CN105381217A - Concha haliotidis tablets capable of calming liver and suppressing yang and preparation method of concha haliotidis tablets - Google Patents
Concha haliotidis tablets capable of calming liver and suppressing yang and preparation method of concha haliotidis tablets Download PDFInfo
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Abstract
The invention provides concha haliotidis tablets capable of calming liver and suppressing yang and a preparation method of the concha haliotidis tablets. The concha haliotidis tablets are prepared from a traditional Chinese medicine extract, a filling agent, a disintegrating agent, a binding agent, a lubricant, a flavoring agent and a flow aid, wherein preferably, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 30 to 45 parts of concha haliotidis, 15 to 25 parts of kapok, 15 to 25 parts of rhizoma pinelliae, 7 to 14 parts of silktree albizia barks, 7 to 14 parts of oroxylum indicum, 7 to 14 parts of polygonatum odoratum, 3 to 6 parts of paederia pertomentosa merr. ex Li, 3 to 6 parts of cleistocalyx operculatus, 3 to 6 pats of plumbago zeylanica linn and 3 to 6 parts of musk. The preparation method comprises the following main steps: (1) preparing the traditional Chinese medicine extract: a, pre-treating the raw materials; b, preparing a mixed extracting solution; c, filtering, concentrating and drying; (2) preparing the concha haliotidis tablets capable of calming the liver and suppressing the yang: a, mixing; b, drying; c, mixing. The concha haliotidis tablets capable of calming liver and suppressing yang, provided by the invention, have the effects of calming the liver and suppressing the yang, nourishing yin and moistening dryness and helping to produce saliva and slaking thirst.
Description
Technical field
the present invention relates to a kind of health product, particularly a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet and preparation method thereof.
Background technology
liver has catharsis effect, likes happy and dislikes depressed.As the liver failing to maintain the normal flow of QI or be in a very depressed state is not relaxed, all depression of liver-QI can be caused.The common hypochondriac pain of clinical manifestation. uncomfortable in chest. gastral cavity is swollen. belch. the diseases such as menoxenia.
the liver failing to maintain the normal flow of QI, the syndrome that depression and stagnation of QI shows.Many because of depressed emotion, or the invasion of unexpected direct stimulation and other pathogenic factor and falling ill.The liver failing to maintain the normal flow of QI, mechanism of qi pent-up, then depressed emotion; Of a specified duration strongly fragrant puzzled, lose its submissive happy property, therefore being irritable and getting angry easily.Production of phlegm due to stagnation of QI, phlegm rising following QI, fights to tie and then sees globus hystericus in pharynx, and accumulating in neck is then goiter, qi disease involving blood, qi depression to blood stasis, disharmony of Chong and Conception Channels, therefore menoxenia or abdominal pain during menstruation.Gas gathers blood agglomeration, with the passing of time becomes Guo abdominal mass to gather.Control suitable dispersing the stagnated live-QI to relieve the stagnation of QI, be equipped with activating QI to eliminate phlegm if desired, the methods such as movable blood soft hard.
liver controlling conveyance and dispersion, has the function of emotion regulation, syndrome of stagnation of liver qi, general depressed emotion, Liver Channel cross position feeling of distension and oppression pain occur, the breast side of body or few abdominal distention is vexed alters pain, uncomfortable in chest, sighing frequently, depressed emotion irritability, or foreign body in pharynx sense, or cervical region goiter, or the lower lump of the side of body.
at present, on market, the medicine of suppressing the hyperactive liver and subsiding YANG or health product have a lot, but the effect of most drug is not fine, and the side effect of most drug is more, can damage health, though health product have certain effect, but its price is high, therefore, market is badly in need of a kind of pure natural, the Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet that has no side effect and preparation method thereof.
Summary of the invention
the object of this invention is to provide a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet and preparation method thereof, long-term taking has suppressing the hyperactive liver and subsiding YANG, nourishing YIN to relieve dryness, effect of promoting the production of body fluid to quench thirst.
object of the present invention is achieved through the following technical solutions:
a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet, be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
described a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet, by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
the preferred weight number of described Chinese medicine extract Raw is: Concha Haliotidis 30-45 part, Flos Bombacis Malabarici 15-25 part, Rhizoma Pinelliae Preparata 15-25 part, Cortex Albiziae 7-14 part, Semen Oroxyli 7-14 part, Rhizoma Polygonati Odorati 7-14 part, white hair fevervine 3-6 part, Flos Cleistocalycis Operculati 3-6 part, Radix Plumbaginis Zeylanicae 3-6 part, Moschus 3-6 part.
the optimum weight number of described Chinese medicine extract Raw is: Concha Haliotidis 40 parts, Flos Bombacis Malabarici 20 parts, Rhizoma Pinelliae Preparata 18 parts, Cortex Albiziae 14 parts, Semen Oroxyli 10 parts, Rhizoma Polygonati Odorati 7 parts, white hair fevervine 6 parts, Flos Cleistocalycis Operculati 5 parts, Radix Plumbaginis Zeylanicae 4 parts, Moschus 3 parts.
described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
described a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet and preparation method thereof, is characterized in that: the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
a, pretreatment of raw material: by weight, choose Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Cortex Albiziae, Semen Oroxyli, Rhizoma Polygonati Odorati, white hair fevervine, Flos Cleistocalycis Operculati, Radix Plumbaginis Zeylanicae, Moschus, clean and remove impurity, for subsequent use;
b, prepare mixed extract: by Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Cortex Albiziae, Semen Oroxyli, Rhizoma Polygonati Odorati, white hair fevervine, Flos Cleistocalycis Operculati, Radix Plumbaginis Zeylanicae, Moschus mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
c, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet is prepared:
a, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
b, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
c, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet.
in medicine: Concha Haliotidis, suppressing the hyperactive liver and subsiding YANG, heat extraction, tomorrow; Control wind-yang and up-boring, have a headache dizzy, frightened to jerk, hectic fever due to YIN-deficiency virtue heat, optic atrophy; Flos Bombacis Malabarici, heat clearing away; Dampness removing; Removing toxic substances; Hemostasis; Master has loose bowels; Dysentery; Hemoptysis; Spit blood; Metrorrhagia; Incised wound is hemorrhage; Sore; Eczema; Rhizoma Pinelliae Preparata, has treatment drying dampness to eliminate phlegm, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, effect of syncope due to accumulation of phlegm headache; Cortex Albiziae, resolving depression, and blood, mind calming, subduing inflammation; Control irritability, melancholy insomnia, lung abscess, carbuncle, scrofula, injured bone; Semen Oroxyli, lung moistening, soothing liver-QI, stomach function regulating, granulation promoting; Control cough, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach, the open sore part is not held back; Rhizoma Polygonati Odorati, nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst; For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst; White hair fevervine, removing food stagnancy is eaten, wind-damp dispelling; Radix Plumbaginis Zeylanicae, dispels the wind, dissipating blood stasis, removing toxic substances, parasite killing; Dispelling the wind and dampness pathogens arthralgia, blood stasis amenorrhea, traumatic injury, toxic swelling malignant boil, scabies; Flos Cleistocalycis Operculati, control exogenous cold aversion fever and headache, dyspepsia is not changed.
beneficial effect of the present invention: a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet of the present invention, based on secret prescription handed down in the family from generation to generation, selected Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Cortex Albiziae, Semen Oroxyli, Rhizoma Polygonati Odorati, white hair fevervine, Flos Cleistocalycis Operculati, Radix Plumbaginis Zeylanicae, Moschus, etc. raw material combine, the drug effect of various medicine is made to produce synergism, thus can be effective, long-term taking has suppressing the hyperactive liver and subsiding YANG, nourishing YIN to relieve dryness, effect of promoting the production of body fluid to quench thirst.
the present invention is through two groups of clinical verifications, and wherein one group is that treatment group takes the present invention, takes the present invention every day once, within 7 days, be a course for the treatment of, another group matched group takes suppressing the hyperactive liver and subsiding YANG capsule, and every day uses once, it within 7 days, is a course for the treatment of, every group selection outpatient 52 example, wherein man 32 example, female 20 example, max age 75 years old, minimal ages 35 years old, clinical manifestation is jerked for headache is dizzy, frightened, hectic fever due to YIN-deficiency virtue heat, and table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.
technological advantage of the present invention is: 1, select raw material science, and production technology is advanced; 2, do not add spice and antiseptic in product, keep local flavor and the nutrition of raw material itself, be easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
embodiment 1
a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet, be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
described a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet, by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
the preferred weight number of described Chinese medicine extract Raw is: Concha Haliotidis 30-45 part, Flos Bombacis Malabarici 15-25 part, Rhizoma Pinelliae Preparata 15-25 part, Cortex Albiziae 7-14 part, Semen Oroxyli 7-14 part, Rhizoma Polygonati Odorati 7-14 part, white hair fevervine 3-6 part, Flos Cleistocalycis Operculati 3-6 part, Radix Plumbaginis Zeylanicae 3-6 part, Moschus 3-6 part.
the optimum weight number of described Chinese medicine extract Raw is: Concha Haliotidis 40 parts, Flos Bombacis Malabarici 20 parts, Rhizoma Pinelliae Preparata 18 parts, Cortex Albiziae 14 parts, Semen Oroxyli 10 parts, Rhizoma Polygonati Odorati 7 parts, white hair fevervine 6 parts, Flos Cleistocalycis Operculati 5 parts, Radix Plumbaginis Zeylanicae 4 parts, Moschus 3 parts.
described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
described a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet and preparation method thereof, the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
a, pretreatment of raw material: by weight, choose Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Cortex Albiziae, Semen Oroxyli, Rhizoma Polygonati Odorati, white hair fevervine, Flos Cleistocalycis Operculati, Radix Plumbaginis Zeylanicae, Moschus, clean and remove impurity, for subsequent use;
b, prepare mixed extract: by Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Cortex Albiziae, Semen Oroxyli, Rhizoma Polygonati Odorati, white hair fevervine, Flos Cleistocalycis Operculati, Radix Plumbaginis Zeylanicae, Moschus mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
c, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet is prepared:
a, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
b, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
c, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet.
Claims (6)
1. a Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet, it is characterized in that: be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
2. a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet according to claim 1, is characterized in that: by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
3. a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet according to claim 1, is characterized in that: the preferred weight number of described Chinese medicine extract Raw is: Concha Haliotidis 30-45 part, Flos Bombacis Malabarici 15-25 part, Rhizoma Pinelliae Preparata 15-25 part, Cortex Albiziae 7-14 part, Semen Oroxyli 7-14 part, Rhizoma Polygonati Odorati 7-14 part, white hair fevervine 3-6 part, Flos Cleistocalycis Operculati 3-6 part, Radix Plumbaginis Zeylanicae 3-6 part, Moschus 3-6 part.
4. a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet according to claim 1, is characterized in that: the optimum weight number of described Chinese medicine extract Raw is: Concha Haliotidis 40 parts, Flos Bombacis Malabarici 20 parts, Rhizoma Pinelliae Preparata 18 parts, Cortex Albiziae 14 parts, Semen Oroxyli 10 parts, Rhizoma Polygonati Odorati 7 parts, white hair fevervine 6 parts, Flos Cleistocalycis Operculati 5 parts, Radix Plumbaginis Zeylanicae 4 parts, Moschus 3 parts.
5. a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet according to claim 1, is characterized in that: described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
6. a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet according to claim 1-5 and preparation method thereof, is characterized in that: the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
A, pretreatment of raw material: by weight, choose Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Cortex Albiziae, Semen Oroxyli, Rhizoma Polygonati Odorati, white hair fevervine, Flos Cleistocalycis Operculati, Radix Plumbaginis Zeylanicae, Moschus, clean and remove impurity, for subsequent use;
B, prepare mixed extract: by Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Cortex Albiziae, Semen Oroxyli, Rhizoma Polygonati Odorati, white hair fevervine, Flos Cleistocalycis Operculati, Radix Plumbaginis Zeylanicae, Moschus mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
C, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet is prepared:
A, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
B, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
C, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Concha Haliotidis suppressing the hyperactive liver and subsiding YANG sheet.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019648A (en) * | 2007-03-28 | 2007-08-22 | 北京艺信堂医药研究所 | Health product for reducing blood pressure |
| CN103989960A (en) * | 2013-02-18 | 2014-08-20 | 九芝堂股份有限公司 | Traditional Chinese medicine composition and preparation method thereof |
| CN104258113A (en) * | 2014-10-24 | 2015-01-07 | 刘树芹 | Traditional Chinese medicine composition for curing cerebral hemorrhage |
-
2015
- 2015-11-27 CN CN201510839205.3A patent/CN105381217A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019648A (en) * | 2007-03-28 | 2007-08-22 | 北京艺信堂医药研究所 | Health product for reducing blood pressure |
| CN103989960A (en) * | 2013-02-18 | 2014-08-20 | 九芝堂股份有限公司 | Traditional Chinese medicine composition and preparation method thereof |
| CN104258113A (en) * | 2014-10-24 | 2015-01-07 | 刘树芹 | Traditional Chinese medicine composition for curing cerebral hemorrhage |
Non-Patent Citations (1)
| Title |
|---|
| 朱文宏: "辨证分型联合硝苯地平治疗高血压脑血管疾病随机平行对照研究", 《实用中医内科杂志》 * |
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