |
AU2018302183B2 (en) * | 2017-07-19 | 2020-08-13 | Colgate-Palmolive Company | Zinc:usnic acid complexes, oral care compositions and methods of use |
AU2018304125B2 (en) * | 2017-07-19 | 2020-08-27 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
US11517512B2 (en) | 2017-07-19 | 2022-12-06 | Colgate-Palmolive Company | Personal care compositions comprising zinc : usnic acid complexes and methods of use |
CN110868991B (en) * | 2017-07-19 | 2023-06-20 | 高露洁-棕榄公司 | Comprises zinc: personal care compositions of lichen acid complexes and methods of use |
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