CN105410508A - Health food and preparation method thereof - Google Patents

Health food and preparation method thereof Download PDF

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Publication number
CN105410508A
CN105410508A CN201410451824.0A CN201410451824A CN105410508A CN 105410508 A CN105410508 A CN 105410508A CN 201410451824 A CN201410451824 A CN 201410451824A CN 105410508 A CN105410508 A CN 105410508A
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parts
health food
gross weight
extract
powder
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Inventor
刘楚新
郑堰心
刘欢
李超
肖丽萍
王俊
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BGI Shenzhen Co Ltd
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BGI Shenzhen Co Ltd
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Priority to CN201410451824.0A priority Critical patent/CN105410508A/en
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Abstract

The present invention relates to the field of biomedicine, and discloses a health food with the function of assisted blood fat lowering, and a preparation method thereof. The health food comprises, by weight, 2-6 parts of panax notoginseng, 6-10 parts of salvia miltiorrhiza, 6-8 parts of ganoderma lucidum, 4-10 parts of hawthorn, 3-6 parts of milkvetch root, 4-8 parts of Chinese wolfberry, 4-10 parts of ziziphus jujuba mill.var.spinosa, and 6-12 parts of tuckahoe. According to the present invention, on the basis of the traditional Chinese medicine syndrome differentiation treatment, the latest modern scientific research results are combined, the results of the assisted blood far lowering function tests and the assisted blood fat lowering human feeding tests show that the health food has the assisted blood fat lowering function, and the health food has characteristics of exact treatment effect, easy taking, safety, reliability and the like, is suitable for middle and old age having high blood fat, and can be taken for a long time.

Description

A kind of health food and preparation method thereof
Technical field
The present invention relates to biomedicine field, particularly relate to health food of a kind of blood-fat-decreasing and preparation method thereof.
Background technology
Hyperlipidemia can be divided into primary and Secondary cases two class.Primary is relevant with heredity, is due to single-gene defect or polygenes defect, makes the acceptor of the transhipment of participation lipoprotein and metabolism, enzyme or apolipoprotein caused by abnormal, or passes through unknown mechanism due to environmental factor (diet, nutrition, medicine) and cause.Secondary cases is multiple is born in metabolic disorder disease (diabetes, hypertension, myxoedema, hypothyroidism, obesity, liver and kidney disease, adrenal cortex function are hyperfunction), or with other factors, as age, sex, season, drink, smoking, diet, physical exertion, mental status, mood etc. be relevant.
Hyperlipemia is a kind of systemic disease, refers to T-CHOL in blood (TC) and/or triglycerides (TG) is too high or HDL-C (HDL-C) is too low, and modern medicine is referred to as dyslipidemia.Lipid is insoluble or be slightly soluble in water, must exist with protein bound with lipoprotein form, and therefore, hyperlipemia is usually also referred to as hyperlipoprotememia.The current high fat of blood incidence of disease is high, has had a strong impact on life-span and the quality of life of people.The object of hyperlipemia therapeutic is intended to by reducing blood lipid level, with the incidence of the illness rate and angiocardiopathy that reduce coronary heart disease further.
Pseudo-ginseng: warm in nature, taste is pungent, has scattered silt hemostasis, effect of detumescence ding-tong, and wherein flavone compound has the effect, sitosterol and the reducing blood lipid of Daucosterol energy that improve myocardial blood supply, increase vessel wall elasticity, coronary artery dilator.
The red sage root: property is bitter, is slightly cold.The thoughts of returning home, pericardium, Liver Channel.Primary efficacy: promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood disappears carbuncle, and relieving restlessness is calmed the nerves.Containing various tanshinone, aldehyde, acids.Pharmacological action: can improve hemorheological property, reduces blood viscosity, suppresses blood platelet and coagulation function, activates fibrinolytic, to antithrombus formation; Erythrocyte membrane can be protected; Energy adjusting blood lipid, suppresses the formation of atherosclerotic plaque.
Hawthorn: property is sour, sweet, tepor.Return spleen, stomach, Liver Channel.Primary efficacy: promoting digestion and removing indigestion, promoting the circulation of qi is fallen apart the stasis of blood.Containing flavonoids, triterpene saponin.Pharmacological action: institute's fatty acids can promote fat digestion, and increases the secretion of peptic digest enzyme, has certain opsonic action to gastrointestinal function.Its extract energy coronary artery dilator, increases coronary flow, Ischemic myocardium anoxic; Reducing blood lipid, antiatherosclerosis, it reduces serum cholesterol and triglycerides, may be that the excretion increasing cholesterol realizes by improving serum middle-high density cholesterol and subfraction concentration thereof.
The Radix Astragali: sweet, tepor.Return spleen, lung channel.Have invigorating the spleen bowl spares, yang invigorating, benefit defends solid table, diuresis, promoting pus discharge and tissue regeneration.。Modern pharmacology research shows: the Radix Astragali can raise hypoglycemia, reduces hyperglycaemia; Can strengthen and conditioner body immunity function, reduce blood pressure, reduce thrombosis; The effect such as also have reducing blood lipid, anti-ageing, anti anoxia, radioresistance, protect the liver.
Matrimony vine: property is sweet, flat, return liver, kidney channel.Effect: nourishing liver and kidney, the benefiting shrewd head Radix Astragali.Pharmacological action: the fruit of Chinese wolfberry has facilitation to immunity, anti-ageing, anti-sudden change in addition, antitumor, reducing blood lipid, protect the liver and AFL, hypoglycemic, hypotensive activity.
Spina date seed: property is sweet, sour, flat, the thoughts of returning home, liver, gallbladder channel.Effect: beneficial liver of nourishing heart, calms the nerves, arrest sweating.Pharmacological action: contained by spina date seed, saponin(e, flavonoid glycoside have tranquilizing soporific and antiarrhythmic effect, and the central inhibitory action of barbiturate can be worked in coordination with; Anticonvulsion, the analgesia in addition of its decocting liquid and alcohol extract, body-temp. reducing, hypotensive effect; In addition, spina date seed can also reducing blood lipid, anti anoxia, antitumor, Antiaggregating activity on platelet, strengthen immunologic function, excited uterus.
Poria cocos: property is sweet, light is flat.The thoughts of returning home, spleen, kidney channel.Effect: inducing diuresis for removing edema, excreting dampness, invigorating the spleen, Ning Xin.Main component is β-pachyman.Pharmacological action: Poria cocos decoction, syrup, alcohol extract, ether extract have diuresis, calmness, antitumor, hypoglycemic, increase the effect of myocardial contractive power.Pachymaran has the effect strengthening immunologic function.
Glossy ganoderma: property is sweet, flat.The thoughts of returning home, lung, liver, kidney channel.Effect: invigorating qi for tranquilization, relieving cough and asthma.Pharmacological action: GL-B has immunological regulation, hypoglycemic, reducing blood lipid, anti-oxidant, anti-ageing and antitumor action.
Summary of the invention
The object of the invention is the health food that a kind of adjusting blood lipid of Be very effective is provided for the present situation in blood fat control.The action effect that health food of the present invention combines according to the proportioning of science is better than single component.
For realizing above object, the present invention adopts following technical scheme:
Have a health food for adjusting blood lipid, described health food comprises pseudo-ginseng, the red sage root, glossy ganoderma, hawthorn, the Radix Astragali, matrimony vine, spina date seed, and Poria cocos forms according to special ratios mixed preparing.
Wherein, pseudo-ginseng 2-6 part, red sage root 6-10 part, glossy ganoderma 6-8 part, hawthorn 4-10 part, Radix Astragali 3-6 part, matrimony vine 4-8 part, spina date seed 4-10 part, Poria cocos 6-12 part.
In the present invention, the formulation of described health food can be tablet, pill, granule, capsule or oral liquid.
In the present invention, the preparation method of described health food comprises:
(1) get fresh pseudo-ginseng, the red sage root, glossy ganoderma, hawthorn, the Radix Astragali, matrimony vine, spina date seed, Poria cocos, mix in proportion, clean, pulverize, for subsequent use;
(2) in step (1) gained powder, add 70 volume % ethanol of 10 times of weight, extract 3 times continuously, each 30 minutes;
(3) extract of combining step (2) gained, leaves standstill, and filter, reduced pressure concentration, freeze drying obtains extract powder, for subsequent use; The temperature wherein arranged in drying is 60 DEG C, and vacuum pressure is-0.08MPa, and vacuum drying obtains extract powder.
Further, in order to make granule, also comprise following preparation process:
Get described extract dry powder, add the dextrin of gross weight 10%, the mogroside of 10%, mixing, uses 80% alcohol granulation, dry, whole grain, and pack, is prepared into granule.
Further, in order to make tablet, also comprise following preparation process:
Get described extract dry powder, add the starch of gross weight 10%, mix, use 80% alcohol granulation, dry, whole grain, through the quantitative compressing tablet of tablet press machine, in 60 DEG C of dry 3-4h, is packaged into tablet.
Further, in order to make soft capsule, also comprise following preparation process:
Get described extract dry powder, add gross weight 10% starch, the mogroside of gross weight 10%, mix and prepare burden as the capsule heart, appropriate demineralized water, is heated to about 60 DEG C, adds after edible gelatin dissolves and adds edible glycerol again, stir, pellet press carries out pelleting, then through sizing; Wash ball, dry process, obtain soft capsule.
Further, in order to make hard shell capsules, also comprise following preparation process:
Get described extract dry powder, gross weight 20% dextrin, mixing, granulate in granulator, whole grain, then adds gross weight 1% pearl powder, and after mixing, Autocapsulefillingmachine is filled, and obtains hard shell capsules.
Further, in order to make oral liquid, also comprise following preparation process:
Get above-mentioned extract dry powder, add the mogroside of gross weight 10%, mixing, adds sterilized water according to 1:5 (weight/volume), filters, and clarification is filling with bottle placer, obtains oral liquid.
In the present invention, in order to make tea in bag, described method comprises following preparation process:
Raw material is dried to water content respectively by proportioning weight and is less than 4%, pulverize, mixing, cross 40 mesh sieves, add the mogroside of gross weight 10%, mixing, on infrared drying oven, 60 DEG C of dry disinfection 30min, are packaged to be tea in bag.
Beneficial effect of the present invention is:
Health food of the present invention shows can significantly reduce serum total cholesterol and content of triglyceride through animal and human's test-meal experiment, and improve hdl concentration, the effect of auxiliary antilipemic is fine.
The present invention selects that have can the Chinese herbal medicine of remarkable adjusting blood lipid, forms, thus ensure effect of its auxiliary antilipemic through scientific matching, and edible safety.For the character of raw material, adopt rational extraction process, its active ingredient is farthest retained.This flow process is succinct, practical, is applicable to big or middle large-scale production.
Detailed description of the invention
Describe health food of the present invention and preparation method thereof in detail below by specific embodiment, following embodiment is only exemplary, not should be understood to limiting the scope of the invention.
Embodiment 1: pulp furnish and production technology
(1) main raw materials in proportion: pseudo-ginseng 6 parts, the red sage root 6 parts, glossy ganoderma 6 parts, hawthorn 4 parts, the Radix Astragali 3 parts, matrimony vine 4 parts, spina date seed 4 parts, 6 parts, Poria cocos, mixes raw material, pulverizes.
(2) in step (1) gained powder, add 70 volume % ethanol of 10 times of weight, extract 3 times continuously, each 30 minutes.
(3) extract of combining step (2) gained, leaves standstill, and filter, reduced pressure concentration, freeze drying obtains extract powder, for subsequent use; Wherein, the temperature arranged in drying is 60 DEG C, and vacuum pressure is-0.08MPa, and vacuum drying obtains extract powder.
Embodiment 2: tablet
The extract dry powder of Example 1, adds the starch of gross weight 10%, mixes, and uses 80% alcohol granulation, and dry, whole grain, through the quantitative compressing tablet of tablet press machine, in 60 DEG C of dry 3-4h, is packaged into tablet.
Embodiment 3: granule
The extract dry powder of Example 1, adds the dextrin of gross weight 10%, the mogroside of 10%, and mixing, uses 80% alcohol granulation, dry, whole grain, and pack, is prepared into granule.
Embodiment 4: soft capsule
The extract dry powder of Example 1, adds gross weight 10% starch, the mogroside of gross weight 10%, mixes and prepares burden as the capsule heart, appropriate demineralized water, is heated to about 60 DEG C, adds after edible gelatin dissolves and adds edible glycerol again, stir, pellet press carries out pelleting, then through sizing; Wash ball, dry process, obtain soft capsule.
Embodiment 5: hard shell capsules
The extract dry powder of Example 1, gross weight 20% dextrin, mixing, granulate in granulator, whole grain, then adds gross weight 1% pearl powder, and after mixing, Autocapsulefillingmachine is filled, and obtains hard shell capsules.
Embodiment 6: oral liquid
The extract dry powder of Example 1, adds the mogroside of gross weight 10%, and mixing, adds sterilized water according to 1:5 (weight/volume), filters, and clarification is filling with bottle placer, obtains oral liquid.
Embodiment 7: tea in bag
By pseudo-ginseng 6 parts, the red sage root 6 parts, glossy ganoderma 6 parts, hawthorn 4 parts, the Radix Astragali 3 parts, matrimony vine 4 parts, spina date seed 4 parts, 6 parts, Poria cocos, is dried to water content respectively by proportioning weight and is less than 4%, pulverize, mixing, cross 40 mesh sieves, add the mogroside of gross weight 10%, mixing, on infrared drying oven, 60 DEG C of dry disinfection 30min, are packaged to be tea in bag.
Embodiment 8: pulp furnish and production technology
(1) main raw materials in proportion: pseudo-ginseng 2 parts, the red sage root 6 parts, glossy ganoderma 8 parts, hawthorn 10 parts, the Radix Astragali 3 parts, matrimony vine 4 parts, spina date seed 6 parts, 12 parts, Poria cocos.
(2) above-mentioned raw materials is mixed, pulverize, in gained powder, add 70 volume % ethanol of 10 times of weight, extract 3 times continuously, each 30 minutes.
(3) extract of combining step (2) gained, leaves standstill, and filter, reduced pressure concentration, freeze drying obtains extract powder, for subsequent use; Wherein, the temperature arranged in drying is 60 DEG C, and vacuum pressure is-0.08MPa, and vacuum drying obtains extract powder.
The method of embodiment 2-7 is adopted to make tablet, granule, soft capsule, hard shell capsules, oral liquid or tea in bag respectively.
Embodiment 9: pulp furnish and production technology
(1) main raw materials in proportion: pseudo-ginseng 4 parts, the red sage root 10 parts, glossy ganoderma 7 parts, hawthorn 8 parts, the Radix Astragali 6 parts, matrimony vine 8 parts, spina date seed 10 parts, 8 parts, Poria cocos.
(2) above-mentioned raw materials is mixed, pulverize, in gained powder, add 70 volume % ethanol of 10 times of weight, extract 3 times continuously, each 30 minutes.
(3) extract of combining step (2) gained, leaves standstill, and filter, reduced pressure concentration, freeze drying obtains extract powder, for subsequent use; Wherein, the temperature arranged in drying is 60 DEG C, and vacuum pressure is-0.08MPa, and vacuum drying obtains extract powder.
The method of embodiment 2-7 is adopted to make tablet, granule, soft capsule, hard shell capsules, oral liquid or tea in bag respectively.
Test example 1: the test-meal of auxiliary antilipemic animal is tested
In order to check auxiliary lipid-lowering function of the present invention, test according to the Ministry of Public Health " health food inspection and assessment technical specification " (2003).
The health food obtained with embodiment 1 is for research object.
The preparation method of Hyperlipemia model rat: get healthy adult SD rat 40, continuous 30 days high lipid foods of feeding (based on high lipid food formula feed 93.8%, cholesterol 1.0%, lard 5.0%, cholate 0.2%).
Product test-meal of the present invention: Hyperlipemia model rat is divided into 4 groups at random, often organizes 10, arranges high, medium and low metering group and high lipid food control group respectively.High, medium and low dosage component is not equivalent to 30,10,5 times of the actual intake of people.Feeding, after 30 days, measures the serum total cholesterol (TC) of rat, triglycerides (TG) and HDL (HDL-C) respectively.Experimental result shows (table 1): feed through low dosage, middle metering and the high product measured, equal energy significantly reduces the concentration of T-CHOL and triglycerides (P<0.05) or extremely remarkable (P<0.01), the concentration of pole increasing high density lipoprotein significantly, illustrates that this invention has good auxiliary lipid-lowering efficacy.
The effectiveness comparison of TC, TG, HDL-C falls in table 1 different experiments group
Note: (1) * represents P<0.05; (2) * * represents P<0.01.
The result that the health food using other embodiment to obtain carries out above-mentioned animal test-meal experiment is substantially identical with the experimental result of the health food of embodiment 1.
Test example 2: auxiliary antilipemic health products human experiment is tested
According to the Ministry of Public Health " health food inspection and assessment technical specification " (2003), select the patient of 115 hyperlipemias as test-meal object, at random they are divided into control group and test-meal group two groups, wherein control group 56 example, test-meal group 59 example.Test-meal group uses the tablet obtained according to the present invention, every day 2 times, each 4; Control group takes placebo.All experimenters keeps life on ordinary days and eating habit.Test-meal, after 30 days, obtains valid data 109 example altogether, wherein control group 56 example, test-meal group 53 example.Experimental result shows, the T-CHOL of test-meal crowd and triglycerides all pole are markedly inferior to control group (P<0.01) (table 2), and fall is greater than 15%; The HDL of test-meal crowd all pole significantly higher than control group (P<0.01) (table 2).Before and after test-meal, stool and urine, blood picture and Liver and kidney function indices are all in normal range (NR), without obviously changing, this invention product are described to health without obvious damage.Pass judgment on according to the relevant rule of the Ministry of Public Health " health food inspection and assessment technical specification " (2003), this invention has effect of auxiliary antilipemic.
Table 2 test-meal crowd lipids detection result
Note: (1) * represents P<0.05; (2) * * represents P<0.01.
The result that the health food using other embodiment to obtain carries out above-mentioned human experiment experiment is substantially identical with the experimental result of the health food of embodiment 1.
Test example 3: rat, the test of chmice acute Oral toxicity, Salmonella reversion test, mouse inbred strain, the nuclear test of mouse dimension
According to the requirement of the Ministry of Public Health " health food inspection and assessment technical specification " (2003), first, second stage toxicity test is carried out to the tablet obtained by the method provided in embodiment.Result shows: first stage large and small mouse acute oral toxicity half lethal dose (LD 50) be all greater than 10000mg/Kg body weight, judge that this product belongs to non-toxic type by acute toxicity grading criteria; Second stage Salmonella reversion test result is negative; The nuclear test of bone marrow cells in mice dimension and mouse inbred strain result are also negative.These results show, this product does not show mutagenicity.
Test example 4: rat 30 days feeding trials
According to the requirement of the Ministry of Public Health " health food inspection and assessment technical specification " (2003), basic, normal, high three dosage groups are set, are equivalent to 25,50,100 times of people's recommended intake respectively.Within 30 days, feed after terminating, all there is not significant change in the indices of rat, shows the tablet safety non-toxic obtained according to the present invention.
Above content is in conjunction with concrete embodiment further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made.

Claims (9)

1. a health food, is characterized in that, comprises the component of following weight proportion: pseudo-ginseng 2-6 part, red sage root 6-10 part, glossy ganoderma 6-8 part, hawthorn 4-10 part, Radix Astragali 3-6 part, matrimony vine 4-8 part, spina date seed 4-10 part, Poria cocos 6-12 part.
2. health food according to claim 1, is characterized in that, the formulation of described health food is tablet, granule, soft capsule, hard shell capsules, oral liquid or tea in bag.
3. a preparation method for health food as claimed in claim 1, is characterized in that, comprises following preparation process:
(1) get fresh pseudo-ginseng, the red sage root, glossy ganoderma, hawthorn, the Radix Astragali, matrimony vine, spina date seed, Poria cocos, mix in proportion, clean, pulverize, for subsequent use;
(2) in step (1) gained powder, add 70 volume % ethanol of 10 times of weight, extract 3 times continuously, each 30 minutes;
(3) extract of combining step (2) gained, leaves standstill, and filter, reduced pressure concentration, freeze drying obtains extract powder, for subsequent use; The temperature wherein arranged in drying is 60 DEG C, and vacuum pressure is-0.08MPa, and vacuum drying obtains extract powder.
4. method according to claim 3, is characterized in that, also comprises following preparation process:
Get described extract dry powder, add the dextrin of gross weight 10%, the mogroside of 10%, mixing, uses 80% alcohol granulation, dry, whole grain, and pack, is prepared into granule.
5. method according to claim 3, is characterized in that, also comprises following preparation process:
Get described extract dry powder, add the starch of gross weight 10%, mix, use 80% alcohol granulation, dry, whole grain, through the quantitative compressing tablet of tablet press machine, in 60 DEG C of dry 3-4h, is packaged into tablet.
6. method according to claim 3, is characterized in that, also comprises following preparation process:
Get described extract dry powder, add gross weight 10% starch, the mogroside of gross weight 10%, mix and prepare burden as the capsule heart, appropriate demineralized water, is heated to about 60 DEG C, adds after edible gelatin dissolves and adds edible glycerol again, stir, pellet press carries out pelleting, then through sizing; Wash ball, dry process, obtain soft capsule.
7. method according to claim 3, is characterized in that, also comprises following preparation process:
Get described extract dry powder, gross weight 20% dextrin, mixing, granulate in granulator, whole grain, then adds gross weight 1% pearl powder, and after mixing, Autocapsulefillingmachine is filled, and obtains hard shell capsules.
8. method according to claim 3, is characterized in that, also comprises following preparation process:
Get above-mentioned extract dry powder, add the mogroside of gross weight 10%, mixing, adds sterilized water according to 1:5 (weight/volume), filters, and clarification is filling with bottle placer, obtains oral liquid.
9. prepare a method for health food as claimed in claim 1, it is characterized in that, comprise following preparation process:
Raw material is dried to water content respectively by proportioning weight and is less than 4%, pulverize, mixing, cross 40 mesh sieves, add the mogroside of gross weight 10%, mixing, on infrared drying oven, 60 DEG C of dry disinfection 30min, are packaged to be tea in bag.
CN201410451824.0A 2014-09-05 2014-09-05 Health food and preparation method thereof Pending CN105410508A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1106286A (en) * 1994-02-04 1995-08-09 湖南省国药开发总公司 Fat-reducing granules
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CN102961503A (en) * 2012-11-23 2013-03-13 西安泰科迈医药科技有限公司 Medicinal composition for improving sleep and strengthening immunity and preparation method thereof
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1106286A (en) * 1994-02-04 1995-08-09 湖南省国药开发总公司 Fat-reducing granules
CN1135308A (en) * 1995-05-05 1996-11-13 郭永年 Natural edible-plant health-care drink and preparation method thereof
CN101229312A (en) * 2007-01-23 2008-07-30 凌泰祥 Medicine compounds capable of regulating hypertension, hyperlipemia and angina
CN102961503A (en) * 2012-11-23 2013-03-13 西安泰科迈医药科技有限公司 Medicinal composition for improving sleep and strengthening immunity and preparation method thereof
CN103933219A (en) * 2014-04-04 2014-07-23 季一艮 Chinese medicinal formula for treating hyperlipidemia

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Application publication date: 20160323