CN105326672B - Selenium disulfide debris removing hair conditioner and preparation method thereof - Google Patents
Selenium disulfide debris removing hair conditioner and preparation method thereof Download PDFInfo
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- CN105326672B CN105326672B CN201510882669.2A CN201510882669A CN105326672B CN 105326672 B CN105326672 B CN 105326672B CN 201510882669 A CN201510882669 A CN 201510882669A CN 105326672 B CN105326672 B CN 105326672B
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention discloses selenium disulfide debris removing hair conditioner and preparation method thereof, belong to hair conditioner field.Excitant be present the invention solves existing selenium disulfide lotion easily makes hair dry and astringent greatly, after use, is not easy the technological deficiency combed.Selenium sulfide debris removing hair conditioner of the present invention is by selenium disulfide composite superfine powder body, lanolin, hexadecanol, octadecyl alcolol, vaseline, chitosan, 10% formic acid：0.5%~1.0%, made of dimethyl amine oxide, soluble perfume and deionized water；Selenium disulfide composite superfine powder particle diameter is 1 μm~50 μm.Method, one, prepare oil phase and aqueous phase respectively；2nd, oil phase, aqueous phase are subjected to emulsifying；3rd, selenium disulfide composite superfine powder body is added, continues stirring 20 minutes, that is, obtains selenium disulfide debris removing hair conditioner.The product excitant of the present invention is small, and hair easily combs, be submissive glossy；And product dispersiveness is homogeneous, stable performance.
Description
Technical field
The invention belongs to hair conditioner field；More particularly to selenium disulfide debris removing hair conditioner and preparation method thereof
Background technology
Selenium disulfide lotion is the externally applied drug copied from foreign countries the nineties, and like product is exactly the graceful of Abbott Laboratories of the U.S.
Lotion.Because the partial supplementary material country of lotion at that time can not copy, therefore in imitated lotion, when accessory formula is by the nineties at that time
The shampoo and milky lotion basic components of phase are compound and are made.In the period nineties at that time, selenium disulfide lotion no matter its product
Formulation, accessory formula, or selenium disulfide micronizing production Technology is all more advanced, is a kind of debris removing, anti-true
Bacterium, the external-use lotion new drug of anti-dandruff dermatitis.
With the development of industrial technology, ultra micro efflorescence New technical use, hair washing, hair products develop rapidly, Yi Jiji
The real information that the clinical practice of selenium disulfide lotion is fed back over 10 years.It is clear that recognize, selenium disulfide lotion of today,
Because being limited by drug registration regulation, its product accessory formula, technique are in the level nineties.Although its product is dispelled
Bits, antimycotic, treatment seborrhea curative effect are affirmed, but there is also many defects and deficiency, are now such as arranged as follows：
First, although product forms name is lotion, the product is exactly supensoid agent in fact.Because selenium disulfide medicinal powder does not dissolve
In Medium Culture, it is suspended in matrix.Because selenium disulfide lotion base auxiliary material and medicinal powder selenium disulfide particle are big (50-200um)
The problems such as, so, the scattered homogeneity of selenium disulfide medicinal powder is poor, suspends unstable, causes drug adhesion scalp inhomogeneities so that
Topical drug's position dose aggregation, easy cleaning, does not damage hair easily (hair bleaches).Second, due to lotion excipient matrix
In containing only detergent surfactant composition, active component of not taking care of hair well, and select detergent surfactant be all
The cleaning product in the period nineties, these detergent surfactants easily do hair because excitant is not big, gentle after hair washing
The shortcomings of puckery, nowadays all eliminated by industry.3rd, clinic feedback：After most patients use selenium disulfide lotion, head
Send out adhesion easy, not easy cleaning, cardability is poor, and hair bleaches.4th, lotion specification " application method "：Rinsed after use dry
Only, it is unrealistic then with " soap " to clean hair formulation；In fact, nowadays people have not had to " soap " cleaning hair, all use
Shampoo, hair cream substitute soap and had one's hair wash；Therefore, lotion specification needs to correct.Most patients unanimously think：Use lotion
Afterwards, it is necessary to relatively good after being cleaned once with hair shampoo articles such as shampoo or hair cream again.
Selenium disulfide lotion, treatment function is exactly to remove fungi dandruff dispelling.Its drug effect is exactly mainly dandruff dispelling, and treatment skin is true
Microbial various skin infections.Selenium disulfide excessively has significantly to dandruff caused by fungus-caused seborrhea really
Therapeutic effect, moreover, its debris removing drug effect is better than ketoconazole.
Selenium disulfide lotion debris removing drug effect does not have the main reason for real domestic consumer recognizes and received：Two domestic sulphur
There are many defects in the formula and production technology for changing selenium lotion, without the graceful curing for truly copying Abbott Laboratories of the good U.S.
Selenium lotion so that the product no matter in organoleptic attribute or in safe handling, produces with external graceful product with graceful lotion
Condition ratio, there is very big difference, and this just creates the main reason for product is not approved by compatriots.
Former lotion formulation selects medium ball milling selenium disulfide medicinal powder, because particle is big (50-200um), excipient matrix is again
Supensoid agent, therefore medicinal powder particle dispersion is poor, excess is easily assembled by inhomogeneity, local application, increases selenium disulfide medicine
The risk of toxic side effect；As patient is bleached using rear hair.
Because containing detergent active (ethoxylated alkyl sulfate, alkanolamide, N~oleoyl in existing former lotion formulation
Base~N~N-methyltaurine sodium etc.), monoglyceride, octadecyl alcolol and hexadecanol etc. easily cause hair adhesion, be not easy the hair washing combed
Active component so that after lotion product use, the easy adhesion of hair, it is not easy to clean up, be not easy to the true cause combed,
And excitant is big.
Consumer is finally allowed to lose the confidence such product for these reasons, here it is result in nowadays selenium disulfide to wash
The main reason for agent can not popularize.
The content of the invention
Excitant be present the invention solves existing selenium disulfide lotion easily makes hair dry and astringent greatly, after use, is not easy to comb
The technological deficiency of reason；And provide selenium disulfide debris removing hair conditioner and preparation method thereof.
In order to solve the above technical problems, selenium disulfide debris removing hair conditioner is by following raw materials by mass percentage in the present invention
It is manufactured：
Selenium disulfide composite superfine powder body：1.5%~2.5%
Lanolin：0.5%~1.5%
Hexadecanol：1.5%~2.5.0%
Octadecyl alcolol：1.5%~2.5%
Vaseline：1.0%~2.0%
Chitosan：0.2%~0.5%
10% (quality) formic acid (aqueous formic acid that i.e. mass fraction is 10%)：0.5%~1.0%
Dimethyl amine oxide (OB-2):1.5%~2.5%
Soluble perfume：0.2%~0.5%
Surplus is deionized water；
Wherein, the selenium disulfide composite superfine powder particle diameter is 1 μm~50 μm.
The selenium disulfide composite superfine powder body is by selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade
Glycerine presses 1:1:2:Made of 3 mass ratio；It is made of operations described below：By selenium disulfide dry powder, purified water, pharmaceutical grade titanium
White powder and pharmaceutical grade glycerine are well mixed, and then add citron acid for adjusting pH value between 3.5~4.5；It is subsequently placed in grinding type
In micronizer, the 30~60min of crushing that mills is carried out in power 1.5kW, speed of mainshaft 1500r/min, that is, has obtained two sulphur
Change selenium ultrafine powder.
The preparation method of selenium disulfide debris removing hair conditioner is carried out in the steps below in the present invention：
Step 1: lanolin, hexadecanol, octadecyl alcolol and vaseline are mixed, 100 DEG C are heated to, is incubated 10~20 minutes,
65~70 DEG C are cooled to, obtains oil phase,
Chitosan, 10% formic acid, dimethyl amine oxide, essence and deionized water are mixed simultaneously, added
Heat is incubated 10~20 minutes, is cooled to 65~70 DEG C, obtains aqueous phase to 100 DEG C；
Step 2: aqueous phase first is put into homogeneous retort, scraper plate agitator is opened, rotating speed is in 10-60 revs/min of scope
Interior, then oil phase is slowly added in aqueous phase, after continuing stirring 5 minutes, closes scraper plate agitator.Open homogeneous switch (homogeneous bar
Part is：Vacuum is -0.09Mpa, rotating speed is 2800 revs/min), carry out emulsifying 30-40 minutes；
Step 3: being then cooled to 35-40 DEG C, the scraper plate agitator in homogeneous retort is opened, scraper plate agitator turns
Speed control adds selenium disulfide composite superfine powder body at 10~60 revs/min, continues stirring 20 minutes, that is, obtains selenium disulfide
Debris removing hair conditioner.
Fragrance can customize fragrance according to product special circumstances；For example, (rose fragrant, jasmin, international style perfume (or spice) etc.).
The selenium disulfide debris removing hair conditioner of the present invention, turns into ultrafine powder or medium ball milling powder body using selenium disulfide,
It is attained by main ingredient selenium disulfide medicinal powder and disperses homogeneity and suspension stability in excipient matrix, improves the drug effect work(of product
Can, reduce uneven, the side effect of hair damages caused by medicine localized clusters because of medicine；Playing debris removing drug effect simultaneously,
Selenium disulfide toxic side effect is reduced, while takes good care of hair, solves the defects of original product lotion hair adhesion, be not easy to comb.
The present invention with selenium disulfide composite superfine powder body (or medium ball milling powder body) for main medicine, 1.5- containing selenium disulfide
2.5%.It is matrix that auxiliary material, which is equipped with hair conditioner, the selenium disulfide debris removing hair conditioner that routinely production technology is prepared.
The present invention solves selenium disulfide lotion and is not easy to clean after, easily damages hair, using the tacky company in back not
The shortcomings that easily combing；And selenium disulfide toxic side effect is reduced, improves safe medication；The product of the present invention is because making for hair conditioner
It is identical with lotion application method with method, therefore, selenium disulfide debris removing hair conditioner play the hair care of hair conditioner, hair care easily combs
While function, debris removing, the therapeutic action of antimycotic, anti-dandruff dermatitis of selenium disulfide medicine have also been given full play to.
Using modern Ultramicro-powder mechanical technique, with wet milling process, setting Ultramicro-powder machinery micro powder granule is at 1-20 μm
Scope；The selenium disulfide composite superfine powder body finally given is that one kind can substitute traditional sucrose ball milling selenium disulfide composite micro-powder
Body, it can be added in the matrix of selenium disulfide lotion.
Improve the inherent quality of selenium disulfide lotion；Composite superfine powder body particle diameter (1-50 μm) is than traditional ball milling powder body
Small 100 times or so of particle diameter (50~200 μm)；Scattered homogeneity, stability in lotion base is more preferable than ball milling powder body；With
Former technique is compared, and simplifies technique, shortens the production time, improves production efficiency, also reduces production cost, is easily applied to
Industrialization.
Selenium disulfide debris removing hair conditioner prepared by the present invention, modern gentle hair conditioner matrix formulations are applied, from two
Selenium sulfide ultrafine powder, not only solve selenium disulfide particle and disperse inhomogeneity, the technical problem of stability difference, even more solve
Hair adhesion, the shortcomings that being not easy to comb.Really play selenium disulfide debris removing and hair conditioner hair care, the double effects of hair care.Two
Auxiliary material is changed over hair conditioner agent by Selsun Blue, its debris removing, hair care, it is antimycotic and treatment seborrhea the effect of can play
To optimum state, and the product excitant of the present invention is small, and hair easily combs, be submissive glossy, can more be dispelled by vast needs
Bits, hair care consumer receive and favor.
Embodiment
Selenium disulfide debris removing hair conditioner is by following raw materials by mass percentage in embodiment one, present embodiment
It is manufactured：
Selenium disulfide composite superfine powder body：2.0%
Lanolin：1.0%
Hexadecanol：2.0%
Octadecyl alcolol：2.0%
Vaseline：1.5%
Chitosan：0.3%
10% (quality) formic acid：0.7%
Dimethyl amine oxide (OB-2):2.0%
Soluble perfume：0.2%
Surplus is deionized water.
Wherein the particle diameter of selenium disulfide ultrafine powder is 10 μm, and its preparation method is carried out in the steps below：
Selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine are well mixed, then add citric acid
PH value is adjusted between 3.5~4.5；It is subsequently placed in grinding type micronizer, in power 1.5kW, speed of mainshaft 1500r/
Min, which mill, crushes 30min, sieving, that is, has obtained selenium disulfide ultrafine powder；Wherein selenium disulfide dry powder, purified water, doctor
The mass ratio of medicine level titanium dioxide and pharmaceutical grade glycerine is 1:1:2:3.
The preparation method of selenium disulfide debris removing hair conditioner is carried out in the steps below in present embodiment：
Step 1: lanolin, hexadecanol, octadecyl alcolol and vaseline are mixed, 100 DEG C are heated to, is incubated 20 minutes, cooling
To 65-70 DEG C, oil phase is obtained,
Chitosan, 10% formic acid, dimethyl amine oxide, essence and deionized water are mixed simultaneously, added
Heat is incubated 20 minutes, is cooled to 65-70 DEG C, obtains aqueous phase to 100 DEG C；
Step 2: aqueous phase first is put into homogeneous retort, scraper plate agitator is opened, rotating speed is in 10-60 revs/min of scope
Interior, then oil phase is slowly added in aqueous phase, after continuing stirring 5 minutes, closes scraper plate agitator.Open homogeneous switch (homogeneous bar
Part is：Vacuum is -0.09Mpa, rotating speed is 2800 revs/min), carry out emulsifying 30-40 minutes；
Step 3: being then cooled to 35 DEG C, the scraper plate agitator in homogeneous retort, the rotating speed control of scraper plate agitator are opened
System adds selenium disulfide composite superfine powder body at 50 revs/min, continues stirring 20 minutes, that is, obtains selenium disulfide debris removing hair care
Element.
Present embodiment be made selenium disulfide debris removing hair conditioner it is dispersed it is homogeneous, stability is good, by 6 monthly output qualities
Measure acceleration and investigate experiment, the quality of product is stability, meets target level of product quality.
Easily combed using present embodiment product maintenance hair, be submissive glossy.
Claims (6)
1. selenium disulfide debris removing hair conditioner, it is characterised in that selenium disulfide debris removing hair conditioner is by following raw materials by mass percentage
It is manufactured：
Selenium disulfide composite superfine powder body：1.5%~2.5%
Lanolin：0.5%~1.5%
Hexadecanol：1.5%~2.5%
Octadecyl alcolol：1.5%~2.5%
Vaseline：1.0%~2.0%
Chitosan：0.2%~0.5%
10% (quality) formic acid：0.5%~1.0%
Dimethyl amine oxide (OB-2)：1.5%~2.5%
Soluble perfume：0.2%~0.5%
Surplus is deionized water；
Wherein, the selenium disulfide composite superfine powder particle diameter is 1 μm~50 μm；
The selenium disulfide composite superfine powder body is by selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine
By 1:1:2:Made of 3 mass ratio.
2. selenium disulfide debris removing hair conditioner according to claim 1, it is characterised in that selenium disulfide debris removing hair conditioner presses matter
It is made of following raw materials to measure percentage：
Selenium disulfide composite superfine powder body：2.0%
Lanolin：1.0%
Hexadecanol：2.0%
Octadecyl alcolol：2.0%
Vaseline：1.5%
Chitosan：0.3%
10% (quality) formic acid：0.7%
Dimethyl amine oxide:2.0%
Soluble perfume：0.2%
Surplus is deionized water.
3. selenium disulfide debris removing hair conditioner according to claim 1, it is characterised in that the grain of selenium disulfide composite superfine powder body
Footpath is 5 μm~30 μm.
4. selenium disulfide debris removing hair conditioner according to claim 1, it is characterised in that the grain of selenium disulfide composite superfine powder body
Footpath is 10 μm.
5. selenium disulfide debris removing hair conditioner according to claim 1, it is characterised in that the selenium disulfide composite superfine powder body
It is made of operations described below：Selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine are well mixed, so
Citron acid for adjusting pH value is added afterwards between 3.5~4.5；It is subsequently placed in grinding type micronizer, in power 1.5kW, master
Rotating speed 1500r/min carries out the 30~60min of crushing that mills, that is, has obtained selenium disulfide ultrafine powder.
6. the preparation method of selenium disulfide debris removing hair conditioner as claimed in claim 1, it is characterised in that selenium disulfide debris removing is protected
The preparation method of hair element is carried out in the steps below：
Step 1: lanolin, hexadecanol, octadecyl alcolol and vaseline are mixed, 100 DEG C are heated to, is incubated 10~20 minutes, cooling
To 65~70 DEG C, oil phase is obtained,
Chitosan, 10% formic acid, dimethyl amine oxide, essence and deionized water are mixed simultaneously, are heated to
100 DEG C, 10~20 minutes are incubated, 65~70 DEG C is cooled to, obtains aqueous phase；
Step 2: aqueous phase first is put into homogeneous retort, scraper plate agitator is opened, rotating speed is in the range of 10~60 revs/min, so
Oil phase is slowly added in aqueous phase afterwards, after continuing stirring 5 minutes, closes scraper plate agitator, homogeneous switch is opened, in vacuum
Emulsifying 30~40 minutes is carried out under the conditions of being 2800 revs/min for -0.09Mpa, rotating speed；
Step 3: being then cooled to 35~40 DEG C, the scraper plate agitator in homogeneous retort, the rotating speed control of scraper plate agitator are opened
System adds selenium disulfide composite superfine powder body at 10~60 revs/min, continues stirring 20 minutes, that is, obtains selenium disulfide debris removing
Hair conditioner.
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| CN112812906A (en) * | 2021-01-22 | 2021-05-18 | 王建功 | Shampoo soap containing selenium sulfide plant extract and preparation method and application thereof |
| CN114010514B (en) * | 2021-10-08 | 2022-10-14 | 张志昂 | Antifungal selenium disulfide lotion composition |
| CN114452228B (en) * | 2022-04-14 | 2022-06-21 | 新基元(北京)医药科技有限公司 | Selenium disulfide foaming agent for hair washing and preparation method thereof |
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| Title |
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| 二硫化硒洗剂在真菌病治疗中的应用;王季尧等;《中国医疗美容》;20140430(第4期);第102-103页 * |
| 原子荧光光谱法测定二硫化硒洗剂中硒的含量;刘彦刚等;《中国药事》;20121020(第10期);第1105-1106,1118页 * |
| 超微粉碎技术的应用现状与发展趋势;谢瑞红等;《中国粉体技术》;20090615;第15卷(第3期);第64-67页 * |
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