CN105396021A - Preparation method of pharmaceutical paste alleviating tumor patient radiotherapy reaction - Google Patents

Preparation method of pharmaceutical paste alleviating tumor patient radiotherapy reaction Download PDF

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CN105396021A
CN105396021A CN201510898894.5A CN201510898894A CN105396021A CN 105396021 A CN105396021 A CN 105396021A CN 201510898894 A CN201510898894 A CN 201510898894A CN 105396021 A CN105396021 A CN 105396021A
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radix
rhizoma
radiotherapy
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
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Abstract

The invention discloses a preparation method of a pharmaceutical paste alleviating tumor patient radiotherapy reaction. The pharmaceutical paste is prepared from the following main raw materials by weight: 3-12 parts of Codonopsis pilosula, 6-15 parts of bighead atractylodes rhizome (stir fried with bran), 2-6 parts of white paeony root, 6-12 parts of Salvia miltiorrhiza, 5-12 parts of bletilla striata, 3-6 parts of rhubarb, 5-11 parts of clove, 3-6 parts of natural indigo, 4-8 parts of cyperus rotundus (processed with vinegar), 3-9 parts of licorice, 6-12 parts of costus root, 4-8 parts of dark plum, 3-8 parts of Kaempferia galanga, and 4-12 parts of Rhizome Pinelliae Preparata. According to the invention, the selected materials are all traditional Chinese medicines, and have no toxic or side effect. The drug sources are easily available, and the drug cost is low, thus causing no burden to patients.

Description

The preparation method of the medicament unguentum of tumor remission patient radiotherapy side effect
divisional application, original applying number 2014101448706, applying date 2014.04.12, the medicament of title tumor remission patient radiotherapy side effect and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, especially relate to a kind of medicament and preparation method of tumor remission patient radiotherapy side effect.
Background technology
Malignant tumor threatens one of human life and healthy most serious disease now, and its mortality rate occupies front three in China always.Malignant tumor not easily finds in early days, and radiotherapy is one of conventional Therapeutic Method of Advanced cancers and metastatic tumo(u)r.Radiotherapy, i.e. radiation treatment are one of large treatment meanss of cancer three.The roentgenization tumor with various different-energy, to suppress and to kill a kind of Therapeutic Method of cancerous cell.Radiotherapy can be used alone, and also can coordinate, as a part for Comprehensive Treatment, to improve the cure rate of cancer with operation, chemotherapy etc.First doing one section of radiotherapy before surgery makes tumor mass reduction a little, and original inoperable patient just can be made to win the chance of operation.Then by Palliative radiotherapy, effects such as alleviating compressing, pain relieving is reached to terminal cancer.Radiotherapy plays certain effect to the pain alleviating malignant tumor patient, but radiotherapy fundamentally can not treat malignant tumor, and radiotherapy also can produce some side effect to patient, easily causes bone marrow depression, can be there is complication such as infecting, hemorrhage in severe one, cause death.
The side reaction main manifestations of radiotherapy is:
1, tired: malignant tumor patient is at radiation period, because the time is longer, so patient just needs a large amount of some energy consuming human body.The pressure that disease is brought, comes and goes treatment every day and radiation all can cause fatigue to Normocellular impact.Most of malignant tumor patient all can be felt tired after several week is carried out in radiotherapy, and along with radiotherapy continue carry out more feeling tired.
2, diet: malignant tumor patient is when carrying out radiotherapy, and patient also there will be the problem of some diet and digestion.In patient treatment procedure, patient may not have appetite completely.
3, general reaction: show as a series of dysfunction and imbalance, as lassitude, appetite declines, and health is weak, tired, nausea and vomiting, and cold perspiration is drowsiness, distension etc. after food.
4, local response: (1) skin: dry skin shows as skin pruritus, pigmentation and decortication, can produce permanent light brown speckle.Moist cutaneous manifestations is irradiated site eczema, blister, can cause erosion, ulceration time serious.(2) mucosa reaction: slight: to show as oral mucosa redness, erythema, hyperemia, secretions reduces.Xerostomia, slightly pain, takes food less slightly.Moderate: the obvious congestion and edema of pars oralis pharyngis, mottled tunica albuginea, ulcer, have obvious pain, eating difficulties.Severe: oral mucosa is extremely congested, rotten to the corn, hemorrhage, and be fused into tunica albuginea, ulcer increases the weight of, and has purulent secretion, severe pain, can not take food, and occasionally has heating.
5, immunologic function degression :radiotherapy can damage the immune system of patient, causes immunodeficiency or decline.Immune function is as CH50, C3 complement, T cell subgroup, and NK cytoactive, interleukin II etc., all can comparatively decline to some extent before radiotherapy to some extent after radiotherapy.
Radiotherapy has certain therapeutic effect to malignant tumor, but due to the toxic and side effects of radiotherapy, especially to the suppression of hemopoietic function, body's immunity, makes many patients cannot complete its course for the treatment of, thus had a strong impact on the therapeutic effect of radiotherapy.So development can reduce the active drug of radiotherapy toxic side effect, makes malignant tumor patient accept radiotherapy, has very important value.
Malignant tumor belongs to that the traditional Chinese medical science " is amassed ", the category of " asthenia ", there is the performance of vital QI being weakened and pathogen being violent.And due to being continuous of the course of disease, the phenomenon of " the kidney usually involved in chronic disease " can be caused.After accepting radiotherapy, disease that it is weakened body resistance is more obvious, causes because vigour is impaired further: lethargy, malaise, dysphoria with feverish sensation in the chest palms and soles, say lazy language etc. less.Hinder and then feel sick indigestion and loss of appetite in stomach, hinder in kidney then dizziness and tinnitus, dedentition loss of hairs, soreness of waist foot is soft, hinders in the heart then shortness of breath and palpitation.
Publication number is CN101549154A(application number 200910031557.0) Chinese patent literature disclose a kind of radioprotective and alleviate the nutritional solution of radiotherapy side effect, this nutritional solution adds carotene, chitosan, vitamin C, vitamin E etc. by normal saline and makes.Application publication number is CN102764371A(application number 201210283513.9) Chinese patent literature disclose a kind of Chinese medicine compound alleviating radiotherapy side effect and its preparation method and application, it is by Radix Pseudostellariae 10-30 part, Radix Asparagi 10-30 part, Radix Ophiopogonis 10-30 part, Fructus Schisandrae Chinensis 5-10 part, Radix Rehmanniae 10-15 part, Radix Notoginseng 3-5 part, Fructus Ligustri Lucidi 10-30 part, Herba Ecliptae 10-30 part, Fructus Lycii 10-30 part, Fructus Corni 10-30 part, Herba Hedyotidis Diffusae 15-30 part, Poria 10-15 part, Rhizoma Dioscoreae 10-30 part, Fructus Broussonetiae 6-12 part forms.
In a word, Chinese medicine achieves certain effect in tumor remission patient radiotherapy side effect, but also there are some problems: desirable not enough to the therapeutic effect of radiotherapy side effect clinically, needs to be improved further.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, the easily medicament of the tumor remission patient radiotherapy side effect of clothes and preparation method for a long time.This curative effect of medicine is definite and without any side effects.
Technical scheme of the present invention is:
The medicament of tumor remission patient radiotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from: Radix Codonopsis 3-12 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 6-15 part, Radix Paeoniae Alba 2-6 part, Radix Salviae Miltiorrhizae 6-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-12 part, Radix Et Rhizoma Rhei 3-6 part, Flos Caryophylli 5-11 part, Indigo Naturalis 3-6 part, Rhizoma Cyperi (vinegar) 4-8 part, Radix Glycyrrhizae 3-9 part, Radix Aucklandiae (Radix Vladimiriae) 6-12 part, Fructus Mume 4-8 part, Rhizoma Kaempferiae 3-8 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-12 part.
The medicament of tumor remission patient radiotherapy side effect, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Codonopsis 6-8 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 8-12 part, Radix Paeoniae Alba 3-5 part, Radix Salviae Miltiorrhizae 8-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-10 part, Radix Et Rhizoma Rhei 3-5 part, Flos Caryophylli 7-9 part, Indigo Naturalis 4-6 part, Rhizoma Cyperi (vinegar) 5-7 part, Radix Glycyrrhizae 5-7 part, Radix Aucklandiae (Radix Vladimiriae) 8-10 part, Fructus Mume 5-7 part, Rhizoma Kaempferiae 4-7 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7-9 part.
The medicament of tumor remission patient radiotherapy side effect, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
Present invention also offers and above-mentioned medicament is made pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
The preparation method of described powder is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; Be more preferably, cross 105 mesh sieves);
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 85-135 mesh sieve and (preferably, cross 100-120 mesh sieve; Be more preferably, cross 110 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described water preparation is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; Be more preferably, cross 105 mesh sieves);
(2) be placed in marmite by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), adding water, (water consumption is that doubly (preferred, 3-4 doubly for the 2.5-4.5 of crude drug gross weight; Be more preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; Be more preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; Be more preferably, 1.0 hours), filtrate merges, and lets cool;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained medicinal liquid, sterile packaged.
The preparation method of described unguentum is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve (preferred, to cross 85-115 mesh sieve, be more preferably, cross 105 mesh sieves);
(2) be placed in marmite by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), adding water, (water consumption is that doubly (preferred, 3-4 doubly for the 2.5-4.5 of crude drug gross weight; Be more preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; Be more preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; Be more preferably, 1.0 hours), filtrate merges, and filters, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained clear paste, sterile packaged.
The preparation method of described granule is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; Be more preferably, cross 105 mesh sieves);
(2) be placed in marmite by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), adding water, (water consumption is that doubly (preferred, 3-4 doubly for the 2.5-4.5 of crude drug gross weight; Be more preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; Be more preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; Be more preferably, 1.0 hours), filtrate merges, and filters, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) qinghuo reagent 0.8-1.2 part (preferably, 0.9-1.1 part; Be more preferably, 1.0 parts), and sucrose 1.5-3.5 part (preferred, 2-3 part; 2.5 parts that are more preferably), and dextrin 0.8-1.2 part (preferred, 0.9-1.1 part; Be more preferably, 1.0 parts), add step (1) gained Radix Et Rhizoma Rhei and Indigo Naturalis fine powder after mixing, mixing, makes granule, dry, obtains granule.
The preparation method of described tablet is: by claim 5 gained medicament powder according to 0.3-0.5g/ sheet (preferably, 0.35-0.45g/ sheet; Be more preferably, 0.4g/ sheet) metering, the tablet dosage form of circle or other shapes is pressed into according to the preparation for processing of tablet.
The preparation method of described capsule is: by claim 5 gained medicament powder according to 0.2-0.6g/ grain (preferably, 0.3-0.5g/ grain; Be more preferably, 0.4g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Codonopsis: nature and flavor: property is sweet is flat.Gui Jing: return spleen, lung meridian.Effect: strengthening spleen, tonifying kidney, supplementing QI for promoting the production of body fluid.Cure mainly: weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, spontaneous perspiration of breathing hard, all diseases of deficiency of both QI and blood.
The Rhizoma Atractylodis Macrocephalae (parched with bran): nature and flavor: bitter in the mouth, sweet, temperature.Gui Jing: return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Cure mainly: deficiency-weakness of spleen-QI weak, lack of appetite abdominal distention, constipation of having loose bowels, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement.
The Radix Paeoniae Alba: nature and flavor: bitter in the mouth, acid, is slightly cold.Gui Jing: return liver, spleen channel.Effect: joint venture of nourishing blood, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly: blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhea, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery is had loose bowels, and has a headache dizzy.
Radix Salviae Miltiorrhizae: nature and flavor: bitter in the mouth, is slightly cold.Gui Jing: GUIXIN, pericardium, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, removing heat from blood eliminating carbuncle.Cure mainly: menoxenia, dysmenorrhea, amenorrhea, stomachache of being retarded by silt puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, and heat enters nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore.
Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor: bitter in the mouth, sweet, puckery, is slightly cold.Gui Jing: return lung, kidney channel.Effect: astringing to arrest bleeding, detumescence and promoting granulation.Cure mainly: spitting of blood, spit blood, epistaxis, has blood in stool, traumatic hemorrhage, carbuncle pyogenic infections from tumour or sore, scalds and burns, rhagadia manus et pedis, anal fissure.
Radix Et Rhizoma Rhei: nature and flavor: bitter in the mouth, cold.Gui Jing: stomach, large intestine, liver, spleen channel.Effect: attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.Cure mainly: solid cubic content constipation, the accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria; Conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spits blood, spitting of blood, and epistaxis, has blood in stool, hematuria; Blood-retention, amenorrhea, stomachache of being retarded by silt puerperal ， lumps in the chest and abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scalds.
Flos Caryophylli: be the alabastrum of Myrtaceae Eugenia plant of clove.Nature and flavor: property is pungent, temperature.Gui Jing: return spleen, stomach, kidney channel.Effect: warming middle-JIAO, sending down the abnormal ascending QI, warming the kidney.Cure mainly: cold syndrome of the stomach singultus, vomiting, regurgitation, dysentery, coldness and pain in the epigastrium, mass beside the umbilicus, hernia, sensation of gas rushing, ringworm.
Indigo Naturalis: nature and flavor: salty in the mouth, cold.Gui Jing: return liver, lung, stomach warp.Effect: heat clearing away, removing heat from blood, removing toxic substances.Cure mainly: warm malicious macule, spit blood, epistaxis, spitting of blood, pediatric epilepsy scared, liver-fire invading the lung is coughed, laryngopharynx swelling and pain, erysipelas, mumps, and skin ulcer swells, snake bite and insect sting.
Rhizoma Cyperi (vinegar): nature and flavor: acrid in the mouth, sweet, micro-hardship, flat.Gui Jing: return liver, tri-jiao channel.Effect: resolving depression of regulating the flow of vital energy, regulating menstruation, antiabortive.Cure mainly: distending pain over the hypochondrium, distending pain of the breast, hernia pain, menoxenia, gastral cavity abdomen feeling of fullness pain, belch acid regurgitation, vomiting and nausea, abdominal pain during menstruation, bleeding not during menses, frequent fetal movement.
Radix Glycyrrhizae: nature and flavor: sweet in the mouth, flat.Gui Jing: return spleen, stomach, the heart, lung meridian.Effect: with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Cure mainly: process and amass weak with controlling taste, asthenia lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, hysteria, consumptive lung disease is coughed; Raw with controlling laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, infantile carbuncle, and medicine, alimentary toxicosis.
Radix Aucklandiae (Radix Vladimiriae): nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return lung, liver, spleen channel.Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Cure mainly: chest and abdomen swelling and pain, vomiting, has loose bowels, dysentery tenesmus.
Fructus Mume: nature and flavor: sour in the mouth is flat.Gui Jing: return liver, spleen, lung, large intestine channel.Effect: astringing lung-QI and relieving cough, relieving diarrhea with astringents, hemostasis, promotes the production of body fluid, relieving colic caused by ascaris.Cure mainly: chronic cough is more than, chronic diarrhea and dysentery, and hematuria is had blood in stool, metrorrhagia, deficiency-heat excessive thirst, the ascariasis of biliary tract is suffered from abdominal pain, carbuncle sore bulbar conjunctiva polyp.
Rhizoma Kaempferiae: be the rhizome of Zingiberaceae Kaempferia plant Rhizoma Kaempferiae.Nature and flavor: property is pungent, temperature, returns stomach, spleen channel.Effect: warming middle-JIAO, wards off dirty, helps digestion, pain relieving.Cure mainly: communicable subtropical diseases, coldness and pain in the epigastrium, cholera is vomited and diarrhoea, food stagnation, toothache, a fishbone or other bone caught in the throat larynx, treating swelling and pain by traumatic injury.
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): nature and flavor: acrid in the mouth, temperature.Gui Jing: return spleen, stomach, lung meridian.Effect: stopping nausea and vomiting by lowering the adverse flow of QI.Cure mainly: vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.
Medicament of the present invention, based on traditional Chinese medical herbal treatment radiotherapy side effect principle, is make on the basis that have studied lot of documents, pharmacology work and clinical trial.This medicament selected materials is Chinese medicine material, without any side effects; And medical material medicine source is easy to get, medical material is with low cost, can not bring financial burden to patient.This medicament according to the body and mind feature of Chinese medicine principle and malignant tumor patient, has good therapeutic effect to the side reaction that radiotherapy causes completely.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the medicament of tumor remission patient radiotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the medicament powder of above-mentioned tumor remission patient radiotherapy side effect is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 110 mesh sieves;
(3) step (1) and (2) gained are mixed.
The instructions of taking of powder of the present invention: powder is divided 3g/ bag; Adopt every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
model case onewoods XX, age: 50 years old, sex: man.Esophagus interrupts the long 5cm of cancer, 5 radiotherapy has been carried out since in March, 2009, there will be tired after patient's readme radiotherapy, general weakness, lassitude, health is weak, and appetite declines, food dysphagia, the symptoms such as nausea and vomiting, took the Chinese medicine and western medicine of many anti-radiotherapy side effects, all without positive effect.Take the medicament powder of the present embodiment gained tumor remission patient radiotherapy side effect, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 10 days, patient's appetite strengthens to some extent, and nausea and vomiting phenomenon is improved; Take 1 month, patient's malaise symptoms obviously improves, and muscle power strengthens to some extent; Continue to take 2 months, patient's malaise symptoms disappears substantially, and muscle power, the mental status are all significantly improved.
embodiment 2the medicament of tumor remission patient radiotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the medicament unguentum of above-mentioned tumor remission patient radiotherapy side effect is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained clear paste, sterile packaged.
Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 5-10g, takes according to the bath of 1:10 ratio, 7 days courses for the treatment of.
model case twolee XX, age: 65 years old, sex: man.Patient does stomach resecting operation, does radiotherapy afterwards always and treats, and there will be many malaise symptoms: lassitude after each radiotherapy of patient's readme, and without appetite, malaise, skin abnormality is dry, drowsiness etc.Take the medicament unguentum of the present embodiment gained tumor remission patient radiotherapy side effect, adopt every day 2 times, each 10g, take according to the ratio bath of 1:10,7 days courses for the treatment of.Take 7 days, patient's appetite strengthens to some extent, and malaise symptoms makes moderate progress; Take 1 month, patient's muscle power strengthens, and the mental status is clearly better; Continue to take 1 month, malaise symptoms fades away.
embodiment 3the medicament of tumor remission patient radiotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the pharmacy particle agent of above-mentioned tumor remission patient radiotherapy side effect is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) qinghuo reagent 1.0 parts, sucrose 2.5 parts, 1.0 parts, dextrin, adds step (1) gained Radix Et Rhizoma Rhei and Indigo Naturalis fine powder after mixing, mixing, makes granule, dry, obtains granule.
Granule instructions of taking of the present invention: granule is divided 4g/ bag, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
model case threeold XX, age: 57 years old, sex: female.Continuous cough 3 months, in February, 2010 is diagnosed as bottom right adenocarcinoma of lung, and treated by radiotherapy, focus reduces to some extent, but has occurred the malaise symptoms such as inappetence, nausea and vomiting, metal fatigue, drowsiness, skin abnormality is dry after radiotherapy.Take the pharmacy particle agent of the present embodiment gained tumor remission patient radiotherapy side effect, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 21 days, patients ' vomiting phenomenon disappears; Take 1 month, patient's appetite is improved, and drowsiness situation takes a turn for the better, and spirit, muscle power significantly strengthen; Continue to take 2 months, patient's self-induction is without malaise symptoms.
embodiment 4the medicament of tumor remission patient radiotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the medicament tablet of above-mentioned tumor remission patient radiotherapy side effect is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 110 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.4g/ sheet, be pressed into the tablet dosage form of circle or other shapes according to the preparation for processing of tablet.
Tablets instructions of taking: tablet adopts every day 3 times, each 4-6 sheet, with warm boiled water, 7 days courses for the treatment of.
model case fourlee XX, age: 69 years old, sex: man.Patient suffers from malignant tumor in 2008, within 2 years, recurs transfer in lung afterwards, accepts radiotherapy and treat, alleviating pain, but occur following malaise symptoms after radiotherapy: cough with asthma has much difficulty in healing, without appetite, and lassitude, malaise, abnormal thirsty, cold perspiration etc.Take the medicament tablet of the present embodiment gained tumor remission patient radiotherapy side effect, adopt every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 14 days, patient's cough with asthma phenomenon is improved, and malaise symptoms is alleviated all to some extent; Take 2 months, malaise symptoms fades away, and spirit, muscle power strengthen; Continue to take 1 month, patient's readme is without malaise symptoms.
embodiment 5the medicament of tumor remission patient radiotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 50g for every part): Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the drug capsule of above-mentioned tumor remission patient radiotherapy side effect is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 110 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.5g/ sheet, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 5-8 grain, with warm boiled water, 7 days courses for the treatment of.
model case fivezheng XX, age: 55 years old, sex: female.In May, 2009 goes to a doctor because of cough expectorant blood, is malignant tumor, adopts radiotheraping method to treat, occur a series of discomfort reaction: entire patient is unable, lethargy, and inappetence has no appetite, and xerosis cutis is abnormal after radiotherapy through diagnosis, thirsty hard to bear etc.Take the drug capsule agent of the present embodiment gained tumor remission patient radiotherapy side effect, adopt every day 3 times, each 8, with warm boiled water, 7 days courses for the treatment of.Take 10 days, appetite strengthens, and spirit takes a turn for the better; Take 2 months, patient's malaise symptoms disappears substantially, and muscle power strengthens; Continue to take 2 months, patient's self-induction is without malaise symptoms.
embodiment 6the medicament of tumor remission patient radiotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 60g for every part): Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the medicament water preparation of above-mentioned tumor remission patient radiotherapy side effect is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, and lets cool;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained medicinal liquid, sterile packaged.
Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 300ml-500ml, 7 days courses for the treatment of.
test example 1the clinical practice of the medicament water preparation of embodiment 6 gained tumor remission patient radiotherapy side effect: in November ,-2010 in February, 2008, screen 150 routine patients in 6 hospitals, wherein women 71 example, male 79 example.Before test 2 weeks, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 6 products obtained therefrom, and matched group takes other medicine conventional medication such as () holy liquid oral liquid, selenium Wei Kang.Using method is: take every day twice (warm), each 300m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or partial disappearance, energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take the checking of embodiment 6 products obtained therefrom therapeutic effect
Therapeutic effect: cure 70 examples (70%), effective 28 examples (28%), invalid 2 examples (2%), total effective rate 98%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
As shown in Table 2: take 15 days, the patient of more than 51% feels to take a turn for the better to some extent, and malaise symptoms improves; Take 30 days, the patient of more than 72% feels to take a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 45 days, the patient of more than 96% feels to take a turn for the better to some extent, and appetite obviously strengthens, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and some patients self-induction is without malaise symptoms.Take more than 45 days in experimental group, effective percentage can reach 96%, and matched group is only 75%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (1)

1. the preparation method of the medicament unguentum of tumor remission patient radiotherapy side effect, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Codonopsis 7 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Flos Caryophylli 8 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, 6 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Fructus Mume 6 parts, Rhizoma Kaempferiae 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts; Step is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Cyperi (vinegar), Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Fructus Mume, Rhizoma Kaempferiae and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrated that relative density is the clear paste of 1.36-1.38;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained clear paste, sterile packaged.
CN201510898894.5A 2014-04-12 2014-04-12 Preparation method of pharmaceutical paste alleviating tumor patient radiotherapy reaction Withdrawn CN105396021A (en)

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