CN105343556A - 一种治疗血栓闭塞性脉管炎的药物及其制备方法 - Google Patents

一种治疗血栓闭塞性脉管炎的药物及其制备方法 Download PDF

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CN105343556A
CN105343556A CN201510914345.2A CN201510914345A CN105343556A CN 105343556 A CN105343556 A CN 105343556A CN 201510914345 A CN201510914345 A CN 201510914345A CN 105343556 A CN105343556 A CN 105343556A
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徐士魁
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徐士魁
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Abstract

本发明公开了一种治疗血栓闭塞性脉管炎的药物及其制备方法,其主要是由金银花、鸡血藤、没药、玄参、芙蓉叶、桂枝、忍冬藤、石斛、鹿角霜、威灵仙、桃仁、川牛膝、萆薢、红花、刺蒺藜、丹参、赤小豆、细辛、赤芍、鹿角胶、水蛭、防风、乳香、紫花地丁、车前子、当归、甘草按一定重量配比制备而成。本发明药物具有活血去瘀,补血和血,活血通脉,治湿盛困脾,风寒湿痹的功能,用于治疗血栓闭塞性脉管炎见效快、疗效好,不复发。

Description

-种治疗血栓闭塞性脉管炎的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗血栓闭塞性脉管炎的药物及其制备方法,属中药领域。
背景技术
[0002] 血栓闭塞性脉管炎是由于小动脉疫李和血栓形成造成闭塞,致使局部缺血,男性 多见,W吸烟者为多。中医则认为血栓闭塞性脉管炎与气虚,疲阻脉络,气血不杨,搏阻不通 有关。由于西药治疗副作用大,因此人们对有效治疗血栓闭塞性脉管炎的中药药物存在极 大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗血栓 闭塞性脉管炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗血栓闭塞性脉管炎的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择金银花、鸡血藤、没药、玄参、芙蓉叶、桂枝、忍冬藤、石解、鹿角 霜、威灵仙、桃仁、川牛膝、革游、红花、刺裝襲、丹参、赤小豆、细辛、赤巧、鹿角胶、水赔、防 风、乳香、紫花地下、车前子、当归、甘草、毛冬青、苍术、益母草药物进行组合制备的,将运些 药物组合使得各药物功效产生协同作用,从而能够有效治疗血栓闭塞性脉管炎。其中,选用 金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治溫病发热,热毒血频,痴瘍, 肿毒,療痛,持漏。选用鸡血藤是因为其性味苦甘,溫,入屯、、脾二经,有活血、舒筋的功能,治 腰膝酸痛,麻木擁痕,月经不调。选用没药是因为其性味苦,平,入肝经,有散血去疲,消肿定 痛的功能,治跌损,金疮,筋骨,屯、腹诸痛,瘤瘤,经闭,痴痘肿痛,持漏,目障。选用玄参是因 为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳 热,夜寐不宁,自汗盗汗,津伤便秘,吐血赃血,咽喉肿痛,痴肿,療痛。选用芙蓉叶是因其性 凉,味微辛,有清肺凉血;解毒消肿。主肺热咳嗽;目赤肿痛;痴痘肿毒;恶疮;缠身蛇丹;脈 瘤疮;肾孟肾炎;水火烫伤;毒蛇咬伤;跌打损伤。选用桂枝是因为其性味辛甘,溫,入膀脫、 屯、、肺经,有发汗解肌,溫经通脉的功能,治风寒表证,肩背肢节酸疼,胸搏疲饮,经闭瘤瘤。 选用忍冬藤是因为其性味甘,寒,入屯、、肺经,有清热,解毒,通络的功能,治溫病发热,热毒 血频,传染性肝炎,痴肿疮毒,筋骨疼痛。选用石解是因为其性味甘淡微咸,寒,入有、肺、肾 经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用鹿角霜 是因为其性味咸,溫,入肝、肾经,有补虚,助阳的功能,治肾阳不足,腰脊酸痛,脾胃虚寒,呕 吐,食少便漉,子宫虚冷,崩漏带下。选用威灵仙是因为其性味辛咸,溫,有毒,入膀脫经,有 桂风湿,通经络,消疲诞,散癖积的功能,治痛风、顽搏、腰膝冷痛,脚气,追疾,瘤瘤积聚,破 伤风,扁桃体炎,诸骨嫂咽。选用桃仁是因为其性味苦甘,平,入屯、、肝、大肠经,有破血行疲, 润燥滑经的功能,治经闭,瘤瘤,热病蓄血,血搏,追疾,跌打损伤,疲血肿痛,血燥便秘。选用 川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有桂风,利湿,通经,活血的功能,治 风湿腰膝疼痛,脚瘦筋李,血淋,尿血,妇女经闭,瘤瘤。选用革游是因为其性味苦,平,入肝、 胃、膀脫经,有桂风,利湿的功能,治风湿顽搏,腰膝疼痛,小便不利,淋浊,遗精,湿热疮毒。 选用红花是因为其性味辛,溫,入屯、、肝经,有活血通经,去疲止痛的功能,治经闭,瘤瘤,难 产,死胎,产后恶露不行,疲血作痛,痴肿,跌扑损伤。选用刺裝襲是因为其性味苦辛,溫,入 肝、肺经,有散风,明目,下气,行血的功能,治头痛,身痒,目赤肿繫,胸满,咳逆,瘤瘤,乳难, 痴痘,療痛。选用丹参是因为其性味苦,微溫,入屯、、肝经,有活血去疲,安神宁屯、,排脈,止痛 的功能,治屯、绞痛,月经不调,痛经,W闭,血崩带下,瘤瘤,积聚,疲血腹痛,骨节疼痛,惊惇 不眠,恶疮肿毒。选用赤小豆是因为其性味甘酸,平,入屯、、小肠经,有利水除湿,和血排脈, 消肿解毒的功能,治水肿,脚气,黄痘,泻频,便血,痴肿。选用细辛是因为其性味辛,溫,入 肺、肾经,有桂风,散寒,行水,开窃的功能,治风冷头痛,鼻渊,止痛,疲饮咳逆,风湿搏痛。选 用赤巧是因为其性味苦,微寒,归肝经,有清热凉血,散疲止痛的功能,治溫毒发狂,吐血赃 血,目赤肿痛,肝郁胁痛,经闭痛经,癖瘤腹痛,跌扑损伤,痴肿疮瘍。选用鹿角胶是因为其性 味甘咸,溫,入肝、肾经,有补血,益精的功能,治肾气不足,虚劳贏瘦,腰痛,阴痘,男子阳瘦、 滑精,妇女子宫虚冷,崩漏,带下。选用水赔是因为其性味咸苦,平,有毒,入肝、膀脫经,有破 血,逐疲,通经的功能,治蓄血,瘤瘤,积聚,妇女经闭,干血成瘦,跌扑损伤,目赤痛,云繫。选 用防风是因为其性味辛甘,溫,入膀脫、肺、脾经,有发表,桂风,胜湿,止痛的功能,治外感风 寒,头痛,目眩,项强,风寒湿搏,骨节酸痛,四肢李急,破伤风。选用乳香是因为其性味辛苦, 溫,入屯、、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,屯、腹疼痛,痴疮肿毒,跌打 损伤,痛经,产后疲血刺痛。选用紫花地下是因为其性味苦、辛、寒,归屯、、肝经,有清热解毒, 凉血消肿的功能,治疗疮肿毒,痴痘发背,丹毒,毒蛇咬伤。选用车前子是因为其性味甘,寒, 入肾、膀脫经,有利水,清热,明目,桂疲的功能,治小便不通,淋浊,带下,尿血,暑湿泻频,咳 嗽多疲,湿搏,目赤障繫。选用当归是因为其性味甘辛,溫,入屯、、肝、脾经,有补血和血,调经 止痛,润燥滑肠的功能,治月经不调,经闭腹痛,瘤瘤结聚,崩漏,血虚头痛,眩晕,瘦搏,肠燥 难便,赤频后重,痴痘疮瘍,金疮,跌扑损伤。选用甘草是因为其性味甘平,入脾、胃、肺经,有 和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便漉,劳倦发热,肺瘦 咳嗽,屯、惇,惊痴,生用治咽喉肿痛,消化性溃瘍,痴痘疮瘍,解药毒及食物中毒。选用毛冬青 是因为其性味微苦甘,性平,无毒,有清热解毒,活血通脉的功能,治风热感冒,肺热喘咳,喉 头水肿,扁桃体炎,频疾,冠屯、病,脑血管意外所致的偏擁,血栓闭塞性脉管炎,丹毒,烫伤, 中屯、性视网膜炎,葡萄膜炎,W及皮肤急性化脈性炎症。选用苍术是因为其性味辛苦,溫,入 脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜邸,腕瘡腹胀,食欲不振,呕 吐,泄泻,频疾,追疾,疲饮,水肿,时气感冒,风寒湿搏,足瘦,夜盲。选用益母草是因为其性 味辛苦,凉,入屯、包、肝经,有活血,桂疲,调经,消水的功能,治月经不调,治漏难产,胞衣不 下,产后血晕,疲血腹痛,崩中漏下,尿血,泻血,痴肿疮瘍。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 金银花20-30克,鸡血藤10-20克,没药7-12克,玄参25-35克,芙蓉叶10-20克,桂枝 5-15克,忍冬藤15-25克,石解5-15克,鹿角霜10-20克,威灵仙5-15克,桃仁5-15克,川 牛膝10-20克,革游10-15克,红花5-10克,刺裝襲10-15克,丹参25-35克,赤小豆10-20 克,细辛4-8克,赤巧10-20克,鹿角胶15-25克,水赔3-5克,防风7-12克,乳香5-15克, 紫花地下15-25克,车前子10-20克,当归15-25克,甘草7-12克,毛冬青15-25克,苍术 10-20克,益母草5-15克。
[000引优选为: 金银花25克,鸡血藤15克,没药9克,玄参30克,芙蓉叶15克,桂枝10克,忍冬藤20 克,石解10克,鹿角霜15克,威灵仙10克,桃仁10克,川牛膝15克,革游12克,红花8克, 刺裝襲12克,丹参30克,赤小豆15克,细辛6克,赤巧15克,鹿角胶20克,水赔5克,防风 9克,乳香10克,紫花地下20克,车前子15克,当归20克,甘草9克,毛冬青20克,苍术15 克,益母草10克。
[0009] 本发明药物的制备方法如下 一、备料 1、 金银花:筛去泥沙,炼净杂质; 2、 鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干; 3、 没药:炼去杂质,打成碎块; 4、 玄参:炼净杂质,除去芦头,洗净润透,切片,惊干; 5、 芙蓉叶:取原药材,除去杂质,喷淋清水,稍润,切碎,干燥; 6、 桂枝:用水稍浸泡,拱出,闷润至透,切片,惊干,筛去屑; 7、 忍冬藤:炼去杂质,用水浸泡,润透,切片,晒干; 8、 石解:取干燥的石解,用水泡约至八成透,炯润,除去残根及黑枝,切段,撞去薄膜,晒 干; 9、 鹿角霜:炼去杂质,祈成小块; 10、 威灵仙:炼净杂质,除去残茎,用水浸泡,拱出润透,切段,晒干; 11、 桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,拱出,浸入凉水中,磋去种皮,晒 干,鑛净; 12、 川牛膝:炼去杂质,惊干; 13、 革游:除去杂质,切片,洗净,浸泡,润透,干燥,筛去碎屑; 14、 红花:炼净杂质,除去茎叶、蒂头,晒干; 15、 刺裝襲:漂去泥沙,除净残留的硬刺; 16、 丹参:炼净杂质,除去根茎,洗净,拱出,润透后切片,惊干; 17、 赤小豆:取原药材,除去杂质,用时捣碎; 18、 细辛:除净杂质,用水喷润,及时切段,晒干; 19、 赤巧:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑; 20、 鹿角胶:取原药材,除去杂质,用时捣碎或研粉; 21、 水赔:洗净,闷软,切段,晒干; 22、 防风:除去残茎,用水浸泡,拱出,润透切片,晒干; 23、 乳香:炼去砂子杂质; 24、 紫花地下:取原药材,除去杂质,洗净,稍惊,切段,干燥; 25、 车前子:炼去杂质,筛去泥屑,空粒; 26、 当归:炼去杂质,洗净,闷润,稍惊,切片晒干; 27、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透,切片,凉干; 28、 毛冬青:用水润透,切段,晒干,筛去灰屑; 29、 苍术:炼去杂质,用水泡至屯、八成透,拱出,润透后切片,晒干 30、 益母草:炼去杂质,洗净,润透,切段,晒干。
[0010] 二、制备 1、将炮制后的金银花、鸡血藤、没药、玄参、芙蓉叶、桂枝、忍冬藤、石解、鹿角霜、威灵 仙、桃仁、川牛膝、革游、红花、刺裝襲、丹参、赤小豆、细辛、赤巧、水赔、防风、乳香、紫花地 下、车前子、当归、甘草、毛冬青、苍术、益母草放入煎药容器内,加水8倍量,浸泡100分钟 后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器 内; 2将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,趁热加入鹿角胶溶化后 过滤得第二次煎煮液; 3将两次煎煮液混合揽拌均匀即得混合药液,分为4剂服用。
[0011] 组方中丹参有活血去疲,安神宁屯、,治血崩带下,通络,积聚,的功能为君药;当归 补血,和血;毛冬青有清热解毒,活血通脉,治血栓闭塞的功能,二者为臣药,=味药共同发 挥活血去疲,补血,活血,治湿盛困脾,风寒湿搏,通络的作用,治疗血栓闭塞性脉管炎效力 全面,且W补血,活血,通络为主可治本,甘草有和中缓急,润肺,解毒,调和诸药,治脾胃虚 弱的功能为佐药,苍术有健脾,燥湿,解郁,治湿盛困脾,风寒湿搏的功能为使药,与余下诸 药是治标。
[0012] 本发明药物具有活血去疲,补血和血,活血通脉,治湿盛困脾,风寒湿搏的功能,用 于治疗血栓闭塞性脉管炎,疗程短、见效快、治愈后不复发。
[0013]
具体实施方式: W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0-2.化g,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用混合药液超常量组为20ml/kg,正常量为lOml/kg,给药方 式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正 常,药物无不良毒副作用。
[0015] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治血栓闭塞性脉管炎口诊患者共29例。
[001引 2、诊断标准 典型症状为患肢呈现一时性或持续性苍白、发组、有灼热及刺痛,病肢下垂时皮色变 红,上举时变白,继之足趾麻木,小腿肌肉疼痛,行走时激发,休息时消失;小腿部常发生浅 表性静脉炎和水肿。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续 服用3个疗程。
[0018] 4、疗效评定标准 显效:血栓闭塞性脉管炎症状消失,体质恢复正常,痊愈; 好转:患者患肢持续性苍白、发组及灼热刺痛感,肌肉疼痛,水肿的症状减轻,血栓闭塞 性脉管炎症状明显好转,体质逐步恢复; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN105343556AD00081
在上述治疗中,用本发明药物治疗血栓闭塞性脉管炎患者29例,结果显效22例,显效 率为75. 86%,好转5例,好转率为17. 24%,无效2例,总有效率为93. 10%。

Claims (3)

1. 一种治疗血栓闭塞性脉管炎的药物,其特征在于:它是由下列重量范围内的原料药 制成: 金银花20-30克,鸡血藤10-20克,没药7-12克,玄参25-35克,芙蓉叶10-20克,桂枝 5-15克,忍冬藤15-25克,石斛5-15克,鹿角霜10-20克,威灵仙5-15克,桃仁5-15克,川 牛膝10-20克,萆蘚10-15克,红花5-10克,刺蒺藜10-15克,丹参25-35克,赤小豆10-20 克,细辛4-8克,赤芍10-20克,鹿角胶15-25克,水蛭3-5克,防风7-12克,乳香5-15克, 紫花地丁 15-25克,车前子10-20克,当归15-25克,甘草7-12克,毛冬青15-25克,苍术 10-20克,益母草5-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 金银花25克,鸡血藤15克,没药9克,玄参30克,芙蓉叶15克,桂枝10克,忍冬藤20 克,石斛10克,鹿角霜15克,威灵仙10克,桃仁10克,川牛膝15克,萆蘚12克,红花8克, 刺蒺藜12克,丹参30克,赤小豆15克,细辛6克,赤芍15克,鹿角胶20克,水蛭5克,防风 9克,乳香10克,紫花地丁 20克,车前子15克,当归20克,甘草9克,毛冬青20克,苍术15 克,益母草10克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 金银花:筛去泥沙,拣净杂质; (2) 鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干; (3) 没药:拣去杂质,打成碎块; (4) 玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; (5) 芙蓉叶:取原药材,除去杂质,喷淋清水,稍润,切碎,干燥; (6) 桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去肩; (7) 忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干; (8) 石斛:取干燥的石斛,用水泡约至八成透,焖润,除去残根及黑枝,切段,撞去薄膜, 晒干; (9) 鹿角霜:拣去杂质,斫成小块; (10) 威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干; (11) 桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒 干,簸净; (12) 川牛膝:拣去杂质,晾干; (13) 萆蘚:除去杂质,切片,洗净,浸泡,润透,干燥,筛去碎肩; (14) 红花:拣净杂质,除去茎叶、蒂头,晒干; (15) 刺蒺藜:漂去泥沙,除净残留的硬刺; (16) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; (17) 赤小豆:取原药材,除去杂质,用时捣碎; (18) 细辛:除净杂质,用水喷润,及时切段,晒干; (19) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (20) 鹿角胶:取原药材,除去杂质,用时捣碎或研粉; (21) 水蛭:洗净,闷软,切段,晒干; (22) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (23) 乳香:拣去砂子杂质; (24)紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; (25) 车前子:拣去杂质,筛去泥肩,空粒; (26)当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (27)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; (28)毛冬青:用水润透,切段,晒干,筛去灰肩; (29)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干 (30)益母草:拣去杂质,洗净,润透,切段,晒干; (二)制备 (1) 将炮制后的金银花、鸡血藤、没药、玄参、芙蓉叶、桂枝、忍冬藤、石斛、鹿角霜、威灵 仙、桃仁、川牛膝、萆蘚、红花、刺漠藜、丹参、赤小豆、细辛、赤苟、水輕、防风、乳香、紫花地 丁、车前子、当归、甘草、毛冬青、苍术、益母草放入煎药容器内,加水8倍量,浸泡100分钟 后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器 内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,趁热加入鹿角胶溶化 后过滤得第二次煎煮液; (3)将两次煎煮液混合搅拌均匀即得混合药液,分为4剂服用。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728940A (zh) * 2016-12-29 2017-05-31 张秀兰 一种治疗血栓闭塞性脉管炎的药物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679843A (zh) * 2005-01-27 2005-10-12 朱腾月 治疗血栓闭塞性脉管炎的口服药
US20090196941A1 (en) * 2005-11-10 2009-08-06 Jose Angel Olalde Rangel Synergistic Phytoceutical Compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679843A (zh) * 2005-01-27 2005-10-12 朱腾月 治疗血栓闭塞性脉管炎的口服药
US20090196941A1 (en) * 2005-11-10 2009-08-06 Jose Angel Olalde Rangel Synergistic Phytoceutical Compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
肖国士等: "《中医秘方全书(珍藏本)超值版》", 30 June 2012, 湖南科学技术出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728940A (zh) * 2016-12-29 2017-05-31 张秀兰 一种治疗血栓闭塞性脉管炎的药物及其制备方法

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