CN105456861A - Rhizoma drynariae kidney tonifying and bone strengthening tablet and preparation method thereof - Google Patents
Rhizoma drynariae kidney tonifying and bone strengthening tablet and preparation method thereof Download PDFInfo
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Abstract
The invention provides a rhizoma drynariae kidney tonifying and bone strengthening tablet and a preparation method thereof. The rhizoma drynariae kidney tonifying and bone strengthening tablet is prepared from traditional Chinese medicine extract, filler, a disintegrating agent, an adhesive, a lubricating agent, corrigent and a glidant. The traditional Chinese medicine extract is preferentially selected from, by weight, 30-45 parts of rhizoma drynariae, 15-25 parts of fresh rehmannia, 15-25 parts of changium smyrnioides, 7-14 parts of concha haliotidis, 7-14 parts of common bombax flowers, 7-14 parts of Rhizoma Pinelliae, 3-6 parts of herba schizonepetae, 3-6 parts of Chinese knotweed herb, 3-6 parts of phellodendri and 3-6 parts of Kaempferia galanga L.. The preparation method includes the main steps of firstly, preparing the traditional Chinese medicine extract, wherein raw material preprocessing is conducted, a mixed extracting solution is prepared, and filtering, concentrating and drying are conducted; secondly, preparing the rhizoma drynariae kidney tonifying and bone strengthening tablet, wherein mixing, drying and mixing are conducted. The rhizoma drynariae kidney tonifying and bone strengthening tablet has the functions of tonifying kidneys, strengthening bones and promoting blood circulation to arrest pain after long-term use.
Description
Technical field
the present invention relates to a kind of health product, particularly a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet and preparation method thereof.
Background technology
the traditional Chinese medical science is thought, suffer from a deficiency of the kidney point deficiency of the kidney yin and insufficiency of kidney-YANG, will do different diagnosis and treatment according to different symptoms.Suffer from a deficiency of the kidney and mostly be long term accumulation and become disease, the medicine of large benefits can't be used because of anxious for success to nourish, or with the kidney invigorating and YANG supporting medicine that composition is failed to understand.Should slowly nurse one's health.
yang deficiency symptom: soreness of waist and knee joint, or back cold type of pain, aversion to cold and cold limbs is very with lower limb especially; The vertigo, lethargy, pale complexion or dark; The fat tongue of light red tongue is white, deep and weak pulse; The easy impotence and premature ejaculation of male, the easy infertility of women; Or stool chronic diarrhea is more than, aqueous-grainy diarrhea, Diarrhoea; Or edema, be very below waist, by depression do not rise, very then abdominal part distending pain, cardiopalmus cough with asthma.
deficiency of YIN symptom: soreness of the waist and knees, two skelasthenia, vertigo and tinnitus, alopecia tooth pine, night sweat is had a sleepless night, and somniloquy is ground one's teeth in sleep, xerostomia, yellowish urine, is hard and dry, man's postcoital protrusion is easily lifted or sexual impotence, premature ejaculation, seminal emission, women's infrequent menstruation amenorrhea, or see metrorrhagia, emaciated physique, hectic fever night sweat, dysphoria with feverish sensation in the chest palms and soles, dry pharynx flushed cheeks, yellow urine dry stool, red tongue with a little fluid, thready and rapid pulse.The kidney being the origin of congenital constitution, and cloudy essence in kidney is total source of cloudy liquid all over the body.Deficiency of YIN-essence can cause various disease, as dizziness and tinnitus, and soreness of the waist and knees, osteopyrexia and fever, quench one's thirst (diabetes) etc.
at present, on market, the medicine of the kidney invigorating bone strengthening or health product have a lot, but the effect of most drug is not fine, and the side effect of most drug is more, can damage health, though health product have certain effect, but its price is high, therefore, market is badly in need of a kind of pure natural, the Rhizoma Drynariae the kidney invigorating bone strengthening sheet that has no side effect and preparation method thereof.
Summary of the invention
the object of this invention is to provide a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet and preparation method thereof, long-term taking has effect of the kidney invigorating bone strengthening, promoting blood circulation and stopping pain.
object of the present invention is achieved through the following technical solutions:
a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet, be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
described a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet, by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
the preferred weight number of described Chinese medicine extract Raw is: Rhizoma Drynariae 30-45 part, Radix Rehmanniae 15-25 part, Radix Changii 15-25 part, Concha Haliotidis 7-14 part, Flos Bombacis Malabarici 7-14 part, Rhizoma Pinelliae Preparata 7-14 part, Herba Schizonepetae 3-6 part, Herb Polygoni Chinensis 3-6 part, river cypress 3-6 part, Rhizoma Kaempferiae 3-6 part.
the optimum weight number of described Chinese medicine extract Raw is: Rhizoma Drynariae 40 parts, Radix Rehmanniae 20 parts, Radix Changii 18 parts, Concha Haliotidis 14 parts, Flos Bombacis Malabarici 10 parts, Rhizoma Pinelliae Preparata 7 parts, Herba Schizonepetae 6 parts, Herb Polygoni Chinensis 5 parts, river cypress 4 parts, Rhizoma Kaempferiae 3 parts.
described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
described a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet and preparation method thereof, is characterized in that: the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
a, pretreatment of raw material: by weight, choose Rhizoma Drynariae, Radix Rehmanniae, Radix Changii, Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Herba Schizonepetae, Herb Polygoni Chinensis, river cypress, Rhizoma Kaempferiae, cleans and remove impurity, for subsequent use;
b, prepare mixed extract: by Rhizoma Drynariae, Radix Rehmanniae, Radix Changii, Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Herba Schizonepetae, Herb Polygoni Chinensis, river cypress, Rhizoma Kaempferiae mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
c, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Rhizoma Drynariae the kidney invigorating bone strengthening sheet is prepared:
a, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
b, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
c, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet.
in medicine: Rhizoma Drynariae, the kidney invigorating bone strengthening; Promoting blood circulation and stopping pain, main lumbago due to renal deficiency; Foot and knee flaccidity; Deaf; Toothache; Chronic diarrhea; The enuresis; Injury and bone fracture and alopecia areata, the kidney invigorating bone strengthening, continues and hinders pain relieving, Radix Rehmanniae, clearing away heat and cooling blood; Promote the production of body fluid and moisturize, main acute calenture; Unconsciousness due to high fever; Macule; Excessive thirst is hindered in Tianjin; The haematemesis of bleeding due to blood-heat; Epistaxis; Metrorrhagia; Have blood in stool; Aphtha of the mouth and tongue; Laryngopharynx swelling and pain; Consumptive fever is coughed; Traumatic pain; Carbuncle, Radix Changii, moistening the lung and resolving phlegm; Yin nourishing stomach function regulating; Removing toxic substances, main cough due to lung-heat; Vomiting regurgitation; Lack of appetite xerostomia; Anemia; Dizzy; Women leucorrhea; Furunculosis skin infection, Concha Haliotidis, suppressing the hyperactive liver and subsiding YANG, heat extraction, tomorrow; Control wind-yang and up-boring, have a headache dizzy, frightened to jerk, hectic fever due to YIN-deficiency virtue heat, optic atrophy; Flos Bombacis Malabarici, heat clearing away; Dampness removing; Removing toxic substances; Hemostasis; Master has loose bowels; Dysentery; Hemoptysis; Spit blood; Metrorrhagia; Incised wound is hemorrhage; Sore; Eczema; Rhizoma Pinelliae Preparata, has treatment drying dampness to eliminate phlegm, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, effect of syncope due to accumulation of phlegm headache; Herba Schizonepetae, delivers, and dispels the wind, treating blood disorders; Parch to black stops blooding; Cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool; Metrorrhagia, puerperal blood faints; Carbuncle, skin ulcer scabies, scrofula; Herba Schizonepetae effectiveness is identical, and the power of only dispersing is stronger; Flos Arecae stomach invigorating; Quench the thirst; Cough-relieving; Main thirsty; Cough; Herb Polygoni Chinensis, controls deficiency of vital energy giddy, tinnitus, deaf, leucorrhea, traumatic injury; River cypress, heat clearing away, dampness, pathogenic fire purging, removing toxic substances; Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, and hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.
beneficial effect of the present invention: a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet of the present invention, based on secret prescription handed down in the family from generation to generation, selected Rhizoma Drynariae, Radix Rehmanniae, Radix Changii, Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Herba Schizonepetae, Herb Polygoni Chinensis, river cypress, Rhizoma Kaempferiae, etc. raw material combine, the drug effect of various medicine is made to produce synergism, thus can be effective, long-term taking has effect of the kidney invigorating bone strengthening, promoting blood circulation and stopping pain.
the present invention is through two groups of clinical verifications, and wherein one group is that treatment group takes the present invention, takes the present invention every day once, within 7 days, be a course for the treatment of, another group matched group takes Bushenqianggu capsule, and every day uses once, it within 7 days, is a course for the treatment of, every group selection outpatient 52 example, wherein man 32 example, female 20 example, max age 75 years old, minimal ages 35 years old, clinical manifestation is lumbago due to renal deficiency, foot and knee flaccidity, deafness, and table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.
technological advantage of the present invention is: 1, select raw material science, and production technology is advanced; 2, do not add spice and antiseptic in product, keep local flavor and the nutrition of raw material itself, be easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
embodiment 1
a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet, be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
described a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet, by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
the preferred weight number of described Chinese medicine extract Raw is: Rhizoma Drynariae 30-45 part, Radix Rehmanniae 15-25 part, Radix Changii 15-25 part, Concha Haliotidis 7-14 part, Flos Bombacis Malabarici 7-14 part, Rhizoma Pinelliae Preparata 7-14 part, Herba Schizonepetae 3-6 part, Herb Polygoni Chinensis 3-6 part, river cypress 3-6 part, Rhizoma Kaempferiae 3-6 part.
the optimum weight number of described Chinese medicine extract Raw is: Rhizoma Drynariae 40 parts, Radix Rehmanniae 20 parts, Radix Changii 18 parts, Concha Haliotidis 14 parts, Flos Bombacis Malabarici 10 parts, Rhizoma Pinelliae Preparata 7 parts, Herba Schizonepetae 6 parts, Herb Polygoni Chinensis 5 parts, river cypress 4 parts, Rhizoma Kaempferiae 3 parts.
described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
described a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet and preparation method thereof, the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
a, pretreatment of raw material: by weight, choose Rhizoma Drynariae, Radix Rehmanniae, Radix Changii, Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Herba Schizonepetae, Herb Polygoni Chinensis, river cypress, Rhizoma Kaempferiae, cleans and remove impurity, for subsequent use;
b, prepare mixed extract: by Rhizoma Drynariae, Radix Rehmanniae, Radix Changii, Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Herba Schizonepetae, Herb Polygoni Chinensis, river cypress, Rhizoma Kaempferiae mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
c, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Rhizoma Drynariae the kidney invigorating bone strengthening sheet is prepared:
a, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
b, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
c, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet.
Claims (6)
1. a Rhizoma Drynariae the kidney invigorating bone strengthening sheet, it is characterized in that: be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
2. a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet according to claim 1, is characterized in that: by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
3. a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet according to claim 1, is characterized in that: the preferred weight number of described Chinese medicine extract Raw is: Rhizoma Drynariae 30-45 part, Radix Rehmanniae 15-25 part, Radix Changii 15-25 part, Concha Haliotidis 7-14 part, Flos Bombacis Malabarici 7-14 part, Rhizoma Pinelliae Preparata 7-14 part, Herba Schizonepetae 3-6 part, Herb Polygoni Chinensis 3-6 part, river cypress 3-6 part, Rhizoma Kaempferiae 3-6 part.
4. a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet according to claim 1, is characterized in that: the optimum weight number of described Chinese medicine extract Raw is: Rhizoma Drynariae 40 parts, Radix Rehmanniae 20 parts, Radix Changii 18 parts, Concha Haliotidis 14 parts, Flos Bombacis Malabarici 10 parts, Rhizoma Pinelliae Preparata 7 parts, Herba Schizonepetae 6 parts, Herb Polygoni Chinensis 5 parts, river cypress 4 parts, Rhizoma Kaempferiae 3 parts.
5. a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet according to claim 1, is characterized in that: described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
6. a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet according to claim 1-5 and preparation method thereof, is characterized in that: the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
A, pretreatment of raw material: by weight, choose Rhizoma Drynariae, Radix Rehmanniae, Radix Changii, Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Herba Schizonepetae, Herb Polygoni Chinensis, river cypress, Rhizoma Kaempferiae, cleans and remove impurity, for subsequent use;
B, prepare mixed extract: by Rhizoma Drynariae, Radix Rehmanniae, Radix Changii, Concha Haliotidis, Flos Bombacis Malabarici, Rhizoma Pinelliae Preparata, Herba Schizonepetae, Herb Polygoni Chinensis, river cypress, Rhizoma Kaempferiae mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
C, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Rhizoma Drynariae the kidney invigorating bone strengthening sheet is prepared:
A, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
B, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
C, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Rhizoma Drynariae the kidney invigorating bone strengthening sheet.
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| Application Number | Priority Date | Filing Date | Title |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185733A (en) * | 2007-08-02 | 2008-05-28 | 江中药业股份有限公司 | Jianweixiaoshi orally disintegrating tablets and preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185733A (en) * | 2007-08-02 | 2008-05-28 | 江中药业股份有限公司 | Jianweixiaoshi orally disintegrating tablets and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 郭雪申等: "《风湿病效方400首》", 31 August 2005, 科学技术文献出版社 * |
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Application publication date: 20160406 |