CN105326682A - Skin-whitening, freckle-removing and skin-care composition - Google Patents

Skin-whitening, freckle-removing and skin-care composition Download PDF

Info

Publication number
CN105326682A
CN105326682A CN201510725001.7A CN201510725001A CN105326682A CN 105326682 A CN105326682 A CN 105326682A CN 201510725001 A CN201510725001 A CN 201510725001A CN 105326682 A CN105326682 A CN 105326682A
Authority
CN
China
Prior art keywords
skin
whitening
rhegf
skin care
speckle dispelling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510725001.7A
Other languages
Chinese (zh)
Inventor
韦忠明
黄启斌
莫冬海
唐申秀
包能创
杨辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HUANUOWEI GENE PHARMAOY CO Ltd GUILIN
Original Assignee
HUANUOWEI GENE PHARMAOY CO Ltd GUILIN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HUANUOWEI GENE PHARMAOY CO Ltd GUILIN filed Critical HUANUOWEI GENE PHARMAOY CO Ltd GUILIN
Priority to CN201510725001.7A priority Critical patent/CN105326682A/en
Publication of CN105326682A publication Critical patent/CN105326682A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a skin-whitening, freckle-removing and skin-care composition, and a skin-whitening, freckle-removing and skin-care product with the skin-whitening, freckle-removing and skin-care composition. The skin-whitening, freckle-removing and skin-care composition is composed of rhEGF, wych-hazel extraction solutions, wax gourd skin aqueous extract and aloe vera gel. The skin-care product contains 1-2 wt% of the skin-whitening, freckle-removing and skin-care composition. By combining wych-hazel extraction solutions, wax gourd skin aqueous extract and aloe vera gel with rhEGF, rhEGF can be effectively prevented from being deactivated, rhEGF efficiency is greatly improved, and meanwhile absorption of rhEGF can be promoted and loss of rhEGF in the permeation process can be reduced. By means of the skin-care product where the skin-whitening, freckle-removing and skin-care composition is added, new skin cells can be promoted and can replace and renew aged cells, the content of melanin and colored corpuscles in skin cells can be decreased, skin chromatosis is relieved, and the aims of whitening skin and removing freckles are achieved.

Description

A kind of whitening and speckle dispelling skin care compositions
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of whitening and speckle dispelling skin care compositions.
Background technology
Epidermal growth factor (EGF) is a kind of multi-functional Growth of Cells promotive factor, there is Promote cell's growth widely active, accelerate human skin cell's speed of growth, promoting the new Growth of Cells breeding of skin, is the deciding factor affecting skin health.But with advancing age and the deterioration of environment, in human body, the content of EGF reduces gradually, causes skin health impaired.Natural EGF is extensively present in mammalian body, and its content is low, and extract difficulty large, cost is high, and people adopt rhEGF to substitute natural EGF usually.RhEGF can stimulate the various cells of outer embryo rhEGF layer and endodermal origin as cornea, epithelium etc., makes it breed.Its biological effect comprises: 1) promote that low molecular weight compound is initiatively transported in cell from extracellular, increase the nutrient substance of cell; 2) glycolysis is activated to increase respiratory metabolism, energy activating phosphatase fructokinase; 3) the outer macromolecular synthesis of irritation cell, as hyaluronic acid and glycoprotein.4) synthesis of RNA and protein is activated; 5) synthesis of DNA is promoted; 6) some materials of body are as the synthesis of fruit acid, prostaglandin to promote cell proliferation to promote.These biological effects show, rhEGF, by conducted signal, causes a series of Biochemical changes in cell, starts the gene relevant with cell division, makes akinete enter cell division phase, thus make cell proliferation.RhEGF promotes that neoplastic skin cell substitutes, upgrades senile cell, the content of melanin and coloured corpuscle in Skin Cell can be reduced, alleviate the calmness of skin pigment, the pigment situation of skin can be improved in Skin Cell level, so just can reach the object of whitening, speckle dispelling.There are the skin care item containing rhEGF in prior art, to aspects such as whitening and speckle dispelling, there is certain positive effect.Because external source rhEGF occurs Physical Loss or Damage and inactivation in the processes such as skin permeation, make the content of rhEGF in skin care item will far beyond EGF concentration several times in human body even hundreds of times just can produce a desired effect, through skin verification experimental verification, the effect that can control symptom clinically just can be reached when the concentration of rhEGF is 100 μ g/ml in skin care item, when the concentration of rhEGF is 300 more than μ g/ml, clinical symptoms just starts to take a turn for the better.In skin care item, the addition of rhEGF is too high, but inefficiency, considerably increase production cost.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of whitening and speckle dispelling skin care compositions, said composition by rhEGF and Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue composite, there is significant cooperative effect, skin metabolism can be promoted, spot fading, makes skin tender, tenderly white.
Technical scheme provided by the invention is a kind of whitening and speckle dispelling skin care compositions, and it is made up of rhEGF, Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue.
Exocarpium Benincasae water extract is by Exocarpium Benincasae extracting in water, and be separated after extracting, vacuum concentration, is Exocarpium Benincase extract.
Further, Exocarpium Benincase extract is pulled an oar by fresh Exocarpium Benincasae, is the ratio extracting in water 1 ~ 3 time of 1:5 ~ 10, extracts 1 ~ 3h, merge extractive liquid, at every turn, filter in solid-liquid ratio, and when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.10 ~ 1.30, to obtain final product.
Aloe glue is pulled an oar by fresh aloe, is separated by glue with Aloe slag, obtained Aloe glue.
Hamamelis virginiana extracting solution, outward appearance: colourless transparent liquid; PH (10% aqueous solution): 5 ~ 6.5; Index of refraction (20 DEG C): 1.4160 ~ 1.4200; Relative density (20 DEG C): 1.03 ~ 1.036.Hamamelis virginiana extracting solution skinfeel height is pleasant fresh and clean, can supplement skin moisture in time, is easy to absorb.
With the total restatement of above-mentioned a kind of whitening and speckle dispelling skin care compositions, the percentage by weight of each component is respectively: rhEGF0.01 ~ 0.05%, Hamamelis virginiana extracting solution 20 ~ 40%, Exocarpium Benincasae water extract 35 ~ 50% and Aloe glue composition 20 ~ 30%.
The percentage by weight of said components is respectively: rhEGF0.03%, Hamamelis virginiana extracting solution 30%, Exocarpium Benincasae water extract 40% and Aloe glue composition 29.97%.
Present invention also offers a kind of whitening and speckle dispelling skin care item, containing above-mentioned whitening and speckle dispelling skin care compositions.The weight content of described whitening and speckle dispelling skin care compositions in these skin care item is 1 ~ 2%, is preferably 1.5%.
Described whitening and speckle dispelling skin care item are whitening and spot eliminating cream or whitening and speckle dispelling emulsion.The conventional formulation of whitening and spot eliminating cream/emulsion:
Whitening and speckle dispelling skin care compositions: 1 ~ 2%;
Emulsifying agent: 0.5 ~ 10%;
Emollient: 5 ~ 40%;
Excipient thickening agent: 0.1 ~ 10%;
Wetting agent: 5 ~ 30%;
Antiseptic: convention amount;
Antioxidant: convention amount;
Deionized water: surplus.
The preparation method of described whitening and speckle dispelling skin care item is: first undertaken primary emulsifying by oil phase in whitening and speckle dispelling skin care item and aqueous phase, adjust the temperature of this emulsification system 35 ~ 40 DEG C time, add rhEGF, Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue composition, system is through stirring, and further cooling is up to the standards discharging.
Compared with prior art, the present invention has following beneficial effect:
1) the peptide bond structure of Exocarpium Benincasae water extract, Aloe glue composition is similar to rhEGF; very easily intersect between peptide bond, coil, the reaction of the space displacement such as compositions; rhEGF is surrounded by the peptide molecule key ring-type of Exocarpium Benincasae water extract and Aloe glue composition; protect rhEGF space structure; avoid rhEGF inactivation, greatly raise the efficiency.
2) Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue composition itself all have effect of whitening, speckle dispelling, greatly can improve the moisturizing moisturizing of skin care compositions, the effect of skin whitening and desalination mottle.
3) Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue composition is easily absorbed by the skin, and rhEGF and Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue forms to combine and be very easily absorbed by the skin, and the rhEGF in minimizing process of osmosis loses.
4) in skin care item of the present invention, the weight content of rhEGF is only 1 ~ 10 μ g/ml, well below conventional addition, conveniently consumption is applied on the face, skin metabolism can be promoted, make skin tender, tenderly white, have very strong inhibitory action to the melanic synthesis in melanoma, the color at the speckle position caused by abnormal pigment can be desalinated rapidly, prevent the chromogenesis because Exposure to Sunlight causes preferably, and the pigment that Exposure to Sunlight of disappearing causes.
Detailed description of the invention
The present invention is further elaborated for following specific embodiment, but not as a limitation of the invention.
Embodiment 1
A kind of whitening and speckle dispelling skin care compositions: rhEGF lyophilized powder 0.01%, Hamamelis virginiana extracting solution 40%, Exocarpium Benincasae water extract 35% and Aloe glue composition 24.99%.
Exocarpium Benincase extract is pulled an oar by fresh Exocarpium Benincasae, is the ratio extracting in water 1 time of 1:5, extracts 1h at every turn in solid-liquid ratio, and by extracting liquid filtering, when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.10, to obtain final product.
Aloe glue is pulled an oar by fresh aloe, is separated by glue with Aloe slag, obtained Aloe glue.
Embodiment 2
A kind of whitening and speckle dispelling skin care compositions: rhEGF lyophilized powder 0.05%, Hamamelis virginiana extracting solution 20%, Exocarpium Benincasae water extract 50% and Aloe glue composition 29.95%.
Exocarpium Benincase extract is pulled an oar by fresh Exocarpium Benincasae, is the ratio extracting in water 3 times of 1:10, extracts 3h, merge extractive liquid, at every turn, filter in solid-liquid ratio, and when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.30, to obtain final product.
Aloe glue is pulled an oar by fresh aloe, is separated by glue with Aloe slag, obtained Aloe glue.
Embodiment 3
A kind of whitening and speckle dispelling skin care compositions: rhEGF lyophilized powder 0.03%, Hamamelis virginiana extracting solution 30%, Exocarpium Benincasae water extract 40% and Aloe glue composition 29.97%.
Exocarpium Benincase extract is pulled an oar by fresh Exocarpium Benincasae, is the ratio extracting in water 2 times of 1:8, extracts 2h, merge extractive liquid, at every turn, filter in solid-liquid ratio, and when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.20, to obtain final product.
Aloe glue is pulled an oar by fresh aloe, is separated by glue with Aloe slag, obtained Aloe glue.
Embodiment 4
The formula following (w%) of whitening and spot eliminating cream:
A kind of whitening and speckle dispelling skin care compositions (the whitening and speckle dispelling skin care compositions of embodiment 1): 1.5%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Preparation method:
1) in oil phase process tank, oil phase material (propylene glycol, cetearyl alcohol, glyceryl stearate, hydrogenation gather certain herbaceous plants with big flowers alkene) is dropped in still, starts agitator simultaneously, be heated to 92 ~ 98 DEG C, start agitator simultaneously, material is melted completely;
2) in aqueous phase pretreatment tank, glycerol is all dropped in still, start stirring, and hydroxyethyl-cellulose is slowly dropped in still in powder form, it is made fully to disperse, then other aqueous phases (water, ceteth-20, cocoanut oil alcohol sodium sulfovinate) are dropped in still, be heated to 92 ~ 98 DEG C, be stirred to evenly;
3) filtered oil phase suck into preheating emulsion tank in, rear suction aqueous phase, and start scraper plate stirring, rapid stirring, homogenizer (start emulsifying kettle rapid stirring and homogenizer about 10 ~ 12 minutes) with this, now emulsifying temperature in the kettle should not lower than 85 DEG C.After carrying out vacuum emulsification, insulated and stirred after 10 ~ 15 minutes, then starts chiller cooling.
4) when temperature drops to 55 ~ 60 DEG C, add essence, temperature drops to 35 ~ 40 DEG C, add rhEGF, Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue composition, antiseptic, continue to stir, when temperature continues to be down to 30 DEG C, discharging after the assay was approved.
Embodiment 5
The whitening and spot eliminating cream of the present embodiment is consistent with the formula of embodiment 4 and preparation method, and only whitening and speckle dispelling skin care compositions adopts the whitening and speckle dispelling skin care compositions of embodiment 2.
Embodiment 6
The whitening and spot eliminating cream of the present embodiment is consistent with the formula of embodiment 4 and preparation method, and only a kind of whitening and speckle dispelling skin care compositions adopts a kind of whitening and speckle dispelling skin care compositions of embodiment 3.
Reference examples 1
The formula following (w%) of whitening and spot eliminating cream:
RhEGF lyophilized powder: 0.01%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 4.
Reference examples 2
The formula following (w%) of whitening and spot eliminating cream:
RhEGF lyophilized powder: 0.01%
Hamamelis virginiana extracting solution: 0.3%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 4.
Reference examples 3
The formula following (w%) of whitening and spot eliminating cream:
RhEGF lyophilized powder: 0.01%
Hamamelis virginiana extracting solution: 0.3%
Exocarpium Benincasae water extract: 0.5%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 4.
Reference examples 4
The formula following (w%) of whitening and spot eliminating cream:
RhEGF lyophilized powder: 0.01%
Hamamelis virginiana extracting solution: 0.3%
Aloe glue forms: 0.3%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 4.
Embodiment 7
Whitening and speckle dispelling emulsion formulations following (w%):
A kind of whitening and speckle dispelling skin care compositions (the whitening and speckle dispelling skin care compositions of embodiment 2): 1%
Glyceryl stearate 1.5%
Cetearyl alcohol 1%
Glycerol 10%
Propylene glycol 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene 5%
Ceteth-201%
Cocoanut oil alcohol sodium sulfovinate 0.5%
Hydroxyethyl-cellulose 0.3%
Preservative qs
Essence is appropriate
Deionized water surplus.
Preparation method:
1) in oil phase pretreatment tank, oil phase material (propylene glycol, cetearyl alcohol, glyceryl stearate, hydrogenation gather certain herbaceous plants with big flowers alkene) is dropped in still, starts agitator simultaneously, be heated to 92 ~ 98 DEG C, start agitator simultaneously, material is melted completely; In aqueous phase pretreatment tank, glycerol in formula is all dropped in still, start stirring, and hydroxyethyl-cellulose is slowly sprinkled in still in powder form, it is made fully to disperse, then unclassified stores in aqueous phase (deionized water, ceteth-20, cocoanut oil alcohol sodium sulfovinate) is dropped in still, be heated to 92 ~ 98 DEG C, be stirred to evenly;
2) filtered oil phase thing suck into preheating emulsion tank in, rear suction aqueous-phase material, and start scraper plate stirrings, rapid stirring, homogenizer (startup emulsifying kettle rapid stirring and homogenizer about 10 ~ 12 minutes) successively, now emulsifying temperature in the kettle should not lower than 85 DEG C.After carrying out vacuum emulsification, insulated and stirred after 10 ~ 15 minutes, then starts chiller cooling;
3) when temperature drops to 55 ~ 60 DEG C, add and add phase (essence), stir, when continuing to cool to 35 ~ 40 DEG C, add rhEGF, Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue composition, antiseptic, stir, when continuing to be cooled to 30 DEG C, discharging after the assay was approved.
Embodiment 8
The whitening and speckle dispelling emulsion of the present embodiment is consistent with the formula of embodiment 7 and preparation method, and the consumption except a kind of whitening and speckle dispelling skin care compositions is 2%.
Experimental example 1
For verifying the effect of skin care item of the present invention in whitening and speckle dispelling, selecting 70 volunteers to carry out effectiveness experiment, adopting double-dummy design, contrast experiment, carry out contrast and investigate.70 volunteers do not limit for men and women, healthy population, and the age, 10 people one group, were divided into 7 groups at random between 22 ~ 49 years old.Be respectively experimental group 1 ~ 3, matched group 1 ~ 4.Experimental group 1 ~ 3 uses the whitening and spot eliminating cream of the embodiment of the present invention 4 ~ 6 respectively, and matched group 1 ~ 4 uses the whitening and spot eliminating cream of reference examples 1 ~ 4 respectively.The whitening and spot eliminating cream that 7 groups of early, middle and late uses are for each person every day once described, using method spreads upon face in right amount for getting, and loops gently to absorbing completely.Experimental period is 3 weeks.
Use color difference meter to measure to often organizing each experimenter the brightness (represent by aberration meansigma methods, aberration meansigma methods is larger, shows that skin is brighter) using front and back skin, and by following standard, observe whitening and spot eliminating cream to the effect of face's speckle.
Evaluation criterion:
Effectively-speckle, freckle obviously go down;
Effective-speckle and freckle slightly go down;
Invalid-unchanged.
Evaluation result:
As seen from the above table, experimental group is better than the whitening and speckle dispelling effect of matched group.
Experimental example 2
The white-skinned face function of extract is verified by external Tyrosinase inhibition assays.In melanic forming process, tryrosinase plays a crucial role, melanin produce number have direct relation with the activity of tryrosinase, skin-whitening agents is generally by acting in dermal melanin generation, metabolic process remittance, the generation of check melanin, accelerates melanic metabolism and plays the effect of skin whitening.
A kind of whitening and speckle dispelling skin care compositions of experimental group 1 ~ 3, matched group 1 ~ 4 is made into respectively the solution of 1%, ultrasonic assistant dissolves 1h, gets supernatant for subsequent use as sample.According to following table 2 application of sample, mixing, 37 DEG C of water bath heat preservation 10min, add the TYR enzyme liquid 0.5ml that concentration is 100U/ml in C1 and T1 pipe, mixing.Make the light absorption value of reference side C1 at 475nm place with C2 after 10 minutes, make reference with T2 and survey the light absorption value of T1 at 475nm place.C1 is the control reaction system not adding sample, and C2 is the reference liquid of C1, and T1 is the reaction system adding testing sample, and T2 is the reference liquid of corresponding T1.Utilize formulae discovery sample to the suppression ratio of tryrosinase.
Suppression ratio=(the C1-T1)/C1 of tryrosinase.
C1 C2 T1 T2
TYR 1 1 1 1
Sample 0 0 1 1
Phosphate buffer 1.5 2 0.5 1
Suppression ratio
Matched group 1 38%
Matched group 2 45%
Matched group 3 48%
Matched group 4 50%
Experimental group 1 90%
Experimental group 2 91%
Experimental group 3 93%
As seen from the above table, the tyrosinase inhibition rate of experimental group is obviously better than matched group.

Claims (7)

1. a whitening and speckle dispelling skin care compositions, is characterized in that: it is made up of rhEGF, Hamamelis virginiana extracting solution, Exocarpium Benincasae water extract and Aloe glue.
2. a kind of whitening and speckle dispelling skin care compositions according to claim 1, it is characterized in that: with the total restatement of said composition, the percentage by weight of each component is respectively: rhEGF0.01 ~ 0.05%, Hamamelis virginiana extracting solution 20 ~ 40%, Exocarpium Benincasae water extract 35 ~ 50% and Aloe glue composition 20 ~ 30%.
3. a kind of whitening and speckle dispelling skin care compositions according to claim 2, is characterized in that: the percentage by weight of each component is respectively: rhEGF0.03%, Hamamelis virginiana extracting solution 30%, Exocarpium Benincasae water extract 40% and Aloe glue composition 29.97%.
4. whitening and speckle dispelling skin care item, is characterized in that: containing a kind of whitening and speckle dispelling skin care compositions according to any one of claims 1 to 3.
5. a kind of whitening and speckle dispelling skin care item according to claim 4, is characterized in that: the weight content of described whitening and speckle dispelling skin care compositions in these skin care item is 1 ~ 2%.
6. whitening and speckle dispelling skin care item according to claim 5, is characterized in that: the weight content of described whitening and speckle dispelling skin care compositions in these skin care item is 1.5%.
7. the whitening and speckle dispelling skin care item according to any one of claim 4 ~ 6, is characterized in that: it is whitening and spot eliminating cream or whitening and speckle dispelling emulsion.
CN201510725001.7A 2015-10-29 2015-10-29 Skin-whitening, freckle-removing and skin-care composition Pending CN105326682A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510725001.7A CN105326682A (en) 2015-10-29 2015-10-29 Skin-whitening, freckle-removing and skin-care composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510725001.7A CN105326682A (en) 2015-10-29 2015-10-29 Skin-whitening, freckle-removing and skin-care composition

Publications (1)

Publication Number Publication Date
CN105326682A true CN105326682A (en) 2016-02-17

Family

ID=55277594

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510725001.7A Pending CN105326682A (en) 2015-10-29 2015-10-29 Skin-whitening, freckle-removing and skin-care composition

Country Status (1)

Country Link
CN (1) CN105326682A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113813192A (en) * 2021-09-30 2021-12-21 奥易生物科技(杭州)有限公司 Cosmetic for helping skin repair and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101507698A (en) * 2009-03-25 2009-08-19 天津郁美净集团有限公司 Composite with whitening function and skin care product thereof and preparation method thereof
CN102357070A (en) * 2011-11-10 2012-02-22 深圳市金因生物技术有限公司 Hydrolyzed silk protein/ recombinant human Epidermal Growth Factor (rhEGF) compound skin care facial mask and preparation method thereof
CN103070814A (en) * 2012-12-14 2013-05-01 北海黑珍珠海洋生物科技有限公司 Moisturizing and water locking mask liquid and its making technology
CN103316068A (en) * 2013-07-18 2013-09-25 苏州市天灵中药饮片有限公司 Preparation method of exocarpium benincasae aqueous extract
CN104069058A (en) * 2014-07-04 2014-10-01 珠海姗拉娜化妆品有限公司 Composition applied to anti-wrinkle skincare products and preparation method of composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101507698A (en) * 2009-03-25 2009-08-19 天津郁美净集团有限公司 Composite with whitening function and skin care product thereof and preparation method thereof
CN102357070A (en) * 2011-11-10 2012-02-22 深圳市金因生物技术有限公司 Hydrolyzed silk protein/ recombinant human Epidermal Growth Factor (rhEGF) compound skin care facial mask and preparation method thereof
CN103070814A (en) * 2012-12-14 2013-05-01 北海黑珍珠海洋生物科技有限公司 Moisturizing and water locking mask liquid and its making technology
CN103316068A (en) * 2013-07-18 2013-09-25 苏州市天灵中药饮片有限公司 Preparation method of exocarpium benincasae aqueous extract
CN104069058A (en) * 2014-07-04 2014-10-01 珠海姗拉娜化妆品有限公司 Composition applied to anti-wrinkle skincare products and preparation method of composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
牛永宁: "《<本草纲目>家庭养生速查》", 31 March 2015, 浙江科学技术出版社 *
肖子英: "《中国药物化妆品》", 31 March 1992, 中国医药科技出版社 *
陈秋冬: "中等纯度重组人表皮生长因子(rhEGF)的分离纯化及在美容产品中的应用", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技I辑》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113813192A (en) * 2021-09-30 2021-12-21 奥易生物科技(杭州)有限公司 Cosmetic for helping skin repair and preparation method thereof

Similar Documents

Publication Publication Date Title
CN103565728B (en) A kind of black Fructus Lycii whitening skin and preserving moisture toner/smoothing toner and preparation method thereof
CN101873847B (en) Composition for skin external application containing complex of herbal extracts
TWI594766B (en) Collagen production promoter, hyaluronic acid production promoter, fibroblast proliferation promoter and anti-wrinkle agent
CN105213287B (en) The solidifying of a kind of low irritant protects massage mud film and preparation method thereof
FR2985424A1 (en) NEW TOPICAL USE OF ZERUMBON
CN103585097A (en) Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof
CN102421412B (en) Composition containing chamaecyparis obtusa polysaccharides to be externally applied to skin
CN109998937A (en) Serial cosmetics and preparation method thereof containing glycosylglycerol (α GG)
CN110123684A (en) A kind of hair follicle former base tax liquid living and preparation method thereof with anticreep, hair regrowth
CN105476950B (en) Moisturizing foam mildy wash and preparation method thereof
CN107822945A (en) One kind is matched unartificial yeast composition, preparation method and applied in cosmetics
CN105193694A (en) Skin care product with whitening and freckle-removing functions
CN105213270A (en) Whitening spot-eliminating composition
KR20140048700A (en) Natural soap by using of ripen and decocted oriental medicine with the function of making age spots and wrinkles better and manufacturing method thereof
CN102971415B (en) PDGF-BB produces reinforcing agent and the mesenchyme lineage stem cells generation accelerator, stem cell stabilizer and the corium regenerative agent that comprise this reinforcing agent
CN105310972A (en) Anti-wrinkle skin care product
JP2006265120A (en) Collagen synthesis accelerator
CN105326682A (en) Skin-whitening, freckle-removing and skin-care composition
CN105748358A (en) Aquilaria agallocha essence activating lotion and preparation method thereof
CN108186438A (en) A kind of after-sun gel containing Porcine HGF and preparation method thereof
CN107823079A (en) A kind of sea cucumber EGF composition skin-care cosmetics and preparation method thereof
JP2009242310A (en) Involucrin production promoter, transglutaminase-1 production promoter, e-cadherin production promoter and skin care preparation for external use for making skin pore inconspicuous
CN105250176A (en) Skin-protecting composition with effects of whitening and removing speckles
CN105213294A (en) There is the skin care compositions of skin effect of compacting
CN105193676A (en) Acne removing composition

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20160217