CN105411871A - Compound medicine toothpaste - Google Patents
Compound medicine toothpaste Download PDFInfo
- Publication number
- CN105411871A CN105411871A CN201510916722.6A CN201510916722A CN105411871A CN 105411871 A CN105411871 A CN 105411871A CN 201510916722 A CN201510916722 A CN 201510916722A CN 105411871 A CN105411871 A CN 105411871A
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- China
- Prior art keywords
- content
- combination
- acid
- zinc
- medicinal toothpaste
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention relates to compound medicine toothpaste. An abradant, a wetting agent and deionized water are taken as the main components, and a composition of tranexamic acid, organic acid zinc, usnic acid and/or usnic acid salt is at least added. According to the compound medicine toothpaste, by adopting the mode of combined usage of the tranexamic acid, the usnic acid and/or usnic acid salt and zinc ions, the toothpaste has the very high hemostasis, anti-bacterium and anti-inflammation functions, gingival bleeding can be quickly prevented, and the symptoms such as red and swollen gums, oral ulcer and dental plaque are effectively relieved; meanwhile, introduced magnolol can generate the synergistic effect with the formula, and then the anti-bacterium and hemostasis effects of the toothpaste are further improved.
Description
Technical field
The present invention relates to a kind of toothpaste, be specifically related to a kind of composite medicinal toothpaste.
Background technology
Gingivitis is common periodontal tissue disease, owing to not noting oral hygiene, tooth is subject to the long-time stimulus caused by tartar of soft tartar that the things such as around teeth food debris, antibacterial form and hard, and incorrect tooth-brushing habit, and the reasons such as vitamin deficiency caused.35 years old ~ 44 years old age bracket crowd periodontal health rate in the whole nation is 14.5%, and city is higher than rural area, and women is higher than male, and west area is the highest; Gingival hemorrhage recall rate is 77.3%, has the tooth number of gingival hemorrhage to be 8.77 per capita, women higher than male, town and country zero difference, middle part is the highest; Periodontal pocket recall rate is 40.9%, and city is lower than rural area, and male is higher than women, and middle part is the highest; Attachment loss equals or the recall rate of 4 millimeters is 38.9%, and male is higher than women, and town and country zero difference, eastern region is the highest.
Also there is the uneven medicated toothpaste of some quality in the market, but the fungistatic effect of some toothpaste is poor, really cannot realizes effect of anti-inflammation.
Summary of the invention
For the deficiencies in the prior art part, the object of the present invention is to provide a kind of composite medicinal toothpaste, it can play and prevent gingival hemorrhage fast, effectively suppresses the object of oral cavity bacterium.
Technical scheme of the present invention is summarized as follows:
A kind of composite medicinal toothpaste, it for main component, and is at least added with the combination of tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate with abrasivus, wetting agent and deionized water.
Preferably, described composite medicinal toothpaste, wherein, the content of described tranexamic acid is 0.01 ~ 1wt%.
Preferably, described composite medicinal toothpaste, wherein, the content of described organic acid zinc is 0.01 ~ 5wt%, and described organic acid zinc is selected from zinc citrate, zinc gluconate, D-lactic acid zinc or its combination.
Preferably, described composite medicinal toothpaste, wherein, the total content of described usnic acid and Usnea hydrochlorate is 0.01 ~ 10wt%, and described Usnea hydrochlorate is selected from usnic acid sodium, usnic acid potassium or its combination.
Preferably, described composite medicinal toothpaste, wherein, described abrasivus is selected from calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydrated silica, aluminium hydroxide or its combination; The content of described abrasivus is 10 ~ 30wt%;
Described wetting agent is selected from glycerol, sorbitol, propylene glycol, Polyethylene Glycol or its combination; The content of described wetting agent is 30 ~ 50wt%.
Preferably, described composite medicinal toothpaste, wherein, also comprises binding agent, surfactant, sweeting agent, essence, freshener and antiseptic.
Preferably, described composite medicinal toothpaste, wherein, described binding agent is selected from guar gum, carrageenan, xanthan gum, sodium carboxymethyl cellulose, aluminium-magnesium silicate, sodium alginate, cellulose gum or its combination; The content of described binding agent is 0.2 ~ 1.5wt%;
Described surfactant is selected from sodium lauryl sulfate or sodium lauryl sulphate; The content of described surfactant is 1 ~ 5wt%;
Described sweeting agent is selected from glucide, saccharin sodium, aspartame, stevioside, sucralose, xylitol or its combination; The content of described sweeting agent is 0.1 ~ 0.5wt%;
Described spice is selected from mint flavouring, Herba Menthae Rotundifoliae material, green tea spice, milk flavour, fruits spice or its combination; The content of described spice is 0.1 ~ 0.5wt%;
Described freshener is selected from Borneolum Syntheticum, Mentholum or its combination; The content of described freshener is 0.1 ~ 0.8wt%;
Described antiseptic is selected from benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methyl hydroxybenzoate, propylparaben, butoben or its combination; The content of described antiseptic is 0.05 ~ 0.5wt%.
Preferably, described composite medicinal toothpaste, wherein, also comprises the magnolol of 0.05 ~ 0.2wt%.
The invention has the beneficial effects as follows: this case adopt tranexamic acid, loose sieve acid and/or loose sieve hydrochlorate, zinc ion conbined usage mode, toothpaste is made to have very strong hemostasis, antibacterial, anti-inflammatory properties, gingival hemorrhage can be prevented fast, effectively alleviate the symptoms such as red swelling of gingiva, oral ulcer, dental plaque; Meanwhile, the magnolol of introducing can produce synergistic effect with above-mentioned formula, improves the antibacterial anti hemorrhagic effect of toothpaste further.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
This case proposes the composite medicinal toothpaste of an embodiment, and it for main component, and is at least added with the combination of tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate with abrasivus, wetting agent and deionized water.Any combination being meant to single usnic acid or single Usnea hydrochlorate or usnic acid+Usnea hydrochlorate of usnic acid and/or Usnea hydrochlorate.Tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate are inseparable organic wholes, can to mutually promote between these compositions generation synergistic effect, the antibacterial anti hemorrhagic ability of common raising toothpaste, such as, tranexamic acid can work in coordination with the anti-microbial property after improving zinc ion and usnic acid or usnic acid salt binding; Zinc ion and usnic acid or Usnea hydrochlorate also can work in coordination with the blood coagulation anthemorrhagic performance improving tranexamic acid.Further, the content of this several composition should be defined, specific as follows:
In the above-described embodiments, the content of tranexamic acid is preferably 0.01 ~ 1wt%.
In the above-described embodiments, the content of organic acid zinc is preferably 0.01 ~ 5wt%, and organic acid zinc is preferably selected from zinc citrate, zinc gluconate, D-lactic acid zinc or its combination.
In the above-described embodiments, the total content of usnic acid and Usnea hydrochlorate is preferably 0.01 ~ 10wt%, can be all usnic acid in total content or be all Usnea hydrochlorate, or any combination of usnic acid+Usnea hydrochlorate, Usnea hydrochlorate is preferably selected from usnic acid sodium, usnic acid potassium or its combination.
If the content of the some compositions in above-mentioned several composition exceeds the scope of restriction, or some compositions of leaving out wherein or have more another new ingredient, the fungistatic effect of toothpaste and haemostatic effect all will be caused to decline.
In the above-described embodiments, abrasivus is preferably selected from calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydrated silica, aluminium hydroxide or its combination; The content of abrasivus is preferably 10 ~ 30wt%;
Wetting agent is preferably selected from glycerol, sorbitol, propylene glycol, Polyethylene Glycol or its combination; The content of wetting agent is preferably 30 ~ 50wt%.
As another embodiment of this case, wherein, binding agent, surfactant, sweeting agent, essence, freshener and antiseptic is also comprised.
Wherein, binding agent is selected from guar gum, carrageenan, xanthan gum, sodium carboxymethyl cellulose, aluminium-magnesium silicate, sodium alginate, cellulose gum or its combination; The content of binding agent is 0.2 ~ 1.5wt%;
Surfactant is selected from sodium lauryl sulfate or sodium lauryl sulphate; The content of surfactant is 1 ~ 5wt%;
Sweeting agent is selected from glucide, saccharin sodium, aspartame, stevioside, sucralose, xylitol or its combination; The content of sweeting agent is 0.1 ~ 0.5wt%;
Spice is selected from mint flavouring, Herba Menthae Rotundifoliae material, green tea spice, milk flavour, fruits spice or its combination; The content of spice is 0.1 ~ 0.5wt%;
Freshener is selected from Borneolum Syntheticum, Mentholum or its combination; The content of freshener is 0.1 ~ 0.8wt%;
Antiseptic is selected from benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methyl hydroxybenzoate, propylparaben, butoben or its combination; The content of antiseptic is 0.05 ~ 0.5wt%.
As the another embodiment of this case, wherein, the magnolol of 0.05 ~ 0.2wt% is also comprised.Magnolol can work in coordination with the antibacterial ability improving tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate, but the synergistic effect of magnolol also needs by the integrity of synergistic height, lack any one in tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate or any one content in these compositions exceeds preferred scope, its synergistic effect all will be caused to reduce, even disappear.If only containing a kind of composition of magnolol in toothpaste, the antibacterial anti hemorrhagic function that it shows is very faint; The content of magnolol also should be restricted, and exceeds preferred scope, and its synergistic effect can be made to be affected.
Table one lists concrete composition and the content thereof of different embodiment and comparative example, and the surplus wherein outside each composition is deionized water, and the summation of each composition and deionized water is 100%, omits deionized water in table one.
Table one
Porphyromonas gingivalis, Prevotella, actinomyces viscosus, escherichia coli, these five kinds of bacterium of staphylococcus aureus carry out antibacterial experiment with reference to GB15979-2002 appendix C 3 are chosen in this case.
Table two lists the antibacterial experiment result of embodiment 1,2 and comparative example 1,2.
Table two
Table three lists the antibacterial experiment result of embodiment 3,4 and comparative example 3,4.
Table three
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and shown here embodiment.
Claims (8)
1. a composite medicinal toothpaste, is characterized in that, it for main component, and is at least added with the combination of tranexamic acid, organic acid zinc, usnic acid and/or Usnea hydrochlorate with abrasivus, wetting agent and deionized water.
2. composite medicinal toothpaste according to claim 1, is characterized in that, the content of described tranexamic acid is 0.01 ~ 1wt%.
3. composite medicinal toothpaste according to claim 1, is characterized in that, the content of described organic acid zinc is 0.01 ~ 5wt%, and described organic acid zinc is selected from zinc citrate, zinc gluconate, D-lactic acid zinc or its combination.
4. composite medicinal toothpaste according to claim 1, is characterized in that, the total content of described usnic acid and Usnea hydrochlorate is 0.01 ~ 10wt%, and described Usnea hydrochlorate is selected from usnic acid sodium, usnic acid potassium or its combination.
5. composite medicinal toothpaste according to claim 1, is characterized in that, described abrasivus is selected from calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydrated silica, aluminium hydroxide or its combination; The content of described abrasivus is 10 ~ 30wt%;
Described wetting agent is selected from glycerol, sorbitol, propylene glycol, Polyethylene Glycol or its combination; The content of described wetting agent is 30 ~ 50wt%.
6. composite medicinal toothpaste according to claim 1, is characterized in that, also comprises binding agent, surfactant, sweeting agent, essence, freshener and antiseptic.
7. composite medicinal toothpaste according to claim 6, is characterized in that, described binding agent is selected from guar gum, carrageenan, xanthan gum, sodium carboxymethyl cellulose, aluminium-magnesium silicate, sodium alginate, cellulose gum or its combination; The content of described binding agent is 0.2 ~ 1.5wt%;
Described surfactant is selected from sodium lauryl sulfate or sodium lauryl sulphate; The content of described surfactant is 1 ~ 5wt%;
Described sweeting agent is selected from glucide, saccharin sodium, aspartame, stevioside, sucralose, xylitol or its combination; The content of described sweeting agent is 0.1 ~ 0.5wt%;
Described spice is selected from mint flavouring, Herba Menthae Rotundifoliae material, green tea spice, milk flavour, fruits spice or its combination; The content of described spice is 0.1 ~ 0.5wt%;
Described freshener is selected from Borneolum Syntheticum, Mentholum or its combination; The content of described freshener is 0.1 ~ 0.8wt%;
Described antiseptic is selected from benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methyl hydroxybenzoate, propylparaben, butoben or its combination; The content of described antiseptic is 0.05 ~ 0.5wt%.
8. composite medicinal toothpaste according to claim 1, is characterized in that, also comprises the magnolol of 0.05 ~ 0.2wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510916722.6A CN105411871A (en) | 2015-12-10 | 2015-12-10 | Compound medicine toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510916722.6A CN105411871A (en) | 2015-12-10 | 2015-12-10 | Compound medicine toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105411871A true CN105411871A (en) | 2016-03-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510916722.6A Pending CN105411871A (en) | 2015-12-10 | 2015-12-10 | Compound medicine toothpaste |
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| CN (1) | CN105411871A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018588A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Zinc:usnic acid complexes, oral care compositions and methods of use |
| WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803123A (en) * | 2001-01-18 | 2006-07-19 | 株式会社资生堂 | Process for producing dry water |
| CN101578045A (en) * | 2006-12-26 | 2009-11-11 | 斯特里莱克斯科技有限责任公司 | Antimicrobial compositions |
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN101973973A (en) * | 2010-07-26 | 2011-02-16 | 南京泽朗农业发展有限公司 | Method for extracting usnic acid from sun-lo |
-
2015
- 2015-12-10 CN CN201510916722.6A patent/CN105411871A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803123A (en) * | 2001-01-18 | 2006-07-19 | 株式会社资生堂 | Process for producing dry water |
| CN101578045A (en) * | 2006-12-26 | 2009-11-11 | 斯特里莱克斯科技有限责任公司 | Antimicrobial compositions |
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN101973973A (en) * | 2010-07-26 | 2011-02-16 | 南京泽朗农业发展有限公司 | Method for extracting usnic acid from sun-lo |
Non-Patent Citations (1)
| Title |
|---|
| 刘青云主编: "《全国高等医药院校中医药系列教材 中药药理学 供中医药类专业本、专科及成人教育用 第2版》", 31 December 1997, 人民卫生出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018588A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Zinc:usnic acid complexes, oral care compositions and methods of use |
| WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
| CN110868992A (en) * | 2017-07-19 | 2020-03-06 | 高露洁-棕榄公司 | Zinc: lichenin complex, oral care compositions and methods of use |
| CN110868991A (en) * | 2017-07-19 | 2020-03-06 | 高露洁-棕榄公司 | Contains zinc: lichenin complex personal care compositions and methods of use |
| AU2018302183B2 (en) * | 2017-07-19 | 2020-08-13 | Colgate-Palmolive Company | Zinc:usnic acid complexes, oral care compositions and methods of use |
| AU2018304125B2 (en) * | 2017-07-19 | 2020-08-27 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
| US11517512B2 (en) | 2017-07-19 | 2022-12-06 | Colgate-Palmolive Company | Personal care compositions comprising zinc : usnic acid complexes and methods of use |
| CN110868991B (en) * | 2017-07-19 | 2023-06-20 | 高露洁-棕榄公司 | Comprises zinc: personal care compositions of lichen acid complexes and methods of use |
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Application publication date: 20160323 |