CN105395886A - Euphorbia antiquorum summer-heat clearing tablet and preparation method thereof - Google Patents
Euphorbia antiquorum summer-heat clearing tablet and preparation method thereof Download PDFInfo
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- CN105395886A CN105395886A CN201510839070.0A CN201510839070A CN105395886A CN 105395886 A CN105395886 A CN 105395886A CN 201510839070 A CN201510839070 A CN 201510839070A CN 105395886 A CN105395886 A CN 105395886A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a euphorbia antiquorum summer-heat clearing tablet and a preparation method thereof. The euphorbia antiquorum summer-heat clearing tablet is prepared from traditional Chinese medicine extract, a filling agent, a disintegrating agent, a binding agent, a lubricating agent, corrigent and glidant; the traditional Chinese medicine extract is prepared from, by weight, 30-45 parts of euphorbia antiquorum, 15-25 parts of hedyotis hedyotidea, 15-25 parts of pigeon peas, 7-14 parts of evodia lepta, 7-14 parts of sambucus chinensis, 7-14 parts of dry dendrobe, 3-6 parts of hypericum sampsonii hance, 3-6 parts of rhizoma polygoni cuspidate, 3-6 parts of rosemary and 3-6 parts of all-grass of longspike uraria. The preparation method of the euphorbia antiquorum summer-heat clearing tablet comprises the main steps that 1, the traditional Chinese medicine extract is prepared, wherein the raw materials are preprocessed, a mixed extracting solution is prepared, and filtering, concentrating and drying are performed; 2, the euphorbia antiquorum summer-heat clearing tablet is prepared, wherein mixing, drying and mixing are performed. According to the euphorbia antiquorum summer-heat clearing tablet, the effects of clearing summer-heat, expelling wind dampness and achieving reunion of the muscles and bones are achieved if the euphorbia antiquorum summer-heat clearing tablet is taken for a long term.
Description
Technical field
the present invention relates to a kind of health product, particularly a kind of Ancients Euphorbia Stem clearing away summer-heat sheet and preparation method thereof.
Background technology
damp and hot pathogenic factor is many because of eating and drinking without temperance, addicted to food delicious food savoury, pungent product, or long-term alcohol, long-pending wet intrinsic heat, store in middle Jiao, or diseases caused by exogenous pathogenic factor is damp and hot, the heresy of heat-damp in summer, burnt in interior house, causes damp and hot amassing in middle Jiao.Stagnation of spleen and stomach damp-heat, dysfunction of the spleen in transportation, stomach loses to accept the enemy's surrender and forms.Card belongs to damp and hot excess syndrome or Primary Asthenia-Secondary Sthenia Syndrome.Sick position is at spleen, stomach.Be common in dampness, cholera, have loose bowels, among the disease such as dysentery, tympanites.
disease sees abdominal distention uncomfortable in chest, stomach is received and is not subject to, headache heavy sensation of the body, afternoon fever of the body, bitter taste and glutinous or throat pain, xerostomia and not tending to drink water, and limbs are tired heavy; yellowish or reddish urine, large loose stool and smelly, or rushes down lower urgent and not well, or stomachache; in vain red under dysentery; or rapid work of vomiting and diarrhoea, vomiting, as spray, is rushed down lower to rice-washed water; or the jaundice of appearance skin; abdominal part swells firmly completely, or has low grade fever, the damp and hot syndrome such as yellowish fur, soft and rapid pulse.
damp and hot is interiorly to produce in stagnation of spleen and stomach damp-heat, so damp and hotly leads to, again by exogenous damp, endogenous dampness are given birth to.Exogenous damp is invaded by extraneous damp, and endogenous dampness is dysfunction of spleen and stomach, can not far change precise and tiny and give birth to, i.e. " insufficiency of the spleen resulting in production of dampness ".Therefore during the prescription legislation for the treatment of dampness disease, the primary and secondary of " insufficiency of the spleen " and " dampness " should be considered, medication of weighing the relative importance.From the beginning of, dampness blocking in middle-JIAO, insufficiency of the spleen is not principal contradiction, and should can select removing dampness by means of aromatics, dispelling the damp pathogen with bitter and warm drugs based on dehumidifying, the product of promoting diuresis with drugs of tasteless flavour go out to draw heresy, even if now there be insufficiency of the spleen resembling, the agent done when get spleen invigorating and removing dampness is share.
at present, on market, the medicine of clearing away summer-heat or health product have a lot, but the effect of most drug is not fine, and the side effect of most drug is more, can damage health, though health product have certain effect, but its price is high, therefore, market is badly in need of a kind of pure natural, the Ancients Euphorbia Stem clearing away summer-heat sheet that has no side effect and preparation method thereof.
Summary of the invention
the object of this invention is to provide a kind of Ancients Euphorbia Stem clearing away summer-heat sheet and preparation method thereof, long-term taking has clearing away summer-heat, wind-damp dispelling, effect of reuniting the fractured tendons and bones.
object of the present invention is achieved through the following technical solutions:
a kind of Ancients Euphorbia Stem clearing away summer-heat sheet, be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
described a kind of Ancients Euphorbia Stem clearing away summer-heat sheet, by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
the preferred weight number of described Chinese medicine extract Raw is: Ancients Euphorbia Stem 30-45 part, Caulis et Folium hedyotis hedyotideae 15-25 part, Semen Cajani 15-25 part, Foliumet Ramulus Evodiae 7-14 part, Herba Sambuci Chiensis 7-14 part, dendrobium chrysanthum 7-14 part, Herba Hyperici Sampsonii 3-6 part, Rhizoma Polygoni Cuspidati 3-6 part, Herba Rosmarini Officinalis 3-6 part, Herba urariae macrostachyae 3-6 part.
the optimum weight number of described Chinese medicine extract Raw is: Ancients Euphorbia Stem 40 parts, Caulis et Folium hedyotis hedyotideae 20 parts, Semen Cajani 18 parts, Foliumet Ramulus Evodiae 14 parts, Herba Sambuci Chiensis 10 parts, dendrobium chrysanthum 7 parts, Herba Hyperici Sampsonii 6 parts, Rhizoma Polygoni Cuspidati 5 parts, Herba Rosmarini Officinalis 4 parts, Herba urariae macrostachyae 3 parts.
described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
described a kind of Ancients Euphorbia Stem clearing away summer-heat sheet and preparation method thereof, is characterized in that: the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
a, pretreatment of raw material: by weight, choose Ancients Euphorbia Stem, Caulis et Folium hedyotis hedyotideae, Semen Cajani, Foliumet Ramulus Evodiae, Herba Sambuci Chiensis, dendrobium chrysanthum, Herba Hyperici Sampsonii, Rhizoma Polygoni Cuspidati, Herba Rosmarini Officinalis, Herba urariae macrostachyae, clean and remove impurity, for subsequent use;
b, prepare mixed extract: by Ancients Euphorbia Stem, Caulis et Folium hedyotis hedyotideae, Semen Cajani, Foliumet Ramulus Evodiae, Herba Sambuci Chiensis, dendrobium chrysanthum, Herba Hyperici Sampsonii, Rhizoma Polygoni Cuspidati, Herba Rosmarini Officinalis, Herba urariae macrostachyae mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
c, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Ancients Euphorbia Stem clearing away summer-heat sheet is prepared:
a, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
b, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
c, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Ancients Euphorbia Stem clearing away summer-heat sheet.
in medicine: Ancients Euphorbia Stem, detumescence, draws out pus by applying a plaster to the affected part, antidiarrheal; For acute gastroenteritis, malaria, treating swelling and pain by traumatic injury; Caulis et Folium hedyotis hedyotideae, clearing away summer-heat, wind-damp dispelling, reuniting the fractured tendons and bones; For heatstroke, cold cough, vomits and diarrhoea, rheumatic arthritis, bleeding hemorrhoids, furuncle carbuncle, traumatic injury, fracture; Semen Cajani, inducing diuresis and reducing edema, eliminating stasis to stop pain; For icterohepatitis, rheumatic arthritis, traumatic injury, swelling and pain due to blood stasis, has blood in stool, epistaxis; Foliumet Ramulus Evodiae, heat-clearing and toxic substances removing, expelling wind and removing dampness; Control the diseases such as laryngopharynx swelling and pain, rheumatic ostalgia, malaria, jaundice, eczema, dermatitis, traumatic injury and worm venom; Herba Sambuci Chiensis, dissipating blood stasis for subsidence of swelling, traumatic injury, for diseases such as traumatic injury, rheumatic arthralgia, oedema due to nephritis, rubella, carbuncle furuncle; Dendrobium chrysanthum, reinforcing stomach reg fluid, nourishing YIN and clearing away heat; Stomach promotes the production of body fluid, nourishing YIN and clearing away heat; Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision; For deficiency of stomach-YIN and consumption of body fluid caused by febrile disease card, syndrome of deficiency of kidney yin; Herba Hyperici Sampsonii, heat-clearing and toxic substances removing, dredge the meridian passage, cooling blood for hemostasis; For infantile hyperpyrexia, dysentery, enteritis, spits blood, epistaxis, menoxenia, leucorrhea; Traumatic hemorrhage is controlled in external, traumatic injury, mastitis, burn and scald, venom; Rhizoma Polygoni Cuspidati, dispels the wind, dampness removing, and removing blood stasis with potent drugs stimulates the menstrual flow; Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia; Injury from falling down, scalds, malignant boil tinea disease; Arrhythmia and anti-cardiac muscle are lost blood, blood circulation promoting and blood stasis dispelling; Herba Rosmarini Officinalis, tranquillizing and allaying excitement, refreshment effect, all have certain curative effect to dyspepsia and stomachache; Testa arachidis hypogaeae nourish blood enrich blood, stop blooding, dissipating blood stasis, detumescence effect.
beneficial effect of the present invention: a kind of Ancients Euphorbia Stem clearing away summer-heat sheet of the present invention, based on secret prescription handed down in the family from generation to generation, selected Ancients Euphorbia Stem, Caulis et Folium hedyotis hedyotideae, Semen Cajani, Foliumet Ramulus Evodiae, Herba Sambuci Chiensis, dendrobium chrysanthum, Herba Hyperici Sampsonii, Rhizoma Polygoni Cuspidati, Herba Rosmarini Officinalis, Herba urariae macrostachyae, etc. raw material combine, the drug effect of various medicine is made to produce synergism, thus can be effective, long-term taking has clearing away summer-heat, wind-damp dispelling, effect of reuniting the fractured tendons and bones.
the present invention is through two groups of clinical verifications, and wherein one group is that treatment group takes the present invention, takes the present invention every day once, within 7 days, be a course for the treatment of, another group matched group takes clearing away summer-heat capsule, and every day uses once, it within 7 days, is a course for the treatment of, every group selection outpatient 52 example, wherein man 32 example, female 20 example, max age 75 years old, minimal ages 35 years old, clinical manifestation is cold cough, vomiting and diarrhoea, rheumatic arthritis, and table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.
technological advantage of the present invention is: 1, select raw material science, and production technology is advanced; 2, do not add spice and antiseptic in product, keep local flavor and the nutrition of raw material itself, be easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
embodiment 1
a kind of Ancients Euphorbia Stem clearing away summer-heat sheet, be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
described a kind of Ancients Euphorbia Stem clearing away summer-heat sheet, by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
the preferred weight number of described Chinese medicine extract Raw is: Ancients Euphorbia Stem 30-45 part, Caulis et Folium hedyotis hedyotideae 15-25 part, Semen Cajani 15-25 part, Foliumet Ramulus Evodiae 7-14 part, Herba Sambuci Chiensis 7-14 part, dendrobium chrysanthum 7-14 part, Herba Hyperici Sampsonii 3-6 part, Rhizoma Polygoni Cuspidati 3-6 part, Herba Rosmarini Officinalis 3-6 part, Herba urariae macrostachyae 3-6 part.
the optimum weight number of described Chinese medicine extract Raw is: Ancients Euphorbia Stem 40 parts, Caulis et Folium hedyotis hedyotideae 20 parts, Semen Cajani 18 parts, Foliumet Ramulus Evodiae 14 parts, Herba Sambuci Chiensis 10 parts, dendrobium chrysanthum 7 parts, Herba Hyperici Sampsonii 6 parts, Rhizoma Polygoni Cuspidati 5 parts, Herba Rosmarini Officinalis 4 parts, Herba urariae macrostachyae 3 parts.
described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
described a kind of Ancients Euphorbia Stem clearing away summer-heat sheet and preparation method thereof, the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
a, pretreatment of raw material: by weight, choose Ancients Euphorbia Stem, Caulis et Folium hedyotis hedyotideae, Semen Cajani, Foliumet Ramulus Evodiae, Herba Sambuci Chiensis, dendrobium chrysanthum, Herba Hyperici Sampsonii, Rhizoma Polygoni Cuspidati, Herba Rosmarini Officinalis, Herba urariae macrostachyae, clean and remove impurity, for subsequent use;
b, prepare mixed extract: by Ancients Euphorbia Stem, Caulis et Folium hedyotis hedyotideae, Semen Cajani, Foliumet Ramulus Evodiae, Herba Sambuci Chiensis, dendrobium chrysanthum, Herba Hyperici Sampsonii, Rhizoma Polygoni Cuspidati, Herba Rosmarini Officinalis, Herba urariae macrostachyae mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
c, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Ancients Euphorbia Stem clearing away summer-heat sheet is prepared:
a, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
b, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
c, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Ancients Euphorbia Stem clearing away summer-heat sheet.
Claims (6)
1. an Ancients Euphorbia Stem clearing away summer-heat sheet, it is characterized in that: be made up of Chinese medicine extract, filler, disintegrating agent, binding agent, lubricant, correctives, fluidizer, by weight percentage, Chinese medicine extract 20-60%, filler 20-50%, disintegrating agent 10-40%, binding agent 1-20%, lubricant 1-5%, correctives 1-5%, fluidizer 1-5%; By weight, Chinese medicine extract 20-60 part, filler 20-50 part, disintegrating agent 10-40 part, binding agent 1-20 part, lubricant 1-5 part, correctives 1-5 part, fluidizer 1-5 part.
2. a kind of Ancients Euphorbia Stem clearing away summer-heat sheet according to claim 1, is characterized in that: by optimum weight number, Chinese medicine extract 40 parts, filler 30 parts, disintegrating agent 15 parts, binding agent 5 parts, lubricant 4 parts, correctives 3 parts, fluidizer 3 parts.
3. a kind of Ancients Euphorbia Stem clearing away summer-heat sheet according to claim 1, is characterized in that: the preferred weight number of described Chinese medicine extract Raw is: Ancients Euphorbia Stem 30-45 part, Caulis et Folium hedyotis hedyotideae 15-25 part, Semen Cajani 15-25 part, Foliumet Ramulus Evodiae 7-14 part, Herba Sambuci Chiensis 7-14 part, dendrobium chrysanthum 7-14 part, Herba Hyperici Sampsonii 3-6 part, Rhizoma Polygoni Cuspidati 3-6 part, Herba Rosmarini Officinalis 3-6 part, Herba urariae macrostachyae 3-6 part.
4. a kind of Ancients Euphorbia Stem clearing away summer-heat sheet according to claim 1, is characterized in that: the optimum weight number of described Chinese medicine extract Raw is: Ancients Euphorbia Stem 40 parts, Caulis et Folium hedyotis hedyotideae 20 parts, Semen Cajani 18 parts, Foliumet Ramulus Evodiae 14 parts, Herba Sambuci Chiensis 10 parts, dendrobium chrysanthum 7 parts, Herba Hyperici Sampsonii 6 parts, Rhizoma Polygoni Cuspidati 5 parts, Herba Rosmarini Officinalis 4 parts, Herba urariae macrostachyae 3 parts.
5. a kind of Ancients Euphorbia Stem clearing away summer-heat sheet according to claim 1, is characterized in that: described filler is the mixing of one or more in microcrystalline Cellulose, starch, lactose, dextrin, sucrose; Described disintegrating agent is low-substituted hydroxypropyl cellulose; Described binding agent is starch slurry or polyvidone k30 or hypromellose; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
6. a kind of Ancients Euphorbia Stem clearing away summer-heat sheet according to claim 1 and preparation method thereof, is characterized in that: the key step of its preparation method is:
(1) Chinese medicine extract is prepared:
A, pretreatment of raw material: by weight, choose Ancients Euphorbia Stem, Caulis et Folium hedyotis hedyotideae, Semen Cajani, Foliumet Ramulus Evodiae, Herba Sambuci Chiensis, dendrobium chrysanthum, Herba Hyperici Sampsonii, Rhizoma Polygoni Cuspidati, Herba Rosmarini Officinalis, Herba urariae macrostachyae, clean and remove impurity, for subsequent use;
B, prepare mixed extract: by Ancients Euphorbia Stem, Caulis et Folium hedyotis hedyotideae, Semen Cajani, Foliumet Ramulus Evodiae, Herba Sambuci Chiensis, dendrobium chrysanthum, Herba Hyperici Sampsonii, Rhizoma Polygoni Cuspidati, Herba Rosmarini Officinalis, Herba urariae macrostachyae mix homogeneously, then use soak by water three times, first time adds the water of 14 times, moderate heat decocts 2-3 hour, filters, and extracts filtrate, second time adds the water of 12 times, and moderate heat decocts 1.5-2 hour, filters, extract filtrate, the water big fire adding 10 for the third time decocts 0.5 hour, filters, extract filtrate, merge three filtrates, obtain mixed extract, for subsequent use;
C, filtration, concentrated, dry: to get mixed extract, filter, then carry out concentrating under reduced pressure, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22-1.3, is then placed in spray dryer and carries out spraying dry, drying is placed in pulverizer and pulverizes, and crosses 60 mesh sieves, obtains Chinese medicine extract;
(2) Ancients Euphorbia Stem clearing away summer-heat sheet is prepared:
A, mixing: by weight, get Chinese medicine extract, filler, disintegrating agent mix homogeneously, be then placed in wet granulator, binding agent is put into feed tank, open machine, adjustment parameter, opens simultaneously and shears fly cutter, 2-5 minute, discharging, use oscillating granulator, cross 16 order nylon screens and granulate, obtained wet granular;
B, drying: wet granular is placed in dehydrator and dries, after oven dry, adopt ultraviolet disinfection, obtain granulate;
C, mixing: by granulate, lubricant, correctives, fluidizer mixing, be placed in three-dimensional motion mixer mixing 15-25 minute, then use rotary tablet machine tabletting, obtained a kind of Ancients Euphorbia Stem clearing away summer-heat sheet.
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| CN201510839070.0A CN105395886A (en) | 2015-11-27 | 2015-11-27 | Euphorbia antiquorum summer-heat clearing tablet and preparation method thereof |
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Application publication date: 20160316 |