CN103989960A - Traditional Chinese medicine composition and preparation method thereof - Google Patents
Traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN103989960A CN103989960A CN201310052433.7A CN201310052433A CN103989960A CN 103989960 A CN103989960 A CN 103989960A CN 201310052433 A CN201310052433 A CN 201310052433A CN 103989960 A CN103989960 A CN 103989960A
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Abstract
A provided traditional Chinese medicine composition is prepared from bulk drugs such as salvia miltiorrhiza, cape jasmine, radix paeoniae rubra, cortex moutan and the like. The traditional Chinese medicine composition is used to treat blood-stasis obstruction and kidney deficiency syndromes at a meridian recovery period of apoplexy, and the syndromes show hemiplegia, deviation of mouth and tongue, stiff tongue and retardation in speech, hemianesthesia, dizziness, soreness and weakness of waist and knees, and the like; the traditional Chinese medicine composition is also used to treat a patient possessing the above symptoms at a cerebral infarction recovery period. The invention also discloses a preparation method of the traditional Chinese medicine composition.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of hold concurrently Chinese medicine composition being prepared from by Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae etc. of syndrome of deficiency of kidney yin of stroke in convalescent stage congestion resistance network that is used for the treatment of, the present invention also relates to preparation method and the purposes of this Chinese medicine composition.
Background technology
Suffering from acute stroke, convalescent period, sequela stage all have different characteristics from theory of Chinese medical science or from modern medicine pathology aspect.Apoplexy is that deficiency in origin worsens and the real result intensifying of mark, and the acute stage that its deficiency in origin problem can not be short after apoplexy is resolved, and this is also the main cause that produces sequela.Therefore must be for deficiency in origin problem in convalescent period, balance specimen weight, focuses on treating both the principal and the secondary aspects of a disease at the same time.And at present many for the Chinese patent medicine of apoplexy, but there are the following problems: 1. the applicable medicine of stroke in convalescent stage is few; 2. treat cerebral thrombosis medicine more, and clearly take another common cause of apoplexy sequela---the medicine that hemiplegia due to cerebral hemorrhage is indication is seldom; 3. from TCM Syndrome Type, the medicine that adapts to blood stasis due to qi deficiency disease is more, and it is less to be adapted to the medicine of convalescent period and other common pattern of syndrome of sequela stage.4. laxativeness untoward reaction.
Summary of the invention
One object of the present invention is to provide a kind of prescription simple, treats safely and effectively the hold concurrently Chinese medicine composition of syndrome of deficiency of kidney yin of stroke in convalescent stage congestion resistance network; Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.
Object of the present invention is achieved through the following technical solutions:
When inventor studies in the prescription side of subtracting to red knee joint granule, premenarcheal clinical observation, red knee joint granule has a small amount of untoward reaction to occur, and is mainly laxativeness.Red knee joint granule prescription has the cephalophyma of promotion Absorption, and Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Cortex Moutan, Radix Achyranthis Bidentatae are improved microcirculation and the confession of brain blood, the effect of anticoagulant and promotion fibrinolytic; Herba Epimedii, Herba Taxilli can promote the recovery of function of brain cell; Rhizoma Gastrodiae, Cortex Moutan, Radix Achyranthis Bidentatae, Herba Taxilli, Semen Cassiae, Fructus Cannabis have hypotensive effect, and can remove cerebral vasospasm, improve the confession of brain blood and promote resuming function of brain cell.Fructus Cannabis and Semen Cassiae have blood pressure lowering and discharge function, and pharmacodynamic study, wherein deducted the drug effect equivalence of Semen Cassiae, Fructus Cannabis group and former compound recipe, and eliminated the laxativeness untoward reaction that former compound recipe occurs postmenstruation.
Chinese medicine composition of the present invention, is processed into through special process by certain compatibility requirement by Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Rehmanniae, Herba Epimedii, Herba Taxilli, Fructus Gardeniae.
Inventor provides a kind of Chinese medicine composition, by the raw material of following weight portion, is prepared from:
Radix Salviae Miltiorrhizae 300-700 part Radix Achyranthis Bidentatae 240-560 part Rhizoma Gastrodiae 60-140 part Cortex Moutan 200-468 part
Radix Paeoniae Rubra 240-560 part Rhizoma Chuanxiong 100-234 part Radix Rehmanniae 240-560 part Herba Epimedii 180-420 part
Herba Taxilli 240-560 part Fructus Gardeniae 120-280 part
The proportioning raw materials of this Chinese medicine composition is preferably:
Radix Salviae Miltiorrhizae 450-550 part Radix Achyranthis Bidentatae 360-440 part Rhizoma Gastrodiae 90-110 part Cortex Moutan 300-370 part
Radix Paeoniae Rubra 360-440 part Rhizoma Chuanxiong 150-185 part Radix Rehmanniae 360-440 part Herba Epimedii 270-330 part
Herba Taxilli 360-440 part Fructus Gardeniae 180-220 part
The proportioning raw materials of this Chinese medicine composition is more preferably:
334 parts of 100 parts of Cortex Moutans of 400 parts of Rhizoma Gastrodiaes of 500 parts of Radix Achyranthis Bidentataes of Radix Salviae Miltiorrhizae
300 parts of 400 parts of Herba Epimedii of 167 portions of Radix Rehmanniae of 400 parts of Rhizoma Chuanxiongs of Radix Paeoniae Rubra
200 parts of 400 portions of Fructus Gardeniaes of Herba Taxilli
The preparation method of Chinese medicine composition of the present invention comprises the following steps: Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Rehmanniae, Herba Epimedii, Herba Taxilli, Fructus Gardeniae ten tastes, get Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes and be ground into coarse powder, with 50-85% alcohol reflux secondary, each return time 1-2 hour, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, decoct with water secondary, boil for the first time 1-2 hour, 1-2 hour for the second time, collecting decoction, filters, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), make required dosage formulation with pharmaceutically acceptable adjuvant thereafter.
The preparation method of Chinese medicine composition of the present invention can be: Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Rehmanniae, Herba Epimedii, Herba Taxilli, Fructus Gardeniae ten tastes, get Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes and be ground into coarse powder, with 70% alcohol reflux secondary, each return time 1 hour, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, decoct with water secondary, boil for the first time 1.5 hours, 1 hour for the second time, collecting decoction, filtered, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), make required dosage formulation with pharmaceutically acceptable adjuvant thereafter.
In the preparation method of Chinese medicine composition of the present invention, made dosage form comprises tablet, capsule, granule, pill or oral liquid.
In the preparation method of Chinese medicine composition of the present invention, adjuvant used is lactose, dextrin, starch, sucrose, microcrystalline Cellulose, methylcellulose, hyprolose, hypromellose, carmellose, carmethose, ethyl cellulose, polyvidone, gelatin, Polyethylene Glycol, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, sodium bicarbonate, citric acid, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, ethanol, one or more in Mel.
Chinese medicine composition of the present invention is mainly used in the treatment treatment stroke in convalescent stage congestion resistance network syndrome of deficiency of kidney yin of holding concurrently.Pharmacodynamic experiment shows that the relatively former red knee joint prescription medical material consumption of Chinese medicine composition provided by the invention reduces, and taking dose reduces, and drug effect reaches the effect of existing red knee joint prescription, and has eliminated the laxativeness untoward reaction being brought by Fructus Cannabis and Semen Cassiae.
The specific embodiment
embodiment 1
prescription:
Radix Salviae Miltiorrhizae 700g Radix Achyranthis Bidentatae 240g Rhizoma Gastrodiae 60g Cortex Moutan 200g
Radix Paeoniae Rubra 240g Rhizoma Chuanxiong 100g Radix Rehmanniae 240g Herba Epimedii 420g
Herba Taxilli 240g Fructus Gardeniae 120g
method for making:above ten tastes, get Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes and are ground into coarse powder, and with 50% alcohol reflux secondary, each return time 1 hour, filters, and filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, and decoct with water secondary, boil for the first time 1 hour, 1 hour for the second time, collecting decoction, filtered, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), adding starch, lactose, carboxymethyl starch sodium mixing, ethanol is binding agent, and soft material processed, granulates, dry, granulate, add appropriate magnesium stearate, mix, be pressed into 2000.
embodiment 2
prescription:
Radix Salviae Miltiorrhizae 350g Radix Achyranthis Bidentatae 280g Rhizoma Gastrodiae 70g Cortex Moutan 234g
Radix Paeoniae Rubra 120g Rhizoma Chuanxiong 117g Radix Rehmanniae 280g Herba Epimedii 90g
Herba Taxilli 280g Fructus Gardeniae 140g
method for making:radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Rehmanniae, Herba Epimedii, Herba Taxilli, Fructus Gardeniae, ten tastes, get Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes and be ground into coarse powder, with 85% alcohol reflux secondary, each return time 2 hours, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, decoct with water secondary, boil for the first time 2 hours, 2 hours for the second time, collecting decoction, filters, and filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), spraying is dry, adds microcrystalline Cellulose, lactose, low-substituted hydroxypropyl cellulose to mix, take water as binding agent, soft material processed, granulate, dry, granulate, add micropowder silica gel, mix, be filled to 2000 capsules.
embodiment 3
prescription?
?
Radix Salviae Miltiorrhizae 500g Radix Achyranthis Bidentatae 400g Rhizoma Gastrodiae 100g Cortex Moutan 334g
Radix Paeoniae Rubra 400g Rhizoma Chuanxiong 167g Radix Rehmanniae 400g Herba Epimedii 300g
Herba Taxilli 400g Fructus Gardeniae 200g
method for making:above ten tastes, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 70% alcohol reflux secondary, each return time 1 hour, filters, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, and decoct with water secondary, boil for the first time 1.5 hours, 1 hour for the second time, collecting decoction, filtered, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), add sucrose, dextrin, mixes, take water as binding agent, soft material processed, granulate, dry, granulate, make 10000g.
embodiment 4
prescription
Radix Salviae Miltiorrhizae 450g Radix Achyranthis Bidentatae 440g Rhizoma Gastrodiae 90g Cortex Moutan 300g
Radix Paeoniae Rubra 360g Rhizoma Chuanxiong 185g Radix Rehmanniae 360g Herba Epimedii 270g
Herba Taxilli 360g Fructus Gardeniae 180g
method for making:above ten tastes, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 70% alcohol reflux secondary, reflux for the first time 2 hours, reflux for the second time 1 hour, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, and decoct with water secondary, boil for the first time 2 hours, 1 hour for the second time, collecting decoction, filters, and filtrate is concentrated into relative density and is about 1.20-1.25(20 ℃) thick paste, Radix Achyranthis Bidentatae is ground into fine powder mixs homogeneously with above-mentioned thick paste, pill bar, gradation, round, dry, make 1300 balls.
embodiment 5
prescription
Radix Salviae Miltiorrhizae 550g Radix Achyranthis Bidentatae 440g Rhizoma Gastrodiae 110g Cortex Moutan 370g
Radix Paeoniae Rubra 360g Rhizoma Chuanxiong 150g Radix Rehmanniae 440g Herba Epimedii 330g
Herba Taxilli 360g Fructus Gardeniae 220g
method for making:above ten tastes, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 70% alcohol reflux secondary, reflux for the first time 1 hour, reflux for the second time 2 hours, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, and decoct with water secondary, boil for the first time 1 hour, 2 hours for the second time, collecting decoction, filters, and filtrate is concentrated into relative density and is about 1.20-1.25(20 ℃) thick paste, adding ethanol makes it contain alcohol amount to reach 75%, standing 24 hours, filter, filtrate is concentrated into 20000ml, be distributed into 500, obtain.
embodiment 6
prescription?
?
Radix Salviae Miltiorrhizae 480g Radix Achyranthis Bidentatae 420g Rhizoma Gastrodiae 105g Cortex Moutan 360g
Radix Paeoniae Rubra 420g Rhizoma Chuanxiong 170g Radix Rehmanniae 380g Herba Epimedii 280g
Herba Taxilli 420g Fructus Gardeniae 200g
method for making:above ten tastes, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 70% alcohol reflux secondary, each return time 1 hour, filters, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, and decoct with water secondary, boil for the first time 1.5 hours, 1 hour for the second time, collecting decoction, filtered, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), add sucrose, dextrin, mixes, take water as binding agent, soft material processed, granulate, dry, granulate, make 10000g.
Below by the effect of pharmacodynamic experiment proved invention Chinese medicine composition.
Being subject to reagent component is red knee joint group and of the present invention group.
Red knee joint group is processed through following, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Rehmanniae, Herba Epimedii, Herba Taxilli, Fructus Gardeniae, Semen Cassiae, Fructus Cannabis, above 12 tastes, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 70% alcohol reflux secondary, each return time 1 hour, filters, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, decoct with water secondary, boil for the first time 1.5 hours, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge to obtain tested material with above-mentioned clear paste, with distilled water, be configured to debita spissitudo, dosage is respectively 56.5g crude drug/kg, adopts gastric infusion, once a day.
Of the present invention group of prescription with embodiment 1 ~ 5 processed through following respectively: Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Rehmanniae, Herba Epimedii, Herba Taxilli, above ten tastes of Fructus Gardeniae, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 70% alcohol reflux secondary, each return time 1 hour, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, decoct with water secondary, boil for the first time 1.5 hours, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge to obtain tested material with above-mentioned clear paste, with distilled water, be configured to debita spissitudo, dosage is 50g crude drug/kg, adopts gastric infusion, once a day.
Positive drug group: NIAOXUEKANG KOUFUYE, Gongzhuling of Jilin Province city HONGGUANG pharmaceutical factory produces, and dosage 16.2g crude drug/kg adopts gastric infusion, once a day.
one, the impact experiment on Intracerebral Hemorrhage in Rats due to VII Collagenase Type
Experiment grouping: red knee joint group, 1 ~ 5 group of embodiment, positive drug group, normal blank group, 8 of the SD rats of every group of female, male half and half, body weight 210 ± 10g.
(1) experimental technique:
Rat 10% chloral hydrate (40mg/100g body weight) intraperitoneal injection of anesthesia, after sphenotresia, injects 0.5 microlitre VII Collagenase Type (0.5unit/ μ l) along aperture and causes Rat Cerebral hemorrhage Model, sterilization, skin suture.Liquid food starts administration two days later.
After administration 10 days, animal is put to death in the dislocation of row cervical vertebra, opens cranium and gets brain, observes its outward appearance, and 10% formalin is fixed.Centered by By Injection of Collagenase pin hole place, make two piece of tissue that coronal section is got respectively each about 3mm of front and back, ethanol dewaters step by step, and dimethylbenzene is transparent, specimens paraffin embedding slices, dyeing, light Microscopic observation.Weighing in cerebral tissue after drawing materials minute both sides, by physics oven drying method, calculates cerebral tissue moisture content.
Separately add up each treated animal diarrhoea number during administration simultaneously.
(2) experimental result:
Open skull, except normal control treated animal, the dot district (being pin hole district) that after each modeling, injection type collagenase position, animal boring below cerebral tissue visible takes on a red color; Some Animals is visible little hematoma outside homonymy cerebral tissue; Along pin hole, do coronal section and cut open, loose, the tarnish of the visible approximately 1 * 2mm size of tangent plane Shang Jin cortical areas are yellow area, and edge is not whole.The cerebral tissue moisture content of each administration group and model group animal is in Table 1.Each treated animal laxativeness information slip is in Table 2.
Table 1 cerebral tissue moisture content comparison (%, M ± SD)
* with strong side comparison, P<0.05;
#with model group comparison, P<0.05
As can be seen from Table 1, with model group comparison, red knee joint group, 1 ~ 5 group of the embodiment of the present invention and NIAOXUEKANG group Ipsilateral cerebral tissue moisture content is all lower than model group animal, and the Ipsilateral that red knee joint group, the embodiment of the present invention are 1 ~ 5 group and strong side be no significant difference relatively.
Each treated animal laxativeness information slip of table 2
* with the comparison of red knee joint group, P<0.05
two, the one-sided common carotid artery ligation of pallasiomy is caused the impact experiment of cerebral ischemia
Experiment grouping: red knee joint group, 1 ~ 5 group of embodiment, positive drug group, water matched group, 8 of pallasiomys are used in every group of experiment, be water matched group (to the distilled water with red knee joint group a great deal of), red knee joint group (56.5g crude drug/kg), 1 ~ 5 group of group of embodiment (50g crude drug/kg) and NIAOXUEKANG group (16.2g crude drug/kg), all adopt gastric infusion, once a day, continuous 10 days.
(1) experimental technique:
Each treated animal is half an hour after last administration, use respectively pentobarbital sodium (60mg/kg) ip anesthesia, dorsal position is fixed, and cervical region median line otch is isolated left neck left artery and overlapped line No. 0, doing binode pricks, between two ligation, cut off, skin suture, puts back in cage, observe nervous symptoms, then do immediately pathological examination.
Stroke index score: observe the symptom occurring in 24 hours, marking, tries to achieve stroke index score score (in Table 3).Score was slight cerebral ischemia at 10 minutes below, and >=10 are divided into serious cerebral ischemia.
Table 3 stroke index score
(2) experimental result:
Table 4 is on the impact of the one-sided common carotid artery ligation of pallasiomy (X ± SD)
With the comparison of water matched group, * P<0.05, with red knee joint group ratio,
#p<0.05
From table 4, with the comparison of water matched group, each administration group stroke index score is all lower than water matched group, and there is a significant difference (P<0.05), illustrate that 1 ~ 5 group of apoplexy symptom that the one-sided common carotid artery ligation of pallasiomy is caused of embodiment has certain inhibitory action, slightly be better than NIAOXUEKANG KOUFUYE effect, and there was no significant difference between 1 ~ 5 group of embodiment and red knee joint group.
three, the impact experiment on rat platelet aggregation function
Experiment grouping: red knee joint group, 1 ~ 5 group of embodiment, positive drug group, water matched group, 8 of rats are used in every group of experiment, body weight 350 ± 20g, male and female half and half, be water matched group (to the distilled water with red knee joint group a great deal of), red knee joint group (56.5g crude drug/kg), 1 ~ 5 group of group of embodiment (50g crude drug/kg) and NIAOXUEKANG group (16.2g crude drug/kg), all adopt gastric infusion, once a day, continuous 10 days.
(1) experimental technique:
Each treated animal after last administration 30 minutes, with the rich and powerful anesthesia of 3% pentobarbital sodium (30mg/kg), from carotid artery, get blood, with 3.8% sodium citrate anticoagulant, prepare platelet rich plasma and platelet poor plasma, take ADP as derivant, by platelet aggregation instrument (AGGRECORDER II PA-3220 type, Japan produces) measure, observe the impact of various dose medicine on rat platelet aggregation function.Result represents with platelet aggregation, and the above results is calculated by following formula, obtains anticoagulant percentage rate.
Platelet aggregation inhibition rate %=
(2) experimental result:
The impact of the red knee joint granules in rats of table 5 platelet aggregation
With matched group comparison, * P<0.001, with red knee joint group ratio,
#p<0.05
From table 5, each administration group platelet aggregation is all lower than water matched group, and anticoagulant percentage rate is consistent with the above results.Illustrate that Chinese medicine composition of the present invention is inhibited to the rat platelet aggregation rate of ADP induction, be slightly better than NIAOXUEKANG group, and with red knee joint group there was no significant difference.
Claims (10)
1. a Chinese medicine composition, is characterized in that being prepared from by the raw material of following weight portion:
Radix Salviae Miltiorrhizae 300-700 part Radix Achyranthis Bidentatae 240-560 part Rhizoma Gastrodiae 60-140 part Cortex Moutan 200-468 part
Radix Paeoniae Rubra 240-560 part Rhizoma Chuanxiong 100-234 part Radix Rehmanniae 240-560 part Herba Epimedii 180-420 part
Herba Taxilli 240-560 part Fructus Gardeniae 120-280 part.
2. a Chinese medicine composition, is characterized in that being prepared from by the raw material of following weight portion:
Radix Salviae Miltiorrhizae 450-550 part Radix Achyranthis Bidentatae 360-440 part Rhizoma Gastrodiae 90-110 part Cortex Moutan 300-370 part
Radix Paeoniae Rubra 360-440 part Rhizoma Chuanxiong 150-185 part Radix Rehmanniae 360-440 part Herba Epimedii 270-330 part
Herba Taxilli 360-440 part Fructus Gardeniae 180-220 part.
3. Chinese medicine composition according to claim 1, is characterized in that being prepared from by the raw material of following weight portion:
334 parts of 100 parts of Cortex Moutans of 400 parts of Rhizoma Gastrodiaes of 500 parts of Radix Achyranthis Bidentataes of Radix Salviae Miltiorrhizae
300 parts of 400 parts of Herba Epimedii of 167 portions of Radix Rehmanniae of 400 parts of Rhizoma Chuanxiongs of Radix Paeoniae Rubra
200 parts of 400 portions of Fructus Gardeniaes of Herba Taxilli.
4. the preparation method of Chinese medicine composition described in arbitrary claim in claims 1 to 3, it is characterized in that passing through following steps: above ten tastes, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 50-85% alcohol reflux secondary, each return time 1-2 hour, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, decoct with water secondary, boil for the first time 1-2 hour, 1-2 hour for the second time, collecting decoction, filters, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), make required dosage formulation with pharmaceutically acceptable adjuvant thereafter.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterized in that passing through following steps: above ten tastes, Radix Achyranthis Bidentatae, Cortex Moutan, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong four tastes are ground into coarse powder, with 70% alcohol reflux secondary, each return time 1 hour, filter, filtrate recycling ethanol is also concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, standby; All the other Six-elements such as medicinal residues and Radix Rehmanniae merge, decoct with water secondary, boil for the first time 1.5 hours, 1 hour for the second time, collecting decoction, filtered, filtrate is concentrated into relative density and is about 1.05-1.15(60 ℃) clear paste, merge with above-mentioned clear paste, being concentrated into relative density is 1.20-1.25(20 ℃), make required dosage formulation with pharmaceutically acceptable adjuvant thereafter.
6. the preparation method of Chinese medicine composition according to claim 4, is characterized in that making tablet, capsule, granule, pill or oral liquid.
7. the preparation method of Chinese medicine composition according to claim 5, is characterized in that making tablet, capsule, granule, pill or oral liquid.
8. the preparation method of Chinese medicine composition according to claim 4, is characterized in that adjuvant used is one or more in lactose, dextrin, starch, sucrose, microcrystalline Cellulose, methylcellulose, hyprolose, hypromellose, carmellose, carmethose, ethyl cellulose, polyvidone, gelatin, Polyethylene Glycol, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, sodium bicarbonate, citric acid, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, ethanol, Mel.
9. the preparation method of Chinese medicine composition according to claim 5, is characterized in that adjuvant used is one or more in lactose, dextrin, starch, sucrose, microcrystalline Cellulose, methylcellulose, hyprolose, hypromellose, carmellose, carmethose, ethyl cellulose, polyvidone, gelatin, Polyethylene Glycol, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, sodium bicarbonate, citric acid, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, ethanol, Mel.
10. the application of the Chinese medicine composition described in claim 1,2 or 3 in preparing stroke in convalescent stage medicine.
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| CN105628851A (en) * | 2014-10-31 | 2016-06-01 | 九芝堂股份有限公司 | Detection method of traditional Chinese medicine preparations |
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